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公开(公告)号:US20100286131A1
公开(公告)日:2010-11-11
申请号:US12671765
申请日:2008-07-31
申请人: Pierre L. Beaulieu , Pasquale Forgione , Alexandre Gagnon , Cedrickx Godbout , Julie Naud , Martin Poirier , Jean Rancourt , Timothy A. Stammers , Bounkham Thavonekham
发明人: Pierre L. Beaulieu , Pasquale Forgione , Alexandre Gagnon , Cedrickx Godbout , Julie Naud , Martin Poirier , Jean Rancourt , Timothy A. Stammers , Bounkham Thavonekham
IPC分类号: A61K31/341
CPC分类号: C07D233/60 , C07D211/38 , C07D213/16 , C07D213/643 , C07D213/65 , C07D213/74 , C07D217/24 , C07D231/12 , C07D231/56 , C07D235/12 , C07D237/20 , C07D239/42 , C07D241/20 , C07D249/06 , C07D249/08 , C07D251/22 , C07D257/06 , C07D261/14 , C07D275/03 , C07D277/24 , C07D277/42 , C07D295/088 , C07D307/20 , C07D309/12 , C07D401/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D471/04 , C07D487/04
摘要: Compounds of formula I: wherein, R2, R5 and R6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.
摘要翻译: 式I化合物:其中,R2,R5和R6如本文所定义,可用作丙型肝炎病毒NS5B聚合酶的抑制剂。
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公开(公告)号:US20110021486A1
公开(公告)日:2011-01-27
申请号:US12808220
申请日:2008-12-03
申请人: Pierre L. Beaulieu , Pasquale Forgione , Alexandre Gagnon , Cedrickx Godbout , Marc-Andre Terrebonne , Montse Llinas-Brunet , Julie Naud , Martin Poirier , Jean Rancourt
发明人: Pierre L. Beaulieu , Pasquale Forgione , Alexandre Gagnon , Cedrickx Godbout , Marc-Andre Terrebonne , Montse Llinas-Brunet , Julie Naud , Martin Poirier , Jean Rancourt
IPC分类号: A61K31/397 , C07D401/12 , A61K31/444 , C07D213/643 , A61K31/44 , C07D401/04 , A61K31/4439 , A61K31/4545 , C07D413/04 , A61K31/5377 , A61K31/497 , C07D417/04 , A61K31/506 , A61K31/551 , A61K31/5355 , C07D471/04 , A61K31/4353 , A61P31/14
CPC分类号: A61K31/444 , A61K31/5377 , C07D211/38 , C07D213/643 , C07D213/69 , C07D213/81 , C07D215/227 , C07D217/24 , C07D239/34 , C07D239/38 , C07D239/47 , C07D239/52 , C07D249/04 , C07D277/24 , C07D307/20 , C07D333/32 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04
摘要: Compounds of formula I: wherein X, R2, R3, R3a, R3b, R5 and R6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.
摘要翻译: 式I化合物:其中X,R2,R3,R3a,R3b,R5和R6如本文所定义,可用作丙型肝炎病毒NS5B聚合酶的抑制剂。
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公开(公告)号:US08541402B2
公开(公告)日:2013-09-24
申请号:US13463093
申请日:2012-05-03
申请人: Pierre L. Beaulieu , Pasquale Forgione , Alexandre Gagnon , Cedrickx Godbout , Marc-Andre Joly , Montse Llinas-Brunet , Julie Naud , Martin Poirier , Jean Rancourt
发明人: Pierre L. Beaulieu , Pasquale Forgione , Alexandre Gagnon , Cedrickx Godbout , Marc-Andre Joly , Montse Llinas-Brunet , Julie Naud , Martin Poirier , Jean Rancourt
IPC分类号: C07D211/38 , C07D213/643 , C07D213/69 , C07D213/81 , C07D215/227 , C07D217/24 , C07D239/38 , C07D239/47 , C07D239/52 , C07D249/04 , C07D277/24 , C07D307/20 , C07D333/32 , C07D401/06 , C07D401/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04 , A61K31/444
CPC分类号: A61K31/444 , A61K31/5377 , C07D211/38 , C07D213/643 , C07D213/69 , C07D213/81 , C07D215/227 , C07D217/24 , C07D239/34 , C07D239/38 , C07D239/47 , C07D239/52 , C07D249/04 , C07D277/24 , C07D307/20 , C07D333/32 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04
摘要: Compounds of formula I: wherein X, R2, R3, R3a, R3b, R5 and R6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.
