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1.
公开(公告)号:US07687508B2
公开(公告)日:2010-03-30
申请号:US11782810
申请日:2007-07-25
申请人: Percy H. Carter , Robert J. Cherney , John Hynes , Soo S. Ko , Anurag S. Srivastava , Zili Xiao , Michael G. Yang
发明人: Percy H. Carter , Robert J. Cherney , John Hynes , Soo S. Ko , Anurag S. Srivastava , Zili Xiao , Michael G. Yang
IPC分类号: A61K31/517 , C07D401/12 , A61K31/501 , A61K31/5025 , A61K31/519 , C07D403/12 , C07D413/12 , C07D417/12 , C07D419/12 , C07D239/36
CPC分类号: C07D403/12 , C07D401/12 , C07D487/04
摘要: This invention relates generally to modulators of chemokine receptor activity having unexpected combination of desirable pharmacological properties. Pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and prevention of inflammatory, allergic, autoimmune, metabolic, cancer and/or cardiovascular diseases, particularly diabetes, Crohn's disease, atherosclerosis, and multiple sclerosis, along with methods of preparing compounds and intermediates therefor. Metabolites of active compounds are also provided herein, pharmaceutical compositions and use thereof are also provided.
摘要翻译: 本发明一般涉及趋化因子受体活性的调节剂,其具有期望的药理学性质的意想不到的组合。 含有它们的药物组合物,以及使用其作为治疗和预防炎性,过敏性,自身免疫性,代谢性,癌症和/或心血管疾病,特别是糖尿病,克罗恩病,动脉粥样硬化和多发性硬化的药物的方法以及方法 制备化合物及其中间体。 本文还提供了活性化合物的代谢物,还提供药物组合物及其用途。
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2.
公开(公告)号:US20080027080A1
公开(公告)日:2008-01-31
申请号:US11782810
申请日:2007-07-25
申请人: Percy H. Carter , Robert J. Cherney , John Hynes , Soo S. Ko , Anurag S. Srivastava , Zili Xiao , Michael G. Yang
发明人: Percy H. Carter , Robert J. Cherney , John Hynes , Soo S. Ko , Anurag S. Srivastava , Zili Xiao , Michael G. Yang
IPC分类号: A61K31/519 , A61K31/4439 , A61K31/506 , A61P19/02 , A61P25/28 , A61P3/04 , A61P31/18 , A61P9/12 , C07D239/94 , C07D487/04 , C07D401/12 , C07D239/26 , A61P35/00 , A61P3/10 , A61P3/00 , A61P25/04 , A61P17/06 , A61K31/517
CPC分类号: C07D403/12 , C07D401/12 , C07D487/04
摘要: This invention relates generally to modulators of chemokine receptor activity having unexpected combination of desirable pharmacological properties. Pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and prevention of inflammatory, allergic, autoimmune, metabolic, cancer and/or cardiovascular diseases, particularly diabetes, Crohn's disease, atherosclerosis, and multiple sclerosis, along with methods of preparing compounds and intermediates therefor. Metabolites of active compounds are also provided herein, pharmaceutical compositions and use thereof are also provided.
摘要翻译: 本发明一般涉及趋化因子受体活性的调节剂,其具有期望的药理学性质的意想不到的组合。 含有它们的药物组合物,以及使用其作为治疗和预防炎性,过敏性,自身免疫性,代谢性,癌症和/或心血管疾病,特别是糖尿病,克罗恩病,动脉粥样硬化和多发性硬化的药物的方法以及方法 制备化合物及其中间体。 本文还提供了活性化合物的代谢物,还提供药物组合物及其用途。
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3.
公开(公告)号:US07482335B2
公开(公告)日:2009-01-27
申请号:US11545415
申请日:2006-10-10
申请人: Percy H. Carter , Robert J. Cherney , Douglas G. Batt , John V. Duncia , Daniel S. Gardner , Soo S. Ko , Anurag S. Srivastava , Michael G. Yang
发明人: Percy H. Carter , Robert J. Cherney , Douglas G. Batt , John V. Duncia , Daniel S. Gardner , Soo S. Ko , Anurag S. Srivastava , Michael G. Yang
IPC分类号: A61K31/397 , A61K31/5383 , A61K31/496 , A61K31/454 , A61K31/4015 , C07D413/12 , C07D403/12 , C07D401/12 , C07D207/277 , C07D207/00 , C07D205/04
CPC分类号: C07D207/273 , C04B35/632 , C07D207/34 , C07D211/86 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/04
摘要: The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the treatment of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma.
