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公开(公告)号:US08158106B2
公开(公告)日:2012-04-17
申请号:US10261110
申请日:2002-09-30
申请人: Patrick E. Guire , Kristin S. Taton , John V. Wall
发明人: Patrick E. Guire , Kristin S. Taton , John V. Wall
CPC分类号: B82Y5/00 , A61K9/1647 , A61K9/1652 , A61K9/2081 , A61K9/5073 , A61K9/5078 , A61K47/6927 , A61K47/6957 , A61K49/0002 , A61K49/1821 , A61K51/1244 , A61L27/54 , A61L29/18 , A61L31/18 , A61L2300/44 , A61L2300/604 , A61L2300/606 , A61L2300/622
摘要: Surface coatings including microparticles immobilized in a matrix of polymeric material on a substrate are described. The microparticles can also include an agent which can be useful for various applications, such as medical applications.This invention relates to the field of surface coatings for use in various applications. More particularly, the invention relates to surface coating useful for drug delivery, imaging and other uses of microparticles immobilized via a polymeric matrix.
摘要翻译: 描述包括固定在基底上的聚合物材料基质中的微粒的表面涂层。 微粒还可以包括可用于各种应用例如医疗应用的试剂。 本发明涉及用于各种应用的表面涂层领域。 更具体地说,本发明涉及可用于通过聚合物基质固定的微粒的药物递送,成像和其它用途的表面涂层。
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公开(公告)号:US07195913B2
公开(公告)日:2007-03-27
申请号:US09972687
申请日:2001-10-05
申请人: Patrick E. Guire , Kristin S. Taton , John V. Wall
发明人: Patrick E. Guire , Kristin S. Taton , John V. Wall
CPC分类号: B82Y30/00 , B01J19/0046 , B01J2219/00466 , B01J2219/005 , B01J2219/00576 , B01J2219/00585 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00725 , B82Y5/00 , B82Y10/00 , C12Q1/6837 , G01N33/54366 , Y10S530/81 , Y10S530/811 , Y10S530/815 , Y10S530/816 , C12Q2563/149
摘要: Arrays including microparticles having probe and marker moieties are used for the detection of a target in a sample. Microparticles are randomly immobilized on at least a portion of a substrate. A detection scheme is performed to detect the marker associated with the microparticle and the identity of the probe, and any target bound to the probe.
摘要翻译: 包括具有探针和标记物部分的微粒的阵列用于检测样品中的靶。 微粒随机固定在底物的至少一部分上。 执行检测方案以检测与微粒相关的标记和探针的身份以及与探针结合的任何靶标。
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公开(公告)号:US08679454B2
公开(公告)日:2014-03-25
申请号:US12383762
申请日:2009-03-27
申请人: Patrick E. Guire , Kristin S. Taton , John V. Wall
发明人: Patrick E. Guire , Kristin S. Taton , John V. Wall
CPC分类号: A61K9/2081 , A61K9/5073 , A61K9/5078 , A61K47/6957 , A61K49/0002 , A61K49/1821 , A61K51/1244 , A61L27/54 , A61L29/18 , A61L31/18 , A61L2300/44 , A61L2300/604 , A61L2300/606 , A61L2300/622 , B82Y5/00
摘要: Surface coatings including microparticles immobilized in a matrix of polymeric material on a substrate are described. The microparticles can also include an agent which can be useful for various applications, such as medical applications.This invention relates to the field of surface coatings for use in various applications. More particularly, the invention relates to surface coating useful for drug delivery, imaging and other uses of microparticles immobilized via a polymeric matrix.
