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公开(公告)号：US20090030342A1
公开(公告)日：2009-01-29
申请号：US11829637
申请日：2007-07-27
申请人： Peggy-Jean P. Flanigan , Bryan S. Behun , Kevin M. Cummings , Tushar A. Kshirsagar , Tera M. Nordby , Jeffrey D. Smith
发明人： Peggy-Jean P. Flanigan , Bryan S. Behun , Kevin M. Cummings , Tushar A. Kshirsagar , Tera M. Nordby , Jeffrey D. Smith
CPC分类号： G01N1/02 , A61B10/0045 , A61B10/0096 , B01L3/5029 , C12M33/02 , G01N2001/028
摘要： A first aspect of the present invention provides for devices to facilitate the release of sample materials from sample acquisition devices. The device comprises an abrasion element comprising at least one constriction or projection. A second aspect of the present invention provides for methods in which to use the devices to facilitate the release of sample materials from a sample acquisition device. Optionally, the device may contain at least one reagent to facilitate the release and/or detection of a microorganism, or component thereof, in a sample. Preferably, the devices and methods may be used in conjunction with a liquid medium in which the sample may be further processed.
摘要翻译： 本发明的第一方面提供了便于从样品采集装置释放样品材料的装置。 该装置包括包括至少一个收缩部或突出部的磨损元件。 本发明的第二方面提供了使用这些装置以便于从样品采集装置释放样品材料的方法。 任选地，该装置可以含有至少一种试剂以促进样品中微生物或其组分的释放和/或检测。 优选地，装置和方法可以与液体介质一起使用，其中可以进一步处理样品。
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公开(公告)号：US20090030341A1
公开(公告)日：2009-01-29
申请号：US11829493
申请日：2007-07-27
申请人： Tushar A. Kshirsagar , Jeffrey D. Smith , Paul J. Cobian , Tera M. Nordby , Manjiri T. Kshirsagar , Patrick A. Mach , Bryan S. Behun
发明人： Tushar A. Kshirsagar , Jeffrey D. Smith , Paul J. Cobian , Tera M. Nordby , Manjiri T. Kshirsagar , Patrick A. Mach , Bryan S. Behun
IPC分类号： A61B10/00
CPC分类号： G01N1/38 , A61B10/0045 , B01L3/0293 , C12M33/02 , G01N1/40 , G01N2001/028 , Y10T436/25
摘要： Devices to process a sample are configured to releasably attach a sample acquisition device to a drive mechanism that provides rotational and/or vibrational motion to the sample acquisition device. The devices can be used in sample processing methods to dislodge sample materials from the sample acquisition device. Sample processing methods using rotational or vibrational motion may further include the use of a liquid medium into which the sample is released. Sample processing methods may further include the detection of an analyte in the sample.
摘要翻译： 用于处理样品的装置被配置为将样品采集装置可释放地附接到向样品采集装置提供旋转和/或振动运动的驱动机构。 这些装置可以用于样品处理方法以从样品采集装置中移除样品材料。 使用旋转或振动运动的样品处理方法还可以包括使用样品释放到其中的液体介质。 样品处理方法还可以包括检测样品中的分析物。
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公开(公告)号：US08969029B2
公开(公告)日：2015-03-03
申请号：US13063945
申请日：2009-10-12
申请人： Sailaja Chandrapati , Jeffrey C. Pederson , Heather M. Webb , Jeffrey D. Smith , Kurt J. Halverson , Bryan S. Behun , Peter D. Ludowise
发明人： Sailaja Chandrapati , Jeffrey C. Pederson , Heather M. Webb , Jeffrey D. Smith , Kurt J. Halverson , Bryan S. Behun , Peter D. Ludowise
摘要： A biological sterilization indicator, system, and methods of determining the effectiveness of a sterilization process. The biological sterilization indicator can include a locus of spores, a reservoir containing a liquid, and a sterilant path positioned to provide fluid communication between ambience and the locus of spores. The reservoir can have a closed state in which the reservoir is not in fluid communication with the locus of spores and an open state in which the reservoir is in fluid communication with the locus of spores. The biological sterilization indicator system can include the biological sterilization indicator and a detection device adapted to be coupled to the biological sterilization indicator. In some embodiments, the method can include assaying the spores for a detectable change in a characteristic, and detecting substantially all of the detectable change.