摘要翻译: 本申请描述了可用于治疗类风湿性关节炎,多发性硬化,动脉粥样硬化和哮喘的式(I)的MCP-1或其药学上可接受的盐形式的调节剂。
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4.
公开(公告)号:US07829571B2
公开(公告)日:2010-11-09
申请号:US12354258
申请日:2009-01-15
申请人: Percy H. Carter , Robert J. Cherney , Douglas G. Batt , John V. Duncia , Daniel S. Gardner , Soo S. Ko , Anurag S. Srivastava , Michael G. Yang
发明人: Percy H. Carter , Robert J. Cherney , Douglas G. Batt , John V. Duncia , Daniel S. Gardner , Soo S. Ko , Anurag S. Srivastava , Michael G. Yang
IPC分类号: A61K31/519 , A61K31/4015 , C07D487/04 , C07D207/273
CPC分类号: C07D207/273 , C04B35/632 , C07D207/34 , C07D211/86 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/04
摘要: The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the treatment of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma.
摘要翻译: 本申请描述了可用于治疗类风湿性关节炎,多发性硬化,动脉粥样硬化和哮喘的式(I)的MCP-1或其药学上可接受的盐形式的调节剂。
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5.
公开(公告)号:US20090124668A1
公开(公告)日:2009-05-14
申请号:US12354258
申请日:2009-01-15
申请人: Percy H. Carter , Robert J. Cherney , Douglas G. Batt , John V. Duncia , Daniel S. Gardner , Soo S. Ko , Anurag S. Srivastava , Michael G. Yang
发明人: Percy H. Carter , Robert J. Cherney , Douglas G. Batt , John V. Duncia , Daniel S. Gardner , Soo S. Ko , Anurag S. Srivastava , Michael G. Yang
IPC分类号: A61K31/44 , C07D207/09 , A61K31/40 , A61P9/10 , A61P19/10 , C07D211/72
CPC分类号: C07D207/273 , C04B35/632 , C07D207/34 , C07D211/86 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/04
摘要: The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the treatment of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma.
摘要翻译: 本申请描述了可用于治疗类风湿性关节炎,多发性硬化,动脉粥样硬化和哮喘的式(I)的MCP-1或其药学上可接受的盐形式的调节剂。
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6.
公开(公告)号:US07163937B2
公开(公告)日:2007-01-16
申请号:US10923619
申请日:2004-08-19
申请人: Percy H. Carter , Robert J. Cherney , Douglas G. Batt , John V. Duncia , Daniel S. Gardner , Soo S. Ko , Anurag S. Srivastava , Michael G. Yang
发明人: Percy H. Carter , Robert J. Cherney , Douglas G. Batt , John V. Duncia , Daniel S. Gardner , Soo S. Ko , Anurag S. Srivastava , Michael G. Yang
IPC分类号: A61K31/397 , A61K31/5383 , A61K31/496 , A61K31/454 , A61K31/4015 , C07D413/12 , C07D403/12
CPC分类号: C07D207/273 , C04B35/632 , C07D207/34 , C07D211/86 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/04
摘要: The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the treatment of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma.
摘要翻译: 本申请描述了可用于治疗类风湿性关节炎,多发性硬化,动脉粥样硬化和哮喘的式(I)的MCP-1或其药学上可接受的盐形式的调节剂。
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公开(公告)号:US5583147A
公开(公告)日:1996-12-10
申请号:US216724
申请日:1994-03-23
申请人: Soo S. Ko , Richard G. Wilde , Indawati DeLucca , Hui-Yin Li , Hollis S. Kezar, III , George A. Boswell , Anurag S. Srivastava
发明人: Soo S. Ko , Richard G. Wilde , Indawati DeLucca , Hui-Yin Li , Hollis S. Kezar, III , George A. Boswell , Anurag S. Srivastava
IPC分类号: C07D213/75 , C07D414/02 , A61K31/44 , C07D213/02
CPC分类号: C07D213/75
摘要: This invention provides amide compounds as inhibitors of acyl-Coenzyme A: cholesterol O-acyltransferase (ACAT), pharmaceutical compositions containing such compounds, processes for the preparation of such compounds, and the use of such compounds as antihypercholesterolemic and/or antiatherosclerotic agents.
