公开(公告)号：US10071196B2

公开(公告)日：2018-09-11

申请号：US13472112

申请日：2012-05-15

Applicant: Oz Cabiri

Inventor： Oz Cabiri

IPC: A61M5/142 ,  A61M5/20

CPC classification number: A61M5/14248 ,  A61M2005/14252 ,  A61M2005/2073 ,  A61M2205/8206

Abstract: A method for selectively powering a battery-operated drug-delivery device, the device having a battery and a battery circuit, the method comprising: providing a battery isolator in a first position whereat it interrupts a battery circuit, whereby no power is provided to the device; and activating a fastening mechanism configured for fastening the device to a user, the activating causing the battery circuit to be uninterrupted by the isolator, such that power is provided to the device. Additionally, there is provided a selectively powered battery-operated drug-delivery device, comprising: a selectively-removable isolator disposed in a first position whereat it interrupts a battery circuit; the isolator movable to a second position whereat the battery circuit is uninterrupted by the isolator; and a mechanism for fastening the device to a user, activation of the fastening mechanism moving the isolator from the first position to the second position.

公开(公告)号：US20170252025A1

公开(公告)日：2017-09-07

申请号：US15057329

申请日：2016-03-01

Applicant: Oz Cabiri ,  Oded Meiri

Inventor： Oz Cabiri ,  Oded Meiri

IPC: A61B17/00

CPC classification number: A61B17/00234 ,  A61B2017/00327 ,  A61M25/0136 ,  A61M25/0147 ,  A61M2025/015

Abstract: A steering tool includes an internal tube disposed inside an external tube. The internal and external tubes are arranged for longitudinal axial movement relative to one another. A distal end of the internal tube is fixedly joined to a distal end of the external tube. A tube manipulator can cause relative axial movement and distal bending of the internal and external tubes. A locking mechanism can switch between a locked position in which the internal and external tubes are locked at a particular longitudinal axial position relative to one another, and an unlocked position in which there is uninhibited free movement of the internal and external tubes relative to one another. The locking mechanism also includes an intermediate locked position in which there is partially inhibited movement of the internal and external tubes relative to one another.

公开(公告)号：US08911494B2

公开(公告)日：2014-12-16

申请号：US12689693

申请日：2010-01-19

Applicant: Tal Hammer ,  Yuval Zipory ,  Yoseph Weitzman ,  Amir Gross ,  Oz Cabiri ,  Aram Ayvazian

Inventor： Tal Hammer ,  Yuval Zipory ,  Yoseph Weitzman ,  Amir Gross ,  Oz Cabiri ,  Aram Ayvazian

IPC: A61F2/24 ,  A61B17/04 ,  A61B17/064 ,  A61B17/068 ,  A61B17/00 ,  A61B17/12 ,  A61B17/29 ,  A61F2/30

CPC classification number: A61F2/2436 ,  A61B17/00234 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/068 ,  A61B17/072 ,  A61B2017/00243 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/0441 ,  A61B2017/0443 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/0647 ,  A61B2017/0648 ,  A61B2017/0649 ,  A61B2017/12095 ,  A61B2017/2923 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2445 ,  A61F2/2451 ,  A61F2/2457 ,  A61F2/2466 ,  A61F2002/30537 ,  A61F2220/0016 ,  A61F2250/0004

Abstract: An anchor driver is provided that includes a driver head having a flexible ring. An anchor is provided that includes a coupling head, which is shaped so as to define: (a) one or more mating elements that engage mechanical coupling elements of the driver head such that rotation of the mechanical coupling elements rotates the mating elements, which in turn rotate the coupling head, and (b) an outer coupling surface, sized to be inserted into and engage the flexible ring. The anchor also includes a tissue coupling element fixed to the coupling head. The rotation of the mechanical coupling elements causes the tissue coupling element of the anchor to screw itself into tissue, thereby causing separation of: (a) the outer coupling surface of the coupling head from the flexible ring, and (b) the mating elements of the coupling head from the corresponding mechanical coupling elements. Other embodiments are also described.