摘要翻译： 一种生物灭菌指标，系统和确定灭菌过程有效性的方法。 生物灭菌指示剂可以包括孢子的位点，含有液体的储存器和定位成在气氛和孢子的位置之间提供流体连通的消毒剂通道。 储存器可以具有闭合状态，其中储存器不与孢子的轨迹流体连通，并且储存器与孢子的轨迹流体连通的打开状态。 生物灭菌指示器系统可以包括生物灭菌指示器和适于联接到生物灭菌指示器的检测装置。 在一些实施方案中，该方法可以包括测定孢子以获得特征的可检测变化，并且检测基本上所有可检测的变化。
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公开(公告)号：US20080317637A1
公开(公告)日：2008-12-25
申请号：US12142188
申请日：2008-06-19
申请人： Jeffrey D. Smith , Bryan S. Behun
发明人： Jeffrey D. Smith , Bryan S. Behun
IPC分类号： B01L3/00
CPC分类号： B01L3/0293 , B01L2200/16 , B01L2400/0644 , B01L2400/0683 , G01N35/1002
摘要： Devices and methods of dispensing and mixing reagents with samples in an enclosed container in which the amounts of the reagents dispensed into the sample are predetermined. The devices include a rotating dispenser element attached to a base, wherein an ampoule is located within a cavity in the base. The dispenser elements contain two or more dispensing chambers that are sealed and that can be opened and any reagent(s) located therein dispensed into the ampoule at selected times.
摘要翻译： 将试剂与封闭容器中样品分配和混合的装置和方法，其中分配到样品中的试剂的量是预定的。 装置包括附接到基座的旋转分配器元件，其中安瓿位于基座中的空腔内。 分配器元件包含两个或更多个分配室，其被密封并且可以打开，并且位于其中的任何试剂在选定的时间分配到安瓿中。
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公开(公告)号：US20110182770A1
公开(公告)日：2011-07-28
申请号：US13063945
申请日：2009-10-12
申请人： Sailaja Chandrapati , Jeffrey C. Pederson , Heather M. Webb , Jeffrey D. Smith , Kurt J. Halverson , Bryan S. Behun , Peter D. Ludowise
发明人： Sailaja Chandrapati , Jeffrey C. Pederson , Heather M. Webb , Jeffrey D. Smith , Kurt J. Halverson , Bryan S. Behun , Peter D. Ludowise
IPC分类号： A61L2/18
摘要： A biological sterilization indicator, system, and methods of determining the effectiveness of a sterilization process. The biological sterilization indicator can include a locus of spores, a reservoir containing a liquid, and a sterilant path positioned to provide fluid communication between ambience and the locus of spores. The reservoir can have a closed state in which the reservoir is not in fluid communication with the locus of spores and an open state in which the reservoir is in fluid communication with the locus of spores. The biological sterilization indicator system can include the biological sterilization indicator and a detection device adapted to be coupled to the biological sterilization indicator. In some embodiments, the method can include assaying the spores for a detectable change in a characteristic, and detecting substantially all of the detectable change.
摘要翻译： 一种生物灭菌指标，系统和确定灭菌过程有效性的方法。 生物灭菌指示剂可以包括孢子的位点，含有液体的储存器和定位成在气氛和孢子的位置之间提供流体连通的消毒剂通道。 储存器可以具有闭合状态，其中储存器不与孢子的轨迹流体连通，并且储存器与孢子的轨迹流体连通的打开状态。 生物灭菌指示器系统可以包括生物灭菌指示器和适于联接到生物灭菌指示器的检测装置。 在一些实施方案中，该方法可以包括测定孢子以获得特征的可检测变化，并且检测基本上所有可检测的变化。
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公开(公告)号：US08840837B2
公开(公告)日：2014-09-23
申请号：US13881154
申请日：2011-10-28
CPC分类号： C12Q1/22
摘要： A biological sterilization indicator (BI) and method of using same. The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The BI can further include a first chamber and a second chamber. The second chamber can include at least one source of biological activity. The BI can further include a first fluid path positioned to fluidly couple the first chamber and the second chamber, and a second fluid path positioned to allow displaced gas to move out of the second chamber. The method can include moving displaced gas out of the second chamber via the second fluid path as a sterilant is moved into the second chamber via the first fluid path and/or as the liquid is moved into the second chamber via the first fluid path.
摘要翻译： 生物灭菌指示剂（BI）及其使用方法。 BI可以包括壳体和位于壳体中的容器。 容器可以容纳液体，容器的至少一部分可以是易碎的。 BI还可以包括第一室和第二室。 第二室可以包括至少一种生物活性来源。 BI还可以包括定位成流体耦合第一室和第二室的第一流体路径，以及定位成允许排出的气体移出第二室的第二流体路径。 该方法可以包括当消毒剂经由第一流体路径移动到第二室中时和/或当液体经由第一流体路径移动到第二室中时，通过第二流体路径将移动的气体移出第二室。
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公开(公告)号：US20130302849A1
公开(公告)日：2013-11-14
申请号：US13881154
申请日：2011-10-28
IPC分类号： C12Q1/22
CPC分类号： C12Q1/22
摘要： A biological sterilization indicator (BI) and method of using same. The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The BI can further include a first chamber and a second chamber. The second chamber can include at least one source of biological activity. The BI can further include a first fluid path positioned to fluidly couple the first chamber and the second chamber, and a second fluid path positioned to allow displaced gas to move out of the second chamber. The method can include moving displaced gas out of the second chamber via the second fluid path as a sterilant is moved into the second chamber via the first fluid path and/or as the liquid is moved into the second chamber via the first fluid path.
