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    Methods and compositions for a microemulsion-based tissue treatment
    4.
    发明授权
    Methods and compositions for a microemulsion-based tissue treatment 有权
    用于微乳液组织处理的方法和组合物

    公开(公告)号：US08288121B2

    公开(公告)日：2012-10-16

    申请号：US12165020

    申请日：2008-06-30

    申请人： Brian H. Kram ,  Christopher Bieniarz ,  Paul D. Drumheller

    发明人： Brian H. Kram ,  Christopher Bieniarz ,  Paul D. Drumheller

    IPC分类号： G01N1/30 ,  C12Q1/00 ,  B01F3/00

    CPC分类号： G01N1/30

    摘要： The invention is directed to methods and compositions for deparaffinizing paraffin-embedded biological samples for subsequent tissue staining. The compositions are microemulsions that may include water/oil/surfactant microemulsions, and optionally a cosurfactant. The microemulsions enable deparaffinization without the use of xylene or toluene, and also enable solvent exchange without the use of intermediary alcohol dehydration or alcohol rehydration compositions.

    摘要翻译： 本发明涉及用于随后组织染色的石蜡包埋生物样品脱蜡的方法和组合物。 组合物是微乳液，其可以包括水/油/表面活性剂微乳液，以及任选的辅助表面活性剂。 微乳液能够在不使用二甲苯或甲苯的情况下脱蜡，并且还可以在不使用中间醇脱水或醇补液组合物的情况下进行溶剂交换。

    Hydrogel Materials
    7.
    发明申请
    Hydrogel Materials 审中-公开
    水凝胶材料

    公开(公告)号：US20080287633A1

    公开(公告)日：2008-11-20

    申请号：US11750673

    申请日：2007-05-18

    申请人： Paul D. Drumheller

    发明人： Paul D. Drumheller

    IPC分类号： C08F210/02

    CPC分类号： A61K9/007 ,  A61K9/06 ,  A61K9/12 ,  A61L24/0031 ,  C08G65/3324 ,  C08G65/33306 ,  C08G65/33337 ,  C08G65/33358 ,  C08L2203/02

    摘要： The present invention relates to biocompatible crosslinked biomaterials made from polycondensation polymerization reactions involving polynucleophilic-polyelectrophilic precursors that address the limitations of steric hindrance, viscosity, and diffusion currently reducing gelation rates and curing thoroughness of the biomaterials. A cross-linking scheme is utilized in the invention that permits rapid gelation and thorough curing of the biomaterial. The biomaterial is made by polycondensation polymerization of polynucleophilic-polyelectrophilic precursors to form a water-soluble polymer crosslinked with a water-soluble crosslinker having at most one core cyclic structure.

    摘要翻译： 本发明涉及由涉及多亲核多亲电子前体的缩聚反应制备的生物相容性交联生物材料，其解决当前降低凝胶化速率和固化生物材料的空间位阻，粘度和扩散的限制。 在本发明中使用交联方案，其允许生物材料的快速凝胶化和彻底固化。 生物材料通过多亲核多亲电子前体的缩聚聚合制成，以形成与具有至多一个核心环状结构的水溶性交联剂交联的水溶性聚合物。

    Materials and methods for the immobilization of bioactive species onto polymeric substrates
    8.
    发明授权
    Materials and methods for the immobilization of bioactive species onto polymeric substrates 有权
    将生物活性物质固定在聚合物基材上的材料和方法

    公开(公告)号：US5897955A

    公开(公告)日：1999-04-27

    申请号：US138197

    申请日：1998-08-21

    申请人： Paul D. Drumheller

    发明人： Paul D. Drumheller

    IPC分类号： A61L27/34 ,  C07K17/08 ,  C12N5/00 ,  C12N11/08 ,  B32B27/00 ,  B32B17/06 ,  G01N33/53

    CPC分类号： C07K17/08 ,  A61L27/34 ,  C12N11/08 ,  C12N5/0068 ,  C12N2533/30 ,  C12N2533/50 ,  Y10T428/249958 ,  Y10T428/31544

    摘要： The present invention is directed to support members having surfaces that are rendered hydrophilic for use as a substrate for the immobilization of bioactive species thereon. The hydrophilic surfaces are chemically stable on the support member. The surfaces are also chemically variable to provide a variety of chemically functional groups for immobilization of bioactive species thereto. The surfaces comprise polymeric surfactants attached onto the surfaces of a support member and covalently cross-linked thereon to form a first layer. Hydrophilic polymers are then attached to the first layer on the support member to form a second layer thereon. The second layer is used to enhance the hydrophilicity of a support member, as well as, to provide a substrate for immobilizing bioactive species thereto. Methods for forming the first and second layers are also provided. In addition, methods for attaching bioactive substances to the hydrophilic polymers are provided.