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公开(公告)号:US08912182B2
公开(公告)日:2014-12-16
申请号:US13967922
申请日:2013-08-15
申请人: Pierre L. Beaulieu , Pasquale Forgione , Alexandre Gagnon , Cedrickx Godbout , Marc-Andre Joly , Montse Llinas-Brunet , Julie Naud , Martin Poirier , Jean Rancourt
发明人: Pierre L. Beaulieu , Pasquale Forgione , Alexandre Gagnon , Cedrickx Godbout , Marc-Andre Joly , Montse Llinas-Brunet , Julie Naud , Martin Poirier , Jean Rancourt
IPC分类号: C07D401/14 , C07D213/81 , C07D213/643 , C07D239/34 , A61K31/444 , C07D215/227 , C07D217/24 , C07D239/38 , C07D401/06 , C07D417/14 , C07D307/20 , C07D471/04 , C07D239/47 , C07D239/52 , C07D413/06 , C07D249/04 , C07D213/69 , A61K31/5377 , C07D211/38 , C07D417/06 , C07D333/32
CPC分类号: A61K31/444 , A61K31/5377 , C07D211/38 , C07D213/643 , C07D213/69 , C07D213/81 , C07D215/227 , C07D217/24 , C07D239/34 , C07D239/38 , C07D239/47 , C07D239/52 , C07D249/04 , C07D277/24 , C07D307/20 , C07D333/32 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04
摘要: Compounds of formula I: wherein X, R2, R3, R3a, R3b, R5 and R6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.
摘要翻译: 式I化合物:其中X,R2,R3,R3a,R3b,R5和R6如本文所定义,可用作丙型肝炎病毒NS5B聚合酶的抑制剂。
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公开(公告)号:US08476257B2
公开(公告)日:2013-07-02
申请号:US12808220
申请日:2008-12-03
申请人: Pierre L. Beaulieu , Pasquale Forgione , Alexandre Gagnon , Cedrickx Godbout , Marc-Andre Joly , Montse Llinas-Brunet , Julie Naud , Martin Poirier , Jean Rancourt
发明人: Pierre L. Beaulieu , Pasquale Forgione , Alexandre Gagnon , Cedrickx Godbout , Marc-Andre Joly , Montse Llinas-Brunet , Julie Naud , Martin Poirier , Jean Rancourt
IPC分类号: A61K31/397 , A61K31/444 , A61K31/44 , A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/497 , A61K31/4353 , A61K31/5355 , A61K31/506 , A61K31/551 , C07D401/12 , C07D401/04 , C07D213/643 , C07D413/04 , C07D417/04 , C07D471/04 , A61P31/14
CPC分类号: A61K31/444 , A61K31/5377 , C07D211/38 , C07D213/643 , C07D213/69 , C07D213/81 , C07D215/227 , C07D217/24 , C07D239/34 , C07D239/38 , C07D239/47 , C07D239/52 , C07D249/04 , C07D277/24 , C07D307/20 , C07D333/32 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04
摘要: Compounds of formula I: wherein X, R2, R3, R3a, R3b, R5 and R6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.
摘要翻译: 式I化合物:其中X,R2,R3,R3a,R3b,R5和R6如本文所定义,可用作丙型肝炎病毒NS5B聚合酶的抑制剂。
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公开(公告)号:US20100087382A1
公开(公告)日:2010-04-08
申请号:US12527200
申请日:2008-02-15
申请人: Murray D. Bailey , Francois Bilodeau , Pasquale Forgione , Vida Gorys , Montse Llinas-Brunet , Julie Naud , Jeffrey O'Meara , Marc-Andre Poupart
发明人: Murray D. Bailey , Francois Bilodeau , Pasquale Forgione , Vida Gorys , Montse Llinas-Brunet , Julie Naud , Jeffrey O'Meara , Marc-Andre Poupart
CPC分类号: C07K14/81 , A61K38/00 , C07D207/16 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07K5/0808 , C07K5/081 , C07K5/0812
摘要: Compounds of formula I: wherein R1, R2, R2a, R3, R4 and R5 are defined herein, are useful as inhibitors of the HCV NS3 protease.
摘要翻译: 式I化合物:其中R1,R2,R2a,R3,R4和R5如本文所定义,可用作HCV NS3蛋白酶的抑制剂。
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公开(公告)号:US20050080005A1
公开(公告)日:2005-04-14
申请号:US10945518
申请日:2004-09-20
申请人: Montse Llinas-Brunet , Murray Bailey , Punit Bhardwaj , Pasquale Forgione , Elise Ghiro , Nathalie Goudreau , Teddy Halmos , Jean Rancourt
发明人: Montse Llinas-Brunet , Murray Bailey , Punit Bhardwaj , Pasquale Forgione , Elise Ghiro , Nathalie Goudreau , Teddy Halmos , Jean Rancourt
CPC分类号: C07K5/0827 , A61K38/00 , C07K5/0802 , C07K5/0812 , Y02A50/463
摘要: Compounds of formula I: wherein D, R4, R3, L0, L1, L2, R2 and Rc are defined herein; or a pharmaceutically acceptable salt thereof, useful as inhibitors of the HCV NS3 protease.
