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公开(公告)号:US20100256158A1
公开(公告)日:2010-10-07
申请号:US12814916
申请日:2010-06-14
申请人: Ondrej SIMO , Jirí Filipcik , Alexandr Martaus , Alexandr Jegorov , Ales Gavenda , Judith Aronhime , Pavel Vraspír , Tamás Koltai , Jirí Faustmann , Roman Gabriel
发明人: Ondrej SIMO , Jirí Filipcik , Alexandr Martaus , Alexandr Jegorov , Ales Gavenda , Judith Aronhime , Pavel Vraspír , Tamás Koltai , Jirí Faustmann , Roman Gabriel
IPC分类号: A61K31/496 , C07D417/14 , A61P35/00
CPC分类号: C07D417/12
摘要: Provided is dasatinib, solvates thereof and their crystalline forms, methods for their preparation, and pharmaceutical compositions thereof.
摘要翻译: 提供达沙替尼,其溶剂合物及其结晶形式,其制备方法及其药物组合物。
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公开(公告)号:US20090118297A1
公开(公告)日:2009-05-07
申请号:US12257338
申请日:2008-10-23
申请人: Ondrej SIMO , Jiri Filipcik , Alexandr Martaus , Alexandr Jegorov , Ales Gavenda , Judith Aronhime , Pavel Vraspir , Tamas Koltai , Jiri Faustmann , Roman Gabriel
发明人: Ondrej SIMO , Jiri Filipcik , Alexandr Martaus , Alexandr Jegorov , Ales Gavenda , Judith Aronhime , Pavel Vraspir , Tamas Koltai , Jiri Faustmann , Roman Gabriel
IPC分类号: A61K31/506 , C07D417/14
CPC分类号: C07D417/12
摘要: Provided is dasatinib, solvates thereof and their crystalline forms, methods for their preparation, and pharmaceutical compositions thereof.
摘要翻译: 提供达沙替尼,其溶剂合物及其结晶形式,其制备方法及其药物组合物。
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公开(公告)号:US07973045B2
公开(公告)日:2011-07-05
申请号:US12814916
申请日:2010-06-14
申请人: Ondrej {hacek over (S)}imo , Ji{hacek over (r)}í Filip{hacek over (c)}ík , Alexandr Martaus , Alexandr Jegorov , Ale{hacek over (s)} Gavenda , Judith Aronhime , Pavel Vraspír , Tamás Koltai , Ji{hacek over (r)}í Faustmann , Roman Gabriel
发明人: Ondrej {hacek over (S)}imo , Ji{hacek over (r)}í Filip{hacek over (c)}ík , Alexandr Martaus , Alexandr Jegorov , Ale{hacek over (s)} Gavenda , Judith Aronhime , Pavel Vraspír , Tamás Koltai , Ji{hacek over (r)}í Faustmann , Roman Gabriel
IPC分类号: C07D239/42 , C07D401/04
CPC分类号: C07D417/12
摘要: The invention provides anhydrous forms of dasatinib, methods for their preparation, and pharmaceutical compositions thereof.
摘要翻译: 本发明提供无水形式的达沙替尼,其制备方法及其药物组合物。
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4.Polymorphs of dasatinib isopropyl alcohol and process for preparation thereof 有权
标题翻译: 达沙替尼异丙醇的多晶型物及其制备方法公开(公告)号:US08067423B2
公开(公告)日:2011-11-29
申请号:US12257338
申请日:2008-10-23
申请人: Ondrej {hacek over (S)}imo , Ji{hacek over (r)}í Filip{hacek over (c)}ík , Alexandr Martaus , Alexandr Jegorov , Ale{hacek over (s)} Gavenda , Judith Aronhime , Pavel Vraspir , Tamás Koltai , Ji{hacek over (r)}í Faustmann , Roman Gabriel
发明人: Ondrej {hacek over (S)}imo , Ji{hacek over (r)}í Filip{hacek over (c)}ík , Alexandr Martaus , Alexandr Jegorov , Ale{hacek over (s)} Gavenda , Judith Aronhime , Pavel Vraspir , Tamás Koltai , Ji{hacek over (r)}í Faustmann , Roman Gabriel
IPC分类号: A01N43/54
CPC分类号: C07D417/12
摘要: The invention provides crystalline forms of isopropyl alcohol solvate of dasatinib, methods for their preparation, and pharmaceutical compositions thereof.
