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公开(公告)号:US20100216746A1
公开(公告)日:2010-08-26
申请号:US12667581
申请日:2008-06-05
IPC分类号: A61K31/675 , C07C233/64 , A61K31/165 , C07D209/42 , A61K31/40 , C07D413/12 , A61K31/5377 , C07D513/04 , A61K31/542 , A61K31/655 , A61K31/551 , A61P31/18 , A61P31/12
CPC分类号: C07C255/54 , C07C311/16 , C07C311/29 , C07C317/44 , C07D207/34 , C07D209/42 , C07D213/81 , C07D233/90 , C07D235/24 , C07D261/18 , C07D285/06 , C07D471/04 , C07D487/04
摘要: The present invention relates to compounds that are a non-nucleoside reverse transcriptase inhibitors, and to processes for the preparation and use of the same. Specifically, the present invention includes methods of using such compounds in the treatment of human immunodeficiency virus infection.
摘要翻译: 本发明涉及作为非核苷逆转录酶抑制剂的化合物及其制备和使用的方法。 具体地,本发明包括使用这些化合物治疗人类免疫缺陷病毒感染的方法。
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公开(公告)号:US08304419B2
公开(公告)日:2012-11-06
申请号:US12667581
申请日:2008-06-05
IPC分类号: A61K31/52 , A61K31/4164 , A61K31/40 , C07D473/00 , C07D233/54 , C07D207/30
CPC分类号: C07C255/54 , C07C311/16 , C07C311/29 , C07C317/44 , C07D207/34 , C07D209/42 , C07D213/81 , C07D233/90 , C07D235/24 , C07D261/18 , C07D285/06 , C07D471/04 , C07D487/04
摘要: The present invention relates to compounds that are a non-nucleoside reverse transcriptase inhibitors, and to processes for the preparation and use of the same. Specifically, the present invention includes methods of using such compounds in the treatment of human immunodeficiency virus infection.
摘要翻译: 本发明涉及作为非核苷逆转录酶抑制剂的化合物及其制备和使用的方法。 具体地,本发明包括使用这些化合物治疗人类免疫缺陷病毒感染的方法。
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公开(公告)号:US06376664B1
公开(公告)日:2002-04-23
申请号:US09528273
申请日:2000-03-17
申请人: Michael K. Chan , Wai H. Kwok , Huichang Zhang , Maosheng Duan
发明人: Michael K. Chan , Wai H. Kwok , Huichang Zhang , Maosheng Duan
IPC分类号: C07D22500
CPC分类号: C07D487/18
摘要: Cyclic bis benzimidazole ligands of the following formula are formed by contacting a (2-aminophenyl)-benzimidazole-4-carboxaldehyde ethylene acetal or a (2-nitrophenyl)-benzimidazole-4-benzaldehyde with an acid optionally in the presence of a metal or a metal salt. wherein R1 and R2 may be the same or different and are selected from H, an alkyl having 1 to 10 carbon atoms, a benzyl group, a substituted 2-ethylphenyl group, a carbonyl group, a phenyl substituent, a tosyl group, and an alkylsulfonate group; R3 and R4 may be the same or different and are selected from H, methyl, and ethyl; and R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, and R18 may be the same or different and are selected from H, alkyl having 1 to 10 carbon atoms, fluoride, chloride, bromide, iodide, nitro, amino, a carboxylate, an ester, and a phenyl group.
摘要翻译: 通过使(2-氨基苯基) - 苯并咪唑-4-甲醛乙醛缩醛或(2-硝基苯基) - 苯并咪唑-4-苯甲醛与酸任选地在金属存在下接触而形成下式的环状双苯并咪唑配体,或 其中R1和R2可以相同或不同,选自H,具有1-10个碳原子的烷基,苄基,取代的2-乙基苯基,羰基,苯基取代基,甲苯磺酰基 和烷基磺酸酯基; R 3和R 4可以相同或不同,并且选自H,甲基和乙基; 和R 5,R 6,R 7,R 8,R 9,R 10,R 11,R 12,R 13,R 14,R 15,R 16,R 17和R 18可以相同或不同,选自H,具有1-10个碳原子的烷基, 氯化物,溴化物,碘化物,硝基,氨基,羧酸酯,酯和苯基。
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