公开(公告)号：US4910314A

公开(公告)日：1990-03-20

申请号：US301843

申请日：1989-01-26

申请人： Pierre M. R. de Montigny ,  Larry A. Sternson ,  Arnold J. Repta ,  John F. Stabaugh ,  Takeru Higuchi, deceased ,  by Martin B. Dickinson, Jr., co-executor ,  by Kenji W. Higuchi, co-executor

发明人： Pierre M. R. de Montigny ,  Larry A. Sternson ,  Arnold J. Repta ,  John F. Stabaugh ,  Takeru Higuchi, deceased ,  by Martin B. Dickinson, Jr., co-executor ,  by Kenji W. Higuchi, co-executor

IPC分类号： G01N33/52 ,  G01N33/68

CPC分类号： G01N33/52 ,  G01N33/6809

摘要： There is provided a fluorescent adduct which is amenable to detection by fluorometric and electrochemical techniques. The adduct is of the formula: ##STR1## wherein X is a radical derived from a primary amine of the formula X--NH.sub.2 and where R.sub.1 --R.sub.6 are selected from various organic or inorganic substituents.

摘要翻译： 提供荧光加合物，其可以通过荧光和电化学技术进行检测。 加合物具有下式：其中X是衍生自式X-NH 2伯胺的基团，其中R 1 -R 6选自各种有机或无机取代基。

公开(公告)号：US4837166A

公开(公告)日：1989-06-06

申请号：US39743

申请日：1987-04-20

申请人： Pierre M. R. de Montigny ,  Larry A. Sternson ,  Arnold J. Repta ,  John F. Stobaugh ,  Takeru Higuchi, deceased ,  Kenji W. Higuchi, co-executor

发明人： Pierre M. R. de Montigny ,  Larry A. Sternson ,  Arnold J. Repta ,  John F. Stobaugh ,  Takeru Higuchi, deceased ,  Kenji W. Higuchi, co-executor

IPC分类号： G01N33/52 ,  G01N33/68

CPC分类号： G01N33/6809 ,  G01N33/52 ,  Y10T436/172307 ,  Y10T436/173845

摘要： A method of assaying primary amines or cyanide is disclosed. The process is carried out by reacting a substituted or unsubstituted naphthalene-2,3-dicarboxaldehyde or o-phthalaldehyde, reactive with primary amines and cyanide, with cyanide ions and at least one primary amine to form an adduct amenable to fluorometric or electrochemical assaying techniques. The adduct is then fluorometrically or electrochemically assayed.Also disclosed are 1-cyano-benz[f]isoindole adducts.

摘要翻译： 公开了一种测定伯胺或氰化物的方法。 该方法通过使取代或未取代的与伯胺和氰化物反应的萘-2,3-二甲醛或邻邻醛与氰化物离子和至少一种伯胺反应以形成适于荧光或电化学测定技术的加合物 。 然后加合物进行荧光测定或电化学测定。 还公开了1-氰基 - 苯并[f]异吲哚加成物。

公开(公告)号：US4845233A

公开(公告)日：1989-07-04

申请号：US96092

申请日：1987-09-11

申请人： Takeru Higuchi, deceased ,  by Kenji W. Higuchi, co-executor ,  Ooi Wong

发明人： Takeru Higuchi, deceased ,  by Kenji W. Higuchi, co-executor ,  Ooi Wong

IPC分类号： C07D233/70

CPC分类号： C07D233/70

摘要： A compound having the formula: ##STR1## wherein R, R.sub.1 and R.sub.2 are independently selected from hydrogen; hydroxy; fluorine; bromine; chlorine; C.sub.1 -C.sub.20 alkyl; C.sub.2 -C.sub.20 alkenyl; C.sub.2 -C.sub.20 alkynyl; C.sub.3 -C.sub.10 cycloalkyl; C.sub.2 -C.sub.20 (monohydroxy or polyhydroxy)alkyl; C.sub.1 -C.sub.20 (monohalo or polyhalo)alkyl; carboxy; C.sub.1 -C.sub.20 alkylcarboxy; C.sub.1 -C.sub.20 alkenylcarboxy; C.sub.1 -C.sub.20 carboxyalkyl; C.sub.1 -C.sub.20 alkanoyl; C.sub.1 -C.sub.20 alkanoyloxy; C.sub.1 -C.sub.20 alkoxycarbonyl; carbamoyl; carbamyl; C.sub.1 -C.sub.20 alkylcarbamyl; sulfo; C.sub.1 -C.sub.20 alkylsulfonyl; C.sub.1 -C.sub.20 alkylsulfinyl; C.sub.1 -C.sub.20 alkylsulfoxide; C.sub.1 -C.sub.20 alkylsulfone; thio; C.sub.1 -C.sub.20 alkylthio; amino; nitro; C.sub.1 -C.sub.20 alkylamino; C.sub.1 -C.sub.20 aminoalkyl; substituted or unsubstituted phenyl or benzyl, the substituents being selected from hydroxy, fluorine, bromine, chlorine, C.sub.1 -C.sub.20 alkyl, C.sub.2 -C.sub.20 alkenyl, C.sub.2 -C.sub.20 (monohydroxy or polyhydroxy)alkyl, X is methyl or oxygen and n is 0 to 20. The invention is also directed to a method for increasing the topical penetration of a physiologically active agent across the skin or membrane of a mammalian organism. Also claimed is a pharmaceutical composition and a novel method for preparing 1-substituted-4-imidazolin-2-one.

摘要翻译： 具有下式的化合物：其中R，R 1和R 2独立地选自氢; 羟基; 氟; 溴; 氯; C 1 -C 20烷基; C2-C20烯基; C2-C20炔基; C3-C10环烷基; C2-C20（单羟基或多羟基）烷基; C 1 -C 20（单卤代或多卤代）烷基; 羧基; C 1 -C 20烷基羧基; C1-C20烯基羧基; C 1 -C 20羧基烷基; C1-C20烷酰基; C1-C20烷酰氧基; C1-C20烷氧基羰基; 氨基甲酰基; 氨基甲酰 C1-C20烷基氨基甲酰基; 磺基 C 1 -C 20烷基磺酰基; C1-C20烷基亚磺酰基; C1-C20烷基亚砜; C1-C20烷基砜; 硫代 C 1 -C 20烷硫基; 氨基; 硝基 C1-C20烷基氨基; C1-C20氨基烷基; 取代或未取代的苯基或苄基，取代基选自羟基，氟，溴，氯，C 1 -C 20烷基，C 2 -C 20烯基，C 2 -C 20（单羟基或多羟基）烷基，X为甲基或氧，n为0至 本发明还涉及增加生理活性剂穿过哺乳动物生物体的皮肤或膜的局部渗透的方法。 还要求保护的是药物组合物和制备1-取代-4-咪唑啉-2-酮的新方法。

公开(公告)号：US5066648A

公开(公告)日：1991-11-19

申请号：US589221

申请日：1990-09-13

申请人： Jose Alexander ,  Takeru Higuchi, deceased

发明人： Jose Alexander ,  Takeru Higuchi, deceased

IPC分类号： A61K47/22

CPC分类号： A61K9/0014 ,  A61K47/22

摘要： The invention relates to pyroglutamic acid esters used as dermal penetration enhancers for therapeutic agents having poor skin permeation.

摘要翻译： 本发明涉及用作皮肤渗透性差的治疗剂的皮肤渗透促进剂的焦谷氨酸酯。