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公开(公告)号：US20050140061A1
公开(公告)日：2005-06-30
申请号：US10748210
申请日：2003-12-31
CPC分类号： B29C45/1642 , B29C45/1603
摘要： A nozzle for an injection molding machine is disclosed. The nozzle includes a nozzle body, an inner nozzle, and an outer nozzle. The nozzle defines two independent flow paths therethrough. The nozzle can simultaneously discharge two materials. A method of using the nozzle and a resulting golf ball product are also disclosed.
摘要翻译： 公开了一种注射成型机用喷嘴。 喷嘴包括喷嘴体，内喷嘴和外喷嘴。 喷嘴限定了穿过其中的两个独立流动路径 喷嘴可以同时排放两种材料。 还公开了使用喷嘴和所得高尔夫球产品的方法。
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公开(公告)号：US07035461B2
公开(公告)日：2006-04-25
申请号：US10225720
申请日：2002-08-22
申请人： Jiebo Luo , David Crandall
发明人： Jiebo Luo , David Crandall
IPC分类号： G06K9/00
CPC分类号： G06K9/0061 , G06K9/00228 , G06T7/11 , G06T2207/30216
摘要： A method for detecting objects in a digital image includes the steps of generating a first segmentation map of the digital image according to a non-object specific criterion, generating a second segmentation map of the digital image according to an object specific criterion, and detecting objects in the digital image using both the first and second segmentation maps. In a preferred embodiment of the invention, the non-object specific criterion is a color homogeneity criterion and the object specific criterion is an object specific color similarity, wherein the object specific color is skin color and the method further comprises the step of detecting red-eye in the detected skin color regions.
摘要翻译： 一种用于检测数字图像中的对象的方法包括以下步骤：根据非对象特定标准产生数字图像的第一分割图，根据对象特定标准生成数字图像的第二分割图，以及检测对象 在使用第一和第二分割图的数字图像中。 在本发明的优选实施例中，非对象特定标准是颜色均匀性标准，并且对象特定标准是对象特定颜色相似度，其中对象特定颜色是肤色，并且该方法还包括检测红色 - 眼睛在检测到的肤色区域。
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公开(公告)号：US20060121591A1
公开(公告)日：2006-06-08
申请号：US11341567
申请日：2006-01-30
IPC分类号： C12N9/99
CPC分类号： G01N33/6845 , C07K14/8121 , C07K16/38 , G01N2333/81 , G01N2500/04
摘要： A library of mutants of metastable proteins, such as proteinase inhibitors, can be screened for the specific loss of a wild-type capability to bind an antibody, yielding valuable drug-design information which otherwise is unavailable. By this approach, for example, a mutant proteinase inhibitor can be obtained that has the amino acid sequence of a wild-type protein, or an active fragment thereof, save for the presence of one or more mutations in at least one epitope, thereby altering interaction of the mutant with an anti-proteinase inhibitor antibody.
摘要翻译： 可以筛选亚稳态蛋白质突变体的文库，例如蛋白酶抑制剂，以便特异性丧失结合抗体的野生型能力，产生否则不可用的有价值的药物设计信息。 通过这种方法，例如，可以获得具有野生型蛋白质的氨基酸序列或其活性片段的突变蛋白酶抑制剂，除了在至少一个表位中存在一个或多个突变，从而改变 突变体与抗蛋白酶抑制剂抗体的相互作用。
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公开(公告)号：US20060020003A1
公开(公告)日：2006-01-26
申请号：US10947710
申请日：2004-09-23
IPC分类号： A61K31/421 , A61K31/4152 , A61K31/41 , A61K31/381 , A61K31/195
CPC分类号： C07D405/12 , C07C233/60 , C07C233/75 , C07C235/56 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2603/18 , C07D209/30 , C07D209/42 , C07D231/14 , C07D307/68 , C07D307/84 , C07D333/38 , C07D333/68 , C07D403/12
摘要： The present invention relates generally to substituted biphenyloxy acids (such as 4′-aryl-amido-biphenyl-4(3)-yloxy-acids and 4′-aryl-amidomethyl-biphenyl-4(3)-yloxy-acids) and methods of using them.
