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公开(公告)号:US20110092551A1
公开(公告)日:2011-04-21
申请号:US12974210
申请日:2010-12-21
申请人: Paul ALLEGRETTI , Seok-Ki CHOI , Roland GENDRON , Paul R. FATHEREE , Keith JENDZA , Robert Murray McKINNELL , Darren McMURTRIE , Brooke OLSON
发明人: Paul ALLEGRETTI , Seok-Ki CHOI , Roland GENDRON , Paul R. FATHEREE , Keith JENDZA , Robert Murray McKINNELL , Darren McMURTRIE , Brooke OLSON
IPC分类号: A61K31/4196 , G01N33/53 , C07D233/64 , C07D257/04 , C07D231/12 , C07D249/08 , C07D211/76 , A61K31/4164 , A61K31/415 , A61K31/41 , A61K31/4412 , A61P9/12
CPC分类号: C07D233/70 , A61K31/415 , A61K31/4164 , A61K31/417 , A61K31/4188 , A61K31/4196 , A61K31/4412 , A61K45/00 , A61K45/06 , C07D207/36 , C07D207/46 , C07D213/64 , C07D213/89 , C07D231/14 , C07D233/64 , C07D233/68 , C07D233/90 , C07D249/08 , C07D255/02 , C07D401/12 , C07D403/10 , C07D513/04 , C07D513/14
摘要: The invention is directed to compounds having the formula: wherein: Ar, r, R2-3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
摘要翻译: 本发明涉及具有下式的化合物:其中:Ar,r,R2-3,X和R5-7如说明书中所定义,及其药学上可接受的盐。 这些化合物具有AT1受体拮抗剂活性和neprilysin抑制活性。 本发明还涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号:US20120114600A1
公开(公告)日:2012-05-10
申请号:US13288216
申请日:2011-11-03
申请人: Robert Murray McKINNELL , Daniel D. LONG , Lori Jean VAN ORDEN , Lan JIANG , Mandy LOO , Daisuke Roland SAITO , Shella ZIPFEL , Eric L. Stangeland , Kassandra Lepack , Gavin Ogawa
发明人: Robert Murray McKINNELL , Daniel D. LONG , Lori Jean VAN ORDEN , Lan JIANG , Mandy LOO , Daisuke Roland SAITO , Shella ZIPFEL , Eric L. Stangeland , Kassandra Lepack , Gavin Ogawa
IPC分类号: A61K38/21 , C07D401/14 , C07D405/14 , C07D413/14 , C07D498/10 , A61K31/496 , C07D417/14 , A61K31/506 , A61K31/497 , A61K31/5377 , A61K31/517 , A61K31/7056 , A61K31/7052 , A61P31/14 , C07D403/14
CPC分类号: C07D401/14 , A61K31/496 , A61K45/06 , C07D403/14
摘要: The invention provides compounds of formula (I): wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of replication of the hepatitis C virus. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat hepatitis C viral infections, and processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明提供式(I)化合物:其中变量在说明书中定义,或其药学上可接受的盐,其是丙型肝炎病毒的复制抑制剂。 本发明还提供包含这些化合物的药物组合物,使用这些化合物治疗丙型肝炎病毒感染的方法,以及可用于制备这些化合物的方法和中间体。
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