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1.
公开(公告)号:US20050107392A1
公开(公告)日:2005-05-19
申请号:US10506270
申请日:2003-04-16
申请人: Philip Wickens , Louis-David Cantin , Ellalahewage Kumarasinghe , Chih-Yuan Chuang , Sidney Liang
发明人: Philip Wickens , Louis-David Cantin , Ellalahewage Kumarasinghe , Chih-Yuan Chuang , Sidney Liang
IPC分类号: A61K31/421 , A61K31/422 , A61K31/426 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K38/28 , A61K45/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , C07C51/09 , C07C51/41 , C07C51/44 , C07C59/72 , C07C69/732 , C07C69/734 , C07C69/738 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/02 , A61K31/497 , A61K31/501 , C07D413/02
CPC分类号: C07D277/32 , C07B2200/07 , C07C51/09 , C07C51/412 , C07C51/44 , C07C59/72 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12
摘要: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases and to pharmaceutical compositions containing these compounds.
摘要翻译: 本发明涉及可用于治疗疾病如糖尿病,肥胖,高脂血症和动脉粥样硬化疾病的新型茚满乙酸衍生物以及含有这些化合物的药物组合物。
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2.
公开(公告)号:US07476742B2
公开(公告)日:2009-01-13
申请号:US10506270
申请日:2003-04-16
申请人: Philip Wickens , Louis-David Cantin , Ellalahewage Kumarasinghe , Chih-Yuan Chuang , Sidney X. Liang
发明人: Philip Wickens , Louis-David Cantin , Ellalahewage Kumarasinghe , Chih-Yuan Chuang , Sidney X. Liang
IPC分类号: A61K31/421 , C07D263/32
CPC分类号: C07D277/32 , C07B2200/07 , C07C51/09 , C07C51/412 , C07C51/44 , C07C59/72 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12
摘要: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases and to pharmaceutical compositions containing these compounds.
摘要翻译: 本发明涉及可用于治疗疾病如糖尿病,肥胖,高脂血症和动脉粥样硬化疾病的新型茚满乙酸衍生物以及含有这些化合物的药物组合物。
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3.
公开(公告)号:US20080064734A1
公开(公告)日:2008-03-13
申请号:US11897620
申请日:2007-08-31
申请人: Joachim Rudolph , Louis-David Cantin , Steven Magnuson , William Bullock , Ann-Marie Bullion , Libing Chen , Chih-Yuan Chuang , Sidney Liang , Dyuti Majumdar , Herbert Ogutu , Alan Olague , Ning Qi , Philip Wickens
发明人: Joachim Rudolph , Louis-David Cantin , Steven Magnuson , William Bullock , Ann-Marie Bullion , Libing Chen , Chih-Yuan Chuang , Sidney Liang , Dyuti Majumdar , Herbert Ogutu , Alan Olague , Ning Qi , Philip Wickens
IPC分类号: A61K31/415 , A61P3/04 , C07D231/10
CPC分类号: C07D231/38 , C07D401/04 , C07D403/12 , C07D413/12 , C07D471/04
摘要: The present invention relates to anilinopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
摘要翻译: 本发明涉及苯胺基吡唑化合物,药物组合物和治疗糖尿病及相关疾病的方法。
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4.1,3-Thiazole-5-Carboxamides Useful as Cancer Chemotherapeutic Agents 审中-公开
标题翻译: 可用作癌症化疗剂的1,3-噻唑-5-羧酰胺公开(公告)号:US20090023753A1
公开(公告)日:2009-01-22
申请号:US11885104
申请日:2006-02-24
申请人: Chih-Yuan Chuang , Philip Wickens , Zhengiu Hong , Catherine Brennan , Julie A. Dixon , Harold C.E. Kluender , Charles Kreiman , Ellalahewage Kumarasinghe
发明人: Chih-Yuan Chuang , Philip Wickens , Zhengiu Hong , Catherine Brennan , Julie A. Dixon , Harold C.E. Kluender , Charles Kreiman , Ellalahewage Kumarasinghe
IPC分类号: A61K31/496 , A61P35/00 , C07D417/12 , A61K31/4535 , C07D403/06
CPC分类号: C07D417/12 , C07D417/14
摘要: This invention relates to novel 1,3-thiazole-5-carboxamide compounds, pharmaceutical compositions containing such compounds, and the use of those compounds or compositions as cancer chemotherapeutic agents.
