公开(公告)号：US06214363B1

公开(公告)日：2001-04-10

申请号：US08969077

申请日：1997-11-12

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Robert Gregory Bartolo ,  Theresa Anne Bakken ,  Mary Elizabeth Carethers ,  Mark Richard Sine ,  Mannie Lee Clapp ,  Raphael Warren

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Robert Gregory Bartolo ,  Theresa Anne Bakken ,  Mary Elizabeth Carethers ,  Mark Richard Sine ,  Mannie Lee Clapp ,  Raphael Warren

IPC分类号： A01N2534

CPC分类号： A61Q17/005 ,  A61K8/347 ,  A61K8/442 ,  A61K8/463 ,  A61Q19/00

摘要： The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.001% to about 5% of an antimicrobial active, from about 1% to about 80% of an anionic surfactant, from about 0.1% to about 12% of a proton donating agent; from about 0.1% to about 30% of a deposition aid; and from about 3% to about 98.8% of water, wherein the composition is adjusted to a pH of from about 3.0 to about 6.0, wherein the rinse-off antimicrobial cleansing composition has a Gram Negative Residual Effectiveness Index of greater than about 0.3, and wherein the rinse-off antimicrobial cleansing composition has a Mildness Index of greater than 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram negative bacteria using these products.

摘要翻译： 本发明涉及一种漂洗抗微生物清洁组合物，其包含约0.001％至约5％的抗微生物活性剂，约1％至约80％的阴离子表面活性剂，约0.1％至约12％的质子 捐赠代理人 约0.1％至约30％的沉积助剂; 和约3％至约98.8％的水，其中将组合物调节至约3.0至约6.0的pH，其中冲洗抗微生物清洁组合物具有大于约0.3的革兰氏阴性残留有效性指数，以及 其中所述洗涤抗微生物清洁组合物的温和指数大于0.3。 本发明还包括使用这些产品的用于清洁皮肤并提供与革兰氏阴性细菌的残留效力的方法。

公开(公告)号：US06190674B1

公开(公告)日：2001-02-20

申请号：US08869117

申请日：1997-06-04

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Robert Gregory Bartolo ,  Theresa Anne Bakken ,  Mark Richard Sine

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Robert Gregory Bartolo ,  Theresa Anne Bakken ,  Mark Richard Sine

IPC分类号： A61K600

CPC分类号： A61K8/466 ,  A61K8/347 ,  A61K8/368 ,  A61K8/463 ,  A61K2800/596 ,  A61Q17/005 ,  A61Q19/10 ,  Y10S514/975

摘要： The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.1% to about 5% of an antimicrobial active, from about 8% to about 18% of an anionic surfactant, from about 2% to about 12% of a proton donating agent; from about 1% to about 30% of a lipophilic skin moisturizing agent; from about 0.1% to about 4% of a stabilizer; and from about 35% to about 88.8% of water. At least about 67% of the anionic surfactant comprises a mixture of Class A and Class C surfactant. The weight ratio of Class A surfactant to Class C surfactant ranges from about 5:1 to about 1:2. The composition is adjusted to a pH of from about 3.5 to about 4.5.

摘要翻译： 本发明涉及一种漂洗抗微生物清洁组合物，其包含约0.1％至约5％的抗微生物活性剂，约8％至约18％的阴离子表面活性剂，约2％至约12％的质子 捐赠代理人 约1％至约30％的亲脂性皮肤保湿剂; 约0.1％至约4％的稳定剂; 和约35％至约88.8％的水。 至少约67％的阴离子表面活性剂包括A类和C类表面活性剂的混合物。 A类表面活性剂与C类表面活性剂的重量比为约5:1至约1:2。 将组合物调节至约3.5至约4.5的pH。

公开(公告)号：US06287577B1

公开(公告)日：2001-09-11

申请号：US08967972

申请日：1997-11-12

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Theresa Anne Bakken ,  Wei Cen ,  Mannie Lee Clapp ,  Raphael Warren

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Theresa Anne Bakken ,  Wei Cen ,  Mannie Lee Clapp ,  Raphael Warren

IPC分类号： A61K700

CPC分类号： A61Q19/00 ,  A61K8/347 ,  A61K8/365 ,  A61K8/463 ,  A61Q17/005

摘要： The present invention relates to a leave-on antimicrobial composition comprising from about 0.001% to about 5% of an antimicrobial active; from about 0.05% to about 10% of an anionic surfactant; from about 0.1% to about 10% of a proton donating agent; and from about 0% to about 99.85% of water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0; wherein the leave-on antimicrobial composition has a Gram Positive Residual Effectiveness Index of greater than about 0.5; and wherein the leave-on antimicrobial composition has a Mildness Index of greater than 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram positive bacteria using these products.