摘要翻译： 本发明一般涉及取代的联苯氧基酸（例如4'-芳基 - 酰氨基 - 联苯-4（3） - 氧基酸和4'-芳基 - 酰氨基甲基 - 联苯-4（3） - 氧基酸）和方法 使用它们。
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5.发明申请Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) 失效取代的萘基吲哚衍生物作为纤溶酶原激活物抑制剂1型（PAI-1）的抑制剂公开(公告)号：US20060014725A1
公开(公告)日：2006-01-19
申请号：US11158881
申请日：2005-06-22
申请人： Scott Mayer , Eric Gundersen , Hassan Elokdah , David Crandall
发明人： Scott Mayer , Eric Gundersen , Hassan Elokdah , David Crandall
IPC分类号： A61K31/415 , A61K31/404 , C07D403/02 , C07D209/12
CPC分类号： C07D403/12 , C07D209/12
摘要： This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R1, R2, R3, and R4 are each H, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R8, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, perfluoroalkoxy; R5 is H, alkyl, perfluoroalkyl, aryl optionally substituted with R8, alkanoyl, aroyl optionally substituted with R8; R6 is H, alkyl, alkylaryl, benzyl optionally substituted with R8, alkanoyl, aroyl optionally substituted with R8; R7 is H, alkyl, alkylaryl, aryl optionally substituted with R8; n is 0-6; A is COOH, or an acid mimic such as tetraazole, SO3H, PO3H2, tetronic acid, etc.; R8 is H, alkyl, cycloalkyl, alkanoyl, halo, OH, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, perfluoroalkoxy; or a pharmaceutically acceptable salt thereof; as well as pharmaceutical compositions and methods of treatment using these compounds.
摘要翻译： 本发明提供了PAI-1抑制式I化合物：其中：R 1，R 2，R 3和R 4 每个H，烷基，烷酰基，卤素，OH，任选被R 8 8，全氟烷基，烷氧基，氨基，烷基氨基，二烷基氨基，全氟烷氧基取代的芳基; R 5是H，烷基，全氟烷基，任选被R 8取代的芳基，烷酰基，任选被R 8取代的芳酰基; R 6是H，烷基，烷基芳基，任选被R 8取代的苄基，烷酰基，任选被R 8取代的芳酰基; R 7是H，烷基，烷芳基，任选被R 8取代的芳基; n为0-6; A是COOH或酸模拟物，例如四唑，SO 3 H，PO 3 H 2 H 2，次ronic酸等; R 8是H，烷基，环烷基，烷酰基，卤素，OH，全氟烷基，烷氧基，氨基，烷基氨基，二烷基氨基，全氟烷氧基; 或其药学上可接受的盐; 以及使用这些化合物的药物组合物和治疗方法。
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公开(公告)号：US20070203220A1
公开(公告)日：2007-08-30
申请号：US11679031
申请日：2007-02-26
申请人： David Crandall , George Vlasuk
发明人： David Crandall , George Vlasuk
IPC分类号： A61K31/405
CPC分类号： A61K31/405 , A61K31/56 , Y02A50/465 , A61K2300/00
摘要： This invention describes novel methods of treating muscle damage, muscle wasting, muscle degeneration, muscle atrophy or reduced rates of muscle repair associated with various conditions such as muscular dystrophy, through the use of small-molecule PAI-1 inhibitors.
摘要翻译： 本发明描述了通过使用小分子PAI-1抑制剂治疗肌肉损伤，肌肉消瘦，肌肉退化，肌肉萎缩或与多种疾病如肌营养不良相关的肌肉修复速率降低的新方法。
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公开(公告)号：US20060048430A1
公开(公告)日：2006-03-09
申请号：US10938921
申请日：2004-09-09
申请人： David Crandall , Richard Watson
发明人： David Crandall , Richard Watson
IPC分类号： F41C23/00
摘要： A forwardly movable assembly for a firearm, the forwardly movable assembly adapted to be disposed in operative relationship relative to the other operative parts of a firearm, the firearm having in operative relationship each with one or more of the others: a barrel, a receiver, and at least one firing mechanism; the forwardly movable assembly comprising: the barrel and the receiver operatively connected with each other; a movable hand support structure to which at least one of the barrel and the receiver is connected, the barrel being movable therewith, the movable hand support structure being adapted to be gripped by an operator of the firearm; the forwardly movable assembly being adapted to be moved forward by an operator upon gripping the movable hand support structure and manually maneuvering the hand support structure forwardly; and, as the forwardly movable assembly is moved forwardly, the firing mechanism is completely disengaged therefrom and held substantially stationary relative thereto.
摘要翻译： 一种用于枪支的可向前移动的组件，所述向前移动的组件适于相对于枪支的其他操作部分设置成可操作的关系，所述枪具具有操作关系，每个具有一个或多个其他操作关系：枪管，接收器， 和至少一个击发机构; 所述可向前移动的组件包括：所述筒和所述接收器可操作地彼此连接; 可移动的手持支撑结构，所述筒和接收器中的至少一个连接到所述可动手持支撑结构，所述筒可随其移动，所述可动手支撑结构适于由所述枪支的操作者夹持; 可向前移动的组件适于在操作者握住可移动的手持支撑结构并向前手动地操纵手部支撑结构时向前移动; 并且当向前移动的组件向前移动时，击发机构完全脱离并且相对于其保持基本上静止。
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公开(公告)号：US20060048429A1
公开(公告)日：2006-03-09
申请号：US10938683
申请日：2004-09-09
申请人： David Crandall , Richard Watson
发明人： David Crandall , Richard Watson
IPC分类号： F41C23/00
摘要： A firearm frame which is adapted to be disposed in operative relationship as a component part of a firearm, the firearm having disposed in operative relationships each with one or more of the others, a barrel, a receiver, and at least one firing mechanism; wherein the barrel and receiver form operative parts of a movable assembly and the at least one firing mechanism is disposed in a substantially stationary operative relationship therewith; the firearm frame including at least one elongated support structure discrete from the barrel and receiver, the elongated support structure being adapted to directly support the movable assembly in an operative movable relationship therewith; whereby at least one of the barrel and receiver is in direct contact with and movable on the elongated support structure; and, a firing mechanism support structure connected to the at least one elongated support structure, the firing mechanism support structure being adapted to have the firing mechanism connected thereto; the firearm frame also directly supporting the movable assembly and the firing mechanism in corresponding movable and stationary operative relationships each with the other.