摘要翻译: 本发明涉及新的1,3-噻唑-5-甲酰胺化合物,含有这些化合物的药物组合物,以及这些化合物或组合物作为癌症化学治疗剂的用途。
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5.
公开(公告)号:US20080293696A1
公开(公告)日:2008-11-27
申请号:US11630850
申请日:2005-06-23
申请人: Catherine Brennan , Julie A. Dixon , William J. Scott , Aniko Redman , Benjamin D. Jones , Barton Phillips , Philip Wickens , Istvan Enyedy , Ellalahewage Kumarasinghe , Charles Kreiman , Jacques Dumas , Uday Khire , Chih-Yuan Chuang , Harold C.E. Kluender , Zhenqiu Hong , Lei Wang , Donald Bierer
发明人: Catherine Brennan , Julie A. Dixon , William J. Scott , Aniko Redman , Benjamin D. Jones , Barton Phillips , Philip Wickens , Istvan Enyedy , Ellalahewage Kumarasinghe , Charles Kreiman , Jacques Dumas , Uday Khire , Chih-Yuan Chuang , Harold C.E. Kluender , Zhenqiu Hong , Lei Wang , Donald Bierer
IPC分类号: A61K31/55 , C07D405/12 , A61K31/4433 , A61K31/444 , A61P35/00 , C07D405/14 , A61K31/506
CPC分类号: C07D319/08
摘要: A compound having the formula (1) in which the ring containing E is a phenyl, a pyridine, or a pyrimidine. In formula (1) the symbol A represents wherein the group R4 represents halogen, CF3, or H, provided that the maximum number of CF3 groups on any A is 2, and the maximum number of hydrogens on A is 2 for the A groups which together with the carbon atoms to which they are attached form 6-membered rings, and the maximum number of hydrogens on A is 1 for the A group which together with the carbon atoms to which it is attached forms a 5-membered ring. Z represents N or CH when E forms a phenyl ring, and represents CH when E forms a pyridine or pyrimidine. The groups R1, R2 and R3 and the subscripts a, b, and d are as defined in the text and claims. Pharmaceutical compositions containing a compound of formula (1) and methods of treating cancer using compounds of formula (1) are also disclosed and claimed.
摘要翻译: 具有式(1)的化合物,其中含有E的环是苯基,吡啶或嘧啶。 在式(1)中,符号A表示其中基团R 4表示卤素,CF 3或H,条件是任何A上的CF 3基团的最大数目为2,并且A组中的最大氢数为2, 与它们连接的碳原子一起形成6元环,并且对于与连接的碳原子一起形成5元环的A基团,A上的最大氢数为1。 当E形成苯环时,Z表示N或CH,当E形成吡啶或嘧啶时,Z表示CH。 基团R1,R2和R3以及下标a,b和d如本文和权利要求中所定义。 还公开并要求保护含有式(1)化合物的药物组合物和使用式(1)化合物治疗癌症的方法。
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公开(公告)号:US20060084680A1
公开(公告)日:2006-04-20
申请号:US10537630
申请日:2003-12-19
申请人: Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Xin Ma , Joachim Rudolph , Sidney Liang , Christiana Akuche , Rico Lavoie , Libing Chen , Dyuti Majumdar , Philip Wickens
发明人: Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Xin Ma , Joachim Rudolph , Sidney Liang , Christiana Akuche , Rico Lavoie , Libing Chen , Dyuti Majumdar , Philip Wickens
IPC分类号: A61K31/445 , A61K31/195 , A61K31/192
CPC分类号: C07D213/30 , C07C59/72 , C07C59/90 , C07C69/734 , C07C211/48 , C07C217/24 , C07C255/54 , C07C327/48 , C07C333/04 , C07C2602/08 , C07D209/08 , C07D213/63 , C07D213/83 , C07D213/84 , C07D215/20 , C07D231/12 , C07D239/26 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/52 , C07D249/06 , C07D249/08 , C07D261/20 , C07D263/32 , C07D263/56 , C07D277/24 , C07D277/34 , C07D277/56 , C07D277/64 , C07D277/66 , C07D285/08 , C07D307/42 , C07D307/79 , C07D333/16 , C07D405/04 , C07D417/04 , C07D513/04
摘要: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
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7.Heteroarylaminopyrazole derivatives useful for the treatment of diabetes 失效
标题翻译: 可用于治疗糖尿病的杂芳基氨基吡唑衍生物公开(公告)号:US20050192294A1
公开(公告)日:2005-09-01
申请号:US11064700
申请日:2005-02-24
