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公开(公告)号：US20110162095A1
公开(公告)日：2011-06-30
申请号：US13055109
申请日：2009-07-18
IPC分类号： C07K19/00 , C07H21/00 , C12N5/10 , C12N1/00 , A01K67/00 , A61K38/19 , A61P29/00 , A61P35/00 , A61P31/00 , A61P37/06 , A61P3/00 , A61P19/02 , A61P25/28
CPC分类号： C07K14/525 , A61K38/00 , C07K14/70575 , C07K14/70578 , C07K16/00 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/22 , C07K2319/30 , C07K2319/32 , C07K2319/35 , C07K2319/74 , C12N15/62 , C12N15/79
摘要： The present invention refers to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and nucleic acid molecules encoding these fusion proteins. The fusion proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
摘要翻译： 本发明涉及包含三种可溶性TNF超家族（TNFSF）细胞因子结构域和编码这些融合蛋白的核酸分子的单链融合蛋白。 融合蛋白基本上非聚集并且适用于治疗，诊断和/或研究应用。
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公开(公告)号：US20090324616A1
公开(公告)日：2009-12-31
申请号：US12306070
申请日：2007-06-21
IPC分类号： A61K39/395 , G01N33/574 , C12Q1/68 , C07K2/00 , C07H21/04 , A61P35/00
CPC分类号： G01N33/57484 , G01N33/6863
摘要： The invention concerns a method for diagnosing a cancer type, whereby the expression of anti-apoptotic cytokines is determined in the tumour cells. The differential diagnosis of the present invention is used to classify tumour disorders and to recommend the required treatment and to monitor the progress and response to the treatment.
摘要翻译： 本发明涉及一种用于诊断癌症类型的方法，由此在肿瘤细胞中测定抗凋亡细胞因子的表达。 本发明的鉴别诊断用于分类肿瘤病症并推荐所需治疗并监测治疗的进展和反应。
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公开(公告)号：US08580273B2
公开(公告)日：2013-11-12
申请号：US13403826
申请日：2012-02-23
IPC分类号： A61K39/00 , A61K38/00 , C07K14/525 , C12N15/00
CPC分类号： C07K14/525 , C07K14/70575 , C07K2319/73
摘要： The present invention refers to fusion proteins comprising a TNF superfamily (TNFSF) cytokine or a receptor binding domain thereof fused to a trimerization domain and a nucleic acid molecule encoding the fusion protein. The fusion protein is present as a trimeric complex or as an oligomer thereof and is suitable for therapeutic, diagnostic and/or research applications.
摘要翻译： 本发明涉及融合蛋白质，其包含融合到三聚结构域的TNF超家族（TNFSF）细胞因子或其受体结合结构域和编码融合蛋白的核酸分子。 融合蛋白以三聚体复合物或其低聚物形式存在，并且适用于治疗，诊断和/或研究应用。
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公开(公告)号：US20100199364A1
公开(公告)日：2010-08-05
申请号：US12668188
申请日：2008-07-10
IPC分类号： A01K67/00 , C07K14/525 , C07H21/00 , C12N15/74 , C12N5/10
CPC分类号： C07K14/70575 , C07K14/42 , C07K14/47 , C07K14/4726 , C07K14/525 , C07K19/00 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/22 , C07K2319/32 , C07K2319/70 , C12N15/62
摘要： The present invention refers to a fusion protein comprising a TNF-superfamily (TNFSF) cytokine or a receptor binding domain thereof fused to a collectin trimerization domain, to a nucleic acid molecule encoding the fusion protein, and to a cell comprising the nucleic acid molecule. The fusion protein is present as a trimeric complex or as an oligomer thereof. The fusion protein, the nucleic acid, and the cell is suitable as pharmaceutical composition or for therapeutic, diagnostic and/or research applications.
摘要翻译： 本发明涉及包含与收集蛋白三聚结构域融合的TNF-超家族（TNFSF）细胞因子或其受体结合结构域的融合蛋白，编码融合蛋白的核酸分子以及包含该核酸分子的细胞。 融合蛋白以三聚体或其低聚物的形式存在。 融合蛋白，核酸和细胞适合作为药物组合物或用于治疗，诊断和/或研究应用。
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公开(公告)号：US08664366B2
公开(公告)日：2014-03-04
申请号：US13143531
申请日：2009-01-09
CPC分类号： C07K14/525 , C07K7/06 , C07K14/00 , C07K14/4726 , C07K14/70575 , C07K16/00 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/70 , C12N15/62
摘要： The present invention refers to fusion proteins comprising a neck region and carbohydrate recognition domain of a collectin trimerization domain, a linker element and an effector polypeptide. Further the invention refers to a nucleic acid encoding the said fusion protein. The fusion proteins, the nucleic acid, and the cell are suitable as pharmaceutical composition or for therapeutic, diagnostic and/or research applications as described herein.
摘要翻译： 本发明涉及包含收集蛋白三聚体结构域的颈部区域和碳水化合物识别结构域，连接子元件和效应子多肽的融合蛋白。 此外，本发明涉及编码所述融合蛋白的核酸。 融合蛋白，核酸和细胞适合作为药物组合物或本文所述的治疗，诊断和/或研究应用。
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公开(公告)号：US08147843B2
公开(公告)日：2012-04-03
申请号：US12439486
申请日：2007-08-28
IPC分类号： A61K39/00 , A61K38/00 , C07K14/525 , C12N15/00
CPC分类号： C07K14/525 , C07K14/70575 , C07K2319/73
摘要： The present invention refers to fusion proteins comprising a TNF superfamily (TNFSF) cytokine or a receptor binding domain thereof fused to a trimerization domain and a nucleic acid molecule encoding the fusion protein. The fusion protein is present as a trimeric complex or as an oligomer thereof and is suitable for therapeutic, diagnostic and/or research applications.