摘要翻译: 本发明提供达沙替尼的异丙醇溶剂合物的结晶形式,其制备方法及其药物组合物。
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5.Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form alpha 有权
标题翻译: 甲磺酸伊马替尼的多晶型形式以及制备新型结晶形式以及无定型和形成α的方法公开(公告)号:US20090264438A1
公开(公告)日:2009-10-22
申请号:US12148492
申请日:2008-04-17
IPC分类号: C07D401/14 , A61K31/496
CPC分类号: C07D401/04
摘要: Solvates and crystalline forms of imatinib mesylate are described. Further, methods for preparing such solvates and crystalline forms of imatinib mesylate are described.
摘要翻译: 描述了甲磺酸伊马替尼的溶剂合物和结晶形式。 此外,描述了制备这种溶剂化物的方法和甲磺酸伊马替尼的结晶形式。
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6.
公开(公告)号:US20100256392A1
公开(公告)日:2010-10-07
申请号:US12743568
申请日:2008-11-21
申请人: Ales Gavenda , Ettore Bigatti , Alexandr Jegorov , Augusto Canavesi , Pavel Vraspir , Judith Aronhime , Peter Lindsay MacDonald , Francesca Scarpitta , Marco Villa , Paolo Angioletti
发明人: Ales Gavenda , Ettore Bigatti , Alexandr Jegorov , Augusto Canavesi , Pavel Vraspir , Judith Aronhime , Peter Lindsay MacDonald , Francesca Scarpitta , Marco Villa , Paolo Angioletti
IPC分类号: C07D403/06
CPC分类号: C07D403/06
摘要: The present invention provides polymorphs of Sunitinib base and processes for preparation thereof.
摘要翻译: 本发明提供舒尼替尼碱基的多晶型物及其制备方法。
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7.Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form alpha 有权
标题翻译: 甲磺酸伊马替尼的多晶型形式以及制备新型结晶形式以及无定型和形成α的方法公开(公告)号:US20080090833A1
公开(公告)日:2008-04-17
申请号:US11796573
申请日:2007-04-27
IPC分类号: A61K31/497 , C07D239/20
CPC分类号: C07D401/04
摘要: Solvates and crystalline forms of imatinib mesylate are described. Further, methods for preparing such solvates and crystalline forms of imatinib mesylate are described.
摘要翻译: 描述了甲磺酸伊马替尼的溶剂合物和结晶形式。 此外,描述了制备这种溶剂化物的方法和甲磺酸伊马替尼的结晶形式。
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公开(公告)号:US20090124642A1
公开(公告)日:2009-05-14
申请号:US12229682
申请日:2008-08-25
申请人: Augusto Canavesi , Marco Villa , Ales Gavenda , Jiri Faustmann , Judith Aronhime , Ettore Gibatti , Alexandr Jegorov
发明人: Augusto Canavesi , Marco Villa , Ales Gavenda , Jiri Faustmann , Judith Aronhime , Ettore Gibatti , Alexandr Jegorov
IPC分类号: A61K31/517 , C07D239/94
CPC分类号: C07D239/94
摘要: The invention provides a novel crystalline form of Erlotinib HCl, processes for its preparation, and formulations thereof.
摘要翻译: 本发明提供了一种新型的埃罗替尼盐酸结晶形式,其制备方法及其制剂。
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9.SOLID STATE FORMS OF CABAZITAXEL AND PROCESSES FOR PREPARATION THEREOF 审中-公开
标题翻译: CABAZITAXEL的固体状态及其制备方法公开(公告)号:US20140011865A1
公开(公告)日:2014-01-09
申请号:US13932147
申请日:2013-07-01
申请人: Ondrej SIMO , Pavel Vraspir , Tomas Holas , Alexandr Jegorov , Roman Gabriel
发明人: Ondrej SIMO , Pavel Vraspir , Tomas Holas , Alexandr Jegorov , Roman Gabriel
IPC分类号: C07D305/14
CPC分类号: C07D305/14 , C07B2200/13
摘要: The invention relates to solid state forms of Cabazitaxel, and processes for preparation, via novel synthetic intermediates, thereof, and formulations comprising one or more of the solid state forms of Cabazitaxel. The present invention further provides pharmaceutical compositions comprising one or more of the solid state forms of Cabazitaxel, and a method of treating hormone-refractory prostate cancer.
摘要翻译: 本发明涉及卡伐他汀的固体形式,以及通过其新型合成中间体以及包含一种或多种固体形式的卡巴他赛的制剂的制备方法。 本发明进一步提供包含卡伐他汀的一种或多种固态形式的药物组合物和治疗激素难治性前列腺癌的方法。
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公开(公告)号:US08618309B2
公开(公告)日:2013-12-31
申请号:US13055609
申请日:2009-07-23
IPC分类号: C07D209/12
CPC分类号: C07D403/06 , C07D209/12
摘要: Process for the preparation of sunitinib malate form I via sunitinib acetate and polymorphs of said intermediate.
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