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公开(公告)号：US08048500B2
公开(公告)日：2011-11-01
申请号：US12389232
申请日：2009-02-19
CPC分类号： A61L27/54 , A61B17/07292 , A61L27/18 , A61L27/48 , A61L27/56 , A61L31/06 , A61L31/129 , A61L31/146 , A61L31/16 , A61L2300/606 , Y10T428/1317 , Y10T428/1376 , Y10T442/10 , C08L67/04
摘要： The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof.
摘要翻译： 本发明涉及具有高孔隙率的可植入生物可吸收的非织造自粘性纤维网材料。 纤维网材料非常柔软和柔软，同时在一个或多个方向上显示成比例地增加的机械强度。 网页材料通常具有高度的阁楼。 网状材料可以形成适合用作可植入医疗装置或其组件的各种形状和形式。
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公开(公告)号：US20090202611A1
公开(公告)日：2009-08-13
申请号：US12389232
申请日：2009-02-19
IPC分类号： A61K9/70 , D03D9/00 , A61K31/573 , A61P29/00
CPC分类号： A61L27/54 , A61B17/07292 , A61L27/18 , A61L27/48 , A61L27/56 , A61L31/06 , A61L31/129 , A61L31/146 , A61L31/16 , A61L2300/606 , Y10T428/1317 , Y10T428/1376 , Y10T442/10 , C08L67/04
摘要： The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof.
摘要翻译： 本发明涉及具有高孔隙率的可植入生物可吸收的非织造自粘性纤维网材料。 纤维网材料非常柔软和柔软，同时在一个或多个方向上显示成比例地增加的机械强度。 网页材料通常具有高度的阁楼。 网状材料可以形成适合用作可植入医疗装置或其组件的各种形状和形式。
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公开(公告)号：US09005269B2
公开(公告)日：2015-04-14
申请号：US12181197
申请日：2008-07-28
申请人： Joseph R. Armstrong , Paul C. Begovac , Robert L. Cleek , Edward H. Cully , Charles Flynn , Byron K. Hayes , Ryan V. Peterson , Michael J. Vonesh , Charles F. White
发明人： Joseph R. Armstrong , Paul C. Begovac , Robert L. Cleek , Edward H. Cully , Charles Flynn , Byron K. Hayes , Ryan V. Peterson , Michael J. Vonesh , Charles F. White
CPC分类号： A61F2/01 , A61B17/12022 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/91 , A61F2/915 , A61F2002/016 , A61F2002/018 , A61F2002/30062 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2210/0004 , A61F2210/0076 , A61F2220/0016 , A61F2230/005 , A61F2230/0054 , A61F2230/0069 , A61F2230/008 , A61F2250/003 , A61L31/06 , A61L31/148 , C08L67/04
摘要： Bioabsorbable self-expanding medical devices formed of an integral framework with a multiplicity of fenestrations are provided. The framework is continuous, non-filamentous, non-braided, and non-interlaced. The devices includes a non-blended hydrolysable co-polymeric material comprising an amorphous component with a glass transition temperature that is below ambient body temperature and a crystallizable component that possesses a crystalline melting point in excess of ambient body temperature. The devices radially expand from a compressed first diameter to an uncompressed second diameter equal to or greater than 1.5 times the first diameter within two minutes in an aqueous medium at 37° C. following release of a compressive force placed on the devices. Additionally, the medical device does not change axial length significantly as the radial dimensions of the devices are changed. Further, the medical devices may be constructed of different bioabsorbable polymers, polymer ratios, and/or different geometries and portions may bioabsorb at different rates.
摘要翻译： 提供由具有多个开窗的整体框架形成的生物可吸收的自扩张医疗装置。 框架是连续的，非丝状的，非编织的和非隔行的。 该装置包括非共混的可水解共聚物材料，其包含玻璃化转变温度低于环境体温的非晶组分和具有超过环境体温的结晶熔点的可结晶组分。 在放置在装置上的压缩力释放之后，装置在37℃下在含水介质中在两分钟内从压缩的第一直径径向膨胀至等于或大于第一直径的1.5倍的未压缩的第二直径。 此外，随着装置的径向尺寸改变，医疗装置不会显着改变轴向长度。 此外，医疗装置可以由不同的生物可吸收聚合物，聚合物比率和/或不同的几何形状构成，并且部分可以以不同的速率生物吸收。
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公开(公告)号：US20080281393A1
公开(公告)日：2008-11-13
申请号：US12181197
申请日：2008-07-28
申请人： Joseph R. Armstrong , Paul C. Begovac , Robert L. Cleek , Edward H. Cully , Charles Flynn , Byron K. Hayes , Ryan V. Peterson , Michael J. Vonesh , Charles F. White
发明人： Joseph R. Armstrong , Paul C. Begovac , Robert L. Cleek , Edward H. Cully , Charles Flynn , Byron K. Hayes , Ryan V. Peterson , Michael J. Vonesh , Charles F. White
IPC分类号： A61F2/92
CPC分类号： A61F2/01 , A61B17/12022 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/91 , A61F2/915 , A61F2002/016 , A61F2002/018 , A61F2002/30062 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2210/0004 , A61F2210/0076 , A61F2220/0016 , A61F2230/005 , A61F2230/0054 , A61F2230/0069 , A61F2230/008 , A61F2250/003 , A61L31/06 , A61L31/148 , C08L67/04
摘要： The present invention is directed to bioabsorbable self-expanding medical devices for use inside or outside body conduits that self-expand at, or below, normal human body temperature without requisite for a polymeric thermal transition.
