公开(公告)号：US09724455B2

公开(公告)日：2017-08-08

申请号：US13599028

申请日：2012-08-30

Applicant: Pascal Kopperschmidt ,  Alfred Gagel

Inventor： Pascal Kopperschmidt ,  Alfred Gagel

IPC: A61M1/14 ,  A61M1/16 ,  A61M1/36

CPC classification number: A61M1/16 ,  A61M1/1605 ,  A61M1/1615 ,  A61M1/36 ,  A61M1/3609 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3368 ,  A61M2205/50

Abstract: Method and apparatus for controlling the dialysate flow in a dialysis device. A change of the value of a control factor, caused by a variation of a property of the dialysate or of the blood or by a change of the dialysate flow, is determined in order to control the dialysate flow. The control factor is a measure for the exchange of substances via the dialyzer and thus the effectiveness of the dialyzer. If the change of the value of the control factor exceeds a limit, the dialysate flow is increased. On the other hand, the dialysate flow is reduced if the change of the value of the control factor falls short of the limit range.

公开(公告)号：US09215985B2

公开(公告)日：2015-12-22

申请号：US14111248

申请日：2012-04-10

Applicant: Malte Gross ,  Pascal Kopperschmidt ,  Andreas Maierhofer ,  Alfred Gagel

Inventor： Malte Gross ,  Pascal Kopperschmidt ,  Andreas Maierhofer ,  Alfred Gagel

IPC: G01N21/00 ,  A61B5/00 ,  A61M1/36 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/64 ,  G01N21/65

CPC classification number: A61B5/0082 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14546 ,  A61B5/14557 ,  A61M1/367 ,  G01N21/6486 ,  G01N21/65

Abstract: A method of monitoring a treatment of a patient, preferably for monitoring hemodialysis, hemodiafiltration and/or peritoneal dialysis, that includes the steps of irradiating a sample of a dialysis liquid used in the treatment with irradiation light of at least a first irradiation wavelength, detecting light emitted by the irradiated sample in at least a first detection wavelength, the detection wavelength being different from the first irradiation wavelength, and determining the presence and/or concentration of at least one analyte in the sample on the basis of the detected light.

Abstract translation: 一种监测患者治疗的方法，优选用于监测血液透析，血液透析滤过和/或腹膜透析，其包括以下步骤：用至少第一照射波长的照射光照射用于治疗的透析液样品，检测 由至少第一检测波长的被照射样品发射的光，检测波长不同于第一照射波长，并且基于检测到的光来确定样品中至少一种分析物的存在和/或浓度。

公开(公告)号：US20120318739A1

公开(公告)日：2012-12-20

申请号：US13512133

申请日：2010-11-16

Applicant: Pascal Kopperschmidt ,  Alfred Gagel

Inventor： Pascal Kopperschmidt ,  Alfred Gagel

IPC: A61M1/16 ,  B01D61/32

CPC classification number: A61M1/342 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1603 ,  A61M1/1613 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/3413 ,  A61M1/3431 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3635 ,  A61M2205/3334 ,  B01D61/243 ,  B01D61/28 ,  B01D61/32 ,  B01D2311/14 ,  B01D2311/16

Abstract: The present invention relates to a method for regulating supply of substituate in an extracorporeal blood treatment with an extracorporeal blood treatment apparatus comprising a dialyzer divided by a semipermeable membrane into a blood chamber and a dialyzing fluid chamber and a device for supplying substituate. Moreover, the present invention relates to an extracorporeal blood treatment apparatus having a device for regulating supply of substituate. Regulation of supply of substituate in the extracorporeal blood treatment takes place as a function of the rheological loading of the dialyzer. To regulate supply of substituate during extracorporeal blood treatment, rheological loading of the dialyzer is determined from transmembrane pressure on the dialyzer and flow resistance of the dialyzer and substituate rate is increased or reduced according to the loading. The selection of dialyzer parameters or blood parameters is therefore no longer necessary and the distinction between pre-dilution and post-dilution is also made obsolete.

