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公开(公告)号:US20100324052A1
公开(公告)日:2010-12-23
申请号:US12855016
申请日:2010-08-12
申请人: Olivier Bezencon , Christoph Boss , Daniel Bur , Austin Chih-Yu Chen , Olivier Corminboeuf , Daniel Dube , Walter Fischli , Corinna Grisostomi , Lubos Remen , Sylvia Richard-Bildstein , Thierry Sifferlen , Michel Therien , Thomas Weller
发明人: Olivier Bezencon , Christoph Boss , Daniel Bur , Austin Chih-Yu Chen , Olivier Corminboeuf , Daniel Dube , Walter Fischli , Corinna Grisostomi , Lubos Remen , Sylvia Richard-Bildstein , Thierry Sifferlen , Michel Therien , Thomas Weller
IPC分类号: A61K31/504 , C07D471/08 , A61P9/00 , A61P13/12 , C07D211/60 , A61K31/451 , C07D213/81 , A61K31/444
CPC分类号: C07D471/08 , C07D211/78 , C07D401/10 , C07D401/12
摘要: The invention relates to novel piperidine carboxylic acid amide derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of these novel compounds, pharmaceutical compositions comprising such compounds and especially the use of such compounds as inhibitors of renin.
摘要翻译: 本发明涉及新型的哌啶羧酸酰胺衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备这些新化合物的方法,包含这些化合物的药物组合物,特别是使用这些化合物作为肾素抑制剂的相关方面。
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公开(公告)号:US07799805B2
公开(公告)日:2010-09-21
申请号:US11915594
申请日:2006-05-23
申请人: Olivier Bezencon , Christoph Boss , Daniel Bur , Austin Chih-Yu Chen , Olivier Corminboeuf , Daniel Dube , Walter Fischli , Corinna Grisostomi , Lubos Remen , Sylvia Richard-Bildstein , Thierry Sifferlen , Michel Therien , Thomas Weller
发明人: Olivier Bezencon , Christoph Boss , Daniel Bur , Austin Chih-Yu Chen , Olivier Corminboeuf , Daniel Dube , Walter Fischli , Corinna Grisostomi , Lubos Remen , Sylvia Richard-Bildstein , Thierry Sifferlen , Michel Therien , Thomas Weller
IPC分类号: A01N43/40 , A61K31/445 , C07D211/68 , C07D211/80 , C07D213/02
CPC分类号: C07D471/08 , C07D211/78 , C07D401/10 , C07D401/12
摘要: The invention relates to novel piperidine carboxylic acid amide derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of these novel compounds, pharmaceutical compositions comprising such compounds and especially the use of such compounds as inhibitors of renin.
摘要翻译: 本发明涉及新型的哌啶羧酸酰胺衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备这些新化合物的方法,包含这些化合物的药物组合物,特别是使用这些化合物作为肾素抑制剂的相关方面。
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公开(公告)号:US20080214598A1
公开(公告)日:2008-09-04
申请号:US11915594
申请日:2006-05-23
申请人: Olivier Bezencon , Christoph Boss , Daniel Bur , Austin Chih-Yu Chen , Olivier Corminboeuf , Daniel Dube , Walter Fischli , Corinna Grisostomi , Lubos Remen , Sylvia Richard-Bildstein , Thierry Sifferlen , Michel Therien , Thomas Weller
发明人: Olivier Bezencon , Christoph Boss , Daniel Bur , Austin Chih-Yu Chen , Olivier Corminboeuf , Daniel Dube , Walter Fischli , Corinna Grisostomi , Lubos Remen , Sylvia Richard-Bildstein , Thierry Sifferlen , Michel Therien , Thomas Weller
IPC分类号: A61K31/4375 , C07D471/02 , A61P9/10 , A61P9/12 , A61P13/12
CPC分类号: C07D471/08 , C07D211/78 , C07D401/10 , C07D401/12
摘要: The invention relates to novel piperidine carboxylic acid amide derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of these novel compounds, pharmaceutical compositions comprising such compounds and especially the use of such compounds as inhibitors of renin.
