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公开(公告)号：US20090239250A1
公开(公告)日：2009-09-24
申请号：US11720740
申请日：2005-12-01
Applicant: David R. Klug , de Mello Andrew , Richard H. Templer , Paul Michael William French , Mark Andrew Aquilla Neil , Oscar Ces , Peter Joseph Jacques Parker , Keith Robert Willison
Inventor： David R. Klug , de Mello Andrew , Richard H. Templer , Paul Michael William French , Mark Andrew Aquilla Neil , Oscar Ces , Peter Joseph Jacques Parker , Keith Robert Willison
CPC classification number: G01N15/1484 , G01N15/1475
Abstract: The present invention provides an improved method of analysing and obtaining reliable data about the plasma membrane of single cells, using a microfluidic cell analyser. The microfluidic cell analyser of the invention comprises a single cell trap, a manipulator arranged to manipulate the outer surface of a cell in the trap, a detection zone in communication with the single cell trap and a detector.
Abstract translation: 本发明提供使用微流控细胞分析仪分析和获得关于单细胞质膜的可靠数据的改进方法。 本发明的微流体细胞分析仪包括单细胞阱，设置成操纵陷阱中的细胞的外表面的操纵器，与单细胞捕获器连通的检测区和检测器。
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公开(公告)号：US5796498A
公开(公告)日：1998-08-18
申请号：US284616
申请日：1994-09-06
Applicant: Paul Michael William French
Inventor： Paul Michael William French
CPC classification number: G03H1/0248 , G03H1/0005 , G03H1/04 , G03H1/0404 , G03H2001/0083 , G03H2001/0268 , G03H2001/0467 , G03H2001/0471 , G03H2001/2244 , G03H2222/33 , G03H2223/26 , G03H2260/54
Abstract: A holographic imaging apparatus having a pulsed laser light source for generating an object beam and a reference beam whereby an object, obscured by a diffusing medium, is illuminated by the object beam. A real time interferogram recording medium is exposed to the coincidence of light reflected from the object and the reference beam to record an interferogram. A holographic image is then reconstructed from the interferogram and may be viewed and recorded. The pulsed laser light source generates a beam which is divided by a conventional beam splitter device into an object beam and a reference beam. The object beam is then diverged by a lens which forms a diverging object beam to illuminate the object. The reference beam is diverged through another lens to form a diverging reference beam which is directed so that it illuminates a photoreactive crystal. The coincidence of the reflected light and diverging reference beam generates a pattern of interference fringes known as an interferogram which is recorded by the crystal. The apparatus can use time-gating in the holographic medium to use ballistic and snake-like light, which arrives before scattered light, to construct a holographic image. The apparatus can also obtain depth information for 3-D images by using the time-gating technique to obtain the image bearing light from a 3-D object. The apparatus also may record light-in-flight images of the object, to record different depths of the object separately, by using an optical delay assembly.
Abstract translation: PCT No.PCT / GB93 / 00316 Sec。 371日期：1994年9月6日 102（e）1994年9月6日PCT PCT 1993年2月15日PCT公布。 出版物WO93 / 16419 日期1993年8月19日具有用于产生物体光束的脉冲激光光源和参考光束的全息成像装置，由此漫射介质遮蔽的物体被物体光束照射。 实时干涉图记录介质暴露于从物体和参考光反射的光的一致记录干涉图。 然后从干涉图重建全息图像，并且可以查看和记录全息图像。 脉冲激光光源产生由传统光束分离器装置划分为物体光束和参考光束的光束。 物体光束然后被形成发散物体光束的透镜发散，以照射物体。 参考光束通过另一个透镜发散以形成发散的参考光束，其被引导为使其照亮光反应晶体。 反射光和发散参考光束的一致产生被称之为由晶体记录的干涉图的干涉条纹图案。 该设备可以在全息介质中使用时间选通，使用到达散射光之前的弹道和蛇状光来构造全息图像。 该装置还可以通过使用时间选通技术获得3D图像的图像承载光，从而获得3-D图像的深度信息。 该装置还可以记录物体的飞行中的图像，以通过使用光学延迟组件来单独记录物体的不同深度。
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公开(公告)号：US08585587B2
公开(公告)日：2013-11-19
申请号：US13003387
申请日：2009-07-09
Applicant: Paul Michael William French , Carl Paterson , Mark Andrew Aquilla Neil , Christopher William Dunsby
Inventor： Paul Michael William French , Carl Paterson , Mark Andrew Aquilla Neil , Christopher William Dunsby
IPC: A61B1/07
CPC classification number: G02B23/2453 , A61B1/00165 , A61B1/00172 , A61B1/043 , A61B5/0068 , A61B5/0071 , A61B5/0084 , G02B23/26
Abstract: An endoscope includes a light source operable to generate coherent incident light, and a plurality of imaging optical fibers that are arranged in a fiber bundle, arranged to receive light at a proximal end of the fiber bundle, and arranged to transmit light to a distal end of the fiber bundle. The endoscope further includes a spatial light phase modulator between the light source and the fiber bundle, and arranged to receive the incident light from the light source and to adjust the relative phase of the incident light entering each of the plurality of imaging optical fibers.
