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19 条记录 (耗时 0.034 秒)

    Drosophila tumor necrosis factor class molecule polynucleotides and variants thereof
    1.
    发明授权
    Drosophila tumor necrosis factor class molecule polynucleotides and variants thereof 有权
    果蝇肿瘤坏死因子类分子（“DmTNFv2”）多核苷酸及其变体

    公开(公告)号：US07037676B2

    公开(公告)日：2006-05-02

    申请号：US09813329

    申请日：2001-03-20

    申请人： Pamela M. Carroll ,  Jian Chen ,  Chandra S. Ramanathan ,  Hong Xiao ,  Michael A. Bowen

    发明人： Pamela M. Carroll ,  Jian Chen ,  Chandra S. Ramanathan ,  Hong Xiao ,  Michael A. Bowen

    IPC分类号： C12P21/06 ,  C12N15/09 ,  C12N15/19 ,  C07H21/04

    CPC分类号： C07K14/525 ,  A01K2217/05

    摘要： The present invention provides novel polynucleotides encoding Drosophila DmTNF polypeptides, fragments and homologs thereof. The present invention also is directed to novel polynucleotides encoding two Drosophila DmTNF variants, DmTNFv1 and DmTNFv2 polypeptides, fragments and homologs thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, in addition to methods of genetically modifying Drosophila or cultured cells to express or mis-express DmTNF, DmTNFv1, or DmTNFv2. The invention also relates to the use of such modified insects or cells to characterize DmTNF activity, identify TNF-like genes and/or genes implicated in modulating TNF, characterize TNF signaling pathways, and/or to identify modulators of DmTNF activity.

    摘要翻译： 本发明提供了编码果蝇DmTNF多肽的新型多核苷酸，其片段和同系物。 本发明还涉及编码两种果蝇DmTNF变体，DmTNFv1和DmTNFv2多肽的新型多核苷酸，其片段和同系物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 除了遗传修饰果蝇或培养细胞以表达或错误表达DmTNF，DmTNFv1或DmTNFv2的方法之外，本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还涉及这种修饰的昆虫或细胞用于表征DmTNF活性，鉴定涉及调节TNF，表征TNF信号传导途径和/或鉴定DmTNF活性调节剂的TNF-样基因和/或基因的用途。

    Dropsophila tumor necrosis factor class molecule (“DmTNFv2”)
    2.
    发明授权
    Dropsophila tumor necrosis factor class molecule (“DmTNFv2”) 有权
    谷类肿瘤坏死因子分子（“DmTNFv2”）

    公开(公告)号：US07288632B2

    公开(公告)日：2007-10-30

    申请号：US11142736

    申请日：2005-06-01

    申请人： Pamela M. Carroll ,  Jian Chen ,  Chandra S. Ramanathan ,  Hong Xiao ,  Bo Guan ,  Michael A. Bowen

    发明人： Pamela M. Carroll ,  Jian Chen ,  Chandra S. Ramanathan ,  Hong Xiao ,  Bo Guan ,  Michael A. Bowen

    IPC分类号： C07K14/00

    CPC分类号： C07K14/525 ,  A01K2217/05

    摘要： The present invention provides novel polynucleotides encoding Drosophila DmTNF polypeptides, fragments and homologs thereof. The present invention also is directed to novel polynucleotides encoding two Drosophila DmTNF variants, DmTNFv1 and DmTNFv2 polypeptides, fragments and homologs thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, in addition to methods of genetically modifying Drosophila or cultured cells to express or mis-express DmTNF, DmTNFv1, or DmTNFv2. The invention also relates to the use of such modified insects or cells to characterize DmTNF activity, identify TNF-like genes and/or genes implicated in modulating TNF, characterize TNF signaling pathways, and/or to identify modulators of DmTNF activity.

