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公开(公告)号:US08198458B2
公开(公告)日:2012-06-12
申请号:US12364551
申请日:2009-02-03
申请人: Patrick DeRoy , Anne-Marie Faucher , Alexandre Gagnon , Serge R. Landry , Sebastien Morin , Jeffrey O'Meara , Bruno Simoneau , Bounkham Thavonekham , Christiane Yoakim
发明人: Patrick DeRoy , Anne-Marie Faucher , Alexandre Gagnon , Serge R. Landry , Sebastien Morin , Jeffrey O'Meara , Bruno Simoneau , Bounkham Thavonekham , Christiane Yoakim
IPC分类号: A61K31/41 , C07D257/04
CPC分类号: C07D257/04 , A61K31/41 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/495 , A61K31/5377 , A61K31/541 , C07D231/18 , C07D233/84 , C07D249/08 , C07D249/12 , C07D277/36 , C07D285/06 , C07D285/125 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要: Compounds of formula (I): wherein Ar, X, R1, R2, R3 and R4 are as defined herein. The compounds are useful as reverse transcriptase inhibitors against wild type and single or double mutant strains of HIV.
摘要翻译: 式(I)化合物:其中Ar,X,R 1,R 2,R 3和R 4如本文所定义。 该化合物可用作针对野生型和单突变或双突变株的逆转录酶抑制剂。
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公开(公告)号:US07956068B2
公开(公告)日:2011-06-07
申请号:US12743143
申请日:2008-11-03
申请人: Rebekah J. Carson , Lee Fader , Stephen Kawai , Serge R. Landry , Youla S. Tsantrizos , Christian Brochu , Sebastien Morin , Mathieu Parisien , Bruno Simoneau
发明人: Rebekah J. Carson , Lee Fader , Stephen Kawai , Serge R. Landry , Youla S. Tsantrizos , Christian Brochu , Sebastien Morin , Mathieu Parisien , Bruno Simoneau
IPC分类号: C07D495/04 , A61K31/4365
CPC分类号: C07D495/04 , C07D519/00
摘要: The present invention relates to compounds of formula (I) wherein c, X, Y, R2, R3, R4 and R6 are as defined herein, compositions and uses thereof for treating human immunodeficiency virus (HIV) infection. In particular, the present invention provides novel inhibitors of HIV integrase, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection.
摘要翻译: 本发明涉及其中c,X,Y,R 2,R 3,R 4和R 6如本文所定义的式(I)化合物,其用于治疗人类免疫缺陷病毒(HIV)感染的组合物和用途。 特别地,本发明提供HIV整合酶的新型抑制剂,含有这些化合物的药物组合物和使用这些化合物治疗HIV感染的方法。
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公开(公告)号:US20100311735A1
公开(公告)日:2010-12-09
申请号:US12742997
申请日:2008-09-11
申请人: Youla S. Tsantrizos , Murray D. Bailey , Francois Bilodeau , Rene Coulombe , Teddy Halmos , Stephen Kawai , Serge R. Landry , Steven LaPlante , Sebastien Morin , Marc-Andre Poupart , Bruno Simoneau , Lee Fader , Rebekah J. Carson , Mathieu Parisien
发明人: Youla S. Tsantrizos , Murray D. Bailey , Francois Bilodeau , Rene Coulombe , Teddy Halmos , Stephen Kawai , Serge R. Landry , Steven LaPlante , Sebastien Morin , Marc-Andre Poupart , Bruno Simoneau , Lee Fader , Rebekah J. Carson , Mathieu Parisien
IPC分类号: A61K31/5383 , C07D215/14 , A61K31/47 , C07D405/10 , A61K31/4709 , C07D401/10 , C07D491/16 , A61K31/4741 , C07D413/10 , A61K31/538 , C07D498/06 , A61P31/18
CPC分类号: C07D215/14 , A61K31/47 , A61K31/4709 , A61K31/473 , A61K31/4741 , A61K31/538 , A61K31/5383 , C07D215/18 , C07D221/16 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D491/06 , C07D498/06
摘要: Compounds of formula I: wherein R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.
