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公开(公告)号:US07741493B2
公开(公告)日:2010-06-22
申请号:US11947442
申请日:2007-11-29
申请人: Patrick Shum , Alexandre Gross , Liang Ma , Daniel G. McGarry , Gregory H. Merriman , David Rampe , Garth Ringheim , Jeffrey Stephen Sabol , Francis A. Volz
发明人: Patrick Shum , Alexandre Gross , Liang Ma , Daniel G. McGarry , Gregory H. Merriman , David Rampe , Garth Ringheim , Jeffrey Stephen Sabol , Francis A. Volz
IPC分类号: A61K31/4184 , C07D235/02
CPC分类号: C07D401/04 , C07D233/20 , C07D233/22 , C07D233/24 , C07D233/42 , C07D233/46 , C07D233/48 , C07D235/30 , C07D401/06 , C07D405/06 , C07D405/12 , C07D409/10
摘要: The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer's disease, etc.
摘要翻译: 本发明涉及式II的新一系列4,5-二苯基-2-氨基-4,5-二氢咪唑衍生物:其中R,R 1,R 2,R 3,R 4,R 5,X和Y为 本文定义。 本发明还涉及制备这些化合物的方法。 本发明的化合物是P2X7离子通道阻断剂,因此可用作药剂,特别是用于治疗和/或预防各种具有炎症成分的疾病,包括炎性肠病,类风湿性关节炎和与中枢相关的疾病状况 神经系统,如中风,阿尔茨海默病等
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公开(公告)号:US07326792B2
公开(公告)日:2008-02-05
申请号:US10896166
申请日:2004-07-21
申请人: Patrick Shum , Alexandre Gross , Liang Ma , Daniel G. McGarry , Gregory H. Merriman , David Rampe , Garth Ringheim , Jeffrey Stephen Sabol , Francis A. Volz
发明人: Patrick Shum , Alexandre Gross , Liang Ma , Daniel G. McGarry , Gregory H. Merriman , David Rampe , Garth Ringheim , Jeffrey Stephen Sabol , Francis A. Volz
IPC分类号: A61K31/4168 , A61K31/417 , C07D233/24 , C07D233/50
CPC分类号: C07D401/04 , C07D233/20 , C07D233/22 , C07D233/24 , C07D233/42 , C07D233/46 , C07D233/48 , C07D235/30 , C07D401/06 , C07D405/06 , C07D405/12 , C07D409/10
摘要: The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer's disease, etc.
摘要翻译: 本发明涉及式II的新一系列4,5-二苯基-2-氨基-4,5-二氢 - 咪唑衍生物:其中R 1,R 2,R 2 R 3,R 4,R 5,X和Y如本文所定义。 本发明还涉及制备这些化合物的方法。 本发明的化合物是P2X7离子通道阻断剂,因此可用作药剂,特别是用于治疗和/或预防各种具有炎症成分的疾病,包括炎性肠病,类风湿性关节炎和与中枢相关的疾病状况 神经系统,如中风,阿尔茨海默病等
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公开(公告)号:US20050026916A1
公开(公告)日:2005-02-03
申请号:US10896166
申请日:2004-07-21
申请人: Patrick Shum , Alexandre Gross , Liang Ma , Daniel McGarry , Gregory Merriman , David Rampe , Garth Ringheim , Jeffrey Sabol , Francis Volz
发明人: Patrick Shum , Alexandre Gross , Liang Ma , Daniel McGarry , Gregory Merriman , David Rampe , Garth Ringheim , Jeffrey Sabol , Francis Volz
IPC分类号: C07D233/20 , C07D233/22 , C07D233/24 , C07D233/42 , C07D233/46 , C07D233/48 , C07D235/30 , C07D401/04 , C07D401/06 , C07D405/06 , C07D405/12 , C07D409/10 , A61K31/5377 , A61K31/4178 , A61K31/4439 , A61K31/4709 , A61K31/496 , A61K31/497
CPC分类号: C07D401/04 , C07D233/20 , C07D233/22 , C07D233/24 , C07D233/42 , C07D233/46 , C07D233/48 , C07D235/30 , C07D401/06 , C07D405/06 , C07D405/12 , C07D409/10
摘要: The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer's disease, etc.
摘要翻译: 本发明涉及式II的新一系列4,5-二苯基-2-氨基-4,5-二氢咪唑衍生物:其中R 1,R 2,R 3,R 4,R 5,X和Y为 本文定义。 本发明还涉及制备这些化合物的方法。 本发明的化合物是P2X7离子通道阻断剂,因此可用作药剂,特别是用于治疗和/或预防各种具有炎症成分的疾病,包括炎性肠病,类风湿性关节炎和与中枢相关的疾病状况 神经系统,如中风,阿尔茨海默病等
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