申请人: Joachim Rudolph , Philip Wickens , Chih-Yuan Chuang , Libing Chen , Steven Magnuson , Alan Olague , Ning Qi
发明人: Joachim Rudolph , Philip Wickens , Chih-Yuan Chuang , Libing Chen , Steven Magnuson , Alan Olague , Ning Qi
IPC分类号: A61K31/4155 , A61K31/4439 , A61K31/506 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/14 , C07D43/02
CPC分类号: C07D401/12 , C07D403/12 , C07D405/12 , C07D409/14
摘要: The present invention relates to heteroarylaminopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
摘要翻译: 本发明涉及杂芳基氨基吡唑化合物,药物组合物和治疗糖尿病和相关疾病的方法。
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8.Heteroarylaminopyrazole derivatives useful for the treatment of diabetes 失效
标题翻译: 可用于治疗糖尿病的杂芳基氨基吡唑衍生物公开(公告)号:US07517878B2
公开(公告)日:2009-04-14
申请号:US11064700
申请日:2005-02-24
申请人: Joachim Rudolph , Philip Wickens , Chih-Yuan Chuang , Libing Chen , Steven Magnuson , Alan Olague , Ning Qi
发明人: Joachim Rudolph , Philip Wickens , Chih-Yuan Chuang , Libing Chen , Steven Magnuson , Alan Olague , Ning Qi
IPC分类号: C07D403/12 , A61K31/4155
CPC分类号: C07D401/12 , C07D403/12 , C07D405/12 , C07D409/14
摘要: The present invention relates to heteroarylaminopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
摘要翻译: 本发明涉及杂芳基氨基吡唑化合物,药物组合物和治疗糖尿病和相关疾病的方法。
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公开(公告)号:US20060205723A1
公开(公告)日:2006-09-14
申请号:US11429136
申请日:2006-05-05
申请人: Derek Lowe , Philip Wickens , Xin Ma , Mingbao Zhang , William Bullock , Philip Coish , Ingo Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James Livingston
发明人: Derek Lowe , Philip Wickens , Xin Ma , Mingbao Zhang , William Bullock , Philip Coish , Ingo Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James Livingston
IPC分类号: A61K31/5377 , A61K31/497 , A61K31/496
CPC分类号: C07D277/32 , C07B2200/07 , C07C51/412 , C07C51/44 , C07C59/72 , C07C67/303 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12 , Y02P20/582
摘要: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
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10.Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation 有权
标题翻译: 茚基乙酸衍生物及其作为药剂,中间体和制备方法的用途公开(公告)号:US20050075338A1
公开(公告)日:2005-04-07
申请号:US10949119
申请日:2004-09-22
申请人: Derek Lowe , Philip Wickens , Xin Ma , Mingbao Zhang , William Bullock , Philip Coish , Ingo Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James Livingston
发明人: Derek Lowe , Philip Wickens , Xin Ma , Mingbao Zhang , William Bullock , Philip Coish , Ingo Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James Livingston
IPC分类号: C12Q1/02 , A61K31/155 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/64 , A61K38/28 , A61K45/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/24 , A61P9/00 , A61P9/10 , A61P9/12 , A61P9/14 , A61P15/00 , A61P17/02 , A61P29/00 , A61P35/00 , A61P37/06 , A61P39/06 , A61P43/00 , C07B57/00 , C07B61/00 , C07C51/41 , C07C51/44 , C07C59/72 , C07C69/732 , C07C69/734 , C07C69/736 , C07C69/738 , C07C237/36 , C07D263/32 , C07D277/20 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/02 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , C07D413/02
CPC分类号: C07D277/32 , C07B2200/07 , C07C51/412 , C07C51/44 , C07C59/72 , C07C67/303 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12 , Y02P20/582
摘要: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
摘要翻译: 本发明涉及可用于治疗疾病如糖尿病,肥胖症,高脂血症和动脉粥样硬化疾病的新型茚满乙酸衍生物。 本发明还涉及可用于制备茚满乙酸衍生物的中间体及其制备方法。
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