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公开(公告)号:US20210260019A1
公开(公告)日:2021-08-26
申请号:US17168291
申请日:2021-02-05
发明人: Roman Blaszczyk , Joanna Brzezinska , Anna Gzik , Adam Golebiowski , Julita Nowicka , Bartlomiej Borek , Marek Dziegielewski , Karol Jedrzejczak , Krzysztof Matyszewski , Jacek Olczak
IPC分类号: A61K31/343 , A61P11/00 , A61K31/133 , A61K31/23 , A61K31/235 , A61K31/33 , A61K31/335 , A61K31/69 , C07F5/02 , C07F5/04
摘要: Disclosed are small molecule therapeutic compounds that are potent inhibitors of arginase 1 and arginase 2 activity. Also disclosed are pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease or condition associated with arginase activity.
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公开(公告)号:US10851099B2
公开(公告)日:2020-12-01
申请号:US16369982
申请日:2019-03-29
发明人: Roman Blaszczyk , Anna Gzik , Bartlomiej Borek , Marek Dziegielewski , Karol Jedrzejczak , Julita Nowicka , Jacek Chrzanowski , Joanna Brzezinska , Adam Golebiowski , Jacek Olczak , Marcin Mikolaj Grzybowski , Jolanta Peczkowicz-Szyszka
IPC分类号: C07F5/02 , A61K31/454 , C07D471/04 , A61P11/16 , A61P9/00 , A61P17/02 , A61P37/00 , A61P35/00 , C07K5/02 , C07D211/60 , A61K45/06
摘要: The disclosure relates to pharmaceutical compositions, to methods of preparing such compositions, and to methods for using such compositions for treating or preventing a disease or condition associated with arginase activity.
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公开(公告)号:US20190300525A1
公开(公告)日:2019-10-03
申请号:US16369982
申请日:2019-03-29
发明人: Roman Blaszczyk , Anna Gzik , Bartlomiej Borek , Marek Dziegielewski , Karol Jedrzejczak , Julita Nowicka , Jacek Chrzanowski , Joanna Brzezinska , Adam Golebiowski , Jacek Olczak , Marcin Mikolaj Grzybowski , Jolanta Peczkowicz-Szyszka
摘要: The disclosure relates to pharmaceutical compositions, to methods of preparing such compositions, and to methods for using such compositions for treating or preventing a disease or condition associated with arginase activity.
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公开(公告)号:US10912755B2
公开(公告)日:2021-02-09
申请号:US16540747
申请日:2019-08-14
发明人: Roman Blaszczyk , Joanna Brzezinska , Anna Gzik , Adam A. Golebiowski , Julita Nowicka , Bartlomiej Borek , Marek Dziegielewski , Karol Jedrzejczak , Krzysztof Matyszewski , Jacek Olczak
IPC分类号: A61K31/69 , A61K31/343 , A61P11/00 , A61K31/23 , A61K31/235 , A61K31/133 , A61K31/335 , C07F5/02 , C07F5/04
摘要: Disclosed are small molecule therapeutic compounds that are potent inhibitors of arginase 1 and arginase 2 activity. Also disclosed are pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease or condition associated with arginase activity.
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公开(公告)号:US10329310B2
公开(公告)日:2019-06-25
申请号:US15540888
申请日:2015-12-22
IPC分类号: C07D211/96 , C07F5/02 , A01N1/02
摘要: The inventive compounds are small molecule therapeutics that are potent inhibitors of arginase 1 and arginase 2 activity. The inventions also provides pharmaceutical compositions and methods for using the inventive compounds for treating or preventing a disease or condition associated with arginase activity.
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公开(公告)号:US10391077B2
公开(公告)日:2019-08-27
申请号:US15584193
申请日:2017-05-02
发明人: Roman Blaszczyk , Joanna Brzezińska , Anna Gzik , Adam Golebiowski , Julita Nowicka , Bartlomiej Borek , Marek Dziegielewski , Karol Jedrzejczak , Krzysztof Matyszewski , Jacek Olczak
IPC分类号: C07F5/02 , A61K31/69 , A61K31/343 , A61K31/23 , A61K31/235 , A61K31/33 , A61K31/335 , C07F5/04
摘要: Disclosed are small molecule therapeutic compounds that are potent inhibitors of arginase 1 and arginase 2 activity. Also disclosed are pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease or condition associated with arginase activity.
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公开(公告)号:US20170319536A1
公开(公告)日:2017-11-09
申请号:US15584193
申请日:2017-05-02
发明人: Roman Blaszczyk , Joanna Brzezinska , Anna Gzik , Adam Golebiowski , Julita Nowicka , Bartlomiej Borek , Marek Dziegielewski , Karol Jedrzejczak , Krzysztof Matyszewski , Jacek Olczak
IPC分类号: A61K31/343 , C07F5/02 , A61K31/335 , A61K31/23 , A61K31/33 , A61K31/235 , C07F5/04 , A61K31/69
CPC分类号: A61K31/343 , A61K31/23 , A61K31/235 , A61K31/33 , A61K31/335 , A61K31/69 , A61P11/00 , C07F5/025 , C07F5/04
摘要: Disclosed are small molecule therapeutic compounds that are potent inhibitors of arginase 1 and arginase 2 activity. Also disclosed are pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease or condition associated with arginase activity.
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