摘要:
Novel pyrimidoindolone compounds are disclosed. Methods of using the pyrimidoindolone compounds and compositions containing the compounds in the treatment and/or prevention of disease and other conditions related to inflammation, neurodegeneration, osteoarthritis and apoptosis are also disclosed.
摘要:
Novel pyrimidoindolone compounds are disclosed. Methods of using the pyrimidoindolone compounds and compositions containing the compounds in the treatment and/or prevention of disease and other conditions related to inflammation, neurodegeneration, osteoarthritis and apoptosis are also disclosed.
摘要:
The present invention relates to methods of making Gonadotropin Releasing Hormone (“GnRH”) (also known as Leutinizing Hormone Releasing Hormone) receptor antagonists.
摘要:
The present invention is directed to novel protease inhibitors that are specific for cathepsin L, cathepsin B, and cathepsin S. Accordingly, the present invention encompasses compositions and methods for treating and preventing diseases and disorders associated with cathepsin L, cathepsin B, or cathepsin S function or activity.
摘要:
Compounds useful for lowering beta amyloid levels are provided. The compounds have the structure of formula Ia: wherein, R1 is lower alkyl, substituted lower alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, benzyloxy, substituted benzyloxy, or SO2R5; R5 is phenyl, substituted phenyl, heterocycle, substituted heterocycle, alkyl, or substituted alkyl; R2 is lower alkyl, substituted lower alkyl, CF3, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, or cycloalkyl; R3 is hydrogen, lower alkyl, or substituted lower alkyl; R4 is phenyl, substituted phenyl, heterocycle, substituted heterocycle, thiophene, or substituted thiophene; R6 is hydrogen, lower alkyl, substituted lower alkyl, CF3, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, cycloalkyl, or substituted cycloalkyl; W, X and Y are independently CR7 or N; and R7 is hydrogen, halogen, lower alkyl, or substituted lower alkyl.
摘要翻译:提供了可用于降低β淀粉样蛋白水平的化合物。 化合物具有式Ia的结构:其中R 1是低级烷基,取代的低级烷基,苯基,取代的苯基,苄基,取代的苄基,苄氧基,取代的苄氧基或SO 2, / 5> 5 R 5是苯基,取代的苯基,杂环,取代的杂环,烷基或取代的烷基; R 2是低级烷基,取代的低级烷基,CF 3,烯基,取代的烯基,炔基,取代的炔基,苯基,取代的苯基或环烷基; R 3是氢,低级烷基或取代的低级烷基; R 4是苯基,取代的苯基,杂环,取代的杂环,噻吩或取代的噻吩; R 6是氢,低级烷基,取代的低级烷基,CF 3,烯基,取代的烯基,炔基,取代的炔基,苯基,取代的苯基,环烷基或取代的环烷基; W,X和Y独立地为CR 7或N; R 7是氢,卤素,低级烷基或取代的低级烷基。