摘要翻译： 本发明涉及一种留下抗微生物组合物，其包含约0.001％至约5％的抗微生物活性物质; 约0.05％至约10％的阴离子表面活性剂; 约0.1％至约10％的质子供体剂; 和约0％至约99.85％的水; 其中将组合物调节至约3.0至约6.0的pH; 其中所述留置抗微生物组合物具有大于约0.5的革兰氏阳性残留有效性指数; 并且其中所述留置的抗微生物组合物具有大于0.3的温和指数。 本发明还包括使用这些产品的用于清洁皮肤并提供残留效力的革兰氏阳性细菌的方法。

公开(公告)号：US06284259B1

公开(公告)日：2001-09-04

申请号：US08969057

申请日：1997-11-12

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Theresa Anne Bakken ,  Wei Cen ,  Mannie Lee Clapp ,  Raphael Warren

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Theresa Anne Bakken ,  Wei Cen ,  Mannie Lee Clapp ,  Raphael Warren

IPC分类号： A61K750

CPC分类号： A61Q17/005 ,  A61K8/0208

摘要： The present invention relates to an antimicrobial wipe comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active; from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant; from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent; and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0; wherein the antimicrobial cleansing composition has a Gram Positive Residual Effectiveness Index of greater than about 0.5; and wherein the antimicrobial cleansing composition has a Mildness Index of less than about 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram positive bacteria using these products.

摘要翻译： 本发明涉及一种抗微生物擦拭物，其包括浸渍有抗微生物清洁组合物的多孔或吸收性片材，其中所述抗微生物清洁组合物包含抗微生物清洁组合物的约0.001％至约5.0％的抗微生物活性成分; 约0.05％至约10％的抗微生物清洁组合物;阴离子表面活性剂; 约0.1重量％至约10重量％的抗微生物清洁组合物;质子供体剂; 和约3％至约99.85％的抗微生物清洁组合物，水; 其中将组合物调节至约3.0至约6.0的pH; 其中所述抗微生物清洁组合物具有大于约0.5的革兰氏阳性残留有效性指数; 并且其中所述抗微生物清洁组合物的温和指数小于约0.3。 本发明还包括使用这些产品的用于清洁皮肤并提供残留效力的革兰氏阳性细菌的方法。

公开(公告)号：US06190675B1

公开(公告)日：2001-02-20

申请号：US08969049

申请日：1997-11-12

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Wei Cen ,  Theresa Anne Bakken ,  Mannie Lee Clapp ,  Raphael Warren

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Wei Cen ,  Theresa Anne Bakken ,  Mannie Lee Clapp ,  Raphael Warren

IPC分类号： A61K600

CPC分类号： A61K8/347 ,  A61K8/36 ,  A61K8/362 ,  A61K8/365 ,  A61K8/368 ,  A61K8/42 ,  A61K8/4933 ,  A61Q5/02 ,  A61Q17/005 ,  A61Q19/10 ,  Y10S514/975

摘要： The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.001% to about 5% of an antimicrobial active, from about 1% to about 80% of an anionic surfactant, from about 0.1% to about 12% of a proton donating agent; and from about 3% to about 98.899% of water, wherein the composition is adjusted to a pH of from about 3.0 to about 6.0, wherein the rinse-off antimicrobial cleansing composition has a Gram Positive Residual Effectiveness Index of greater than about 1.8, and wherein the rinse-off antimicrobial cleansing composition has a Mildness Index of greater than 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram positive bacteria using these products.