Abstract translation: 内窥镜包括可操作以产生相干入射光的光源和布置成纤维束中的多个成像光纤，其布置成在光纤束的近端处接收光，并且布置成将光透射到远端 的纤维束。 内窥镜还包括在光源和光纤束之间的空间光相位调制器，并被布置成接收来自光源的入射光并调节入射到多个成像光纤中的每一个的入射光的相对相位。
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4.发明申请Optical Device, an Optical System and a Method of Manufacturing a Holographic Optical Element 审中-公开光学装置，光学系统和制造全息光学元件的方法
公开(公告)号：US20070258119A1
公开(公告)日：2007-11-08
申请号：US11631894
申请日：2005-07-07
Applicant: Robert Munday , Paul Michael William French , Ollvier Pitavy
Inventor： Robert Munday , Paul Michael William French , Ollvier Pitavy
CPC classification number: G03H1/30 , G03H2001/0296 , G03H2001/0413 , G03H2001/0482 , G03H2001/0497 , G03H2260/62 , G03H2260/63
Abstract: This invention relates to an optical device and system for producing a holographic optical element or digital hologram. Various techniques of producing digital holograms have been proposed. However, they tend to suffer from long exposure times, as well as problems associated with control of two or more independent beams of coherent light used to produce a hologram. Problems become even more acute as pixel size decreases. The present invention provides an optical device including: a beam deflector, adapted to deflect a collimated beam of coherent light to produce an incident beam; a beam splitter for producing first and second beams, said beams being displaced so that the angle of deflection of the first beam is the same but opposite to the angle of deflection of the second beam; and a combiner combines the first and second beams so as to produce an interference pattern at an output plane.
Abstract translation: 本发明涉及一种用于制造全息光学元件或数字全息图的光学装置和系统。 已经提出了生产数字全息图的各种技术。 然而，它们倾向于遭受长时间的曝光时间，以及与用于产生全息图的两个或更多个相干光的独立光束的控制相关的问题。 当像素尺寸减小时，问题变得更加尖锐。 本发明提供了一种光学装置，其包括：光束偏转器，适于偏转准直的相干光束以产生入射光束; 用于产生第一和第二光束的分束器，所述光束被移位，使得第一光束的偏转角度与第二光束的偏转角相同但相反; 并且组合器组合第一和第二光束以便在输出平面处产生干涉图案。
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公开(公告)号：US07427733B2
公开(公告)日：2008-09-23
申请号：US10577735
申请日：2004-09-23
Applicant: Jonathan David Hares , Paul Michael William French
Inventor： Jonathan David Hares , Paul Michael William French
IPC: H01J40/14
CPC classification number: H01J31/507
Abstract: A gated optical image intensifier 10 is provided with multiple intensifying channels 20, 22, 24, 26 each supplied with radiation via a respective optical channel of an optical splitter. The separate intensifying channels are subject to gating by a sequence of time spaced gating signals generated by an electronic gating signal generator. The multi-channel gated optical image intensifier has particular utility in the field of fluorescence lifetime imaging.