摘要翻译： 本发明涉及融合蛋白质，其包含融合到三聚结构域的TNF超家族（TNFSF）细胞因子或其受体结合结构域和编码融合蛋白的核酸分子。 融合蛋白以三聚体复合物或其低聚物形式存在，并且适用于治疗，诊断和/或研究应用。
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7.发明申请BINDING AGENTS DIRECTED AGAINST IL-4 RECEPTOR FOR THE TREATMENT OF TUMORS, INFLAMMATORY AND IMMUNOLOGICAL DISORDERS 审中-公开针对治疗肿瘤，炎症和免疫疾病的IL-4受体指导的结合剂公开(公告)号：US20110008326A1
公开(公告)日：2011-01-13
申请号：US12922433
申请日：2009-03-30
IPC分类号： A61K39/395 , C07K16/28 , A61P11/06 , A61P35/00 , A61P37/00 , A61P29/00 , A61P19/02 , A61P31/06 , A61P17/00
CPC分类号： C07K16/2866 , A61K45/06 , A61K2039/505 , C07K16/247 , C07K2317/24 , C07K2317/31 , C07K2317/34
摘要： The present invention relates to the use of an antigen-binding agent directed against human interleukin-4 receptor for the prevention and/or treatment of tumors, inflammatory and immunological disorders. Further the invention relates to methods of inhibiting the bioactivity of IL-4 without inhibiting binding of IL-4 to IL-4R and particularly to methods for treatment and/or prevention of tumors, inflammatory and immunological disorders, the methods comprising administering to an individual in need thereof an antigen-binding agent with binding affinity for IL-4R.
摘要翻译： 本发明涉及针对人白细胞介素-4受体的抗原结合剂用于预防和/或治疗肿瘤，炎症和免疫疾病的用途。 此外，本发明涉及抑制IL-4的生物活性而不抑制IL-4与IL-4R的结合的方法，特别涉及用于治疗和/或预防肿瘤，炎症和免疫学疾病的方法，所述方法包括对个体施用 需要其具有对IL-4R具有结合亲和力的抗原结合剂。
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公开(公告)号：US08450460B2
公开(公告)日：2013-05-28
申请号：US13055109
申请日：2009-07-18
IPC分类号： C07K1/00 , C07K14/00 , C07K17/00 , C12P21/06 , C12N1/20 , C12N15/00 , C12N5/00 , C12N5/02 , C12N15/74 , C07H21/04
CPC分类号： C07K14/525 , A61K38/00 , C07K14/70575 , C07K14/70578 , C07K16/00 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/22 , C07K2319/30 , C07K2319/32 , C07K2319/35 , C07K2319/74 , C12N15/62 , C12N15/79
摘要： The present invention refers to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and nucleic acid molecules encoding these fusion proteins. The fusion proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
摘要翻译： 本发明涉及包含三种可溶性TNF超家族（TNFSF）细胞因子结构域和编码这些融合蛋白的核酸分子的单链融合蛋白。 融合蛋白基本上非聚集并且适用于治疗，诊断和/或研究应用。
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公开(公告)号：US08383774B2
公开(公告)日：2013-02-26
申请号：US12668188
申请日：2008-07-10
IPC分类号： C07K1/00 , C07K14/00 , C07K17/00 , C07K16/00 , C12P21/06 , C12N1/20 , C12N15/00 , C12N5/00 , C12N5/02 , C12N15/74 , C07H21/04
CPC分类号： C07K14/70575 , C07K14/42 , C07K14/47 , C07K14/4726 , C07K14/525 , C07K19/00 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/22 , C07K2319/32 , C07K2319/70 , C12N15/62
摘要： The present invention refers to a fusion protein comprising a TNF-superfamily (TNFSF) cytokine or a receptor binding domain thereof fused to a collectin trimerization domain, to a nucleic acid molecule encoding the fusion protein, and to a cell comprising the nucleic acid molecule. The fusion protein is present as a trimeric complex or as an oligomer thereof. The fusion protein, the nucleic acid, and the cell is suitable as pharmaceutical composition or for therapeutic, diagnostic and/or research applications.
摘要翻译： 本发明涉及包含与收集蛋白三聚结构域融合的TNF-超家族（TNFSF）细胞因子或其受体结合结构域的融合蛋白，编码融合蛋白的核酸分子以及包含该核酸分子的细胞。 融合蛋白以三聚体或其低聚物的形式存在。 融合蛋白，核酸和细胞适合作为药物组合物或用于治疗，诊断和/或研究应用。
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公开(公告)号：US20120148527A1
公开(公告)日：2012-06-14
申请号：US13403826
申请日：2012-02-23
IPC分类号： A61K38/16 , C12N15/62 , A61P35/00 , A61P31/00 , A61P29/00 , C12N5/10 , A61P37/00 , A61P19/02 , A61P25/00 , C12N15/63 , C12N1/21 , C12N1/19 , C07K19/00 , A61P3/00
CPC分类号： C07K14/525 , C07K14/70575 , C07K2319/73
摘要： The present invention refers to fusion proteins comprising a TNF superfamily (TNFSF) cytokine or a receptor binding domain thereof fused to a trimerization domain and a nucleic acid molecule encoding the fusion protein. The fusion protein is present as a trimeric complex or as an oligomer thereof and is suitable for therapeutic, diagnostic and/or research applications.
摘要翻译： 本发明涉及融合蛋白质，其包含融合到三聚结构域的TNF超家族（TNFSF）细胞因子或其受体结合结构域和编码融合蛋白的核酸分子。 融合蛋白以三聚体复合物或其低聚物形式存在，并且适用于治疗，诊断和/或研究应用。
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