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公开(公告)号:US08710077B2
公开(公告)日:2014-04-29
申请号:US12487503
申请日:2009-06-18
申请人: Oliver Plettenburg , Katrin Lorenz , Jochen Goerlitzer , Matthias Löhn , Sandrine Biscarrat , Fréderic Jeannot , Olivier Duclos
发明人: Oliver Plettenburg , Katrin Lorenz , Jochen Goerlitzer , Matthias Löhn , Sandrine Biscarrat , Fréderic Jeannot , Olivier Duclos
IPC分类号: A61K31/47 , C07D217/00
CPC分类号: C07D217/24
摘要: The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译: 本发明涉及用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式(I)的6-取代异喹啉和异喹啉酮衍生物, 化合物。