    摘要翻译： 本发明提供了编码果蝇DmTNF多肽的新型多核苷酸，其片段和同系物。 本发明还涉及编码两种果蝇DmTNF变体，DmTNFv1和DmTNFv2多肽的新型多核苷酸，其片段和同系物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 除了遗传修饰果蝇或培养细胞以表达或错误表达DmTNF，DmTNFv1或DmTNFv2的方法之外，本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还涉及这种修饰的昆虫或细胞用于表征DmTNF活性，鉴定涉及调节TNF，表征TNF信号传导途径和/或鉴定DmTNF活性调节剂的TNF-样基因和/或基因的用途。

    Method and apparatus for a plastic evaporator fan shroud assembly
    5.
    发明授权
    Method and apparatus for a plastic evaporator fan shroud assembly 有权
    塑料蒸发器风扇护罩组件的方法和装置

    公开(公告)号：US06772606B2

    公开(公告)日：2004-08-10

    申请号：US10195174

    申请日：2002-07-15

    申请人： Bruce A. Kopf ,  Tim L. Coulter ,  Richard A. Kirchner ,  Michael A. Bowen ,  Troy M. Anderson ,  Eric K. Silbaugh

    发明人： Bruce A. Kopf ,  Tim L. Coulter ,  Richard A. Kirchner ,  Michael A. Bowen ,  Troy M. Anderson ,  Eric K. Silbaugh

    IPC分类号： F25D1706

    CPC分类号： F25D17/067 ,  F04D29/646 ,  F25D2317/0681

    摘要： An evaporator fan assembly includes a shroud have a plurality of irregularly staggered shroud legs radially outwardly spaced from a fan orifice and terminating in a motor mount. A motor is removably secured to the motor mount by a motor clip. The motor clip preferably includes a pair of legs terminating in a catch or hook that may be secured to a cross-member or support bar between the shroud legs. The motor is secured in a centered position to properly align a fan blade in the fan orifice. The fan blade is secured to the drive shaft of the motor which passes through a hole in the motor mount. A shroud cover may be secured to the shroud.

    摘要翻译： 蒸发器风扇组件包括护罩，其具有与风扇孔径向向外间隔开并终止于电动机安装件的多个不规则交错的护罩腿。 电动机通过电动机夹可拆卸地固定到电动机支架上。 马达夹优选地包括终止于卡扣或钩的一对腿，所述钩可以固定到护罩腿之间的横向构件或支撑杆上。 电机固定在中心位置，以正确对准风扇孔中的风扇叶片。 风扇叶片固定到电动机的驱动轴上，该驱动轴通过电动机支架的孔。 护罩盖可以固定到护罩上。

    Method for performing coupling analysis
    6.
    发明授权
    Method for performing coupling analysis 失效
    执行耦合分析的方法

    公开(公告)号：US06546529B1

    公开(公告)日：2003-04-08

    申请号：US09677362

    申请日：2000-10-02

    申请人： Allan H. Dansky ,  Michael A. Bowen ,  Peter J. Camporese ,  Alina Deutsch ,  Howard H. Smith

    发明人： Allan H. Dansky ,  Michael A. Bowen ,  Peter J. Camporese ,  Alina Deutsch ,  Howard H. Smith

    IPC分类号： G06F945

    CPC分类号： G06F17/5036

    摘要： Deterministic evaluation of coupling noise voltage is a function of many physical and electrical parameters such as wiring level, widths, spacing, net topologies, drv impedance and slew rates. This evaluation requires electrical modeling and subsequent circuit simulation to assess the sensitivities of these parameters. These sensitivities can be categorized as coupling guidelines that can be directly linked through extracted physical design data. This invention discloses the development and implementation of a technique for using a coupling guideline table early in the design of an integrated circuit when all the parameters generally required for coupling noise voltage calculations are not available. The steps include: creating a flat wire routing map of the integrated circuit, identifying the coupled wire segments on the integrated circuit, tracking wire interconnection patterns on the integrated circuit, deriving electrical parameters for the coupled wire segments, and generating a coupling guideline table with parameters for a plurality of electrical parameters. The parameters in the coupling guideline table are applied to the derived electrical parameters and a report is generated that lists the derived electrical parameters that fail to comply with the parameters in the coupling guideline table.

    摘要翻译： 耦合噪声电压的确定性评估是许多物理和电气参数的函数，如布线级别，宽度，间距，网络拓扑，drv阻抗和转换速率。 该评估需要电气建模和后续电路仿真来评估这些参数的灵敏度。 这些敏感性可以归类为可以通过提取的物理设计数据直接相关联的耦合准则。 本发明公开了当耦合噪声电压计算通常需要的所有参数不可用时，在集成电路设计早期使用耦合指南表的技术的开发和实现。 步骤包括：创建集成电路的扁平布线图，识别集成电路上的耦合线段，跟踪集成电路上的导线互连图案，导出耦合的线段的电参数，以及生成具有 用于多个电参数的参数。 耦合准则表中的参数应用于导出的电气参数，并生成报告，列出导出的电气参数不符合耦合指南表中的参数。