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    Insulin derivatives
    3.
    发明授权
    Insulin derivatives 有权
    胰岛素衍生物

    公开(公告)号：US08476228B2

    公开(公告)日：2013-07-02

    申请号：US13273659

    申请日：2011-10-14

    申请人： János Tibor Kodra ,  Patrick William Garibay ,  Thomas Hoeg-Jensen ,  Ib Jonassen ,  Peter Madsen ,  Tina Møller Tagmose

    发明人： János Tibor Kodra ,  Patrick William Garibay ,  Thomas Hoeg-Jensen ,  Ib Jonassen ,  Peter Madsen ,  Tina Møller Tagmose

    IPC分类号： A61K38/28 ,  C07K14/62

    CPC分类号： A61K38/28 ,  C07K14/62

    摘要： The present invention relates to insulin derivatives having a side chain attached either to the α-amino group of the N-terminal amino acid residue of the B chain or to the ε-amino group of a Lys residue present in the B chain of the parent insulin via an amide bond which side chain comprises at least one aromatic group; at least one free carboxylic acid group or a group which is negatively charged at neutral pH, a fatty acid moiety with 4 to 22 carbon atoms in the carbon chain; and possible linkers which link the individual components in the side chain together via amide bonds.

    摘要翻译： 本发明涉及具有侧链连接到B链的N末端氨基酸残基的α-氨基或母体B链中存在的Lys残基的ε-氨基的胰岛素衍生物 胰岛素通过酰胺键，该侧链包含至少一个芳族基团; 至少一个游离羧酸基团或在中性pH下带负电荷的基团，碳链中具有4-22个碳原子的脂肪酸部分; 以及通过酰胺键将侧链中各个组分连接在一起的可能接头。

    Insulin Derivatives
    7.
    发明申请
    Insulin Derivatives 审中-公开
    胰岛素衍生物

    公开(公告)号：US20080171695A1

    公开(公告)日：2008-07-17

    申请号：US11814374

    申请日：2006-02-01

    申请人： Patrick William Garibay ,  Thomas Hoeg-Jensen ,  Ib Jonassen ,  Svend Havelund ,  Peter Madsen ,  Palle Jakobsen

    发明人： Patrick William Garibay ,  Thomas Hoeg-Jensen ,  Ib Jonassen ,  Svend Havelund ,  Peter Madsen ,  Palle Jakobsen

    IPC分类号： A61K38/28 ,  C07K14/62 ,  A61P3/10

    CPC分类号： A61K47/60 ,  A61K38/00 ,  C07K14/62

    摘要： The present invention is related to insulin derivatives having a side chain attached either to the α-amino group of the N-terminal amino acid residue of B chain or to an ε-amino group of a Lys residue present in the B chain of the parent insulin molecule via an amide bond which side chain comprises one or more residues of ethyleneglycol, propyleneglycol and/or butyleneglycol containing independently at each termini a group selected from —NH2 and —COOH; a fatty diacid moiety with 4 to 22 carbon atoms, at least one free carboxylic acid group or a group which is negatively charged at neutral pH; and possible linkers which link the individual components in the side chain together via amide or ether bonds, said linkers optionally comprising a free carboxylic acid group.

    摘要翻译： 本发明涉及具有侧链连接到B链的N末端氨基酸残基的α-氨基或母体B链中存在的Lys残基的ε-氨基的胰岛素衍生物 胰岛素分子，该侧链包含一个或多个在每个末端独立地含有选自-NH 2和-COOH的乙二醇，丙二醇和/或丁二醇的残基; 具有4至22个碳原子的脂肪二酸部分，至少一个游离羧酸基团或在中性pH下带负电荷的基团; 以及通过酰胺或醚键将侧链中各个组分连接在一起的可能接头，所述接头任选地包含游离羧酸基团。

    Insulin derivatives
    8.
    发明授权
    Insulin derivatives 有权
    胰岛素衍生物

    公开(公告)号：US08859493B2

    公开(公告)日：2014-10-14

    申请号：US13506292

    申请日：2012-04-09

    申请人： Patrick William Garibay ,  Thomas Hoeg-Jensen ,  Ib Jonassen ,  Svend Havelund ,  Peter Madsen ,  Palle Jakobsen

