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1.发明授权Compositions and methods of sensitizing methicillin resistant Staphylococcus aureus to beta-lactam antibiotics 有权使耐甲氧西林金黄色葡萄球菌对β-内酰胺抗生素敏感的组合物和方法公开(公告)号：US08338476B2
公开(公告)日：2012-12-25
申请号：US12095960
申请日：2005-12-29
申请人： Paul Stapleton , Yukihiko Hara , Peter Taylor
发明人： Paul Stapleton , Yukihiko Hara , Peter Taylor
IPC分类号： A61K31/352 , A61K31/397 , A01N43/16 , A01N43/44 , A01N43/90
CPC分类号： A61K31/353 , A61K31/05 , A61K45/06 , A61K2300/00
摘要： Contemplated methods and compositions further increase susceptibility of sensitized MRSA against various antibiotic drugs. Most preferably, the MRSA is already sensitized with a galloylated catechin (e.g., ECG), and further sensitization is achieved by exposure to a non-galloylated catechin (e.g., EC), and most preferably the corresponding non-galloylated catechin.
摘要翻译： 考虑的方法和组合物进一步增加致敏MRSA对各种抗生素药物的敏感性。 最优选地，MRSA已经被乳糖化儿茶素（例如ECG）敏化，并且通过暴露于非半乳糖化儿茶素（例如EC），最优选相应的非乙酰化儿茶素来实现进一步的敏化。
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2.发明申请Compositions and Methods of Sensitizing Methicillin Resistant Staphylococcus Aureus to Oxacillin 有权将耐甲氧西林金黄色葡萄球菌对奥西西林敏化的组合物和方法公开(公告)号：US20100035979A1
公开(公告)日：2010-02-11
申请号：US12095960
申请日：2005-12-29
申请人： Paul Stapleton , Yukihiko Hara , Peter Taylor
发明人： Paul Stapleton , Yukihiko Hara , Peter Taylor
IPC分类号： A61K31/352 , C12N1/20
CPC分类号： A61K31/353 , A61K31/05 , A61K45/06 , A61K2300/00
摘要： Contemplated methods and compositions further increase susceptibility of sensitized MRSA against various antibiotic drugs. Most preferably, the MRSA is already sensitized with a galloylated catechin (e.g., ECG), and further sensitization is achieved by exposure to a non-galloylated catechin (e.g., EC), and most preferably the corresponding non-galloylated catechin.
摘要翻译： 考虑的方法和组合物进一步增加致敏MRSA对各种抗生素药物的敏感性。 最优选地，MRSA已经被乳糖化儿茶素（例如ECG）敏化，并且通过暴露于非半乳糖化儿茶素（例如EC），最优选相应的非乙酰化儿茶素来实现进一步的敏化。
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公开(公告)号：US20070082944A1
公开(公告)日：2007-04-12
申请号：US10569526
申请日：2003-09-12
申请人： Paul Stapleton , Shinich Uesato , Peter Taylor , Yukihiko Hara
发明人： Paul Stapleton , Shinich Uesato , Peter Taylor , Yukihiko Hara
IPC分类号： A61K31/353 , G06Q50/00
CPC分类号： A61K31/353 , G06Q50/22
摘要： A catechin is modified in at least one position (most preferably in the 3-position of the C-ring) to increase its lipophilicity. Contemplated catechins are demonstrated to have significantly improved antibacterial properties, likely due to catastrophic membrane damage.
摘要翻译： 儿茶素在至少一个位置（最优选在C环的3-位）被修饰以增加其亲油性。 被证明的儿茶素具有显着改善的抗菌性能，可能是由于灾难性的膜损伤。
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公开(公告)号：US20090082429A1
公开(公告)日：2009-03-26
申请号：US12250202
申请日：2008-10-13
申请人： Paul Stapleton , Shinich Uesato , Peter W. Taylor , Yukihiko Hara
发明人： Paul Stapleton , Shinich Uesato , Peter W. Taylor , Yukihiko Hara
IPC分类号： A61K31/353 , A61P31/04
CPC分类号： A61K31/353 , G06Q50/22
摘要： A catechin is modified in at least one position (most preferably in the 3-position of the C-ring) to increase its lipophilicity. Contemplated catechins are demonstrated to have significantly improved antibacterial properties, likely due to catastrophic membrane damage.
