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公开(公告)号：US10466258B2
公开(公告)日：2019-11-05
申请号：US15477692
申请日：2017-04-03
Applicant: Omrix Biopharmaceuticals Ltd.
Inventor： Elena Grimberg , Roberto Meidler , Yonit Tiberman , Nadav Orr , Nadav Ashkenazy
Abstract: Provided is a method, device and system for an in-situ preparation of a sample, for example, for use in detecting the presence of, and/or quantifying, clottable fibrinogen in such a sample.
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公开(公告)号：US20160060614A1
公开(公告)日：2016-03-03
申请号：US14935743
申请日：2015-11-09
Applicant: Omrix Biopharmaceuticals Ltd.
Inventor： Roberto Meidler , Oleg Belyaev , Liliana Bar , Israel Nur
Abstract: Provided are methods for lyophilization of an aqueous thrombin solution, thrombin solutions for use in such lyophilization methods, and solid thrombin compositions produced by such methods.
Abstract translation: 提供冻干凝血酶水溶液，用于这种冻干方法的凝血酶溶液，以及通过这些方法制备的固体凝血酶组合物的方法。
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3.发明申请
公开(公告)号：US20150210754A1
公开(公告)日：2015-07-30
申请号：US14678319
申请日：2015-04-03
Applicant: Omrix Biopharmaceuticals Ltd.
Inventor： Roni Mintz , Oleg Belyaev , Israel Nur , Liliana Bar , Roberto Meidler
IPC: C07K16/06
CPC classification number: C07K16/065 , A61K39/39591 , A61K2039/505 , C07K1/18 , C07K2317/10 , Y10S530/83 , Y10S530/831
Abstract: The invention relates to an immunoglobulin composition reduced in thrombogenic agents and to methods for its preparation. One method comprises subjecting an immunoglobulin containing solution to a negative cation exchanger chromatography at a pH in the range of higher than 3.8 to equal to or lower than 5.3. The solution can also be subjected to a negative anion exchanger chromatography at a pH in the range of 7 to 8.2.
Abstract translation: 本发明涉及减少血栓形成剂的免疫球蛋白组合物及其制备方法。 一种方法包括在高于3.8至等于或低于5.3的pH范围内使含免疫球蛋白的溶液进行负阳离子交换层析。 该溶液也可以在7至8.2范围内的pH下进行阴离子交换层析。
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公开(公告)号：US11993797B2
公开(公告)日：2024-05-28
申请号：US17546447
申请日：2021-12-09
Applicant: Omrix Biopharmaceuticals Ltd.
Inventor： Roberto Meidler , Oleg Belyaev , Liliana Bar , Israel Nur
CPC classification number: C12N9/96 , A61K9/19 , A61K38/4833 , A61K47/26 , A61K47/42 , C12N9/6429 , C12Y304/21005
Abstract: Provided are methods for lyophilization of an aqueous thrombin solution, thrombin solutions for use in such lyophilization methods, and solid thrombin compositions produced by such methods.
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公开(公告)号：US10479987B2
公开(公告)日：2019-11-19
申请号：US14935743
申请日：2015-11-09
Applicant: Omrix Biopharmaceuticals Ltd.
Inventor： Roberto Meidler , Oleg Belyaev , Liliana Bar , Israel Nur
Abstract: Provided are methods for lyophilization of an aqueous thrombin solution, thrombin solutions for use in such lyophilization methods, and solid thrombin compositions produced by such methods.
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公开(公告)号：US11009513B2
公开(公告)日：2021-05-18
申请号：US16566387
申请日：2019-09-10
Applicant: Omrix Biopharmaceuticals Ltd.
Inventor： Elena Grimberg , Roberto Meidler , Yonit Tiberman , Nadav Orr , Nadav Ashkenazy
Abstract: The present invention is directed to devices having a substance receiving portion; a membrane; and at least one blocking member configured for taking one position and another position to allow fluid communication when a vacuum force is applied to the bottom of the substance receiving portion for the purpose of an in-situ preparation of a sample to detect the presence of, and/or quantify, clottable fibrinogen. The present invention is also directed to corresponding methods, processes and systems.
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公开(公告)号：US10806755B2
公开(公告)日：2020-10-20
申请号：US14631099
申请日：2015-02-25
Applicant: Omrix Biopharmaceuticals Ltd.
Inventor： Roberto Meidler , Elena Grimberg , Oleg Belyaev , Yonit Tiberman , Israel Nur , Tamar Auerbach-Nevo
Abstract: Provided herein is a plasma-supplemented fibrinogen and/or fibrin formulation, method for the preparation and use thereof.
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公开(公告)号：US09796770B2
公开(公告)日：2017-10-24
申请号：US14678319
申请日：2015-04-03
Applicant: Omrix Biopharmaceuticals Ltd.
Inventor： Roni Mintz , Oleg Belyaev , Israel Nur , Liliana Bar , Roberto Meidler
IPC: C07K1/18 , A61K39/395 , C07K16/06 , A61K39/00
CPC classification number: C07K16/065 , A61K39/39591 , A61K2039/505 , C07K1/18 , C07K2317/10 , Y10S530/83 , Y10S530/831
Abstract: The invention relates to an immunoglobulin composition reduced in thrombogenic agents and to methods for its preparation. One method comprises subjecting an immunoglobulin containing solution to a negative cation exchanger chromatography at a pH in the range of higher than 3.8 to equal to or lower than 5.3. The solution can also be subjected to a negative anion exchanger chromatography at a pH in the range of 7 to 8.2.
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公开(公告)号：US09212357B2
公开(公告)日：2015-12-15
申请号：US13783592
申请日：2013-03-04
Applicant: Omrix Biopharmaceuticals Ltd.
Inventor： Roberto Meidler , Oleg Belyaev , Liliana Bar , Israel Nur
CPC classification number: C12N9/96 , A61K9/19 , A61K38/4833 , A61K47/26 , A61K47/42 , C12N9/6429 , C12Y304/21005
Abstract: Provided are methods for lyophilization of an aqueous thrombin solution, thrombin solutions for use in such lyophilization methods, and solid thrombin compositions produced by such methods.
Abstract translation: 提供冻干凝血酶水溶液，用于这种冻干方法的凝血酶溶液和通过这些方法制备的固体凝血酶组合物的方法。
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公开(公告)号：US20240376459A1
公开(公告)日：2024-11-14
申请号：US18640385
申请日：2024-04-19
Applicant: Omrix Biopharmaceuticals Ltd.
Inventor： Roberto Meidler , Oleg Belyaev , Liliana Bar , Israel Nur
Abstract: Provided are methods for lyophilization of an aqueous thrombin solution, thrombin solutions for use in such lyophilization methods, and solid thrombin compositions produced by such methods.