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公开(公告)号：US08348966B2
公开(公告)日：2013-01-08
申请号：US12852348
申请日：2010-08-06
申请人： Bruce M. McCormack , Edward Fletcher Eyster , Jeffrey D. Smith , Edward Liou , Jonathan Carver , Peter How , Joshua Druker , Martin Leugers , Shigeru Tanaka
发明人： Bruce M. McCormack , Edward Fletcher Eyster , Jeffrey D. Smith , Edward Liou , Jonathan Carver , Peter How , Joshua Druker , Martin Leugers , Shigeru Tanaka
IPC分类号： A61B17/32
CPC分类号： A61B17/320036 , A61B5/04005 , A61B5/4893 , A61B17/00234 , A61B17/149 , A61B18/148 , A61B2017/0042 , A61B2017/32006 , A61G13/124
摘要： Disclosed herein is a system for releasing a ligament. In one embodiment, the system includes a proximal handle, a tubular body, and a flexible body. The tubular body includes a proximal end and a distal end. The handle is coupled to the proximal end. The flexible body extends through the tubular body and includes a tissue cutting portion. The flexible body is longitudinally displaceable relative to the tubular body to move the tissue cutting portion between a non-deployed state and a deployed state.
摘要翻译： 本文公开了用于释放韧带的系统。 在一个实施例中，系统包括近端手柄，管状主体和柔性主体。 管状体包括近端和远端。 把手与近端相连。 柔性体延伸穿过管状主体并且包括组织切割部分。 柔性体可以相对于管状体纵向移位，以在非展开状态和展开状态之间移动组织切割部分。
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公开(公告)号：US20120291565A1
公开(公告)日：2012-11-22
申请号：US13474779
申请日：2012-05-18
IPC分类号： G01N1/10
CPC分类号： B01L3/502738 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/0803 , B01L2300/087 , B01L2300/0887 , B01L2400/0406 , B01L2400/0409 , B01L2400/0677 , B01L2400/0688
摘要： A system and method for valving on a sample processing device. The system can include a valve chamber, a process chamber, and a valve septum located between the valve chamber and the process chamber. The system can further include a fluid pathway in fluid communication with an inlet of the valve chamber, wherein the fluid pathway is configured to inhibit a liquid from entering the valve chamber and collecting adjacent the valve septum when the valve septum is in a closed configuration. The method can include rotating the sample processing device to exert a first force on the liquid that is insufficient to move the liquid into the valve chamber; forming an opening in the valve septum; and rotating the sample processing device to exert a second force on the liquid to move the liquid into the valve chamber.
摘要翻译： 一种用于在样品处理装置上进行阀门的系统和方法。 该系统可以包括阀室，处理室和位于阀室和处理室之间的阀隔膜。 该系统可进一步包括与阀室的入口流体连通的流体通路，其中，当阀隔膜处于关闭构型时，该流体通道被配置为阻止液体进入阀室并且邻近阀隔开收集。 该方法可以包括旋转样品处理装置以对液体施加不足以将液体移动到阀室中的第一力; 在阀隔膜中形成开口; 并且使样品处理装置旋转以对液体施加第二力以将液体移动到阀室中。
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10.发明申请公开(公告)号：US20100069912A1
公开(公告)日：2010-03-18
申请号：US12559193
申请日：2009-09-14
IPC分类号： A61B17/60
CPC分类号： A61F2/442 , A61B17/025 , A61B17/562 , A61B17/7062 , A61B17/7064 , A61B17/7065 , A61B17/8822 , A61B2017/00557 , A61B2017/0256 , A61B2090/037 , A61F2/4405 , A61F2002/30438 , A61F2002/30579 , A61F2002/30622 , A61F2002/30841 , A61F2220/0041
摘要： Systems for distracting a facet joint and positioning a permanent implant in the joint are disclosed. The implants serve to retain a distracted position of the facet joint which is achieved with positioning of the leading end of a distraction tool in the facet joint and then distracting or enlarging the joint a desired amount. The permanent implant could be part of the distraction mechanism which can be separated from the delivery tool once the joint has been distracted or an auxiliary implant may be positioned before the distraction mechanism is removed from the distracted joint. The permanent implants can be solid, mechanical devices that may have fixation means thereon to hold them in place or injected fluids such as hydrogels or fluids confined within balloons.
摘要翻译： 公开了用于分散小关节并将永久性植入物定位在关节中的系统。 植入物用于保持小关节的分散位置，其通过将牵引工具的前端定位在小关节中，然后使关节分散或扩大所需的量来实现。 永久性植入物可以是牵引机构的一部分，一旦接头被分散就可以与输送工具分离，或者在牵引机构从分心的关节中移除之前可以定位辅助植入物。 永久性植入物可以是可以具有固定装置的固体机械装置，以将它们保持在适当位置或注入流体，例如限制在气囊内的水凝胶或流体。
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