摘要翻译: 式I化合物(其中R 4,R 6和R 7在本文中定义)可用作HIV复制的抑制剂。
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公开(公告)号:US20100305115A1
公开(公告)日:2010-12-02
申请号:US12743143
申请日:2008-11-03
申请人: Rebekah J. Carson , Lee Fader , Stephen Kawai , Serge R. Landry , Youla S. Tsantrizos , Christian Brochu , Sebastien Morin , Mathieu Parisien , Bruno Simoneau
发明人: Rebekah J. Carson , Lee Fader , Stephen Kawai , Serge R. Landry , Youla S. Tsantrizos , Christian Brochu , Sebastien Morin , Mathieu Parisien , Bruno Simoneau
IPC分类号: A61K31/538 , C07D495/04 , A61K31/4365 , C07D491/06 , A61K31/436 , A61P31/18
CPC分类号: C07D495/04 , C07D519/00
摘要: The present invention relates to compounds of formula (I) wherein c, X, Y, R2, R3, R4 and R6 are as defined herein, compositions and uses thereof for treating human immunodeficiency virus (HIV) infection. In particular, the present invention provides novel inhibitors of HIV integrase, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection
摘要翻译: 本发明涉及其中c,X,Y,R 2,R 3,R 4和R 6如本文所定义的式(I)化合物,其用于治疗人类免疫缺陷病毒(HIV)感染的组合物和用途。 特别地,本发明提供HIV整合酶的新型抑制剂,含有这些化合物的药物组合物和使用这些化合物治疗HIV感染的方法
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公开(公告)号:US20110028464A1
公开(公告)日:2011-02-03
申请号:US12743138
申请日:2008-11-03
申请人: Youla S. Tsantrizos , Murray D. Bailey , François Bilodeau , Rebekah J. Carson , Lee Fader , Teddy Halmos , Stephen Kawai , Serge R. Landry , Steven Laplante , Bruno Simoneau
发明人: Youla S. Tsantrizos , Murray D. Bailey , François Bilodeau , Rebekah J. Carson , Lee Fader , Teddy Halmos , Stephen Kawai , Serge R. Landry , Steven Laplante , Bruno Simoneau
IPC分类号: A61K31/538 , C07D413/14 , A61P31/18 , C07D405/10 , A61K31/4709 , C07D491/06 , A61K31/4741 , A61K31/506 , C07D405/14 , A61K31/496
CPC分类号: C07D413/14 , C07D215/14 , C07D215/18 , C07D215/20 , C07D215/38 , C07D215/48 , C07D401/04 , C07D405/04 , C07D405/14 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/12 , C07D417/14 , C07D491/04
摘要: Compounds of formula I: wherein c, R2, R3, R4, R5, R6, R7 and R8 are defined herein, are useful as inhibitors of HIV replication.
摘要翻译: 式I化合物:其中c,R 2,R 3,R 4,R 5,R 6,R 7和R 8在本文中定义,可用作HIV复制的抑制剂。
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公开(公告)号:US08377960B2
公开(公告)日:2013-02-19
申请号:US12743138
申请日:2008-11-03
申请人: Youla S. Tsantrizos , Murray D. Bailey , François Bilodeau , Rebekah J. Carson , Lee Fader , Teddy Halmos , Stephen Kawai , Serge R. Landry , Steven Laplantea , Bruno Simoneau
发明人: Youla S. Tsantrizos , Murray D. Bailey , François Bilodeau , Rebekah J. Carson , Lee Fader , Teddy Halmos , Stephen Kawai , Serge R. Landry , Steven Laplantea , Bruno Simoneau
IPC分类号: A61K31/47
CPC分类号: C07D413/14 , C07D215/14 , C07D215/18 , C07D215/20 , C07D215/38 , C07D215/48 , C07D401/04 , C07D405/04 , C07D405/14 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/12 , C07D417/14 , C07D491/04
摘要: Compounds of formula I: wherein c, R2, R3, R4, R5, R6, R7 and R8 are defined herein, are useful as inhibitors of HIV replication.
摘要翻译: 式I化合物:其中c,R 2,R 3,R 4,R 5,R 6,R 7和R 8在本文中定义,可用作HIV复制的抑制剂。
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