摘要翻译： 儿茶素在至少一个位置（最优选在C环的3-位）被修饰以增加其亲油性。 被证明的儿茶素具有显着改善的抗菌性能，可能是由于灾难性的膜损伤。
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公开(公告)号：US20080300302A1
公开(公告)日：2008-12-04
申请号：US11996933
申请日：2005-07-26
申请人： Yukihiko Hara , Hiroshi Hojo , Slobodan Jovanovic
发明人： Yukihiko Hara , Hiroshi Hojo , Slobodan Jovanovic
IPC分类号： A61K31/352 , A61K31/353 , C07D311/04
CPC分类号： C07D311/62
摘要： Compositions and methods are directed to covalent adducts between reducing agents and optionally substituted 3-hydroxyflavans, wherein the reducing agent is covalently bound to the B-ring of the 3-hydroxyflavan. Such adducts exhibit markedly increased stability towards oxidation as compared to the unmodified 3-hydroxyflavan. Particularly preferred 3-hydroxyflavans include green tea catechins, and especially EGCG, while especially preferred reducing agents include NAC and glutathione.
摘要翻译： 组合物和方法涉及还原剂和任选取代的3-羟基黄酮之间的共价加合物，其中还原剂与3-羟基黄烷的B-环共价结合。 与未改性的3-羟基黄烷相比，这种加合物显示出显着增加的氧化稳定性。 特别优选的3-羟基黄烷包括绿茶儿茶素，特别是EGCG，而特别优选的还原剂包括NAC和谷胱甘肽。
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公开(公告)号：US5968973A
公开(公告)日：1999-10-19
申请号：US56378
申请日：1998-04-07
申请人： Shu Jun Cheng , De Chang Wang , Yukihiko Hara
发明人： Shu Jun Cheng , De Chang Wang , Yukihiko Hara
IPC分类号： A61K31/353 , A61K31/35
CPC分类号： A61K31/353
摘要： A method for a treatment of hyperplasia caused by papilloma virus, such as for treating Condyloma acuminata which comprises administering tea catechin. Tea catechins do not involve the risk of side-effects and may be easily applied to or inserted in the infected area by the patients themselves.
摘要翻译： 一种治疗由乳头瘤病毒引起的增生的方法，例如用于治疗尖锐湿疣，其包括施用茶儿茶素。 茶儿茶素不涉及副作用的风险，并且可以容易地由患者本身应用于或插入感染区域。
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公开(公告)号：US5747053A
公开(公告)日：1998-05-05
申请号：US647012
申请日：1996-05-09
CPC分类号： A61L9/16 , A61K9/0095 , A61L2/0017 , A61L2/022 , F24F2003/1664 , F24F6/00
摘要： The present invention provides a medicated gargling cup with which it is possible to form a liquid for gargling effective for preventing cold by merely pouring water into the cup; an antiviral mask having a nonwoven fabric impregnated with a tea extract, which mask can be easily produced commercially and is capable of maintaining a high virus trapping performance, inactivating the trapped viruses and preventing them from being rescattered; an antiviral filter and an antifungal, antibacterial and antiviral filter comprising in laminations a dust collecting filter and a filter impregnated with a tea extract; an air cleaner and an air cleaner-humidifier comprising the antiviral filter.