摘要翻译： 本发明涉及用于在正常人体温度下或在正常人体温度下自膨胀而不在聚合物热转变条件下自身膨胀的身体导管内部或外部的生物可吸收自膨胀医疗装置。
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公开(公告)号：US6165217A
公开(公告)日：2000-12-26
申请号：US942371
申请日：1997-10-02
申请人： Byron K. Hayes
发明人： Byron K. Hayes
IPC分类号： A61L27/00 , A61L31/06 , A61L31/14 , D04H3/03 , D04H3/14 , D04H3/16 , A61F2/02 , A61K9/70 , B32B5/12 , C08L69/00
CPC分类号： D04H3/03 , A61L31/06 , A61L31/14 , D01D5/0985 , D01F6/84 , D04H3/011 , D04H3/077 , D04H3/14 , Y10T428/1372 , Y10T428/1376 , Y10T428/249928 , C08L67/04
摘要： A web of continuous filaments which are made of at least one semi-crystalline polymeric component covalently bonded as a linear block copolymer with or blended with one or more semi-crystalline or amorphous polymeric components. The filaments are intermingled together to form a porous web of filaments, the filaments having multiple contact points with each other within the web. The filaments are bonded at the contact points without requisite for added adhesive binders, adjuncts or post extrusion melt processing. The web may be bioresorbable. The web may also be provided in forms with relatively high cohesive shear strength. The polymeric components of the filaments exist, at least temporarily, in a homogenous substantially phase miscible uncrystallized state. If preserved in the homogenous substantially phase miscible uncrystallized state, the object can then be manipulated into a distinct desirable molded shape and then subsequently set or crystallized to retain the desired form particularly suitable for a specific use or application.
摘要翻译： 由至少一种半结晶聚合物组分制成的连续长丝纤维网，其共价键合为线性嵌段共聚物或与一种或多种半结晶或无定形聚合物组分共混。 将细丝混合在一起以形成多孔纤维网，该丝在网内彼此具有多个接触点。 长丝在接触点处粘合，无需添加粘合剂粘合剂，助剂或后挤出熔融加工。 网可以是生物可再吸收的。 纤维网也可以具有相对高的内聚剪切强度的形式提供。 长丝的聚合物组分至少暂时存在于均匀的基本相混合的未结晶状态。 如果保持在均匀的基本相混合的未结晶状态，则可以将物体操作成不同的期望的模制形状，然后随后设定或结晶以保持特别适用于特定用途或应用的所需形状。
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公开(公告)号：US06309423B2
公开(公告)日：2001-10-30
申请号：US09730644
申请日：2000-12-05
申请人： Byron K. Hayes
发明人： Byron K. Hayes
IPC分类号： A61F202
CPC分类号： D04H3/03 , A61L31/06 , A61L31/14 , D01D5/0985 , D01F6/84 , D04H3/011 , D04H3/077 , D04H3/14 , Y10T428/1372 , Y10T428/1376 , Y10T428/249928 , C08L67/04
摘要： A web of continuous filaments which are made of at least one semi-crystalline polymeric component covalently bonded as a linear block copolymer with or blended with one or more semi-crystalline or amorphous polymeric components. The filaments are intermingled together to form a porous web of filaments, the filaments having multiple contact points with each other within the web. The filaments are bonded at the contact points without requisite for added adhesive binders, adjuncts or post extrusion melt processing. The web may be bioresorbable. The web may also be provided in forms with relatively high cohesive shear strength. The polymeric components of the filaments exist, at least temporarily, in a homogenous substantially phase miscible uncrystallized state. If preserved in the homogenous substantially phase miscible uncrystallized state, the object can then be manipulated into a distinct desirable molded shape and then subsequently set or crystallized to retain the desired form particularly suitable for a specific use or application.
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