利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

61 条记录 (耗时 0.032 秒)

    Method and device for enhancing transdermal agent flux
    1.
    发明申请
    Method and device for enhancing transdermal agent flux 审中-公开
    增强透皮剂通量的方法和装置

    公开(公告)号：US20060030811A1

    公开(公告)日：2006-02-09

    申请号：US10910915

    申请日：2004-08-03

    申请人： Patrick Wong ,  Peter Daddona

    发明人： Patrick Wong ,  Peter Daddona

    IPC分类号： A61B17/20

    CPC分类号： A61B17/205

    摘要： A microprojection array having at least first and second microprojections, the first and second microprojections having inner and outer faces, the first microprojection inner face being disposed substantially parallel to the second microprojection inner face; and a biocompatible coating disposed on the first and second microprojection inner faces, the first and second microprojections being adapted to substantially restrict contact of the coating with biological tissue during insertion of the first and second microprojections into the tissue.

    摘要翻译： 一种具有至少第一和第二微突出物的微突出物阵列，所述第一和第二微突出物具有内表面和外表面，所述第一微突出物内表面基本上平行于所述第二微突出物内表面设置; 以及设置在所述第一和第二微突出物内表面上的生物相容性涂层，所述第一和第二微突出物适于在将所述第一和第二微突出物插入所述组织期间基本上限制所述涂层与生物组织的接触。

    Method and device for enhancing transdermal agent flux
    3.
    发明申请
    Method and device for enhancing transdermal agent flux 审中-公开
    增强透皮剂通量的方法和装置

    公开(公告)号：US20050031676A1

    公开(公告)日：2005-02-10

    申请号：US10910889

    申请日：2004-08-03

    申请人： Patrick Wong ,  Peter Daddona

    发明人： Patrick Wong ,  Peter Daddona

    IPC分类号： A61B10/00 ,  A61B17/20 ,  A61M37/00 ,  A61K38/19 ,  A61L15/16

    CPC分类号： A61M37/0015 ,  A61B10/0064 ,  A61B17/205 ,  A61B2010/0009 ,  A61M2037/003 ,  A61M2037/0053

    摘要： A porous microprojection member for insertion into biological tissue surrounded by interstitial fluid having a wall that includes interior and exterior surfaces, the exterior surface substantially enclosing the interior surface; and a biocompatible coating disposed on the interior surface, the microprojection member being adapted to substantially restrict contact of the coating with the tissue during insertion of the microprojection member into the tissue, the microprojection member having sufficient porosity to allow migration of the interstitial fluid through the wall of the microprojection member.

    摘要翻译： 一种用于插入由间隙液包围的生物组织的多孔微突出构件，其具有包括内表面和外表面的壁，所述外表面基本上包围所述内表面; 以及设置在所述内表面上的生物相容性涂层，所述微突出物构件适于基本上限制所述涂层与所述组织在所述微突出物构件插入所述组织期间的接触，所述微突出物构件具有足够的孔隙率以允许所述间质液体通过 微突起构件的壁。

    Dosage Form for Time-Varying Patterns of Drug Delivery
    5.
    发明申请
    Dosage Form for Time-Varying Patterns of Drug Delivery 审中-公开
    药物递送时间变化模式的剂型

    公开(公告)号：US20070207204A1

    公开(公告)日：2007-09-06

    申请号：US11744999

    申请日：2007-05-07

    申请人： David Edgren ,  Patrick Wong ,  Shu Li

    发明人： David Edgren ,  Patrick Wong ,  Shu Li

    IPC分类号： A61K9/66

    CPC分类号： A61K9/0004 ,  A61K31/277

    摘要： The present invention provides a multi-release oral drug delivery system that initiates drug release following an initial drug-free release interval, after administration to a subject, and a second drug-free release period before release of another dose of drug. The system has (1) inner compartments enclosed within a semipermeable membrane, and (2) a drug coating on the exterior of the semipermeable membrane surrounded by a microporous membrane, which microporous membrane is permeable to fluid and drug. The drug coating is released after the initial drug-free release interval. An inner compartment drug is released after a second drug-free release interval provided by a drug-free inner compartment.