Abstract translation: 提供一种锚驱动器，其包括具有柔性环的驱动头。 提供了一种锚，其包括联接头，该联接头被成形为限定：（a）一个或多个匹配元件，其接合驾驶员头部的机械联接元件，使得机械联接元件的旋转使配合元件旋转， 旋转联接头，和（b）外部联接表面，其尺寸被设计成插入并接合柔性环。 锚固件还包括固定到联接头的组织连接元件。 机械联接元件的旋转导致锚固件的组织连接元件将自身螺钉自身拧入组织中，从而分离出：（a）联接头的外部联接表面与柔性环的分离，以及（b） 联接头从相应的机械耦合元件。 还描述了其它实施例。

公开(公告)号：US08790394B2

公开(公告)日：2014-07-29

申请号：US12785717

申请日：2010-05-24

Applicant: Eran Miller ,  Oz Cabiri

Inventor： Eran Miller ,  Oz Cabiri

IPC: A61F2/24 ,  A61B17/04

CPC classification number: A61B17/0401 ,  A61B17/0482 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/0441 ,  A61B2017/0496 ,  A61F2/2457

Abstract: Apparatus is provided, including an artificial-chordeae-tendineae-adjustment mechanism and at least one primary artificial chordea tendinea coupled at a distal portion thereof to the artificial-chordeae-tendineae-adjustment mechanism. A degree of tension of the at least one primary artificial chordea tendinea is adjustable by the artificial-chordeae-tendineae-adjustment mechanism. One or more loops are coupled at a proximal portion of the at least one primary artificial chordea tendinea. The one or more loops are configured to facilitate suturing of the one or more loops to respective portions of a leaflet of an atrioventricular valve of a patient. Other applications are also described.

Abstract translation: 提供了装置，其包括人造腱 - 腱索调节机构和在其远端部分与人造腱 - 腱调节机构联接的至少一个初级人造腱索。 所述至少一个原发性人造大戟属植物的张力可以通过人造腱 - 腱调节机制来调节。 一个或多个环在所述至少一个原始人造大戟属的近端部分联接。 一个或多个环被构造成便于将一个或多个环缝合到患者的房室瓣的小叶的相应部分。 还描述了其它应用。

公开(公告)号：US08734467B2

公开(公告)日：2014-05-27

申请号：US12926673

申请日：2010-12-02

Applicant: Eran Miller ,  Uriel A. Pomerantz ,  Francesco Maisano ,  Oz Cabiri ,  Yaron Herman ,  Yoseph Weitzman ,  Yossi Gross

Inventor： Eran Miller ,  Uriel A. Pomerantz ,  Francesco Maisano ,  Oz Cabiri ,  Yaron Herman ,  Yoseph Weitzman ,  Yossi Gross

IPC: A61B17/10

CPC classification number: A61F2/2466 ,  A61B17/0401 ,  A61B17/0469 ,  A61B2017/00243 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/044 ,  A61B2017/0441 ,  A61B2017/0464 ,  A61B2017/048 ,  A61F2/2427 ,  A61F2/2457

Abstract: Apparatus is provided, including a tissue-adjusting member configured to be coupled to tissue of a patient, a rotatable structure that is configured to adjust a tension of the tissue-adjusting member, a tissue anchor coupled to the tissue-adjusting member and configured to screw into the tissue of the patient, and a delivery tool reversibly coupleable to the rotatable structure. The delivery tool comprises a first actuating element configured to rotate the tissue anchor so as to facilitate screwing of the tissue anchor into the tissue of the patient while not facilitating rotation of the rotatable structure, and a second actuating element configured to rotate the rotatable structure while not facilitating rotation of the tissue anchor. Other applications are also described.