    发明人： Patrick William Garibay ,  Thomas Hoeg-Jensen ,  Ib Jonassen ,  Svend Havelund ,  Peter Madsen ,  Palle Jakobsen

    IPC分类号： A61K38/28 ,  C07K14/62 ,  A61K47/48 ,  A61K38/00

    CPC分类号： A61K47/48215 ,  A61K38/00 ,  A61K47/60 ,  C07K14/62

    摘要： The present invention is related to insulin derivatives having a side chain attached either to the α-amino group of the N-terminal amino acid residue of B chain or to an ε-amino group of a Lys residue present in the B chain of the parent insulin molecule via an amide bond which side chain comprises one or more residues of ethyleneglycol, propyleneglycol and/or butyleneglycol containing independently at each termini a group selected from —NH2 and —COOH; a fatty diacid moiety with 4 to 22 carbon atoms, at least one free carboxylic acid group or a group which is negatively charged at neutral pH; and possible linkers which link the individual components in the side chain together via amide or ether bonds, said linkers optionally comprising a free carboxylic acid group.

    摘要翻译： 本发明涉及具有侧链连接到B链的N末端氨基酸残基的α-氨基或存在于B链的B链中的Lys残基的亚氨基的胰岛素衍生物 母体胰岛素分子通过酰胺键，该侧链包含在每个末端独立地含有选自-NH 2和-COOH的一个或多个乙二醇，丙二醇和/或丁二醇残基; 具有4至22个碳原子的脂肪二酸部分，至少一个游离羧酸基团或在中性pH下带负电荷的基团; 以及通过酰胺或醚键将侧链中各个组分连接在一起的可能接头，所述接头任选地包含游离羧酸基团。

    Insulin derivatives
    10.
    发明申请
    Insulin derivatives 有权
    胰岛素衍生物

    公开(公告)号：US20120208749A1

    公开(公告)日：2012-08-16

    申请号：US13506292

    申请日：2012-04-09

    申请人： Patrick William Garibay ,  Thomas Hoeg-Jensen ,  Ib Jonassen ,  Svend Havelund ,  Peter Madsen ,  Palle Jakobsen

    发明人： Patrick William Garibay ,  Thomas Hoeg-Jensen ,  Ib Jonassen ,  Svend Havelund ,  Peter Madsen ,  Palle Jakobsen

    IPC分类号： A61K38/28 ,  A61P3/10 ,  C07K14/62

    CPC分类号： A61K47/48215 ,  A61K38/00 ,  A61K47/60 ,  C07K14/62

    摘要： The present invention is related to insulin derivatives having a side chain attached either to the α-amino group of the N-terminal amino acid residue of B chain or to an ε-amino group of a Lys residue present in the B chain of the parent insulin molecule via an amide bond which side chain comprises one or more residues of ethyleneglycol, propyleneglycol and/or butyleneglycol containing independently at each termini a group selected from —NH2 and —COOH; a fatty diacid moiety with 4 to 22 carbon atoms, at least one free carboxylic acid group or a group which is negatively charged at neutral pH; and possible linkers which link the individual components in the side chain together via amide or ether bonds, said linkers optionally comprising a free carboxylic acid group.

    摘要翻译： 本发明涉及具有侧链连接到B链的N末端氨基酸残基的α-氨基或存在于B链的B链中的Lys残基的亚氨基的胰岛素衍生物 母体胰岛素分子通过酰胺键，该侧链包含在每个末端独立地含有选自-NH 2和-COOH的一个或多个乙二醇，丙二醇和/或丁二醇残基; 具有4至22个碳原子的脂肪二酸部分，至少一个游离羧酸基团或在中性pH下带负电荷的基团; 以及通过酰胺或醚键将侧链中各个组分连接在一起的可能接头，所述接头任选地包含游离羧酸基团。