Abstract translation: 本发明涉及一种用体外血液处理装置调节供体取代物的方法，所述体外血液处理装置包括由半透膜分隔成血液室的透析器和透析液室以及用于供给取代基的装置。 此外，本发明涉及具有用于调节供体的装置的体外血液处理装置。 对体外血液治疗中取代基的供应调节作为透析器流变负荷的函数。 为了调节体外血液处理中取代基的供应，透析器的流变学载量由透析器上的跨膜压力和透析器的流动阻力确定，并且根据负载增加或降低取代率。 因此，不再需要选择透析器参数或血液参数，并且预稀释和稀释后的区别也被淘汰。

公开(公告)号：US20140098359A1

公开(公告)日：2014-04-10

申请号：US14111248

申请日：2012-04-10

Applicant: Malte Gross ,  Pascal Kopperschmidt ,  Andreas Malerhofer ,  Alfred Gagel

Inventor： Malte Gross ,  Pascal Kopperschmidt ,  Andreas Malerhofer ,  Alfred Gagel

IPC: A61B5/00 ,  G01N21/65 ,  G01N21/64

CPC classification number: A61B5/0082 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14546 ,  A61B5/14557 ,  A61M1/367 ,  G01N21/6486 ,  G01N21/65

Abstract: The present invention pertains to a method for monitoring a treatment of a patient, preferably for monitoring hemodialysis, hemodiafiltration and/or peritoneal dialysis, the method comprising the steps of irradiating a sample of a dialysis liquid used in the treatment with irradiation light of at least a first irradiation wavelength, detecting light emitted by the irradiated sample in at least a first detection wavelength, the detection wavelength being different from the first irradiation wavelength, and determining the presence and/or concentration of at least one analyte in the sample on the basis of the detected light.

Abstract translation: 本发明涉及一种用于监测患者治疗的方法，优选用于监测血液透析，血液透析滤过和/或腹膜透析，所述方法包括以下步骤：将用于治疗的透析液样品至少照射至少 第一照射波长，检测由至少第一检测波长的被照射样品发射的光，检测波长与第一照射波长不同，并且基于该基准确定样品中至少一种分析物的存在和/或浓度 的检测光。

公开(公告)号：US11376353B2

公开(公告)日：2022-07-05

申请号：US13512133

申请日：2010-11-16

Applicant: Pascal Kopperschmidt ,  Alfred Gagel

Inventor： Pascal Kopperschmidt ,  Alfred Gagel

IPC: B01D61/32 ,  B01D61/28 ,  B01D61/24 ,  A61M1/16 ,  A61M1/36 ,  A61M1/34

Abstract: The present invention relates to a method for regulating supply of substituate in an extracorporeal blood treatment with an extracorporeal blood treatment apparatus comprising a dialyzer divided by a semipermeable membrane into a blood chamber and a dialyzing fluid chamber and a device for supplying substituate. Moreover, the present invention relates to an extracorporeal blood treatment apparatus having a device for regulating supply of substituate. Regulation of supply of substituate in the extracorporeal blood treatment takes place as a function of the rheological loading of the dialyzer. To regulate supply of substituate during extracorporeal blood treatment, rheological loading of the dialyzer is determined from transmembrane pressure on the dialyzer and flow resistance of the dialyzer and substituate rate is increased or reduced according to the loading. The selection of dialyzer parameters or blood parameters is therefore no longer necessary and the distinction between pre-dilution and post-dilution is also made obsolete.

公开(公告)号：US08315654B2

公开(公告)日：2012-11-20

申请号：US12438775

申请日：2007-08-22

Applicant: Klaus Balschat ,  Pascal Kopperschmidt ,  Reiner Spickermann

Inventor： Klaus Balschat ,  Pascal Kopperschmidt ,  Reiner Spickermann

IPC: H04W4/12

CPC classification number: A61M1/14 ,  A61M1/16 ,  A61M1/168 ,  A61M1/1682 ,  A61M1/34 ,  A61M1/3643 ,  A61M1/3644 ,  A61M2205/3553 ,  A61M2205/3584 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/60 ,  A61M2205/70

Abstract: The present invention relates to an extracorporeal blood treatment device comprising a treatment unit and a device for controlling the treatment unit for preparing and carrying out the blood treatment. The blood treatment device also comprises an internal communication unit for communicating with an external communication unit. In order to the prepare the device blood treatment, the patient sends an initiation code by means of an external communication unit to the internal communication device. Routines required for preparing the blood treatment are then started. One main advantage is that the patient, for example during home dialysis, does not need to be present when the device is preparing for dialysis and the dialysis preparation can be started when the patient thinks of returning home in time for the beginning of the preparation phase.