摘要翻译: 描述包括固定在基底上的聚合物材料基质中的微粒的表面涂层。 微粒还可以包括可用于各种应用例如医疗应用的试剂。 本发明涉及用于各种应用的表面涂层领域。 更具体地说,本发明涉及可用于通过聚合物基质固定的微粒的药物递送,成像和其它用途的表面涂层。
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公开(公告)号:US20090186070A1
公开(公告)日:2009-07-23
申请号:US12383762
申请日:2009-03-27
申请人: Patrick E. Guire , Kristin S. Taton , John V. Wall
发明人: Patrick E. Guire , Kristin S. Taton , John V. Wall
CPC分类号: A61K9/2081 , A61K9/5073 , A61K9/5078 , A61K47/6957 , A61K49/0002 , A61K49/1821 , A61K51/1244 , A61L27/54 , A61L29/18 , A61L31/18 , A61L2300/44 , A61L2300/604 , A61L2300/606 , A61L2300/622 , B82Y5/00
摘要: Surface coatings including microparticles immobilized in a matrix of polymeric material on a substrate are described. The microparticles can also include an agent which can be useful for various applications, such as medical applications.This invention relates to the field of surface coatings for use in various applications. More particularly, the invention relates to surface coating useful for drug delivery, imaging and other uses of microparticles immobilized via a polymeric matrix.
摘要翻译: 描述包括固定在基底上的聚合物材料基质中的微粒的表面涂层。 微粒还可以包括可用于各种应用例如医疗应用的试剂。 本发明涉及用于各种应用的表面涂层领域。 更具体地说,本发明涉及可用于通过聚合物基质固定的微粒的药物递送,成像和其它用途的表面涂层。
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公开(公告)号:US08815259B2
公开(公告)日:2014-08-26
申请号:US13119756
申请日:2009-09-15
申请人: Kristin S. Taton , Patrick E. Guire , Laurie R. Lawin , Jie Wen
发明人: Kristin S. Taton , Patrick E. Guire , Laurie R. Lawin , Jie Wen
CPC分类号: A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/404 , A61L2300/624 , A61L2400/12 , A61L2420/04
摘要: The invention describes nanotextured super hydrophobic coatings that contain active agents which can elute from the coating over a period of time.
摘要翻译: 本发明描述了纳米纹理超疏水涂层,其包含可在一段时间内从涂层中洗脱的活性剂。
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公开(公告)号:US07807750B2
公开(公告)日:2010-10-05
申请号:US10944384
申请日:2004-09-17
申请人: Kristin S. Taton , Patrick E. Guire
发明人: Kristin S. Taton , Patrick E. Guire
IPC分类号: C08F279/02 , C08F251/00 , C08F253/00 , C08F255/00 , C08F261/00 , C08F297/00
CPC分类号: A61L31/14 , A61L31/10 , C08F220/54 , C08F220/60 , C08F226/10 , C08L2312/00 , C09D133/26 , C08L77/10
摘要: A thermally-reactive polymer that forms a polymer-coupled reactive species upon heating is described and useful for forming coated surfaces. The polymer-coated surface has improved lubricity and passivity. A thermally-reactive quaternary amine-containing polymer was produced that provides passivity and anti-microbial activity.
摘要翻译: 描述了在加热时形成聚合物偶联反应性物质的热反应性聚合物,并且可用于形成涂覆表面。 聚合物涂覆的表面具有改善的润滑性和被动性。 制备了一种提供无源和抗微生物活性的热反应性含季胺的聚合物。
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公开(公告)号:US07361724B2
公开(公告)日:2008-04-22
申请号:US10759853
申请日:2004-01-15
申请人: Patrick E. Guire , Kristin S. Taton
发明人: Patrick E. Guire , Kristin S. Taton
IPC分类号: C08G64/00
CPC分类号: B82Y30/00 , A61L27/34 , A61L31/10 , B05D1/185 , B82Y40/00 , Y10T428/261 , Y10T428/268 , Y10T428/31507 , Y10T428/31551 , Y10T428/31678
摘要: A surface coating composition for providing a self-assembling monolayer, in stable form, on a material surface or at a suitable interface, as well as a method of preparing such a composition and a method of using such a composition to coat a surface, such as the surface of an implantable medical device, in order to provide the surface with desirable properties. The method provides the covalent attachment of a SAM to a surface in a manner that substantially retains or improves the characteristics and/or performance of both the SAM and the surface itself. Covalent attachment is accomplished by the use of one or more latent reactive groups, e.g., provided by either the surface and/or by the SAM-forming molecules themselves.
