公开(公告)号：US20070032489A1

公开(公告)日：2007-02-08

申请号：US11535127

申请日：2006-09-26

申请人： Philip Weintraub ,  Paul Eastwood ,  Shujaath Mehdi ,  David Stefany ,  Kwon Musick ,  Neil Moorcroft ,  Sungtaek Lim ,  John Jiang ,  Hartmut Rutten ,  Stefan Peukert ,  Uwe Schwahn

发明人： Philip Weintraub ,  Paul Eastwood ,  Shujaath Mehdi ,  David Stefany ,  Kwon Musick ,  Neil Moorcroft ,  Sungtaek Lim ,  John Jiang ,  Hartmut Rutten ,  Stefan Peukert ,  Uwe Schwahn

IPC分类号： A61K31/5377 ,  A61K31/44 ,  C07D413/02 ,  C07D211/72

CPC分类号： C07D213/64 ,  C07D217/24 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/14

摘要： The present invention relates to a series of 2,3,5-substituted pyridone derivatives of formula I: wherein R, R1, R2, R3 and R4 are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5′-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.

摘要翻译： 本发明涉及一系列式I的2,3,5-取代吡啶酮衍生物：其中R 1，R 2，R 2，R 3， R 3和R 4如本文所定义。 本发明还涉及制备这些化合物的方法。 本发明的化合物是聚（腺苷5'-二磷酸核糖）聚合酶（PARP）的抑制剂，因此可用作药剂，特别是用于治疗和/或预防各种疾病，包括与中枢神经相关的疾病 系统和心血管疾病。

公开(公告)号：US20050054631A1

公开(公告)日：2005-03-10

申请号：US10933098

申请日：2004-09-01

申请人： John Jiang ,  Jack Koehl ,  Shujaath Mehdi ,  Neil Moorcroft ,  Kwon Musick ,  Philip Weintraub ,  Paul Eastwood

发明人： John Jiang ,  Jack Koehl ,  Shujaath Mehdi ,  Neil Moorcroft ,  Kwon Musick ,  Philip Weintraub ,  Paul Eastwood

IPC分类号： A61K31/404 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/503 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61P9/10 ,  C07D209/40 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D471/04 ,  C07D487/08

CPC分类号： C04B35/632 ,  A61K31/404 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/503 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  C07D209/40 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D471/04 ,  C07D487/08

摘要： The present invention relates to a series of substituted indole derivatives of the formula I: wherein R, R1, R2, R3, R4, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5′-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.

摘要翻译： 本发明涉及一系列式I的取代的吲哚衍生物：其中R，R 1，R 2，R 3，R 4，X和Y如本文所定义。 本发明还涉及制备这些化合物的方法。 本发明的化合物是聚（腺苷5'-二磷酸核糖）聚合酶（PARP）的抑制剂，因此可用作药剂，特别是用于治疗和/或预防各种疾病，包括与中枢神经相关的疾病 系统和心血管疾病。

公开(公告)号：US20070254937A1

公开(公告)日：2007-11-01

申请号：US11368566

申请日：2006-03-06

申请人： John Jurcak ,  Matthieu Barrague ,  Timothy Gillespy ,  Michael Edwards ,  Kwon Musick ,  Philip Weintraub ,  Yan Du ,  Ramalinga Dharanipragada ,  Ashfaq Parkar

发明人： John Jurcak ,  Matthieu Barrague ,  Timothy Gillespy ,  Michael Edwards ,  Kwon Musick ,  Philip Weintraub ,  Yan Du ,  Ramalinga Dharanipragada ,  Ashfaq Parkar

IPC分类号： A61K31/415 ,  C07D231/54

CPC分类号： C07D495/04

摘要： Thienopyrazoles of formula I, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical uses in the treatment of disease states capable of being modulated by the inhibition of the protein kinases, in particular interleukin-2 inducible tyrosine kinase (ITK).

摘要翻译： 式I的噻吩并吡唑类，其制备方法，包含这些化合物的药物组合物及其在治疗能够通过抑制蛋白激酶（特别是白细胞介素-2诱导型酪氨酸激酶（ITK））调节的疾病状态的药物用途。

公开(公告)号：US10777088B2

公开(公告)日：2020-09-15

申请号：US14632805

申请日：2015-02-26

申请人： Philip Weintraub

发明人： Philip Weintraub

IPC分类号： G09B7/00 ,  G09B19/00

摘要： A method and apparatus for the development of educational courses and curriculum using a secure web based server computer platform and software application that aligns course outcomes and course learning objectives with core and specialized course competencies and uniquely develops course summary and compliance reports that may be used for course approval and accreditation of an educational institution. The course development software program provides a course syllabus that includes presentation summaries, textbook, video, test and other materials and assignments for a teacher to easily organize and present daily activities for the classroom.

公开(公告)号：US20160071425A1

公开(公告)日：2016-03-10

申请号：US14632805

申请日：2015-02-26

申请人： Philip Weintraub

发明人： Philip Weintraub

IPC分类号： G09B7/00

摘要： A method and apparatus for the development of educational courses and curriculum using a secure web based server computer platform and software application that aligns course outcomes and course learning objectives with core and specialized course competencies and uniquely develops course summary and compliance reports that may be used for course approval and accreditation of an educational institution. The course development software program provides a course syllabus that includes presentation summaries, textbook, video, test and other materials and assignments for a teacher to easily organize and present daily activities for the classroom.

摘要翻译： 一种用于开发教育课程和课程的方法和设备，使用安全的基于Web的服务器计算机平台和软件应用程序，将课程结果和课程学习目标与核心和专业课程能力相结合，并独特地开发课程摘要和合规性报告，可用于 课程批准和认证的教育机构。 课程开发软件程序提供课程大纲，其中包括演讲摘要，教科书，视频，测试和其他教材的作业，以便轻松组织和呈现课堂的日常活动。