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1.Methods of inhibition of protein fucosylation in vivo using fucose analogs 有权
标题翻译: 使用岩藻糖类似物抑制体内蛋白质岩藻糖基化的方法公开(公告)号:US09504702B2
公开(公告)日:2016-11-29
申请号:US13814083
申请日:2011-08-05
申请人: Peter Senter , Stephen Alley , Dennis Benjamin
发明人: Peter Senter , Stephen Alley , Dennis Benjamin
IPC分类号: A61K31/70 , A61K31/7004 , A61K31/7024 , A61K31/7042 , A61K31/706 , A61K39/00 , C07K16/00 , C07K16/18 , A61K31/7048
CPC分类号: A61K31/7004 , A61K9/0053 , A61K31/7024 , A61K31/7042 , A61K31/7048 , A61K31/706 , A61K39/0011 , A61K45/06 , A61K2039/5152 , A61K2039/545 , C07K16/00 , C07K16/18 , C07K2317/41 , Y02A50/386 , Y02A50/388 , Y02A50/401 , Y02A50/403 , Y02A50/412 , Y02A50/484
摘要: The invention provides methods and compositions for the inhibition of fucosylation of proteins, including antibodies, in vivo by administration of a fucose analog.
摘要翻译: 本发明提供通过施用岩藻糖类似物在体内抑制蛋白质包括抗体的岩藻糖基化的方法和组合物。
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2.METHODS OF INHIBITION OF PROTEIN FUCOSYLATION IN VIVO USING FUCOSE ANALOGS 有权
标题翻译: 使用FUCOSE模拟抑制蛋白质纤维蛋白的方法公开(公告)号:US20130129784A1
公开(公告)日:2013-05-23
申请号:US13814083
申请日:2011-08-05
申请人: Peter Senter , Stephen Alley , Dennis Benjamin
发明人: Peter Senter , Stephen Alley , Dennis Benjamin
IPC分类号: A61K31/7004 , A61K31/7048 , A61K31/7024
CPC分类号: A61K31/7004 , A61K9/0053 , A61K31/7024 , A61K31/7042 , A61K31/7048 , A61K31/706 , A61K39/0011 , A61K45/06 , A61K2039/5152 , A61K2039/545 , C07K16/00 , C07K16/18 , C07K2317/41 , Y02A50/386 , Y02A50/388 , Y02A50/401 , Y02A50/403 , Y02A50/412 , Y02A50/484
摘要: The invention provides methods and compositions for the inhibition of fucosylation of proteins, including antibodies, in vivo by administration of a fucose analog.
摘要翻译: 本发明提供通过施用岩藻糖类似物在体内抑制蛋白质包括抗体的岩藻糖基化的方法和组合物。
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