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    2-thienylimidazo[2,1-.beta.]benzothiazole-3-acetic acid derivatives, their preparation and their use
    1.
    发明授权
    2-thienylimidazo[2,1-.beta.]benzothiazole-3-acetic acid derivatives, their preparation and their use 失效
    2-噻吩基咪唑并[2,1-β]苯并噻唑-3-乙酸衍生物，其制备及其应用

    公开(公告)号：US5418248A

    公开(公告)日：1995-05-23

    申请号：US175249

    申请日：1993-12-29

    申请人： Mireille Sevrin ,  Claude Morel ,  Michel Mangane ,  Pascal George

    发明人： Mireille Sevrin ,  Claude Morel ,  Michel Mangane ,  Pascal George

    IPC分类号： A61K31/425 ,  A61P25/08 ,  A61P25/20 ,  C07D233/84 ,  C07D277/82 ,  C07D513/04

    CPC分类号： C07D513/04

    摘要： Compounds of the formula: ##STR1## in which R.sub.1 represents a hydroxy group, a C.sub.1 -C.sub.4 alkoxy group or an amino group of general formula --NR.sub.4 R.sub.5 in which R.sub.4 and R.sub.5 each represent, independently of each other, a hydrogen atom, a straight or branched C.sub.1 -C.sub.4 alkyl group, an allyl group or a methoxyethyl group, or alternatively --NR.sub.4 R.sub.5 represents a heterocycle containing 3 to 6 carbon atoms,Y represents a thienyl group optionally substituted by an alkyl group, andX represents a hydrogen or halogen atom,are useful as anticonvulsants and auxiolytics.

    摘要翻译： 下式的化合物：其中R 1表示羟基，C 1 -C 4烷氧基或通式-NR 4 R 5的氨基，其中R 4和R 5各自独立地表示氢原子 直链或支链C 1 -C 4烷基，烯丙基或甲氧基乙基，或者-NR4R5表示含有3至6个碳原子的杂环，Y表示任选被烷基取代的噻吩基，X表示氢 或卤素原子，可用作抗惊厥药和辅助溶剂。

    (4-piperidyl)methyl-2,3-dihydro-1H-isoindole and -2,3,4,5-tetrahydro-1H-benzazepine derivatives, their preparation and their application in therapy
    2.
    发明授权
    (4-piperidyl)methyl-2,3-dihydro-1H-isoindole and -2,3,4,5-tetrahydro-1H-benzazepine derivatives, their preparation and their application in therapy 失效
    （4-哌啶基）甲基-2,3-二氢-1H-茚并-2,3,4,5-四氢-1H-苯并恶嗪衍生物及其制备及其在治疗中的应用

    公开(公告)号：US5096900A

    公开(公告)日：1992-03-17

    申请号：US503941

    申请日：1990-02-08

    申请人： Pascal George ,  Mireille Sevrin ,  Michel Mangane

    发明人： Pascal George ,  Mireille Sevrin ,  Michel Mangane

    IPC分类号： C07D401/06

    CPC分类号： C07D401/06

    摘要： A benzazepine derivative which is a compound of formula (I): ##STR1## in which: each of m and n denotes the number 1, oreach of m and n denoted the number 2, orm denotes the number 3 and n denoted the number 1; andR denotes hydrogen or a group of formula --Z--R' in which Z denotes a --CO-- or --CH.sub.2 -- group and R' denotes a phenyl group which is unsubstituted or substituted with from one to three substituents selected from halogen atoms, linear or branch (C.sub.1 -C.sub.3) groups and linear or branched (C.sub.1 -C.sub.3) alkoxy groups,or a pharmacologically acceptable acid addition salt.