Abstract translation: 提供了一种设备，包括构造成联接到患者组织的组织调节构件，被配置为调节组织调节构件的张力的可旋转结构，耦合到组织调节构件的组织锚固件， 螺钉进入患者的组织，以及可逆地联接到可旋转结构的输送工具。 递送工具包括构造成旋转组织锚固件的第一致动元件，以便于促使组织锚定件旋转到患者的组织中，同时不促进旋转结构的旋转;以及第二致动元件，其构造成使可旋转结构旋转同时 不利于组织锚的旋转。 还描述了其它应用。

公开(公告)号：US08715342B2

公开(公告)日：2014-05-06

申请号：US12437103

申请日：2009-05-07

Applicant: Yuval Zipory ,  Oz Cabiri ,  Yossi Gross

Inventor： Yuval Zipory ,  Oz Cabiri ,  Yossi Gross

IPC: A61F2/24

CPC classification number: A61F2/2466 ,  A61B17/00234 ,  A61B17/064 ,  A61B17/068 ,  A61B2017/00243 ,  A61B2017/0647 ,  A61B2017/0649 ,  A61F2/2442 ,  A61F2/2445 ,  A61F2220/0016

Abstract: Apparatus is provided that includes an annuloplasty system for use on a subject. The system includes an annuloplasty ring, which includes a sleeve having a lumen, and at least one anchor, shaped so as to define a coupling head and a tissue coupling element, which tissue coupling element is shaped so as to define a longitudinal axis, and is configured to penetrate cardiac tissue of the subject in a direction parallel to the longitudinal axis. The system further includes an anchor deployment manipulator, configured to be removably positioned within the lumen of the sleeve, and, while so positioned, to deploy the tissue coupling element from a distal end of the deployment manipulator through a wall of the sleeve into the cardiac tissue in the direction parallel to the longitudinal axis of the tissue coupling element and parallel to a central longitudinal axis through the distal end of the deployment manipulator.

Abstract translation: 提供了包括用于受试者的瓣膜成形术系统的装置。 该系统包括瓣环成形术环，其包括具有内腔的套筒和至少一个锚固件，该锚定件成形为限定联接头部和组织连接元件，该组织连接元件成形为限定纵向轴线，以及 构造成在平行于纵向轴线的方向上穿透受试者的心脏组织。 所述系统还包括锚定部署操纵器，其构造成可移除地定位在所述套管的内腔内，并且在如此定位的同时将所述组织连接元件从所述展开操纵器的远端部分穿过所述套筒的壁部分进入心脏 组织在平行于组织连接元件的纵向轴线的方向上并且平行于通过展开机械手的远端的中心纵向轴线。

公开(公告)号：US08690939B2

公开(公告)日：2014-04-08

申请号：US12795192

申请日：2010-06-07

Applicant: Eran Miller ,  Oz Cabiri

Inventor： Eran Miller ,  Oz Cabiri

IPC: A61F2/24

CPC classification number: A61B17/0401 ,  A61B2017/00243 ,  A61B2017/0441 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61F2/2442 ,  A61F2/2454 ,  A61F2/2457

Abstract: A method is provided including coupling a tissue-engaging element to a first portion of cardiac tissue of a heart of a patient and advancing toward the tissue-engaging element an adjustment mechanism along at least one guide member that is removably coupled to the tissue-engaging element. The adjustment mechanism engages a first portion of a first flexible longitudinal member. A second portion of the first flexible longitudinal member is coupled to a second portion of cardiac tissue. Following the coupling of the second portion of the first flexible longitudinal member to the second portion of cardiac tissue, the adjustment mechanism is slid further along the guide member and coupled to the tissue-engaging element. Using the adjustment mechanism, a length of the first flexible longitudinal member is adjusted between the first and second portions of cardiac tissue. Other applications are also described.

Abstract translation: 提供了一种方法，包括将组织接合元件耦合到患者心脏的心脏组织的第一部分并且沿着至少一个引导构件向着组织接合元件推进调节机构，所述至少一个引导构件可移除地联接到组织接合 元件。 调节机构接合第一柔性纵向构件的第一部分。 第一柔性纵向构件的第二部分联接到心脏组织的第二部分。 在第一柔性纵向构件的第二部分与心脏组织的第二部分的联接之后，调节机构沿着引导构件进一步滑动并联接到组织接合元件。 使用调节机构，在心脏组织的第一和第二部分之间调节第一柔性纵向构件的长度。 还描述了其它应用。

公开(公告)号：US08684953B2

公开(公告)日：2014-04-01

申请号：US13470319

申请日：2012-05-13

Applicant: Oz Cabiri

Inventor： Oz Cabiri

IPC: A61B5/00

CPC classification number: A61M25/0147 ,  A61B1/00078 ,  A61B1/00135 ,  A61M25/0138 ,  A61M2025/0161

Abstract: A steering tool including an internal tube disposed inside an external tube, the internal and external tubes being arranged for longitudinal axial movement relative to one another, wherein a distal end of the internal tube is fixedly joined to a distal end of the external tube, and at least one of the internal and external tubes is slotted near the distal end thereof, and wherein the longitudinal axial movement causes bending of the distal ends of the tubes.

