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公开(公告)号：US07988988B2
公开(公告)日：2011-08-02
申请号：US11283632
申请日：2005-11-21
CPC分类号： C08J7/047 , A61L27/34 , C08J2443/00 , G02B1/043 , C08L101/02
摘要： A biomedical device, such as a contact lens, has a surface linked to a polymer comprising boronic acid moieties. The boronic acid monomeric units may be derived from an ethylenically unsaturated monomer containing a boronic acid moiety, such as a vinylphenyl boronic acid or a (meth)acrylamido phenyl boronic acid. The boronic acid moieties may be complexed with mucin, especially epithelial mucin.
摘要翻译： 诸如隐形眼镜的生物医学装置具有与包含硼酸部分的聚合物连接的表面。 硼酸单体单元可以衍生自含有硼酸部分的乙烯性不饱和单体，例如乙烯基苯基硼酸或（甲基）丙烯酰胺基苯基硼酸。 硼酸部分可能与粘蛋白，特别是上皮粘蛋白复合。
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公开(公告)号：US06440571B1
公开(公告)日：2002-08-27
申请号：US09315620
申请日：1999-05-20
IPC分类号： B32B2708
CPC分类号： C08J7/047 , A61L27/34 , C08J2383/04 , G02B1/043 , Y10T428/31663 , C08L83/10
摘要： The present invention is directed toward the surface treatment of silicone medical devices such as contact lenses and medical implants. In particular, the present invention is directed to a method of modifying the surface of a medical device to increase its biocompatibility or hydrophilicity by coating the device with a hydrophilic polymer by means of reaction between reactive functionalities on the hydrophilic polymer which functionalities are complementary to reactive functionalities on or near the surface of the medical device. The present invention is also directed to a contact lens or other medical device having such a surface coating.
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公开(公告)号：US06638563B2
公开(公告)日：2003-10-28
申请号：US10128172
申请日：2002-04-22
IPC分类号： C08J704
摘要： The present invention is directed toward the renewable surface treatment of medical devices such as contact lenses and medical implants. In particular, the present invention is directed to a method of modifying the surface of a medical device to increase its biocompatibility or hydrophilicity by coating the device with a removable hydrophilic polymer by means of reaction between reactive functionalities on the hydrophilic polymer which functionalities are complementary to reactive functionalities on or near the surface of the medical device at reaction temperatures of less than about 55° C.
摘要翻译： 本发明涉及医疗装置如隐形眼镜和医用植入物的可再生表面处理。 特别地，本发明涉及通过借助亲水性聚合物上的反应性官能团之间的反应涂覆具有可去除的亲水性聚合物的装置来改变医疗装置的表面以增加其生物相容性或亲水性的方法，其功能性与 在小于约55℃的反应温度下，医疗器械表面上或附近的反应性官能团
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4.发明授权Surface modification of functional group-containing medical devices with catalyst-containing reactive polymer system 失效含有催化剂的反应性聚合物体系的含官能团医疗器械的表面改性公开(公告)号：US07270678B2
公开(公告)日：2007-09-18
申请号：US10187154
申请日：2002-06-28
CPC分类号： C08J7/12 , A61F2/16 , A61L27/34 , A61L2400/18 , C08J2333/00
摘要： Surface modified medical devices such as intraocular lens implants formed from one or more functional group-containing materials using reactive, hydrophilic polymers with catalyst functionality for the purpose of reducing or eliminating lens epithelial cell growth thereon, reducing or eliminating silicone oil absorption upon subsequent surgical exposure and/or reducing implantation inserter friction is provided herein. Additionally, a method of making and using surface modified intraocular lens implants is provided.
摘要翻译： 使用具有催化剂官能团的反应性亲水性聚合物由一种或多种含官能团的材料形成的表面改性的医疗装置，例如用于减少或消除其上的镜片上皮细胞生长的目的，减少或消除随后手术暴露时的硅油吸收 和/或减少植入插入物摩擦。 另外，提供了制造和使用表面改性的眼内透镜植入物的方法。
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公开(公告)号：US07083646B2
公开(公告)日：2006-08-01
申请号：US10187056
申请日：2002-06-28
申请人： Paul L. Valint, Jr. , Joseph A. McGee , Wenyan Yan , Joseph C. Salamone , Daniel M. Ammon, Jr. , Jay F. Kunzler
发明人： Paul L. Valint, Jr. , Joseph A. McGee , Wenyan Yan , Joseph C. Salamone , Daniel M. Ammon, Jr. , Jay F. Kunzler
IPC分类号： A61F2/16
CPC分类号： C08J7/12 , A61F2/14 , A61F2/16 , A61L27/34 , A61L2400/18 , A61L2430/16
摘要： Surface modified medical devices such as intraocular lens implants formed from one or more functional group-containing materials using reactive, hydrophilic polymers for the purpose of reducing or eliminating lens epithelial cell growth thereon, reducing or eliminating silicone oil absorption upon subsequent surgical exposure and/or reducing or eliminating implantation inserter friction is provided herein. Additionally, a method of making and using surface modified intraocular lens implants is provided.