Abstract translation: 本发明涉及一种体外血液处理装置，其包括处理单元和用于控制用于制备和进行血液处理的处理单元的装置。 血液处理装置还包括用于与外部通信单元通信的内部通信单元。 为了准备用于血液处理的装置，患者通过外部通信单元向内部通信装置发送启动代码。 然后开始准备血液处理所需的程序。 一个主要的优点是，例如在家庭透析期间，当设备准备透析时，患者不需要存在患者，并且当患者认为在准备阶段开始时及时回家时可以开始透析准备 。

公开(公告)号：US08177736B2

公开(公告)日：2012-05-15

申请号：US12282568

申请日：2006-12-08

Applicant: Pascal Kopperschmidt

Inventor： Pascal Kopperschmidt

IPC: A61M37/00 ,  A61M1/00 ,  A41F1/00 ,  A41F1/08 ,  A44B1/04 ,  A44B1/18 ,  A44B11/25 ,  A44B17/00 ,  B42F1/00 ,  F16D1/08 ,  F16D3/80 ,  F16L17/00

CPC classification number: A61M1/3653 ,  A61M1/3655 ,  A61M1/3656 ,  A61M1/3659 ,  A61M5/1418 ,  A61M2205/18 ,  Y10T24/3439 ,  Y10T24/44 ,  Y10T24/44538 ,  Y10T403/22

Abstract: The invention relates to a device and to a method for monitoring access to vessels during extracorporeal blood treatment. The invention forms a loop in the arterial and/or venous line and provides device for fixing a section of the line in a loop. When the line is stressed under tension, the loop contracts and the line finally kinks. The modification of the diameter of the line and the formation of a kink in the line leads to a rise of pressure in the line, which is monitored by a pressure monitoring device. If the pressure exceeds a predetermined threshold value, the aspirating cannula is in danger of slipping out of the vessel access or has partially or completely slipped out, thus allowing the threshold value to be determined for alarms.

Abstract translation: 本发明涉及在体外血液处理期间监测血管通路的装置和方法。 本发明在动脉和/或静脉线中形成环，并提供用于将线的一部分固定在环中的装置。 当线路受到紧张的压力时，环路收缩，线路终于扭结。 线的直径的改变和线中的扭结的形成导致管线中的压力升高，这由压力监测装置监测。 如果压力超过预定的阈值，则抽吸插管有可能从容器进入或从部分或全部滑出，从而允许为报警确定阈值。

公开(公告)号：US07985196B2

公开(公告)日：2011-07-26

申请号：US12086593

申请日：2007-03-06

Applicant: Pascal Kopperschmidt ,  Joachim Noack

Inventor： Pascal Kopperschmidt ,  Joachim Noack

IPC: A61M37/00 ,  C02F1/44

CPC classification number: A61M1/3643 ,  A61M1/1682 ,  A61M1/3644 ,  A61M1/3646 ,  A61M1/365 ,  A61M1/3652

Abstract: A method and a hemodialysis machine provide for at least partial emptying of an extracorporeal blood circulation after patient blood in the circulation has been returned to the patient via an infusion liquid which displaces the blood. The method includes emptying at least a blood chamber of a hemodialyzer subdivided by a semipermeable membrane into the blood chamber and a dialysis fluid chamber without additionally connecting an arterial blood line and a venous blood line of the circulation to one another. The arterial blood line is actively or passively aerated at a first point and the venous blood line is actively or passively aerated at a second point. The infusion liquid is emptied through the membrane into the dialysis fluid chamber and then via a dialysis fluid discharge line. The method is operable by a control program that runs automatically without requiring any manual input after activation of the program.

