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    Cephalosporin compounds
    1.
    发明授权
    Cephalosporin compounds 失效
    头孢菌素化合物

    公开(公告)号：US4393058A

    公开(公告)日：1983-07-12

    申请号：US188417

    申请日：1980-09-18

    申请人： Osamu Makabe ,  Yasushi Murai ,  Tuneo Okonogi ,  Masahiro Onodera ,  Yoshiyuki Koyama ,  Takashi Yoshida

    发明人： Osamu Makabe ,  Yasushi Murai ,  Tuneo Okonogi ,  Masahiro Onodera ,  Yoshiyuki Koyama ,  Takashi Yoshida

    IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C45/71 ,  C07D213/80 ,  C07D213/82 ,  C07D213/85 ,  C07D501/36

    CPC分类号： C07D213/80 ,  C07C45/71 ,  C07D213/82 ,  C07D213/85

    摘要： Cephalosporin compounds, intermediate compounds therefor, and processes for preparation thereof are described; the compounds have the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 can each represent hydrogen, a hydroxyl group, a lower alkoxy group, or a substituted or unsubstituted phenylalkoxy group; R.sub.3 represents hydrogen or a lower alkyl group; R.sub.4 represents hydrogen or a hydroxyl group; and R.sub.5 represents ##STR2## wherein R.sub.6 is hydrogen, a lower alkyl group, an aminoalkyl group, an aminoaralkyl group, a --(CH.sub.2).sub.n --SO.sub.3 Na group, or a --(CH.sub.2).sub.n --COR.sub.9 group [wherein R.sub.9 is a hydroxyl group, an OM group (wherein M is an alkali metal), an alkoxy group, or an ##STR3## group, (wherein R.sub.10 and R.sub.11, which may be the same or different, can represent hydrogen or an alkyl group), and n is 0 or an integer of from 1 to 4]; R.sub.7 is hydrogen, a lower alkyl group, an amino group, or a substituted or unsubstituted aryl group; and R.sub.8 represents hydrogen or a lower alkyl group; or, a pharmaceutically acceptable salt thereof.

    摘要翻译： 描述头孢菌素化合物，其中间体化合物及其制备方法; 化合物具有式（I）其中R 1和R 2各自表示氢，羟基，低级烷氧基或取代或未取代的苯基烷氧基; R3表示氢或低级烷基; R4代表氢或羟基; 其中R6为氢，低级烷基，氨基烷基，氨基烷基， - （CH2）n-SO3Na基或 - （CH2）n-COR9基[ 其中R 9为羟基，OM基（其中M为碱金属），烷氧基或基团（其中R10和R11可以相同或不同，表示氢或烷基 组），n为0或1〜4的整数]。 R7是氢，低级烷基，氨基或取代或未取代的芳基; R8代表氢或低级烷基; 或其药学上可接受的盐。

    Gene coding for signal peptides and utilization thereof
    4.
    发明授权
    Gene coding for signal peptides and utilization thereof 失效
    信号肽的基因编码及其利用

    公开(公告)号：US4783415A

    公开(公告)日：1988-11-08

    申请号：US716495

    申请日：1985-03-27

    申请人： Shigeru Hoshiko ,  Osamu Makabe ,  Shunzo Fukatsu ,  Kozo Nagaoka

    发明人： Shigeru Hoshiko ,  Osamu Makabe ,  Shunzo Fukatsu ,  Kozo Nagaoka

    IPC分类号： C12N9/28 ,  C12N15/76 ,  C12N15/00 ,  C07H21/04 ,  C12N1/20 ,  C12P19/34 ,  C12P21/00 ,  C12P21/02 ,  C12P21/04

    CPC分类号： C12N9/2417 ,  C12N15/76 ,  C07K2319/00 ,  C07K2319/02 ,  Y10S930/30

    摘要： A DNA segment of a gene coding for a signal peptide is disclosed the segment is to be used in a host-vector system employing a bacterium belonging to the genus Streptomyces as a host by incorporation in the vector DNA. The segment comprises a DNA having a base sequence coding for the peptide having the amino acid sequence from X to Y in the annexed FIG. 1.A vector plasmid to be used for transformation of bacteria belonging to the genus Streptomyces is also disclosed. The plasmid comprises a DNA segment with a base sequence coding for an extra-cellular .alpha.-amylase derived from Streptomyces hygroscopicus SF-1084 strain or a mutant thereof the DNA segment incorporated into a vector plasmid is to be used in a host-vector system employing a bacterium belonging to the genus Streptomyces as a host and also having a DNA segment necessary for expression of the gene information of the DNA segment.The present invention may be applied to the production of a desired protein which will be secreted outside the host microorganism. .

    摘要翻译： 公开了编码信号肽的基因的DNA片段，该片段将用于通过掺入载体DNA中而使用属于链霉菌属（Streptomyces）属的细菌作为宿主的宿主 - 载体系统。 该片段包含具有编码在附图中具有X至Y的氨基酸序列的肽的碱基序列的DNA。 还公开了用于转化属于链霉菌属的细菌的载体质粒。 质粒包含编码来自吸水链霉菌SF-1084株的细胞外α-淀粉酶的碱基序列的DNA片段或其突变体，并入载体质粒中的DNA片段将用于使用 属于链霉菌属的细菌作为宿主，并且还具有表达DNA片段的基因信息所需的DNA片段。 本发明可以用于生产将被分泌到宿主微生物外部的所需蛋白质。 。