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公开(公告)号：US11129405B2
公开(公告)日：2021-09-28
申请号：US16179107
申请日：2018-11-02
Applicant: Philip Morris USA Inc.
Inventor： Gerd Kobal , Justin Heynekamp , Timothy B. Langston , Peter Reeh , Munmaya K. Mishra , Jason W. Flora
Abstract: An orally-enjoyable tobacco product includes a portion of smokeless tobacco comprising an active ingredient and either: (1) a collection of tobacco particles at least partially enclosed by a coating comprising a water-soluble non-crosslinked component and a substantially water-insoluble cross-linked component, or (2) a pouch comprising smokeless tobacco enclosed in a water-permeable wrapper. The active ingredient is selected from the group consisting of a mercaptan, camphor, borneol, isoborneol, bornyl acetate, isobornyl acetate, mono-bornyl succinate, mono-isobornyl succinate, mono-bornyl formate, and mono-isobornyl formate. The active ingredient is present in an amount effective to reduce or eliminate the sensory irritation arising from the smokeless tobacco. Also disclosed is a method of making such a product.
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2.发明申请INHIBITION OF SENSORY IRRITATION DURING CONSUMPTION OF NON-SMOKEABLE TOBACCO PRODUCTS 审中-公开在不可吸烟的烟草制品消费期间进行感觉刺激的抑制
公开(公告)号：US20150250227A1
公开(公告)日：2015-09-10
申请号：US14719510
申请日：2015-05-22
Applicant: Philip Morris USA Inc.
Inventor： Gerd Kobal , Justin Heynekamp , Timothy B. Langston , Peter Reeh , Munmaya K. Mishra , Jason W. Flora
CPC classification number: A24B13/00 , A24B15/18 , A24B15/282 , A24B15/30
Abstract: An orally-enjoyable tobacco product includes a portion of smokeless tobacco comprising an active ingredient and either: (1) a collection of tobacco particles at least partially enclosed by a coating comprising a water-soluble non-crosslinked component and a substantially water-insoluble cross-linked component, or (2) a pouch comprising smokeless tobacco enclosed in a water-permeable wrapper. The active ingredient is selected from the group consisting of a mercaptan, camphor, borneol, isoborneol, bornyl acetate, isobornyl acetate, mono-bornyl succinate, mono-isobornyl succinate, mono-bornyl formate, and mono-isobornyl formate. The active ingredient is present in an amount effective to reduce or eliminate the sensory irritation arising from the smokeless tobacco. Also disclosed is a method of making such a product.
Abstract translation: 口感愉悦的烟草产品包括一部分无烟烟草，其包含活性成分，并且：（1）至少部分地由包含水溶性非交联组分和基本上水不溶性交联的涂层包围的烟草颗粒的集合 连接的部件，或（2）包含封闭在透水包装中的无烟烟草的小袋。 活性成分选自硫醇，樟脑，冰片，异冰片，乙酸冰片酯，乙酸异冰片酯，琥珀酸单冰片酯，琥珀酸单异冰片酯，甲酸单冰片酯和甲酸单异冰片酯。 活性成分以有效减少或消除由无烟烟草产生的感觉刺激的量存在。 还公开了制造这种产品的方法。
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公开(公告)号：US20190069595A1
公开(公告)日：2019-03-07
申请号：US16179107
申请日：2018-11-02
Applicant: Philip Morris USA Inc.
Inventor： Gerd Kobal , Justin Heynekamp , Timothy B. Langston , Peter Reeh , Munmaya K. Mishra , Jason W. Flora
Abstract: An orally-enjoyable tobacco product includes a portion of smokeless tobacco comprising an active ingredient and either: (1) a collection of tobacco particles at least partially enclosed by a coating comprising a water-soluble non-crosslinked component and a substantially water-insoluble cross-linked component, or (2) a pouch comprising smokeless tobacco enclosed in a water-permeable wrapper. The active ingredient is selected from the group consisting of a mercaptan, camphor, borneol, isoborneol, bornyl acetate, isobornyl acetate, mono-bornyl succinate, mono-isobornyl succinate, mono-bornyl formate, and mono-isobornyl formate. The active ingredient is present in an amount effective to reduce or eliminate the sensory irritation arising from the smokeless tobacco. Also disclosed is a method of making such a product.
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4.发明申请INHIBITION OF CENTRAL NERVOUS SYSTEM EFFECTS FROM SMOKING AND SENSORY EFFECTS FROM SMOKING 审中-公开抑制吸烟和感染影响的中枢神经系统对吸烟的影响
公开(公告)号：US20140271733A1
公开(公告)日：2014-09-18
申请号：US14208619
申请日：2014-03-13
Applicant: Philip Morris USA Inc
Inventor： Gerd Kobal , Justin Heynekamp , Peter Reeh , Munmaya K. Mishra
IPC: A61K31/125 , A61K31/045
CPC classification number: A61K31/125 , A61K31/045 , A61K31/22 , A61K45/06 , A61K2300/00
Abstract: Pharmaceutical compositions and methods of use therefor for reducing the desire to engage in smoking are disclosed. More specifically, the pharmaceutical composition utilizes an active ingredient to reduce the side effects of smoking cessation and to limit the molecular feedback caused by nicotine-mediated activation of acetylcholine receptors.
Abstract translation: 公开了用于减少吸烟欲望的药物组合物及其使用方法。 更具体地，药物组合物利用活性成分来减少戒烟的副作用并限制由尼古丁介导的乙酰胆碱受体活化引起的分子反馈。
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公开(公告)号：US12161145B2
公开(公告)日：2024-12-10
申请号：US17412564
申请日：2021-08-26
Applicant: Philip Morris USA Inc.
Inventor： Gerd Kobal , Justin Heynekamp , Timothy B. Langston , Peter Reeh , Munmaya K. Mishra , Jason W. Flora
Abstract: An orally-enjoyable tobacco product includes a portion of smokeless tobacco comprising an active ingredient and either: (1) a collection of tobacco particles at least partially enclosed by a coating comprising a water-soluble non-crosslinked component and a substantially water-insoluble cross-linked component, or (2) a pouch comprising smokeless tobacco enclosed in a water-permeable wrapper. The active ingredient is selected from the group consisting of a mercaptan, camphor, borneol, isoborneol, bornyl acetate, isobornyl acetate, mono-bornyl succinate, mono-isobornyl succinate, mono-bornyl formate, and mono-isobornyl formate. The active ingredient is present in an amount effective to reduce or eliminate the sensory irritation arising from the smokeless tobacco.
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公开(公告)号：US10117453B2
公开(公告)日：2018-11-06
申请号：US14719510
申请日：2015-05-22
Applicant: Philip Morris USA Inc.
Inventor： Gerd Kobal , Justin Heynekamp , Timothy B. Langston , Peter Reeh , Munmaya K. Mishra , Jason W. Flora
Abstract: An orally-enjoyable tobacco product includes a portion of smokeless tobacco comprising an active ingredient and either: (1) a collection of tobacco particles at least partially enclosed by a coating comprising a water-soluble non-crosslinked component and a substantially water-insoluble cross-linked component, or (2) a pouch comprising smokeless tobacco enclosed in a water-permeable wrapper. The active ingredient is selected from the group consisting of a mercaptan, camphor, borneol, isoborneol, bornyl acetate, isobornyl acetate, mono-bornyl succinate, mono-isobornyl succinate, mono-bornyl formate, and mono-isobornyl formate. The active ingredient is present in an amount effective to reduce or eliminate the sensory irritation arising from the smokeless tobacco. Also disclosed is a method of making such a product.
