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8 条记录 (耗时 0.025 秒)

    Penicillin derivatives and compositions containing them
    1.
    发明授权
    Penicillin derivatives and compositions containing them 失效
    青霉素衍生物和含有它们的组合物

    公开(公告)号：US4349551A

    公开(公告)日：1982-09-14

    申请号：US271007

    申请日：1981-06-05

    申请人： Peter H. Bentley ,  Kenneth D. Hardy ,  Peter H. Milner

    发明人： Peter H. Bentley ,  Kenneth D. Hardy ,  Peter H. Milner

    IPC分类号： C07D499/12 ,  A61K31/43 ,  A61P31/04 ,  C07D499/00 ,  C07D499/04 ,  C07D499/21 ,  C07D499/64 ,  C07D499/68 ,  C07D499/70 ,  A61K31/495

    CPC分类号： C07D499/00

    摘要： A compound of formula (I) or a pharmaceutically acceptable salt or in vivo hydrolyzable ester thereof: ##STR1## wherein R is phenyl 4-hydroxy phenyl, or a 5- 6- membered heterocyclic ring containing up to three heteroatoms selected from oxygen, sulphur or nitrogen, optionally substituted with hydroxy, amino, halogen or C.sub.1-6 alkoxy;R.sup.1 represents hydrogen or C.sub.1-6 alkyl;R.sup.2 and R.sup.3 are the same or different and represent hydrogen, C.sub.1-6 alkyl, halogen, amino, hydroxy, or C.sub.1-6 alkoxy.Their preparation and use is described.

    摘要翻译： 式（I）化合物或其药学上可接受的盐或体内可水解的酯：其中R是苯基4-羟基苯基或含有至多三个选自以下的杂原子的5-6元杂环： 氧，硫或氮，任选被羟基，氨基，卤素或C 1-6烷氧基取代; R1代表氢或C1-6烷基; R2和R3相同或不同，表示氢，C1-6烷基，卤素，氨基，羟基或C1-6烷氧基。 描述了它们的制备和使用。

    Cephalosporin derivatives, and compositions containing them
    2.
    发明授权
    Cephalosporin derivatives, and compositions containing them 失效
    头孢菌素衍生物和含有它们的组合物

    公开(公告)号：US4394375A

    公开(公告)日：1983-07-19

    申请号：US271008

    申请日：1981-06-05

    申请人： Peter H. Bentley ,  Kenneth D. Hardy ,  Peter H. Milner

    发明人： Peter H. Bentley ,  Kenneth D. Hardy ,  Peter H. Milner

    IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/57 ,  C07D505/00

    CPC分类号： C07D505/00 ,  A61K31/545

    摘要： A compound of formula (I) or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof: ##STR1## wherein R is phenyl, 4-hydroxyphenyl, or a 5- or 6-membered heterocyclic ring containing up to three heteroatoms selected from oxygen, sulphur or nitrogen, optionally substituted with hydroxy, amino, halogen or C.sub.1-6 alkoxy;R.sup.1 represents hydrogen or C.sub.1-6 alkyl;R.sup.2 and R.sup.3 are the same or different and represent hydrogen, C.sub.1-6 alkyl, halogen, amino, hydroxy, or C.sub.1-6 alkoxy;X represents oxygen or sulphur; andA represents hydrogen, pyridyl, acetoxy, carbamoyloxy or a heterocyclicthio group;Their preparation and use is described.

    摘要翻译： 式（I）化合物或其药学上可接受的盐或体内可水解的酯：其中R是苯基，4-羟基苯基或含有至多三个杂原子的5-或6-元杂环， 任选被羟基，氨基，卤素或C 1-6烷氧基取代的氧，硫或氮; R1代表氢或C1-6烷基; R2和R3相同或不同，表示氢，C1-6烷基，卤素，氨基，羟基或C1-6烷氧基; X表示氧或硫; A代表氢，吡啶基，乙酰氧基，氨基甲酰氧基或杂环硫基; 描述了它们的制备和使用。

    Formamido oxacephems
    6.
    发明授权
    Formamido oxacephems 失效
    甲酰胺氧基

    公开(公告)号：US4661480A

    公开(公告)日：1987-04-28

    申请号：US572186

    申请日：1984-01-19

    申请人： Peter H. Milner

    发明人： Peter H. Milner

    IPC分类号： C07D505/00 ,  A61K31/535 ,  C07D498/04

    CPC分类号： C07D505/00

    摘要： A compound of formula (I) or a pharmaceutically acceptable salt or in vivo hydrolyzable ester thereof: ##STR1## R is phenyl, substituted phenyl, C.sub.3-6 cycloalkyl cyclohexenyl, cyclohexadienyl, or a 5- or 6-membered heterocyclic ring containing up to three hetero-atoms slected from oxygen, sulphur or nitrogen, optionally substituted with hydroxy, amino, halogen, substituted amino or C.sub.1-6 alkoxy; Q represents acetoxy, carbamoyloxy, heterocyclylthio group, or a nitrogen containing heterocyclic group bonded via nitrogen; R.sup.1 is hydrogen or a C.sub.1-6 alkyl group and R.sup.2 is an optionally substituted 5- or 6-membered heterocyclic group containing one or two heteroatoms; or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached form an optionally substituted five- or six-membered heterocyclic group containing one or two nitrogen heteroatoms; a process for the preparation of such compounds and pharmaceutical compositions comprising them.

    摘要翻译： 式（I）化合物或其药学上可接受的盐或体内可水解的酯：（I）R是苯基，取代的苯基，C 3-6环烷基环己烯基，环己二烯基或5-或6-元杂环 含有多至三个选自氧，硫或氮的杂原子，任选被羟基，氨基，卤素，取代的氨基或C 1-6烷氧基取代; Q表示通过氮键合的乙酰氧基，氨基甲酰氧基，杂环硫基或含氮杂环基; R 1是氢或C 1-6烷基，R 2是任选取代的含有一个或两个杂原子的5或6元杂环基; 或R 1和R 2与它们所连接的氮原子一起形成含有一个或两个氮杂原子的任选取代的五元或六元杂环基; 制备这些化合物的方法和包含它们的药物组合物。