Abstract translation: 门控光学图像增强器10设置有多个增强通道20,22,24,26，每个增强通道20,22,24,26经由光分路器的相应光通道被提供有辐射。 单独的增强通道由电子门控信号发生器产生的时间间隔门控信号的序列进行选通。 多通道门控光学图像增强器在荧光寿命成像领域具有特殊的应用。
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公开(公告)号：US08269881B2
公开(公告)日：2012-09-18
申请号：US11579490
申请日：2005-05-10
Applicant: Mark Andrew Aquilla Neil , Paul Michael William French
Inventor： Mark Andrew Aquilla Neil , Paul Michael William French
CPC classification number: H04N5/2355 , H04N5/235
Abstract: An imaging apparatus comprising: A spatial light modulator (30) operable to receive incident light (34) representing an incident light image and to intensity modulate said incident light to form spatially modulated (38) light; and an image capture device (42) operable to receive said spatially modulated light and to detect an intensity value for different portions of said spatially modulated light to form a modulated light image therefrom; wherein said spatial light modulator attenuates different parts of said incident light by different proportions such that intensity values of said incident light image are given by a combination of intensity values of said modulated light image captured by said image capture device and data representing proportions of attenuation applied to corresponding parts of said incident light image by said spatial light modulator.
Abstract translation: 一种成像设备，包括：空间光调制器（30），其可操作以接收表示入射光图像的入射光（34），并强度调制所述入射光以形成空间调制光（38）; 以及图像捕获装置（42），其可操作以接收所述空间调制光并且检测所述空间调制光的不同部分的强度值以从其形成调制的光图像; 其中所述空间光调制器以不同的比例衰减所述入射光的不同部分，使得所述入射光图像的强度值由所述图像捕获装置捕获的所述调制光图像的强度值与表示衰减应用比例的数据的组合给出 通过所述空间光调制器到所述入射光图像的对应部分。
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公开(公告)号：US20110137126A1
公开(公告)日：2011-06-09
申请号：US13003387
申请日：2009-07-09
Applicant: Paul Michael William French , Carl Paterson , Mark Andrew Aquilla Neil , Christopher William Dunsby
Inventor： Paul Michael William French , Carl Paterson , Mark Andrew Aquilla Neil , Christopher William Dunsby
IPC: A61B1/07
CPC classification number: G02B23/2453 , A61B1/00165 , A61B1/00172 , A61B1/043 , A61B5/0068 , A61B5/0071 , A61B5/0084 , G02B23/26
Abstract: An endoscope includes a light source operable to generate coherent incident light, and a plurality of imaging optical fibres that are arranged in a fibre bundle, arranged to receive light at a proximal end of the fibre bundle, and arranged to transmit light to a distal end of the fibre bundle. The endoscope further includes a spatial light phase modulator between the light source and the fibre bundle, and arranged to receive the incident light from the light source and to adjust the relative phase of the incident light entering each of the plurality of imaging optical fibres.
Abstract translation: 内窥镜包括可操作以产生相干入射光的光源和布置成纤维束中的多个成像光纤，其布置成在光纤束的近端处接收光，并且布置成将光透射到远端 的纤维束。 内窥镜还包括在光源和光纤束之间的空间光相位调制器，并被布置成接收来自光源的入射光并调节入射到多个成像光纤中的每一个的入射光的相对相位。
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8.发明申请
公开(公告)号：US20090218527A1
公开(公告)日：2009-09-03
申请号：US12295661
申请日：2007-03-20
CPC classification number: G02B21/004 , G02B21/008
Abstract: A confocal microscope 2 uses as a light source a two-dimensional array of light emitting diodes 4. A two-dimensional array of detector cells 18 in the form of a CCD camera array or a CMOS camera array is provided. A sequence of illumination patterns are generated by the array of light emitting diodes 4. A corresponding sequence of detection patterns are read from the two-dimensional array of detector cells 18. The light emitting diodes may be A1GaInN light emitting diodes generating light in the wavelength 250 nm to 500 nm. The confocal microscope 2 may be fitted to the tip of an endoscope 30.
Abstract translation: 共焦显微镜2使用发光二极管2的二维阵列作为光源。提供CCD摄像机阵列或CMOS照相机阵列形式的检测器单元18的二维阵列。 由发光二极管阵列4产生一系列照明图案。从检测器单元18的二维阵列中读取相应的检测图案序列。发光二极管可以是产生波长为的光的AlGaInN发光二极管 250nm至500nm。 共聚焦显微镜2可以安装在内窥镜30的前端。
