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公开(公告)号：US06984744B2
公开(公告)日：2006-01-10
申请号：US10721038
申请日：2003-11-21
CPC分类号： C07B53/00 , C07F9/65683 , C07F9/65685 , C07F15/0073
摘要： The invention is concerned with new phosphine ligands of formula I wherein R1 and R2 are independently of each other unsubstituted alkyl, aryl, cycloalkyl or heteroaryl, or alkyl, aryl, cycloalkyl or heteroaryl each of which independently is substituted by alkyl, alkoxy, halogen, hydroxy, amino, mono- or dialkylamino, aryl, —SO2—R7, —SO3−, —CO—NR8R8′, carboxy, alkoxycarbonyl, trialkylsilyl, diarylalkylsilyl, dialkylarylsilyl or triarylsilyl; R3 is alkyl, cycloalkyl, aryl or heteroaryl; R4′ and R4 are independently of each other hydrogen, alkyl or optionally substituted aryl; or R4′ and R4 together with the C-atom they are attached, form a 3-8-membered carbocyclic ring; dotted line is optionally a double bond; R5 and R6 are independently of each other hydrogen, alkyl or aryl, R7 is alkyl or aryl; and R8 and R8′ are independently of each other hydrogen, alkyl or aryl; the substituents attached by the bold bonds are in cis relation to each other; metal complexes with such ligands in asymmetric reactions.
摘要翻译： 本发明涉及式I的新的膦配体，其中R 1和R 2彼此独立地为未取代的烷基，芳基，环烷基或杂芳基，或烷基，芳基， 环烷基或杂芳基，其各自独立地被烷基，烷氧基，卤素，羟基，氨基，一或二烷基氨基，芳基，-SO 2 -R 7，-SO 3 -CO-NR 8 R 8，羧基，烷氧基羰基，三烷基甲硅烷基，二芳基烷基甲硅烷基，二烷基芳基甲硅烷基或二芳基烷基甲硅烷基 三芳基甲硅烷基 R 3是烷基，环烷基，芳基或杂芳基; R 4'和R 4彼此独立地为氢，烷基或任选取代的芳基; 或R 4'和R 4与它们所连接的C原子一起形成3-8元碳环; 虚线可选地是双键; R 5和R 6彼此独立地为氢，烷基或芳基，R 7为烷基或芳基; R 8和R 8'彼此独立地为氢，烷基或芳基; 通过粗体键连接的取代基彼此成顺式关系; 与不对称反应中的这种配体的金属络合物。
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公开(公告)号：US07642366B2
公开(公告)日：2010-01-05
申请号：US11591277
申请日：2006-11-01
申请人： Hans Iding , Ernst Kupfer , Bruno Lohri , Kazimierz Michal Pietrusiewicz , Kurt Puentener , Michelangelo Scalone , Wioleta Swierczynska , Beat Wirz
发明人： Hans Iding , Ernst Kupfer , Bruno Lohri , Kazimierz Michal Pietrusiewicz , Kurt Puentener , Michelangelo Scalone , Wioleta Swierczynska , Beat Wirz
IPC分类号： C07F15/04
CPC分类号： C07F15/006 , C07B53/00 , C07F9/65683 , C07F15/0066
摘要： The invention is concerned with new phosphine ligands of the formula I wherein R1 and R2 are independently of each other alkyl, aryl, cycloalkyl or heteroaryl, said alkyl, aryl, cycloalkyl or heteroaryl may be substituted by alkyl, alkoxy, halogen, hydroxy, amino, mono- or dialkylamino, aryl, —SO2—R7, —SO3−, —CO—NR8R8′, carboxy, alkoxycarbonyl, trialkylsilyl, diarylalkylsilyl, dialkylarylsilyl or triarylsilyl; R3 is alkyl, cycloalkyl, aryl or heteroaryl; R4′ and R4 signify independently of each other hydrogen, alkyl or optionally substituted aryl; or R4′ and R4 together with the C-atom they are attached to form a 3-8-membered carbocyclic ring; dotted line is absent or is present and forms a double bond; R5 and R6 are independently of each other hydrogen, alkyl or aryl; or linked together to form a 3-8-membered carbocyclic ring or an aromatic ring; R7 is alkyl, aryl or NR8R8′; and R8 and R8′ are independently of each other hydrogen, alkyl or aryl; metal complexes with such ligands as well as the use of such metal complexes as catalysts in asymmetric reactions.
