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公开(公告)号:US20100056553A1
公开(公告)日:2010-03-04
申请号:US12487503
申请日:2009-06-18
申请人: Oliver PLETTENBURG , Katrin LORENZ , Jochen GOERLITZER , Matthias Löhn , Sandrine BISCARRAT , Fréderic JEANNOT , Olivier DUCLOS
发明人: Oliver PLETTENBURG , Katrin LORENZ , Jochen GOERLITZER , Matthias Löhn , Sandrine BISCARRAT , Fréderic JEANNOT , Olivier DUCLOS
CPC分类号: C07D217/24
摘要: The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译: 本发明涉及用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式(I)的6-取代异喹啉和异喹啉酮衍生物, 化合物。
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公开(公告)号:US20100056566A1
公开(公告)日:2010-03-04
申请号:US12487409
申请日:2009-06-18
IPC分类号: A61K31/4725 , C07D401/02
CPC分类号: C07D401/12 , C07D401/14 , C07D405/14 , C07D451/06
摘要: The invention relates to 6-substituted isoquinoline and isochinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译: 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式(I)的6-取代异喹啉和异诺酮酮衍生物, 化合物。
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公开(公告)号:US20100056518A1
公开(公告)日:2010-03-04
申请号:US12487479
申请日:2009-06-18
申请人: Oliver PLETTENBURG , Armin HOFMEISTER , Katrin LORENZ , Joachim BRENDEL , Matthias Löhn , John Weston
发明人: Oliver PLETTENBURG , Armin HOFMEISTER , Katrin LORENZ , Joachim BRENDEL , Matthias Löhn , John Weston
IPC分类号: A61K31/5377 , C07D217/22 , A61K31/47 , C07D413/02 , C07D403/02 , A61K31/496 , A61P9/00 , A61P25/00 , A61P37/00 , A61P3/00
CPC分类号: C07D217/24 , C07D401/12
摘要: The invention relates to 6-substituted isoquinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译: 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式(I)的6-取代的异喹诺酮衍生物和含有这些化合物的组合物。
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公开(公告)号:US20130109715A1
公开(公告)日:2013-05-02
申请号:US13715111
申请日:2012-12-14
IPC分类号: C07D417/12 , C07D409/12 , C07D405/12 , C07D217/24 , C07D217/02
CPC分类号: C07D417/12 , C07D217/02 , C07D217/22 , C07D217/24 , C07D405/12 , C07D409/12
摘要: The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) t,21useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译: 本发明涉及式(I)t,21的6-取代异喹啉和异喹啉酮衍生物,其用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化相关的疾病,以及 含有这些化合物的组合物。
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公开(公告)号:US20110190339A1
公开(公告)日:2011-08-04
申请号:US12970376
申请日:2010-12-16
IPC分类号: A61K31/472 , C07D405/12 , A61K31/4725 , C07D217/24 , C07D217/02 , C07D409/12 , C07D417/12 , A61P25/24 , A61P25/08 , A61P9/10 , A61P35/00 , A61P15/10 , A61P1/16 , A61P11/00 , A61P9/12 , A61P3/10 , A61P25/28 , A61P3/04 , A61P7/02
CPC分类号: C07D417/12 , C07D217/02 , C07D217/22 , C07D217/24 , C07D405/12 , C07D409/12
摘要: The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译: 本发明涉及用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式(I)的6-取代异喹啉和异喹啉酮衍生物, 化合物。
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