摘要翻译: 用于在材料表面或合适的界面上提供稳定形式的自组装单层的表面涂料组合物,以及制备这种组合物的方法以及使用这种组合物涂覆表面的方法,例如 作为可植入医疗装置的表面,以便为表面提供期望的性质。 该方法以基本上保持或改善SAM和表面本身的特性和/或性能的方式提供SAM到表面的共价附着。 通过使用一种或多种潜在反应性基团来实现共价连接,例如由表面和/或由SAM形成分子本身提供的。
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公开(公告)号:US20110223212A1
公开(公告)日:2011-09-15
申请号:US13119756
申请日:2009-09-15
申请人: Kristin S. Taton , Patrick E. Guire , Laurie R. Lawin , Jie Wen
发明人: Kristin S. Taton , Patrick E. Guire , Laurie R. Lawin , Jie Wen
CPC分类号: A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/404 , A61L2300/624 , A61L2400/12 , A61L2420/04
摘要: The invention describes nanotextured super hydrophobic coatings that contain active agents which can elute from the coating over a period of time.
摘要翻译: 本发明描述了纳米纹理超疏水涂层,其包含可在一段时间内从涂层中洗脱的活性剂。
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公开(公告)号:US06689473B2
公开(公告)日:2004-02-10
申请号:US10163012
申请日:2002-06-04
申请人: Patrick E. Guire , Kristin S. Taton
发明人: Patrick E. Guire , Kristin S. Taton
IPC分类号: B32B2736
CPC分类号: B82Y30/00 , A61L27/34 , A61L31/10 , B05D1/185 , B82Y40/00 , Y10T428/261 , Y10T428/268 , Y10T428/31507 , Y10T428/31551 , Y10T428/31678
摘要: A surface coating composition for providing a self-assembling monolayer, in stable form, on a material surface or at a suitable interface, as well as a method of preparing such a composition and a method of using such a composition to coat a surface, such as the surface of an implantable medical device, in order to provide the surface with desirable properties. The method provides the covalent attachment of a SAM to a surface in a manner that substantially retains or improves the characteristics and/or performance of both the SAM and the surface itself. Covalent attachment is accomplished by the use of one or more latent reactive groups, e.g., provided by either the surface and/or by the SAM-forming molecules themselves.
摘要翻译: 用于在材料表面或合适的界面上提供稳定形式的自组装单层的表面涂料组合物,以及制备这种组合物的方法以及使用这种组合物涂覆表面的方法,例如 作为可植入医疗装置的表面,以便为表面提供期望的性质。 该方法以基本上保持或改善SAM和表面本身的特性和/或性能的方式提供SAM到表面的共价附着。 通过使用一种或多种潜在反应性基团来实现共价连接,例如由表面和/或由SAM形成分子本身提供的。
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公开(公告)号:US06444318B1
公开(公告)日:2002-09-03
申请号:US09907303
申请日:2001-07-17
申请人: Patrick E. Guire , Kristin S. Taton
发明人: Patrick E. Guire , Kristin S. Taton
IPC分类号: B32B2736
CPC分类号: B82Y30/00 , A61L27/34 , A61L31/10 , B05D1/185 , B82Y40/00 , Y10T428/261 , Y10T428/268 , Y10T428/31507 , Y10T428/31551 , Y10T428/31678
摘要: A surface coating composition for providing a self-assembling monolayer, in stable form, on a material surface or at a suitable interface, as well as a method of preparing such a composition and a method of using such a composition to coat a surface, such as the surface of an implantable medical device, in order to provide the surface with desirable properties. The method provides the covalent attachment of a SAM to a surface in a manner that substantially retains or improves the characteristics and/or performance of both the SAM and the surface itself. Covalent attachment is accomplished by the use of one or more latent reactive groups, e.g., provided by either the surface and/or by the SAM-forming molecules themselves.
摘要翻译: 用于在材料表面或合适的界面上提供稳定形式的自组装单层的表面涂料组合物,以及制备这种组合物的方法以及使用这种组合物涂覆表面的方法,例如 作为可植入医疗装置的表面,以便为表面提供期望的性质。 该方法以基本上保持或改善SAM和表面本身的特性和/或性能的方式提供SAM到表面的共价附着。 通过使用一种或多种潜在反应性基团来实现共价连接,例如由表面和/或由SAM形成分子本身提供的。
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