Abstract translation: 一种转向工具，其包括设置在外管内的内管，所述内管和外管彼此相对地纵向轴向移动，其中所述内管的远端固定地连接到所述外管的远端， 内管和外管中的至少一个在其远端附近开槽，并且其中纵向轴向移动导致管的远端弯曲。

公开(公告)号：US08617126B2

公开(公告)日：2013-12-31

申请号：US13063236

申请日：2009-09-14

Applicant: Yossi Gross ,  Oz Cabiri

Inventor： Yossi Gross ,  Oz Cabiri

IPC: A61M5/00 ,  A61M5/32 ,  A61M5/31

CPC classification number: A61M5/425 ,  A61M5/31511 ,  A61M37/0015 ,  A61M37/0069 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0061

Abstract: Apparatus for use with tissue (22) of a subject, including a substance (24) configured to be injected into the tissue, and first and second tissue-squeezing surfaces (20) configured to be placed on first and second sides of the tissue, to exert pressure on the tissue by being moved toward each other in response to a squeezing force (F), and to facilitate injection of the substance into the tissue by releasing the substance in response to application of the squeezing force.

Abstract translation: 用于受试者的组织（22）的装置，包括被配置为注入组织的物质（24）以及被配置为放置在组织的第一和第二侧上的第一和第二组织挤压表面（20） 通过响应于挤压力（F）而朝向彼此移动而对组织施加压力，并且通过响应于挤压力的释放释放物质，便于将物质注入组织。

公开(公告)号：US20120136436A1

公开(公告)日：2012-05-31

申请号：US13141606

申请日：2009-12-22

Applicant: Oz Cabiri ,  Tal Sheps ,  Meir Kutzik ,  Amir Gross ,  Yossi Gross ,  Yuval Zipory

Inventor： Oz Cabiri ,  Tal Sheps ,  Meir Kutzik ,  Amir Gross ,  Yossi Gross ,  Yuval Zipory

IPC: A61F2/24

CPC classification number: A61F2/2445 ,  A61B17/0401 ,  A61B2017/00243 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/0441 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/0649 ,  A61B2017/12095 ,  A61F2/2442 ,  A61F2/2466 ,  A61F2250/0004 ,  A61F2250/001

Abstract: Apparatus is provided including an implant structure (22, 122, 1122), a rotatable structure (2900) coupled to the implant structure (22, 122, 1122) in a vicinity of a first portion thereof, and a flexible member (30). At least a first portion of the 5 flexible member (30) is disposed in contact with the rotatable structure (2900), and at least one end portion of the flexible member (30) is not disposed in contact with the rotatable structure (30). In response to rotation of the rotatable structure (2900) in a first direction thereof, successive portions of the flexible member (30) contact the rotatable structure (2900) to pull the at least one end portion of the flexible member 0 (30) toward the first portion of the implant structure (22, 122, 1122), and responsively to draw the first and second portions of the implant structure (22, 122, 1122) toward each other. Other applications are also described.

Abstract translation: 提供了包括植入结构（22,122,1122）的装置，在其第一部分附近与植入结构（22,122,1122）相连的可旋转结构（2900）和柔性构件（30）。 所述柔性构件（30）的至少第一部分设置成与所述可旋转结构（2900）接触，并且所述柔性构件（30）的至少一个端部未设置成与所述可旋转结构（30）接触， 。 响应于可旋转结构（2900）沿其第一方向的旋转，柔性构件（30）的连续部分接触可旋转结构（2900）以将柔性构件0（30）的至少一个端部向着 植入结构（22,122,1122）的第一部分，并且响应于将植入物结构（22,122,1122）的第一和第二部分彼此拉出。 还描述了其它应用。