摘要翻译： 本发明涉及式I的新膦配体，其中R 1和R 2彼此独立地为烷基，芳基，环烷基或杂芳基，所述烷基，芳基，环烷基或杂芳基可以被烷基，烷氧基，卤素，羟基，氨基 ，一或二烷基氨基，芳基，-SO 2 -R 7，-SO 3 - ，-CO-NR 8 R 8'，羧基，烷氧基羰基，三烷基甲硅烷基，二芳基烷基甲硅烷基，二烷基芳基甲硅烷基或三芳基甲硅烷基; R3是烷基，环烷基，芳基或杂芳基; R4'和R4独立地表示氢，烷基或任选取代的芳基; 或R 4'和R 4与它们所连接的C原子一起形成3-8-元碳环; 虚线不存在或存在并形成双键; R5和R6彼此独立地为氢，烷基或芳基; 或连接在一起形成3-8元碳环或芳环; R7是烷基，芳基或NR8R8'; R8和R8'彼此独立地为氢，烷基或芳基; 与这种配体的金属络合物以及在不对称反应中使用这样的金属络合物作为催化剂。
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公开(公告)号：US20090326253A1
公开(公告)日：2009-12-31
申请号：US12557553
申请日：2009-09-11
申请人： Hans Iding , Ernst Kupfer , Bruno Lohri , Kazimierz Michal Pietrusiewicz , Kurt Puentener , Michelangelo Scalone , Wioleta Swierczynska , Beat Wirz
发明人： Hans Iding , Ernst Kupfer , Bruno Lohri , Kazimierz Michal Pietrusiewicz , Kurt Puentener , Michelangelo Scalone , Wioleta Swierczynska , Beat Wirz
IPC分类号： C07F15/04
CPC分类号： C07F15/006 , C07B53/00 , C07F9/65683 , C07F15/0066
摘要： The invention is concerned with new phosphine ligands of the formula I whereinR1 and R2 are independently of each other alkyl, aryl, cycloalkyl or heteroaryl, said alkyl, aryl, cycloalkyl or heteroaryl may be substituted by alkyl, alkoxy, halogen, hydroxy, amino, mono- or dialkylamino, aryl, —SO2—R7, —SO3−, —CO—NR8R8′, carboxy, alkoxycarbonyl, trialkylsilyl, diarylalkylsilyl, dialkylarylsilyl or triarylsilyl;R3 is alkyl, cycloalkyl, aryl or heteroaryl; R4′ and R4 signify independently of each other hydrogen, alkyl or optionally substituted aryl; or R4′ and R4 together with the C-atom they are attached to form a 3-8-membered carbocyclic ring; dotted line is absent or is present and forms a double bond; R5 and R6 are independently of each other hydrogen, alkyl or aryl; or linked together to form a 3-8-membered carbocyclic ring or an aromatic ring; R7 is alkyl, aryl or NR8R8′; and R8 and R8′ are independently of each other hydrogen, alkyl or aryl;metal complexes with such ligands as well as the use of such metal complexes as catalysts in asymmetric reactions.
摘要翻译： 本发明涉及式I的新膦配体，其中R 1和R 2彼此独立地为烷基，芳基，环烷基或杂芳基，所述烷基，芳基，环烷基或杂芳基可以被烷基，烷氧基，卤素，羟基，氨基 ，一或二烷基氨基，芳基，-SO 2 -R 7，-SO 3 - ，-CO-NR 8 R 8'，羧基，烷氧基羰基，三烷基甲硅烷基，二芳基烷基甲硅烷基，二烷基芳基甲硅烷基或三芳基甲硅烷基; R3是烷基，环烷基，芳基或杂芳基; R4'和R4独立地表示氢，烷基或任选取代的芳基; 或R 4'和R 4与它们所连接的C原子一起形成3-8-元碳环; 虚线不存在或存在并形成双键; R5和R6彼此独立地为氢，烷基或芳基; 或连接在一起形成3-8元碳环或芳环; R7是烷基，芳基或NR8R8'; R8和R8'彼此独立地为氢，烷基或芳基; 与这种配体的金属络合物以及在不对称反应中使用这样的金属络合物作为催化剂。
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