摘要翻译: 式I化合物:其中D,R 4,R 3,L 0,L 1,L 2,R 2和R c在本文中定义; 或其药学上可接受的盐,其可用作HCV NS3蛋白酶的抑制剂。
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公开(公告)号:US07705146B2
公开(公告)日:2010-04-27
申请号:US10595108
申请日:2005-06-22
申请人: Murray D. Bailey , Punit Bhardwaj , Pasquale Forgione , Elise Ghiro , Nathalie Goudreau , Teddy Halmos , Montse Llinas-Brunet , Marc-Andre Poupart , Jean Rancourt
发明人: Murray D. Bailey , Punit Bhardwaj , Pasquale Forgione , Elise Ghiro , Nathalie Goudreau , Teddy Halmos , Montse Llinas-Brunet , Marc-Andre Poupart , Jean Rancourt
IPC分类号: A61K31/535 , C07D413/00 , C07D401/00
CPC分类号: C07D413/04 , C07D207/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/04 , C07D495/04 , C07D498/04 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0819 , C07K5/0827
摘要: The invention relates to compounds of formula (I) wherein R′, R2, R3, R4, R5, R6, Y, n and m are as defined herein. The compounds are useful for the treatment and prevention of hepatitis C viral infections in mammals by inhibiting HCV NS3 protease. The invention further relates to azalactone compounds of the formula (III) which can be reacted with an amide anion to produce the compounds of formula (I).
摘要翻译: 本发明涉及式(I)化合物,其中R 1,R 2,R 3,R 4,R 5,R 6,Y,n和m如本文所定义。 该化合物可用于通过抑制HCV NS3蛋白酶治疗和预防哺乳动物中丙型肝炎病毒感染。 本发明还涉及可与酰胺阴离子反应以制备式(I)化合物的式(III)的吖内酯化合物。
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公开(公告)号:US07585845B2
公开(公告)日:2009-09-08
申请号:US10850101
申请日:2004-05-20
申请人: Montse Llinas-Brunet , Murray Bailey , Punit Bhardwaj , Josee Bordeleau , Pasquale Forgione , Elise Ghiro , Vida Gorys , Nathalie Goudreau , Sylvie Goulet , Teddy Halmos , Jean Rancourt
发明人: Montse Llinas-Brunet , Murray Bailey , Punit Bhardwaj , Josee Bordeleau , Pasquale Forgione , Elise Ghiro , Vida Gorys , Nathalie Goudreau , Sylvie Goulet , Teddy Halmos , Jean Rancourt
IPC分类号: A61K31/47 , C07D215/38
CPC分类号: A61K31/4709 , A61K38/06 , A61K38/212 , C07K5/0808 , C07K5/0827 , Y02A50/463 , A61K2300/00
摘要: Compounds of formula (I): wherein B, X, R3, L0, L1, L2, R2, R1 and RC are defined herein. The compounds are useful as inhibitors of HCV NS3 protease for the treatment of hepatitis C viral infection.
摘要翻译: 式(I)化合物:其中B,X,R3,L0,L1,L2,R2,R1和RC如本文所定义。 该化合物可用作用于治疗丙型肝炎病毒感染的HCV NS3蛋白酶的抑制剂。
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公开(公告)号:US08067438B2
公开(公告)日:2011-11-29
申请号:US13078225
申请日:2011-04-01
申请人: Montse Llinas-Brunet , Murray Douglas Bailey , Punit R. Bhardwaj , Josee Bordeleau , Pasquale Forgione , Elise Ghiro , Vida J. Gorys , Nathalie Goudreau , Sylvie Goulet , Teddy Halmos , Jean Rancourt
发明人: Montse Llinas-Brunet , Murray Douglas Bailey , Punit R. Bhardwaj , Josee Bordeleau , Pasquale Forgione , Elise Ghiro , Vida J. Gorys , Nathalie Goudreau , Sylvie Goulet , Teddy Halmos , Jean Rancourt
IPC分类号: A61K31/04 , C07D215/38
CPC分类号: A61K31/4709 , A61K38/06 , A61K38/212 , C07K5/0808 , C07K5/0827 , Y02A50/463 , A61K2300/00
摘要: Compounds of formula (I): wherein B, X, R3, L0, L1, L2, R2, R1 and RC are defined herein. The compounds are useful as inhibitors of HCV NS3 protease for the treatment of hepatitis C viral infection.
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