摘要翻译： 本发明涉及一种漂洗抗微生物清洁组合物，其包含约0.001％至约5％的抗微生物活性剂，约1％至约80％的阴离子表面活性剂，约0.1％至约12％的质子 捐赠代理人 和约3％至约98.899％的水，其中将组合物调节至约3.0至约6.0的pH，其中冲洗抗微生物清洁组合物具有大于约1.8的革兰氏阳性残留效力指数，以及 其中所述洗涤抗微生物清洁组合物的温和指数大于0.3。 本发明还包括使用这些产品的用于清洁皮肤并提供残留效力的革兰氏阳性细菌的方法。

公开(公告)号：US06258368B1

公开(公告)日：2001-07-10

申请号：US08868717

申请日：1997-06-04

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Theresa Anne Bakken ,  Marcus Wayne Evans

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Theresa Anne Bakken ,  Marcus Wayne Evans

IPC分类号： A01N2500

CPC分类号： A61Q17/005 ,  A61K8/0208 ,  C11D1/37 ,  C11D3/042 ,  C11D3/2034 ,  C11D3/2075 ,  C11D3/3769 ,  C11D3/48 ,  C11D17/049

摘要： The present invention relates to an antimicrobial wipe comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active; from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant; from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent; and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0. The invention also encompasses methods for cleansing skin, reducing the number of germs on the skin, and providing residual effectiveness versus Gram positive and Gram negative bacteria using these products.

摘要翻译： 本发明涉及一种抗微生物擦拭物，其包括浸渍有抗微生物清洁组合物的多孔或吸收性片材，其中所述抗微生物清洁组合物包含抗微生物清洁组合物的约0.001％至约5.0％的抗微生物活性成分; 约0.05％至约10％的抗微生物清洁组合物;阴离子表面活性剂; 约0.1重量％至约10重量％的抗微生物清洁组合物;质子供体剂; 和约3％至约99.85％的抗微生物清洁组合物，水; 其中将组合物调节至约3.0至约6.0的pH。 本发明还包括用于清洁皮肤的方法，减少皮肤上的细菌数量，以及使用这些产品对革兰氏阳性和革兰氏阴性菌提供残留效力。

公开(公告)号：US06210695B1

公开(公告)日：2001-04-03

申请号：US08869129

申请日：1997-06-04

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Theresa Anne Bakken ,  Marcus Wayne Evans

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Theresa Anne Bakken ,  Marcus Wayne Evans

IPC分类号： A01N2534

CPC分类号： A61Q17/005 ,  A61K8/347 ,  A61K8/368 ,  A61K8/463 ,  A61K8/466 ,  A61Q19/00

摘要： The present invention relates to a leave-on antimicrobial composition comprising from about 0.001% to about 5.0%, by weight of the leave-on antimicrobial composition, of an antimicrobial active; from about 0.05% to about 10%, by weight of the leave-on antimicrobial composition, of an anionic surfactant; from about 0.1% to about 10%, by weight of the leave-on antimicrobial composition, of a proton donating agent; and from about 0% to about 99.85%, by weight of the leave-on antimicrobial composition, water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0. The invention also encompasses methods for moisturizing, reducing the number of germs on the skin, and decreasing the spread of transient Gram negative and Gram positive bacteria using the leave-on antimicrobial compositions described herein.

摘要翻译： 本发明涉及一种留下的抗微生物组合物，其包含约0.001％至约5.0％（重量）的所述免疫抗微生物组合物，抗微生物活性物质; 约0.05％至约10％的剩余抗微生物组合物;阴离子表面活性剂; 约0.1％至约10％重量的留置抗微生物组合物;质子供体剂; 和约0％至约99.85％（重量）的剩余抗微生物组合物，水; 其中将组合物调节至约3.0至约6.0的pH。 本发明还包括使用本文所述的留下的抗微生物组合物来保湿，减少皮肤上的细菌数量以及减少瞬时革兰氏阴性和革兰氏阳性细菌的扩散的方法。

公开(公告)号：US5968539A

公开(公告)日：1999-10-19

申请号：US868783

申请日：1997-06-04

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Wei Cen ,  Theresa Anne Bakken

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Wei Cen ,  Theresa Anne Bakken

IPC分类号： A01N25/00 ,  A61K8/34 ,  A61K8/36 ,  A61K8/362 ,  A61K8/365 ,  A61K8/368 ,  A61K8/42 ,  A61K8/49 ,  A61Q5/02 ,  A61Q17/00 ,  A61Q19/10 ,  C11D3/20

CPC分类号： A61K8/365 ,  A61K8/347 ,  A61K8/36 ,  A61K8/362 ,  A61K8/368 ,  A61K8/42 ,  A61K8/4926 ,  A61K8/4933 ,  A61Q17/005 ,  A61Q19/10 ,  A61Q5/02

摘要： The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.001% to about 5% of an antimicrobial active, from about 1% to about 80% of an anionic surfactant, from about 0.1% to about 12% of a proton donating agent; and from about 3% to about 98.899% of water, wherein the composition is adjusted to a pH of from about 3.0 to about 6.0, wherein the rinse-off antimicrobial cleansing composition has a Gram Negative Residual Effectiveness Index of greater than about 0.3, and wherein the rinse-off antimicrobial cleansing composition has a Mildness Index of greater than 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram negative bacteria using these products.