摘要翻译: 本发明涉及新型的哌啶羧酸酰胺衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备这些新化合物的方法,包含这些化合物的药物组合物,特别是使用这些化合物作为肾素抑制剂的相关方面。
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公开(公告)号:US07968720B2
公开(公告)日:2011-06-28
申请号:US12223597
申请日:2007-01-31
申请人: Olivier Bezencon , Daniel Bur , Olivier Corminboeuf , Daniel Dube , Corinna Grisostomi , Dwight MacDonald , Dan McKay , David Powell , Lubos Remen , Sylvia Richard-Bildstein , John Scheigetz , Michel Therien , Thomas Weller
发明人: Olivier Bezencon , Daniel Bur , Olivier Corminboeuf , Daniel Dube , Corinna Grisostomi , Dwight MacDonald , Dan McKay , David Powell , Lubos Remen , Sylvia Richard-Bildstein , John Scheigetz , Michel Therien , Thomas Weller
IPC分类号: C07D221/02 , C07C211/00
CPC分类号: C07D211/78 , C07D211/34 , C07D211/70 , C07D401/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D451/02 , C07D471/08
摘要: The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
摘要翻译: 本发明涉及式(I)的新型仲胺衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法,含有一种或多种这些化合物的药物组合物,特别是其作为肾素抑制剂的用途的相关方面。
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公开(公告)号:US20090176823A1
公开(公告)日:2009-07-09
申请号:US12223597
申请日:2007-01-31
申请人: Olivier Bezencon , Daniel Bur , Olivier Corminboeuf , Daniel Dube , Corinna Grisostomi , Dwight MacDonald , Dan McKay , David Powell , Lubos Remen , Sylvia Richard-Bildstein , John Scheigetz , Michel Therien , Thomas Weller
发明人: Olivier Bezencon , Daniel Bur , Olivier Corminboeuf , Daniel Dube , Corinna Grisostomi , Dwight MacDonald , Dan McKay , David Powell , Lubos Remen , Sylvia Richard-Bildstein , John Scheigetz , Michel Therien , Thomas Weller
IPC分类号: A61K31/437 , C07D471/04 , C07D413/14 , A61K31/444 , A61P9/12
CPC分类号: C07D211/78 , C07D211/34 , C07D211/70 , C07D401/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D451/02 , C07D471/08
摘要: The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
摘要翻译: 本发明涉及式(I)的新型仲胺衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法,含有一种或多种这些化合物的药物组合物,特别是其作为肾素抑制剂的用途的相关方面。
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公开(公告)号:US20110152316A1
公开(公告)日:2011-06-23
申请号:US12993127
申请日:2009-05-21
申请人: Austin Chih-Yu Chen , Daniel Dube , Pierre-Andre Fournier , Erich L. Grimm , Patrick Lacombe , Sebastien Laliberte , Dwight MacDonald , D. Bruce MacKay , Daniel James McKay , Tom Yao-Hsiang Wu
发明人: Austin Chih-Yu Chen , Daniel Dube , Pierre-Andre Fournier , Erich L. Grimm , Patrick Lacombe , Sebastien Laliberte , Dwight MacDonald , D. Bruce MacKay , Daniel James McKay , Tom Yao-Hsiang Wu
IPC分类号: A61K31/4709 , C07D401/04 , A61P9/12 , A61P9/00 , A61P11/00 , A61P13/12 , A61P27/06 , A61P15/10 , A61P25/22
CPC分类号: C07D401/04 , C07D401/14
摘要: The present invention relates to 3,4-substituted piperidinyl-based renin inhibitor compounds bearing at 4-position Isoqumolone and having the Formula (I): The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.
摘要翻译: 本发明涉及在4-位异亮霉素下具有式(I)的3,4-取代哌啶基肾素抑制剂化合物:本发明还涉及含有所述化合物的药物组合物及其在治疗心血管事件中的用途 和肾功能不全。
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公开(公告)号:US20110237622A1
公开(公告)日:2011-09-29
申请号:US13139012
申请日:2009-12-08
申请人: Austin Chih-Yu Chen , Daniel Dube , Pierre-Andre Fournier , Erich L. Grimm , Patrick Lacombe , Sebastien Laliberte , Dwight Macdonald , D. Bruce Mackay , Daniel James Mckay , Tom Yao-Hsiang Wu
发明人: Austin Chih-Yu Chen , Daniel Dube , Pierre-Andre Fournier , Erich L. Grimm , Patrick Lacombe , Sebastien Laliberte , Dwight Macdonald , D. Bruce Mackay , Daniel James Mckay , Tom Yao-Hsiang Wu
IPC分类号: A61K31/4545 , C07D401/04 , A61P9/12 , A61P9/00 , A61P9/10 , A61P13/12 , A61P11/00 , A61P25/22 , A61P25/00 , A61P15/10 , A61P27/06
CPC分类号: C07D401/04
摘要: The present invention relates to 3,4-substituted piperidinyl—based renin inhibitor compounds bearing at 4-position oxopyridine or Isoquinolone and having the formula (I): wherein S is Formula (IIa) or Formula (IIb). The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.
