摘要:
A tunable optical cavity can be tuned by relative movement between two reflection surfaces, such as by deforming elastomer spacers connected between mirrors or other light-reflective components that include the reflection surfaces. The optical cavity structure includes an analyte region in its light-transmissive region, and presence of analyte in the analyte region affects output light when the optical cavity is tuned to a set of positions. Electrodes that cause deformation of the spacers can also be used to capacitively sense the distance between them. Control circuitry that provides tuning signals can cause continuous movement across a range of positions, allowing continuous photosensing of analyte-affected output light by a detector.
摘要:
An inhomogeneous optical cavity is tuned by changing its shape, such as by changing reflection surface positions to change tilt angle, thickness, or both. Deformable components such as elastomer spacers can be connected so that, when deformed, they change relative positions of structures with light-reflective components such as mirrors, changing cavity shape. Electrodes can cause deformation, such as electrostatically, electromagnetically, or piezoelectrically, and can also be used to measure thicknesses of the cavity. The cavity can be tuned, for example, across a continuous spectrum, to a specific wavelength band, to a shape that increases or decreases the number of modes it has, to a series of transmission ranges each suitable for a respective light source, with a modulation that allows lock-in with photosensing for greater sensitivity, and so forth. The optical cavity can be a linear variable filter fabricated on the photosensitive surface of a photosensing component such as a photosensor array or a position-sensitive detector.
摘要:
An inhomogeneous optical cavity is tuned by changing its shape, such as by changing reflection surface positions to change tilt angle, thickness, or both. Deformable components such as elastomer spacers can be connected so that, when deformed, they change relative positions of structures with light-reflective components such as mirrors, changing cavity shape. Electrodes can cause deformation, such as electrostatically, electromagnetically, or piezoelectrically, and can also be used to measure thicknesses of the cavity. The cavity can be tuned, for example, across a continuous spectrum, to a specific wavelength band, to a shape that increases or decreases the number of modes it has, to a series of transmission ranges each suitable for a respective light source, with a modulation that allows lock-in with photosensing for greater sensitivity, and so forth. The optical cavity can be a linear variable filter fabricated on the photosensitive surface of a photosensing component such as a photosensor array or a position-sensitive detector.
摘要:
A tunable optical cavity can be tuned by relative movement between two reflection surfaces, such as by deforming elastomer spacers connected between mirrors or other light-reflective components that include the reflection surfaces. The optical cavity structure includes an analyte region in its light-transmissive region, and presence of analyte in the analyte region affects output light when the optical cavity is tuned to a set of positions. Electrodes that cause deformation of the spacers can also be used to capacitively sense the distance between them. Control circuitry that provides tuning signals can cause continuous movement across a range of positions, allowing continuous photosensing of analyte-affected output light by a detector.
摘要:
A tunable optical cavity can be tuned by relative movement between two reflection surfaces, such as by deforming elastomer spacers connected between mirrors or other light-reflective components that include the reflection surfaces. The optical cavity structure includes an analyte region in its light-transmissive region, and presence of analyte in the analyte region affects output light when the optical cavity is tuned to a set of positions. Electrodes that cause deformation of the spacers can also be used to capacitively sense the distance between them. Control circuitry that provides tuning signals can cause continuous movement across a range of positions, allowing continuous photosensing of analyte-affected output light by a detector.
摘要:
A tunable optical cavity can be tuned by relative movement between two reflection surfaces, such as by deforming elastomer spacers connected between mirrors or other light-reflective components that include the reflection surfaces. The optical cavity structure includes an analyte region in its light-transmissive region, and presence of analyte in the analyte region affects output light when the optical cavity is tuned to a set of positions. Electrodes that cause deformation of the spacers can also be used to capacitively sense the distance between them. Control circuitry that provides tuning signals can cause continuous movement across a range of positions, allowing continuous photosensing of analyte-affected output light by a detector.
摘要:
A method is provided for extracting the position of a particle, e.g., a moving or stationary particle that is excited or is emitting light. The method includes, among other steps, detecting and recording a signal based on, for example, the movement of the particle, a correlation step to eliminate noise and to create a transformed signal, a matching or fitting step to match the transformed signal to a fit function and an extracting or determining step to determine the position of the particle from the fit function. In one form, at least two particle positions are detected so that the distance between the subject particles can be determined.
摘要:
A device can include both a photosensing component and an optical cavity structure, with the optical cavity structure including a part that can operate as an optical cavity in response to input light, providing laterally varying output light. For example, the optical cavity can be a graded linearly varying filter (LVF) or other inhomogeneous optical cavity, and the photosensing component can have a photosensitive surface that receives its output light without it passing through another optical component, thus avoiding loss of information. The optical cavity part can include a region that can contain analyte. Presence of the analyte affects the optical cavity part's output light, and the photosensing component can respond to the output light, providing sensing results indicating the analyte's optical characteristics.
摘要:
While two or more analytes within an optical cavity move relative to an array of photosensing elements, the cavity provides output light that has a position/time varying intensity function that depends on optical characteristics of the analytes and on the relative movement. The output light is photosensed to obtain sensing results that depend on the position/time varying intensity function. The sensing results are used to obtain information about at least one of the analytes. The relative movement can, for example, be caused by moving analytes within channels within the cavity, such as by causing flow of a medium that carries the analytes through the channels. Or the analytes can be in wells of a biochip, with the cavity defined by reflective slides on opposite surfaces of the biochip, and the slides and biochip can be caused to move together relative to the array.
摘要:
Output light from an optical cavity includes, for each of a set of modes, an intensity function, and a mode's intensity function includes information, such as about an optical characteristic of an analyte or of a region. For example, the intensity function can include a peak, and its central energy, maximum intensity, contrast, or intermediate intensity width (e.g. FWHM) can indicate the optical characteristic. The output light can be photosensed, providing electrical signals that depend on the optical characteristic. Information about the analyte or region can then be obtained using the electrical signals. For example, the information can be about both refractive index and absorption of an analyte. Cavity-only absorption values, independent, for example, of absorption outside the cavity and of inhomogeneous illumination, can be obtained based on contrast or intermediate intensity width. For detection of glucose in bodily fluid, derivatives of absorption can be obtained.