Abstract translation: 一种方法和血液透析机在循环中的患者血液已经通过置换血液的输注液体返回给患者之后，至少部分排空体外血液循环。 所述方法包括将至少由半透膜细分的血液透析器的血液室排空到血液室中，以及透析液室，而不将动脉血管和循环的静脉血液线彼此连接。 动脉血液线在第一点被主动地或被动地通气，并且静脉血液线在第二点被主动或被动地充气。 将输液通过膜排空到透析液室中，然后通过透析液排出管。 该方法可通过自动运行的控制程序进行操作，而不需要在激活程序之后进行任何手动输入。

公开(公告)号：US20100204633A1

公开(公告)日：2010-08-12

申请号：US12733702

申请日：2008-08-26

Applicant: Pascal Kopperschmidt

Inventor： Pascal Kopperschmidt

IPC: A61M1/14 ,  G06F15/00 ,  G08B21/00

CPC classification number: A61M1/342 ,  A61M1/3639 ,  A61M1/3672 ,  A61M5/1452 ,  A61M5/16859 ,  A61M2205/14 ,  A61M2205/3331

Abstract: The present invention relates to a method for checking and/or monitoring the correct operation of an adding device of a medical apparatus, wherein the medical apparatus includes an extracorporeal circuit with which the adding device is connected such that an agent can be introduced into the extracorporeal circuit by means of the adding device, the pressure loss in the extracorporeal circuit being measured and evaluated for checking and/or monitoring the correct operation of the adding device. In accordance with the invention, the adding device for this purpose generates an oscillating pressure course.

Abstract translation: 本发明涉及一种用于检查和/或监视医疗装置的添加装置的正确操作的方法，其中所述医疗装置包括与所述添加装置连接的体外电路，使得可以将药剂引入体外 通过加法装置对体外循环中的压力损失进行测量和评估，以检查和/或监视加法装置的正确操作。 根据本发明，用于该目的的添加装置产生振荡压力进程。

公开(公告)号：US20110230812A1

公开(公告)日：2011-09-22

申请号：US13130116

申请日：2009-11-14

Applicant: Pascal Kopperschmidt ,  Gross Malte ,  Spickermann Reiner

Inventor： Pascal Kopperschmidt ,  Gross Malte ,  Spickermann Reiner

IPC: A61M37/00 ,  A61B5/02

CPC classification number: A61B5/02042 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M2205/18 ,  A61M2205/3331

Abstract: A method and a device for recognition of paravasal bleeding upon a supplying of blood to a vascular access via a line and/or upon the removal of blood from a vascular access via a line, particularly paravasal bleeding during extra-corporeal blood treatment, such as for hemodialysis, hemofiltration or hemodiafiltration is provided. A device for extra-corporeal blood treatment, particularly for hemodialysis, hemofiltration or hemodiafiltration, comprising a device for recognition of paravasal bleeding is also provided. The method and the device are based on the change of arterial pressure in the arterial branch or the venous pressure in the venous branch of the extra-corporeal circuit being registered during the extra-corporeal blood treatment. If paravasal bleeding occurs during the blood treatment, the positive dynamic pressure on the line leading to the vascular access rises on the venous cannula during the extra-corporeal blood treatment, or the suction pressure on the line leaving the vascular access, such as the arterial cannula during extra-corporeal blood treatment, rises; that is, the suction pressure becomes more negative. The pressure rise begins moderately at first and then becomes increasingly greater. Decisive for the method and the device, therefore, is that pressure changes that come from a pressure level exhibiting a large difference from the reference value find stronger consideration than those that come from a pressure level that exhibits only a minor difference from the reference value.

Abstract translation: 一种方法和装置，用于在通过管线向血管通路供血时和/或通过管线从血管通路中取出血液，特别是在体外血液处理期间特别是paravasal出血，例如 用于血液透析，提供血液滤过或血液透析滤过。 还提供了一种用于体外血液处理的装置，特别是用于血液透析，血液滤过或血液透析滤过的装置，其包括用于识别旁路出血的装置。 该方法和装置基于在体外血液处理期间记录的动脉分支中的动脉压的变化或在体外循环的静脉分支中的静脉压。 如果在血液治疗期间发生paravasal渗血，则导致血管通路的线上的积极动态压力在体外血液处理期间在静脉插管上升，或者离开血管通路的线路上的吸入压力，例如动脉 套管在体外血液治疗中升高; 也就是说，吸入压力变得更负。 首先压力上升开始适度，然后变得越来越大。 因此，对于该方法和装置来说，与来自与参考值显示较大差异的压力水平的压力变化比从与参考值仅显示微小差异的压力水平的压力变化相比更强烈地考虑。