摘要翻译: 本发明涉及在4-位氧代吡啶或异喹啉酮上具有式(I)的3,4-取代哌啶基肾素抑制剂化合物:其中S为式(IIa)或式(IIb)。 本发明还涉及含有所述化合物的药物组合物,以及它们在治疗心血管事件和肾功能不全中的用途。
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公开(公告)号:US20110053940A1
公开(公告)日:2011-03-03
申请号:US12990927
申请日:2009-05-04
申请人: Austin Chih-Yu Chen , Daniel Dube , Pierre-Andre Fournier , Erich L. Grimm , Patrick Lacombe , Sebastien Laliberte , Dwight MacDonald , D. Bruce MacKay , Daniel James McKay , Tom Yao-Hsiang Wu , Louis-Charles Campeau , Jeremy Peter Scott , Nadine Bremeyer
发明人: Austin Chih-Yu Chen , Daniel Dube , Pierre-Andre Fournier , Erich L. Grimm , Patrick Lacombe , Sebastien Laliberte , Dwight MacDonald , D. Bruce MacKay , Daniel James McKay , Tom Yao-Hsiang Wu , Louis-Charles Campeau , Jeremy Peter Scott , Nadine Bremeyer
IPC分类号: A61K31/4545 , C07D401/04 , C07D401/14 , C07D413/14 , A61K31/5377 , A61K31/4709 , A61K31/4725 , A61P9/12 , A61P9/00 , A61P27/02 , A61P25/00 , A61P11/00 , A61P9/10 , A61P13/12
CPC分类号: C07D401/14 , C07D401/04 , C07D417/14
摘要: The present invention relates to 3,4-substituted piperidinyl-based renin inhibitor compounds bearing at 4-position oxopyridine and having the formula (I). The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.
摘要翻译: 本发明涉及在4-位氧代吡啶上具有式(I)的3,4-取代的哌啶基肾素抑制剂化合物。 本发明还涉及含有所述化合物的药物组合物,以及它们在治疗心血管事件和肾功能不全中的用途。
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公开(公告)号:US08889714B2
公开(公告)日:2014-11-18
申请号:US12990927
申请日:2009-05-04
申请人: Austin Chih-Yu Chen , Daniel Dube , Pierre-Andre Fournier , Erich L. Grimm , Patrick Lacombe , Sebastien Laliberte , Dwight Macdonald , D. Bruce MacKay , Daniel James McKay , Tom Yao-Hsiang Wu , Louis-Charles Campeau , Jeremy Peter Scott , Nadine Bremeyer
发明人: Austin Chih-Yu Chen , Daniel Dube , Pierre-Andre Fournier , Erich L. Grimm , Patrick Lacombe , Sebastien Laliberte , Dwight Macdonald , D. Bruce MacKay , Daniel James McKay , Tom Yao-Hsiang Wu , Louis-Charles Campeau , Jeremy Peter Scott , Nadine Bremeyer
IPC分类号: A61K31/4545 , C07D401/14 , C07D417/14 , C07D401/04
CPC分类号: C07D401/14 , C07D401/04 , C07D417/14
摘要: The present invention relates to 3,4-substituted piperidinyl-based renin inhibitor compounds bearing at 4-position oxopyridine and having the formula (I). The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.
摘要翻译: 本发明涉及在4-位氧代吡啶上具有式(I)的3,4-取代的哌啶基肾素抑制剂化合物。 本发明还涉及含有所述化合物的药物组合物,以及它们在治疗心血管事件和肾功能不全中的用途。
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公开(公告)号:US08334308B2
公开(公告)日:2012-12-18
申请号:US12674040
申请日:2008-08-18
申请人: Helene Juteau , Michel Gallant , Daniel Dube , Patrick Roy , Renee Aspiotis , Rejean Fortin , Patrick Lacombe , Daniel McKay , Tom Yao-Hsiang Wu
发明人: Helene Juteau , Michel Gallant , Daniel Dube , Patrick Roy , Renee Aspiotis , Rejean Fortin , Patrick Lacombe , Daniel McKay , Tom Yao-Hsiang Wu
IPC分类号: A01N43/40 , A01N37/34 , A01N37/12 , A01N33/02 , A61K31/44 , A61K31/275 , C07D213/78 , C07D213/24 , C07C211/00
CPC分类号: C07C217/62 , C07C217/48 , C07C229/38 , C07C237/10 , C07C237/20 , C07C255/43 , C07C271/12 , C07C323/32 , C07D213/38 , C07D213/64 , C07D213/89 , C07D317/60
摘要: The present invention relates to biphenyl-based renin inhibitor compounds having amino-terminal groups, and their use in treating cardiovascular events and renal insufficiency.
摘要翻译: 本发明涉及具有氨基末端基团的联苯基肾素抑制剂化合物及其在治疗心血管事件和肾功能不全中的用途。
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