    摘要翻译： 作为式（I）的化合物的苯并氮杂衍生物：其中：m和n分别表示数1，或m和n分别表示数2，或m表示数3，n表示 1号; 并且R表示氢或式-ZR'的基团，其中Z表示-CO-或-CH2-基团，R'表示未取代的或被1至3个选自以下的取代基取代的苯基：卤原子，直链或 支链（C1-C3）基团和直链或支链（C1-C3）烷氧基，或药理学上可接受的酸加成盐。

    2,3-dihydro-1H-isoindole derivatives and their application in therapy
    3.
    发明授权
    2,3-dihydro-1H-isoindole derivatives and their application in therapy 失效
    2,3-二氢-1H-茚-2-酮衍生物及其在治疗中的应用

    公开(公告)号：US5081128A

    公开(公告)日：1992-01-14

    申请号：US377929

    申请日：1989-07-11

    申请人： Pascal George ,  Mireille Sevrin ,  Michel Mangane ,  Jean-Pierre Merly ,  Dennis Bigg

    发明人： Pascal George ,  Mireille Sevrin ,  Michel Mangane ,  Jean-Pierre Merly ,  Dennis Bigg

    IPC分类号： A61K31/4427 ,  A61K31/445 ,  A61K31/55 ,  A61P43/00 ,  C07D401/06

    CPC分类号： C07D401/06

    摘要： A benzazepine derivative which is a compound of formula (I): ##STR1## in which each of m and n denotes the number 1, oreach of m and n denotes the number 2, orm denotes the number 3 and n denotes the number 1; and R denotes hydrogen or a group of formula --Z--R' in which Z denotes a --CO-- or --CH.sub.2 -- group and R' denotes a phenyl group which is unsubtituted or substituted with from one to three substituents selected from halogen atoms, linear or branch (C.sub.1 -C.sub.3) alkyl groups and linear or branched (C.sub.1 -C.sub.3) alkoxy groups, or a pharmacologically acceptable acid addition salt.

    摘要翻译： 作为式（I）的化合物的苯并吖庚因衍生物：其中m和n各自表示数1，或m和n各自表示数2，或m表示数3，n表示数 1; 并且R表示氢或式-ZR'的基团，其中Z表示-CO-或-CH2-基，R'表示未取代或被一至三个选自以下的取代基取代的苯基：卤原子，直链或 支链（C1-C3）烷基和直链或支链（C1-C3）烷氧基，或药理学上可接受的酸加成盐。

    2-aminopyrimidine-4-carboxamide derivatives, their preparaton and their application in therapy
    4.
    发明授权
    2-aminopyrimidine-4-carboxamide derivatives, their preparaton and their application in therapy 失效
    2-氨基嘧啶-4-羧酰胺衍生物及其制剂及其在治疗中的应用

    公开(公告)号：US5229392A

    公开(公告)日：1993-07-20

    申请号：US872028

    申请日：1992-04-23

    申请人： Pascal George ,  Philippe Manoury ,  Michel Mangane ,  Jean-Pierre Merly

    发明人： Pascal George ,  Philippe Manoury ,  Michel Mangane ,  Jean-Pierre Merly

    IPC分类号： A61K31/505 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D239/42

    CPC分类号： C07D239/42

    摘要： A compound which is a 2-aminopyrimidine-4-carboxamide derivative represented by general formula (I) ##STR1## in which m represents 2 or 3,n represents 2 or 3,R.sub.1 represents hydrogen or methyl, andX represents a substituent selected from the group consisting of hydrogen, fluorine, chlorine, methoxy, ethoxy, methyl and 1-methylethyl, with the proviso that more than one substituent X may be present in which case each X may be the same or different, or a pharmaceutically acceptable acid addition salt thereof.

    摘要翻译： 作为通式（I）表示的2-氨基嘧啶-4-甲酰胺衍生物的化合物，其中m表示2或3，n表示2或3，R 1表示氢或甲基，X表示 选自氢，氟，氯，甲氧基，乙氧基，甲基和1-甲基乙基的取代基，条件是可以存在多于一个取代基X，在这种情况下，每个X可以相同或不同，或药学上 其可接受的酸加成盐。