公开(公告)号：US20170198031A1

公开(公告)日：2017-07-13

申请号：US15298527

申请日：2016-10-20

申请人： OncoMed Pharmaceuticals, Inc.

发明人： Austin L. GURNEY ,  Timothy Charles HOEY ,  Edward Thein Htun van der HORST ,  Aaron Ken SATO ,  Yuan Ching LIU ,  Maureen Fitch BRUHNS ,  John A. LEWICKI

IPC分类号： C07K16/22 ,  A61K45/06 ,  A61K31/337 ,  A61K39/395

CPC分类号： C07K16/22 ,  A61K31/337 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61N5/10 ,  C07H21/04 ,  C07K14/435 ,  C07K14/71 ,  C07K16/28 ,  C07K16/30 ,  C07K16/3046 ,  C07K16/462 ,  C07K16/464 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  C12N5/0693 ,  C12N5/12 ,  C12N15/63 ,  C12N15/79 ,  C12N2501/998

摘要： The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.

公开(公告)号：US20130243774A1

公开(公告)日：2013-09-19

申请号：US13797374

申请日：2013-03-12

申请人： ONCOMED PHARMACEUTICALS, INC.

发明人： Edward Thein Htun van der HORST ,  Austin L. GURNEY ,  Timothy Charles HOEY ,  Maureen Fitch BRUHNS ,  Fumiko Takada AXELROD

IPC分类号： A61K39/395 ,  A61K45/06 ,  C07K16/28

CPC分类号： A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to Notch1 binding agents and methods of using the agents for treating diseases, such as hematologic cancers. The present invention provides antibodies that specifically bind to a non-ligand binding membrane proximal region of the extracellular domain of human Notch1. The present invention further provides methods of using agents that inhibit Notch1 activity for treating cancer. Also described are methods of treating hematologic cancers comprising administering a therapeutically effective amount of a binding agent or antibody of the present invention to a subject having a hematologic cancer such as T-cell lymphoblastic leukemia.

摘要翻译： 本发明涉及Notch1结合剂和使用该药物治疗疾病如血液癌症的方法。 本发明提供特异性结合人Notch1细胞外结构域的非配体结合膜近端区域的抗体。 本发明还提供使用抑制Notch1活性治疗癌症的药剂的方法。 还描述了治疗血液癌症的方法，包括将治疗有效量的本发明的结合剂或抗体给予具有血液学癌症如T细胞淋巴细胞白血病的受试者。