摘要翻译： 表面改性的医疗装置，例如由一种或多种含官能团的材料形成的眼内透镜植入物，其使用反应性亲水性聚合物，用于减少或消除其上的晶状体上皮细胞生长，减少或消除随后手术暴露时的硅油吸收和/或 本文提供减少或消除植入插入物摩擦。 另外，提供了制造和使用表面改性的眼内透镜植入物的方法。
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6.发明授权Renewable surface treatment of silicone medical devices with reactive hydrophilic polymers 失效具有反应性亲水聚合物的有机硅医疗器械的可再生表面处理公开(公告)号：US06858310B2
公开(公告)日：2005-02-22
申请号：US10427055
申请日：2003-04-30
CPC分类号： G02B1/043 , A61L27/34 , C08J7/047 , Y10T428/31511 , Y10T428/31663 , C08L83/00 , C08L43/04
摘要： The present invention is directed toward the renewable surface treatment of medical devices such as contact lenses and medical implants. In particular, the present invention is directed to a method of modifying the surface of a medical device to increase its biocompatibility or hydrophilicity by coating the device with a removable hydrophilic polymer by means of reaction between reactive functionalities on the hydrophilic polymer which functionalities are complementary to reactive functionalities on or near the surface of the medical device. The present invention is also directed to a contact lens or other medical device having such a surface coating.
摘要翻译： 本发明涉及医疗装置如隐形眼镜和医用植入物的可再生表面处理。 特别地，本发明涉及通过借助亲水性聚合物上的反应性官能团之间的反应涂覆具有可去除的亲水性聚合物的装置来改变医疗装置的表面以增加其生物相容性或亲水性的方法，其功能性与 在医疗装置的表面上或附近的反应性功能。 本发明还涉及具有这种表面涂层的隐形眼镜或其它医疗装置。
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公开(公告)号：US5364918A
公开(公告)日：1994-11-15
申请号：US38384
申请日：1993-03-29
IPC分类号： C08F2/00 , C08F290/00 , C08F290/04 , C08F290/06 , C08F290/14 , C08F299/00 , C08J7/04 , C08L101/00 , G02B1/04 , G02C7/04 , C08F18/20 , C08F12/30 , C08F20/10
CPC分类号： C08F290/14 , C08F290/04 , G02B1/043
摘要： A method of modifying the surfaces of the polymeric objects by adding a polymerizable surfactant to the monomer mix used to form the object. Also disclosed are surface-modified objects prepared by this method, which is particularly suited for modifying the surfaces of contact lenses.
摘要翻译： 通过向用于形成物体的单体混合物中加入可聚合表面活性剂来改性聚合物体的表面的方法。 还公开了通过该方法制备的表面改性物体，其特别适用于改变隐形眼镜的表面。
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公开(公告)号：US5336797A
公开(公告)日：1994-08-09
申请号：US998346
申请日：1992-12-30
IPC分类号： G02C7/04 , C08F2/38 , C08F30/08 , C08F290/00 , C08F290/04 , C08F299/00 , G02B1/04 , C07F7/08 , C08F228/02 , C08F230/08
CPC分类号： C08F290/04 , C08F2/38 , G02B1/043
摘要： Siloxane macromonomers are disclosed which can be copolymerized with hydrophilic monomers or hydrophobic monomers to prepare polymeric materials useful as biomedical devices. The copolymers made from hydrophilic monomers exhibit good oxygen permeability and are particularly suitable for use in contact lenses.
摘要翻译： 公开了可与亲水单体或疏水单体共聚以制备可用作生物医学装置的聚合物材料的硅氧烷大分子单体。 由亲水性单体制得的共聚物表现出良好的透氧性，特别适用于隐形眼镜。
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公开(公告)号：US5219965A
公开(公告)日：1993-06-15
申请号：US619282
申请日：1990-11-27
IPC分类号： C08F2/00 , C08F290/00 , C08F290/04 , C08F290/06 , C08F290/14 , C08F299/00 , C08J7/04 , C08L101/00 , G02B1/04 , G02C7/04
CPC分类号： C08F290/14 , C08F290/04 , G02B1/043
摘要： A method of modifying the surfaces of polymeric objects by adding a polymerizable surfactant to the monomer mix used to form the object. Also disclosed are surface-modified objects prepared by this method, which is particularly suited for modifying the surfaces of contact lenses.
摘要翻译： 一种通过向用于形成物体的单体混合物中加入可聚合表面活性剂来改性聚合物体表面的方法。 还公开了通过该方法制备的表面改性物体，其特别适用于改变隐形眼镜的表面。
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公开(公告)号：US06759496B2
公开(公告)日：2004-07-06
申请号：US10008441
申请日：2001-12-06
IPC分类号： C08F12600
摘要： Biomedical devices are formed from the polymerization product of a monomeric mixture including a poly(2-oxazoline) endcapped with an ethylenically unsaturated radical, such as poly(2-oxazoline) macromonomers and telechelics. Preferred devices are ophthalmic lenses, especially contact lenses and intraocular lenses.
摘要翻译： 生物医学装置由包含与烯键式不饱和基团（例如聚（2-恶唑啉））大分子单体和电视电解质封端的聚（2-恶唑啉）的单体混合物的聚合产物形成。 优选的装置是眼科镜片，特别是隐形眼镜和人工晶状体。
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