    摘要翻译： 本发明提供一种多次释放的口服药物递送系统，其在给予受试者之后，在初始无药物释放间隔之后启动药物释放，以及释放另一剂量药物之前的第二无药物释放期。 该系统具有（1）封闭在半透膜内的内隔室，（2）由微孔膜包围的半透膜外部的药物涂层，该微孔膜可渗透流体和药物。 药物涂层在初始无药物释放间隔后释放。 在由无药物的内隔室提供的第二无药物释放间隔后释放内室药物。

    Volume Efficient Controlled Release Dosage Form
    6.
    发明申请
    Volume Efficient Controlled Release Dosage Form 审中-公开
    体积有效的控制释放剂型

    公开(公告)号：US20070184112A1

    公开(公告)日：2007-08-09

    申请号：US11684821

    申请日：2007-03-12

    申请人： Patrick Wong ,  Francisco Jao ,  David Edgren ,  Robert Skluzacek ,  Shu Li

    发明人： Patrick Wong ,  Francisco Jao ,  David Edgren ,  Robert Skluzacek ,  Shu Li

    IPC分类号： A61K9/24

    CPC分类号： A61K9/0004

    摘要： A dosage form that facilitates the controlled release of an active agent at a desired release rate or release rate profile includes a bi-layer membrane system and an osmotic core. The bi-layer membrane system includes a semipermeable membrane and an osmosensitive membrane and forms an internal compartment occupied by the osmotic core. The osmotic core includes an active agent composition and a light push layer. A passageway is formed through the bi-layer membrane system and permits expulsion of the active agent composition from the dosage form during operation. The bi-layer membrane system and the osmotic core are formulated and formed to provide controlled release of the active agent included in the active agent composition, while simultaneously facilitating increased loading of active agent within a dosage form of given dimension and increasing the delivery efficiency of such active agent relative to prior osmotic dosage forms including a push layer.

    摘要翻译： 有利于以期望的释放速率或释放速率曲线控制释放活性剂的剂型包括双层膜系统和渗透核。 双层膜系统包括半透膜和渗透膜，并形成由渗透芯占据的内部隔室。 渗透芯包括活性剂组合物和轻推层。 通过双层膜系统形成通道，并允许活性剂组合物在操作期间从剂型中排出。 双层膜系统和渗透芯被配制和形成以提供包含在活性剂组合物中的活性剂的受控释放，同时促进活性剂在给定维度的剂型中的负载增加，并且提高 这种活性剂相对于包括推层的先前的渗透剂型。

    Dosage forms and layered deposition processes for fabricating dosage forms
    10.
    发明申请
    Dosage forms and layered deposition processes for fabricating dosage forms 审中-公开
    用于制备剂型的剂量形式和分层沉积方法

    公开(公告)号：US20050118246A1

    公开(公告)日：2005-06-02

    申请号：US10976589

    申请日：2004-10-29

    申请人： Patrick Wong ,  B. Silber

    发明人： Patrick Wong ,  B. Silber

    IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K9/14

    CPC分类号： A61K9/0065 ,  A61F2013/0296 ,  A61K9/703 ,  A61K9/7084 ,  A61K9/7092

    摘要： Disclosed are transdermal or transmucosal dosage forms which include a matrix and a drug where the total amount of drug present in the dosage form exceeds the solubility limit of the drug in the matrix. Also disclosed are transdermal or transmucosal dosage forms which include two or more drug-containing layers and one or more intervening hydrophilic layers where the two or more drug-containing layers being separated from one another by the one or more intervening hydrophilic layers. Methods for delaying release and delivery of an active from an active layer disposed in a transdermal or transmucosal dosage form are also disclosed, as well as methods for manufacturing transdermal or transmucosal dosage forms by providing a substrate and disposing at least one transdermal or transmucosal dosage form layer on the substrate using a printing process.

    摘要翻译： 公开了透皮或透粘膜剂型，其包括基质和药物，其中存在于剂型中的药物的总量超过药物在基质中的溶解度极限。 还公开了透皮或透粘膜剂型，其包括两个或更多个药物含有层和一个或多个中间亲水层，其中两个或更多个药物含有层通过一个或多个中间亲水层彼此分离。 还公开了延缓活性物质从透皮或经粘膜剂型形成的活性层的释放和递送的方法，以及通过提供底物和设置至少一种透皮或透粘膜剂型形成透皮或经粘膜剂型的方法 使用印刷方法在基板上。