摘要翻译: 本发明提供作为酰基辅酶A:胆固醇O-酰基转移酶(ACAT)的抑制剂的酰胺化合物,含有这些化合物的药物组合物,制备这些化合物的方法,以及使用这些化合物作为抗高血胆固醇血症和/或抗动脉粥样硬化剂。
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公开(公告)号:US5349109A
公开(公告)日:1994-09-20
申请号:US112908
申请日:1993-08-26
IPC分类号: C07C209/60
CPC分类号: C07C209/60
摘要: A process for making unsaturated .alpha.-amines from olefins wherein the process includes adding an aminating agent, an olefin and a molybdenum based catalyst to a reaction vessel having a nitrogen atmosphere. The catalyst may be described by the general formula LL'MoO.sub.2, L.sub.2 L'MoO.sub.2, or LL'MoO(X-Y).
摘要翻译: 从烯烃制备不饱和α-胺的方法,其中所述方法包括将胺化剂,烯烃和钼基催化剂加入到具有氮气氛的反应容器中。 催化剂可以用通式LL'MoO2,L2L'MoO2或LL'MoO(X-Y)来描述。
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公开(公告)号:US08822510B2
公开(公告)日:2014-09-02
申请号:US13811032
申请日:2011-07-20
IPC分类号: C07D413/10 , C07D413/14 , C07D413/08 , C07D413/06 , C07D271/06 , A61K31/454 , A61K31/4439 , A61K31/4245 , C07D487/10
CPC分类号: C07D413/10 , A61K31/4245 , A61K31/4439 , A61K31/454 , C07D271/06 , C07D413/06 , C07D413/08 , C07D413/14 , C07D487/10
摘要: Disclosed are compounds of Formula (I): (I) or stereoisomers, salts, or prodrugs thereof, wherein: (i) R1 and R2 are independently C1-C4 alkyl, or (ii) R1 and R2 together with the carbon atom to which they are attached, form a cyclic group; and Q is H, C1-6alkyl, phenyl or 5- to 6-membered heteroaryl substituted with zero to 3 substituents, and G is defined herein. Also disclosed are method of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. There compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and chronic inflammatory disease.
摘要翻译: 公开了式(I)的化合物:(I)或其立体异构体,盐或前药,其中:(i)R 1和R 2独立地为C 1 -C 4烷基,或(ii)R 1和R 2与其中 它们相连,形成一个环状基团; 并且Q是H,C 1-6烷基,苯基或被0至3个取代基取代的5至6元杂芳基,并且G在本文中定义。 还公开了使用这些化合物作为G蛋白偶联受体S1P1的选择性激动剂的方法,以及包含这些化合物的药物组合物。 其中化合物可用于治疗,预防或减缓各种治疗领域(例如自身免疫性疾病和慢性炎症性疾病)中的疾病或病症的进展。
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公开(公告)号:US20130158001A1
公开(公告)日:2013-06-20
申请号:US13811032
申请日:2011-07-20
IPC分类号: C07D413/10 , C07D413/08 , C07D413/06 , C07D487/10 , C07D271/06 , C07D413/14
CPC分类号: C07D413/10 , A61K31/4245 , A61K31/4439 , A61K31/454 , C07D271/06 , C07D413/06 , C07D413/08 , C07D413/14 , C07D487/10
摘要: Disclosed are compounds of Formula (I): (I) or stereoisomers, salts, or prodrugs thereof, wherein: (i) R1 and R2 are independently C1-C4 alkyl, or (ii) R1 and R2 together with the carbon atom to which they are attached, form a cyclic group; and Q is H, C1-6alkyl, phenyl or 5- to 6-membered heteroaryl substituted with zero to 3 substituents, and G is defined herein. Also disclosed are method of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. There compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and chronic inflammatory disease.
摘要翻译: 公开了式(I)的化合物:(I)或其立体异构体,盐或前药,其中:(i)R 1和R 2独立地为C 1 -C 4烷基,或(ii)R 1和R 2与其中 它们相连,形成一个环状基团; 并且Q是H,C 1-6烷基,苯基或被0至3个取代基取代的5至6元杂芳基,并且G在本文中定义。 还公开了使用这些化合物作为G蛋白偶联受体S1P1的选择性激动剂的方法,以及包含这些化合物的药物组合物。 其中化合物可用于治疗,预防或减缓各种治疗领域(例如自身免疫性疾病和慢性炎症性疾病)中的疾病或病症的进展。
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