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公开(公告)号：US09914771B2
公开(公告)日：2018-03-13
申请号：US15059668
申请日：2016-03-03
发明人： Austin L. Gurney , Aaron K. Sato
IPC分类号： C07K16/22 , A61K39/395 , A61K51/10 , A61K45/06 , C07K16/18 , C07K16/46 , C12N15/00 , A61K39/00 , A61K47/68
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K51/1021 , A61K2039/505 , C07K16/18 , C07K16/468 , C07K2317/20 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/55 , C07K2317/565 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C12N15/00
摘要： Methods for making heteromultimeric molecules, such as bispecific antibodies, and compositions comprising these molecules are disclosed. The methods include introducing mutations in amino acids that are in contact at the interface of two polypeptides, such that the electrostatic interaction between the ion pairs is altered.
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公开(公告)号：US20150337050A1
公开(公告)日：2015-11-26
申请号：US14693648
申请日：2015-04-22
发明人： Austin L. GURNEY , Aaron K. Sato
IPC分类号： C07K16/30
CPC分类号： A61K39/39558 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/723 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in solid tumor stem cell. The present invention further identifies an interaction between RSPO1 and LGR5 as an alternative pathway for the activation of beta-catenin signaling. In certain embodiments, the present invention provides biomolecules that disrupt functional signaling via a LGR protein, including, in certain embodiments, molecules that inhibit the interaction between one or more RSPO proteins and one or more LGR proteins, such as LGR5. In certain embodiments, the present invention provides methods of treating cancer comprising disrupting functional LGR signaling and inhibiting growth of a solid tumor comprising solid tumor stem cells.
摘要翻译： 本发明涉及用于表征，诊断和治疗癌症的组合物和方法。 特别地，本发明将LGR5鉴定为在实体瘤干细胞中过表达的蛋白质。 本发明进一步鉴定了RSPO1和LGR5之间的相互作用，作为β-连环蛋白信号传导活化的替代途径。 在某些实施方案中，本发明提供了通过LGR蛋白破坏功能性信号传导的生物分子，包括在某些实施方案中抑制一种或多种RSPO蛋白与一种或多种LGR蛋白如LGR5之间相互作用的分子。 在某些实施方案中，本发明提供了治疗癌症的方法，包括破坏功能性LGR信号并抑制包含固体肿瘤干细胞的实体瘤的生长。
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公开(公告)号：US09309311B2
公开(公告)日：2016-04-12
申请号：US13801189
申请日：2013-03-13
发明人： Austin L. Gurney , Aaron K. Sato
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K51/1021 , A61K2039/505 , C07K16/18 , C07K16/468 , C07K2317/20 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/55 , C07K2317/565 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C12N15/00
摘要： Methods for making heteromultimeric molecules, such as bispecific antibodies, and compositions comprising these molecules are disclosed. The methods include introducing mutations in amino acids that are in contact at the interface of two polypeptides, such that the electrostatic interaction between the ion pairs is altered.
摘要翻译： 公开了制备异源多聚体分子的方法，例如双特异性抗体，以及包含这些分子的组合物。 所述方法包括在两个多肽的界面处接触的氨基酸中引入突变，从而改变离子对之间的静电相互作用。
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公开(公告)号：US09040044B2
公开(公告)日：2015-05-26
申请号：US14087853
申请日：2013-11-22
发明人： Austin L. Gurney , Aaron K. Sato
CPC分类号： A61K39/39558 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/723 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in solid tumor stem cell. The present invention further identifies an interaction between RSPO1 and LGR5 as an alternative pathway for the activation of beta-catenin signaling. In certain embodiments, the present invention provides biomolecules that disrupt functional signaling via a LGR protein, including, in certain embodiments, molecules that inhibit the interaction between one or more RSPO proteins and one or more LGR proteins, such as LGR5. In certain embodiments, the present invention provides methods of treating cancer comprising disrupting functional LGR signaling and inhibiting growth of a solid tumor comprising solid tumor stem cells.
摘要翻译： 本发明涉及用于表征，诊断和治疗癌症的组合物和方法。 特别地，本发明将LGR5鉴定为在实体瘤干细胞中过表达的蛋白质。 本发明进一步鉴定了RSPO1和LGR5之间的相互作用，作为β-连环蛋白信号传导活化的替代途径。 在某些实施方案中，本发明提供了通过LGR蛋白破坏功能性信号传导的生物分子，包括在某些实施方案中抑制一种或多种RSPO蛋白与一种或多种LGR蛋白如LGR5之间相互作用的分子。 在某些实施方案中，本发明提供了治疗癌症的方法，包括破坏功能性LGR信号并抑制包含固体肿瘤干细胞的实体瘤的生长。
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公开(公告)号：US09717794B2
公开(公告)日：2017-08-01
申请号：US14693648
申请日：2015-04-22
发明人： Austin L. Gurney , Aaron K. Sato
CPC分类号： A61K39/39558 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/723 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in solid tumor stem cell. The present invention further identifies an interaction between RSPO1 and LGR5 as an alternative pathway for the activation of beta-catenin signaling. In certain embodiments, the present invention provides biomolecules that disrupt functional signaling via a LGR protein, including, in certain embodiments, molecules that inhibit the interaction between one or more RSPO proteins and one or more LGR proteins, such as LGR5. In certain embodiments, the present invention provides methods of treating cancer comprising disrupting functional LGR signaling and inhibiting growth of a solid tumor comprising solid tumor stem cells.
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公开(公告)号：US20160280774A1
公开(公告)日：2016-09-29
申请号：US15059668
申请日：2016-03-03
发明人： Austin L. GURNEY , Aaron K. Sato
IPC分类号： C07K16/22 , A61K45/06 , A61K51/10 , A61K39/395
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K51/1021 , A61K2039/505 , C07K16/18 , C07K16/468 , C07K2317/20 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/55 , C07K2317/565 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C12N15/00
摘要： Methods for making heteromultimeric molecules, such as bispecific antibodies, and compositions comprising these molecules are disclosed. The methods include introducing mutations in amino acids that are in contact at the interface of two polypeptides, such that the electrostatic interaction between the ion pairs is altered.
摘要翻译： 公开了制备异源多聚体分子的方法，例如双特异性抗体，以及包含这些分子的组合物。 所述方法包括在两个多肽的界面处接触的氨基酸中引入突变，从而改变离子对之间的静电相互作用。
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