    摘要翻译： 本发明涉及具有使其具有亲水性的表面的支撑构件，其用作固定生物活性物质的基底。 亲水表面在支撑构件上是化学稳定的。 表面也是化学变化的，以提供用于将生物活性物质固定化的各种化学官能团。 表面包括附着在支撑构件的表面上并且共价交联在其上以形成第一层的聚合物表面活性剂。 然后将亲水性聚合物连接到支撑构件上的第一层上以在其上形成第二层。 第二层用于增强支撑构件的亲水性，以及提供用于固定生物活性物质的基底。 还提供了形成第一层和第二层的方法。 此外，提供了将生物活性物质附着到亲水性聚合物上的方法。

    Multifunctional organic polymers
    9.
    发明授权
    Multifunctional organic polymers 失效
    多功能有机聚合物

    公开(公告)号：US5462990A

    公开(公告)日：1995-10-31

    申请号：US132507

    申请日：1993-10-05

    申请人： Jeffrey A. Hubbell ,  Donald Elbert ,  Jennifer L. Hill-West ,  Paul D. Drumheller ,  Sanghamitra Chowdhury ,  Amarpreet Sawhney

    发明人： Jeffrey A. Hubbell ,  Donald Elbert ,  Jennifer L. Hill-West ,  Paul D. Drumheller ,  Sanghamitra Chowdhury ,  Amarpreet Sawhney

    IPC分类号： A61L27/00 ,  A61K9/50 ,  A61K47/48 ,  A61L31/06 ,  A61L33/00 ,  C08G63/91 ,  C08G73/00 ,  C08G81/00 ,  C08G81/02 ,  C08L77/00 ,  C08L79/00 ,  C08L101/00 ,  C09D187/00 ,  C08L1/00

    CPC分类号： C08G81/00 ,  A61K47/48238 ,  A61K47/48315 ,  A61K9/5031 ,  A61K9/5073 ,  A61L31/06

    摘要： Described herein is a multi-functional polymeric material for use in inhibiting adhesion and immune recognition between cells and cells, cells and tissues, and tissues and tissues. One component of the polymeric material adsorbs well to cells or tissue, and the other component of the polymeric material does not adsorb well to tissues. A water-soluble polymer that does not bear charge (polynonion) is used as the non-binding component, and a water soluble polymer that is positively charged at physiological pH (polycation) is used as the tissue binding component. When the bi-functional polymeric material contacts a tissue, the tissue-binding component binds and thus immobilizes the attached non-binding component, which will then extend generally away from the tissue surface and sterically block the attachment of other tissues. The method and compositions are useful in inhibiting formation of post-surgical adhesions, protecting damaged blood vessels from thrombosis and restenosis, and decreasing the extent of metastasis of attachment-dependent tumor cells.

    摘要翻译： 本文描述的是用于抑制细胞和细胞，细胞和组织以及组织和组织之间的粘附和免疫识别的多功能聚合物材料。 聚合物材料的一个组分很好地吸附到细胞或组织上，而聚合物材料的其它组分不能很好地吸附到组织上。 使用不带电荷的水溶性聚合物（多项式）作为非结合成分，使用在生理pH（聚阳离子）下带正电的水溶性聚合物作为组织结合成分。 当双官能聚合物材料接触组织时，组织结合组分结合并因此固定所连接的非结合组分，其然后将一般远离组织表面延伸，并空间阻断其它组织的附着。 该方法和组合物可用于抑制手术后粘连的形成，保护受损的血管免受血栓形成和再狭窄，并降低附着依赖性肿瘤细胞的转移程度。