摘要:
The present invention relates to certain novel substituted heterocycles which are 1-pyrimidinylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these substituted heterocycles, processes for preparing the substituted heterocycles, pharmaceutical compositions containing such substituted heterocycles and methods for their use.
摘要:
The present invention relates to certain novel substituted ketones which are 1-pyrimidinylacetamide derivatives of formula I, ##STR1## set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates ##STR2## useful in the synthesis of these substituted ketones processes for preparing the substituted ketones pharmaceutical compositions containing such substituted ketones and methods for their use.
摘要:
The present invention relates to certain novel amide derivatives which are pyrido[3,4-d]pyrimidin-7-ylacetamides which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these amide derivatives, processes for preparing the amide derivatives, pharmaceutical compositions containing such amide derivatives and methods for their use.
摘要:
The present invention relates to certain novel heterocyclic ketones which are 1-pyridylacetamide ketones of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic ketones, processes for preparing the heterocyclic ketones, pharmaceutical compositions containing such heterocyclic ketones and methods for their use.
摘要:
The present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic amides, processes for preparing the heterocyclic amides, pharmaceutical compositions containing such heterocyclic amides and methods for their use.
摘要:
The present invention relates to certain novel amide ##STR1## derivatives which are pyrido[3,4-b]indol-2-ylacetamides which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these amide derivatives, processes for preparing the amide derivatives, pharmaceutical compositions containing such amide derivatives and methods for their use.
摘要:
A non-transitory machine readable medium that has a computer program for adjusting color values of an image represented in a color space is described. The image includes a set of pixels. Each pixel includes a set of color values. The computer program displays a composite bump on a tonal adjustment graph that is defined along a particular color component of the color space. The composite bump is generated by blending several bumps on the tonal adjustment graph. In response to receiving an input on a location on the tonal adjustment graph, the computer program creates a new bump based on the input and blending the new bump with the composite bump to create a modified composite bump. The computer program adjusts the color values of the image based on the modified composite bump.
摘要:
A non-transitory machine readable medium that has a computer program for adjusting color values of an image represented in a color space is described. The computer program displays the image on a display device. The computer program receives several inputs on the displayed image. The several inputs include a selection of a point on the displayed image and a vector input. The computer program identifies a pixel of the image that corresponds to the selected point. Based on the color values of the identified pixel and the vector input, the program determines a color space transform for mapping a set of color values defined within the color space to a different set of color values.
摘要:
Some embodiments provide a computer program that provides a graphical user interface (GUI) for controlling an application. The GUI includes a contiguous two-dimensional sliding region for defining several values. The GUI also includes several sliders for moving within the sliding region. Each slider selects one or more values from the several values based on a position of the slider within the sliding region. The selected values are parameters for controlling one or more operations of the application.
摘要:
A method for determining a depth ordering between two planes in a 3D workspace of an application is provided. The method includes projecting vectors from a reference position through points of interest on the planes, determining corresponding points on the other plane, determining a number of points of interest on a first plane having a depth lower than its corresponding point and a number of points of interest on a second plane having a depth lower than its corresponding point, and setting the depth ordering based on these numbers. A method for displaying interconnects between nodes of a tree displayed in an application is provided. A node represents a multimedia item or a function and an interconnect represents data passed between two nodes. The method includes displaying an interconnect in the tree having an appearance indicating at least one characteristic of the data being passed between two nodes.