摘要翻译： 一种适于以操作关系设置为枪械的组成部分的枪支框架，所述枪械具有各自具有一个或多个操作关系的操作关系，枪管，接收器和至少一个击发机构; 其中所述枪管和接收器形成可移动组件的操作部分，并且所述至少一个击发机构设置成与其基本上静止的操作关系; 所述枪支框架包括从所述枪管和接收器离散的至少一个细长支撑结构，所述细长支撑结构适于以可操作的可移动关系直接支撑所述可移动组件; 由此筒和接收器中的至少一个与细长支撑结构直接接触并可移动; 以及与所述至少一个细长支撑结构连接的击发机构支撑结构，所述击发机构支撑结构适于具有与其连接的所述击发机构; 枪支架还可以相应地可移动和固定的操作关系直接支撑可移动组件和击发机构。
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公开(公告)号：US20050244893A1
公开(公告)日：2005-11-03
申请号：US11106904
申请日：2005-04-15
申请人： David Crandall , Duane Day
发明人： David Crandall , Duane Day
IPC分类号： G01N33/53 , G01N33/543 , G01N33/573 , G01N33/86
CPC分类号： G01N33/573 , G01N33/54393 , G01N33/86
摘要： The invention provides a novel assay system for measuring the amount of active PAI-1 in a sample with sensitivity, and correlation to an active PAI-1 amount. The assay determines the amount of active PAI-1 in a sample by utilizing a novel standard curve. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. 37 CFR 1.72(b).
摘要翻译： 本发明提供了一种用于测量样品中活性PAI-1的量的新型测定系统，其灵敏度以及与活性PAI-1量的相关性。 该测定通过利用新的标准曲线来确定样品中活性PAI-1的量。 要强调的是，该摘要被提供以符合要求抽象的规则，允许搜索者或其他读者快速确定技术公开的主题。 提交它的理解是，它不会用于解释或限制权利要求的范围或含义。 37 CFR 1.72（b）。
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公开(公告)号：US20060048427A1
公开(公告)日：2006-03-09
申请号：US10939016
申请日：2004-09-09
申请人： David Crandall , Richard Watson
发明人： David Crandall , Richard Watson
IPC分类号： F41A19/00
摘要： A firearm trigger assembly adapted to be disposed in operative relationship within a firearm, the firearm having in operative relationship one with another a barrel a forestock and a receiver connected in a forward assembly; and firing mechanisms including a sear assembly, and a combination of a firearm hammer and a firing pin; the trigger assembly being disposed at least partly shrouded within the forestock of the forward assembly and being adapted to be operably engaged by the user's forwardly-placed support hand when the support hand is in a substantially conventional forwardly-placed support hand position gripping the forestock of the firearm, the trigger assembly including: a translationally-movable trigger mechanism including: a trigger button, and an elongated trigger member, the trigger button being connected to and adapted to move the elongated trigger member in a substantially translational manner; the elongated trigger member is adapted to engage the sear assembly for the activation of the firearm hammer and firing pin; and, the trigger button being adapted to be engaged and depressed by a digit of the user's forwardly-placed support hand when the support hand is in a substantially conventional forwardly-placed support hand position gripping the forestock of the firearm.
摘要翻译： 一种枪支触发器组件，其适于在枪支内以操作关系设置，所述枪具具有操作关系，其中一个与另一个枪管相连;前架和连接在前部组件中的接收器; 以及包括杵组件和火炬锤和撞针的组合的击发机构; 触发器组件至少部分地被覆盖在前部组件的前座中，并且当支撑手处于基本上常规的向前放置的支撑手位置时，可以由使用者的向前放置的支撑手可操作地接合， 所述枪支，所述触发器组件包括：平移可动触发机构，包括触发按钮和细长触发器构件，所述触发器按钮被连接到并适于以基本上平移的方式移动所述细长触发器构件; 细长的触发构件适于接合掣子组件以激活枪槌和击发销; 并且当支撑手处于握住枪支的前排的基本上常规的向前放置的支撑手位置时，触发按钮适于被用户的向前支撑手的数字接合和按压。
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