摘要翻译： 本发明提供了一种药物漱口杯，可以通过仅将水倒入杯中形成用于漱口的液体，以有效地防止感冒; 具有浸渍有茶提取物的无纺织物的抗病毒面膜，该面膜可以容易地商业生产，并且能够保持高的病毒捕获性能，灭活被捕获的病毒并防止它们被再沉淀; 抗病毒过滤器和抗真菌，抗菌和抗病毒过滤器，其包括叠层的集尘过滤器和浸有茶提取物的过滤器; 包括抗病毒过滤器的空气净化器和空气净化器 - 加湿器。
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公开(公告)号：US08138359B2
公开(公告)日：2012-03-20
申请号：US11996933
申请日：2005-07-26
申请人： Yukihiko Hara , Hiroshi Hojo , Slobodan Jovanovic
发明人： Yukihiko Hara , Hiroshi Hojo , Slobodan Jovanovic
IPC分类号： C07D311/62 , C07F9/50
CPC分类号： C07D311/62
摘要： Compositions and methods are directed to covalent adducts between reducing agents and optionally substituted 3-hydroxyflavans, wherein the reducing agent is covalently bound to the B-ring of the 3-hydroxyflavan. Such adducts exhibit markedly increased stability towards oxidation as compared to the unmodified 3-hydroxyflavan. Particularly preferred 3-hydroxyflavans include green tea catechins, and especially EGCG, while especially preferred reducing agents include NAC and glutathione.
摘要翻译： 组合物和方法涉及还原剂和任选取代的3-羟基黄酮之间的共价加合物，其中还原剂共价结合到3-羟基黄烷的B-环上。 与未改性的3-羟基黄烷相比，这种加合物显示出显着增加的氧化稳定性。 特别优选的3-羟基黄烷包括绿茶儿茶素，特别是EGCG，而特别优选的还原剂包括NAC和谷胱甘肽。
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公开(公告)号：US07763291B2
公开(公告)日：2010-07-27
申请号：US12631504
申请日：2009-12-04
申请人： Yukihiko Hara , Ryota Seto
发明人： Yukihiko Hara , Ryota Seto
CPC分类号： A61K36/82 , A23L33/105 , A23V2002/00 , A61K8/97 , A61Q11/00 , A23V2250/214 , A23V2250/2132
摘要： The objective of the present invention is to provide a tea polyphenol composition that has reduced bitterness and astringency while containing catechins with high purity. The present invention provides a tea polyphenol composition, (A) comprising 85% by weight to 95% by weight of catechins, (B) wherein the catechins contains epigallocatechin gallate and gallocatechin gallate at a ratio of 65% by weight to 80% by weight and (C) wherein the ratio given by (epigallocatechin gallate+gallocatechin gallate)/(epicatechin+catechin+epigallocatechin+gallocatechin+epicatechin gallate+catechin gallate) is from 2 to 4.
摘要翻译： 本发明的目的是提供一种含有高纯度儿茶素的苦味和涩味降低的茶多酚组合物。 本发明提供一种茶多酚组合物，（A）包含85重量％至95重量％的儿茶素类，（B）其中儿茶素含有表没食子儿茶素没食子酸酯和没食子儿茶素没食子酸酯，比例为65重量％至80重量％ 和（C）其中由（表没食子儿茶素没食子酸没食子酸+没食子儿茶素没食子酸酯）/（表儿茶素+儿茶素+表没食子儿茶素+角叉菜胶+表儿茶素没食子酸酯没食子儿+没食子酸儿茶素没食子酸酯）给出的比例为2〜4。
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公开(公告)号：US5807564A
公开(公告)日：1998-09-15
申请号：US649819
申请日：1996-05-17
申请人： Tadakatsu Shimamura , Yukihiko Hara
发明人： Tadakatsu Shimamura , Yukihiko Hara
IPC分类号： A61K31/35 , A61K31/43 , A61K31/54 , A61K31/65 , A61K31/70 , A61K36/18 , A61K36/82 , A61K36/899 , A61P31/04 , A61P43/00 , A01N25/32
摘要： A method of increasing the activity of an antibiotic against methicillin resistant Staphylococcus aureus in a patient by administering to the patient the antibiotic in combination with a catechin and/or a theaflavin.
摘要翻译： 通过向患者施用抗生素与儿茶素和/或茶黄素组合来增加抗生素对耐甲氧西林金黄色葡萄球菌的活性的方法。
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