摘要翻译： 本发明涉及一种漂洗抗微生物清洁组合物，其包含约0.001％至约5％的抗微生物活性剂，约1％至约80％的阴离子表面活性剂，约0.1％至约12％的质子 捐赠代理人 和约3％至约98.899％的水，其中将组合物调节至约3.0至约6.0的pH，其中冲洗抗微生物清洁组合物具有大于约0.3的革兰氏阴性残留有效性指数，以及 其中所述洗涤抗微生物清洁组合物的温和指数大于0.3。 本发明还包括使用这些产品的用于清洁皮肤并提供与革兰氏阴性细菌的残留效力的方法。

公开(公告)号：US06197315B1

公开(公告)日：2001-03-06

申请号：US08869116

申请日：1997-06-04

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Wei Cen ,  Theresa Anne Bakken

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Wei Cen ,  Theresa Anne Bakken

IPC分类号： A61K600

CPC分类号： A61Q17/005 ,  A61K8/0208

摘要： The present invention relates to an antimicrobial wipe comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active; from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant; from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent; and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0; wherein the antimicrobial cleansing composition has a Gram Negative Residual Effectiveness Index of greater than about 0.3. The invention also relates to these antibacterial wipes wherein the antimicrobial cleansing composition has a Mildness Index of greater than about 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram negative bacteria using these products.

摘要翻译： 本发明涉及一种抗微生物擦拭物，其包括浸渍有抗微生物清洁组合物的多孔或吸收性片材，其中所述抗微生物清洁组合物包含抗微生物清洁组合物的约0.001％至约5.0％的抗微生物活性成分; 约0.05％至约10％的抗微生物清洁组合物;阴离子表面活性剂; 约0.1重量％至约10重量％的抗微生物清洁组合物;质子供体剂; 和约3％至约99.85％的抗微生物清洁组合物，水; 其中将组合物调节至约3.0至约6.0的pH; 其中所述抗微生物清洁组合物具有大于约0.3的革兰氏阴性残留有效性指数。 本发明还涉及这些抗菌擦拭物，其中抗微生物清洁组合物的温和指数大于约0.3。 本发明还包括使用这些产品的用于清洁皮肤并提供与革兰氏阴性细菌的残留效力的方法。

公开(公告)号：US06183763B2

公开(公告)日：2001-02-06

申请号：US08868687

申请日：1997-06-04

申请人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Wei Cen ,  Theresa Anne Bakken

发明人： Peter William Beerse ,  Jeffrey Michael Morgan ,  Kathleen Grieshop Baier ,  Wei Cen ,  Theresa Anne Bakken

IPC分类号： A01N2534

CPC分类号： A61Q17/005 ,  A61K8/0208

摘要： The present invention relates to an antimicrobial wipe effective against Gram positive bacteria, Gram negative bacteria, fungi, yeasts, molds, and viruses comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active; from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant; from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent; and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0; wherein the antimicrobial cleansing composition an One-wash Immediate Germ Reduction Index of greater than about 1.3; and wherein the rinse-off antimicrobial cleansing composition has a Mildness Index of greater than 0.3. The present invention also relates to methods for removing germs from the skin using the antimicrobial wipes described herein.

摘要翻译： 本发明涉及对抗革兰氏阳性细菌，革兰氏阴性细菌，真菌，酵母，霉菌和病毒的抗微生物擦拭物，其包含浸渍有抗微生物清洁组合物的多孔或吸收性片材，其中所述抗微生物清洁组合物包含约0.001％至 约5.0％的抗微生物清洁组合物;抗微生物活性物质; 约0.05％至约10％的抗微生物清洁组合物;阴离子表面活性剂; 约0.1重量％至约10重量％的抗微生物清洁组合物;质子供体剂; 和约3％至约99.85％的抗微生物清洁组合物，水; 其中将组合物调节至约3.0至约6.0的pH; 其中所述抗微生物清洁组合物具有大于约1.3的单洗立即生物降解指数; 并且其中所述洗涤抗微生物清洁组合物具有大于0.3的温和指数。 本发明还涉及使用本文所述的抗微生物擦拭剂从皮肤除去细菌的方法。