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    Biaryl substituted triazoles as sodium channnel blockers
    1.
    发明申请
    Biaryl substituted triazoles as sodium channnel blockers 有权
    二芳基取代三唑作为钠通道阻断剂

    公开(公告)号：US20050119261A1

    公开(公告)日：2005-06-02

    申请号：US10799230

    申请日：2004-03-12

    申请人： Prasun Chakravarty ,  Michael Fisher ,  Jeffrey Fisher ,  Brenda Palucki ,  Min Park ,  William Parsons ,  Bishan Zhou ,  James Carey ,  Douglas Frantz ,  Michael Kress ,  Damian Weaver

    发明人： Prasun Chakravarty ,  Michael Fisher ,  Jeffrey Fisher ,  Brenda Palucki ,  Min Park ,  William Parsons ,  Bishan Zhou ,  James Carey ,  Douglas Frantz ,  Michael Kress ,  Damian Weaver

    IPC分类号： A61K31/4196 ,  A61P25/00 ,  C07D249/08 ,  C07D249/10 ,  C07D413/02 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  C07D417/02 ,  C07D43/02

    CPC分类号： C07D249/08 ,  C07D249/10

    摘要： Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

    摘要翻译： 由式I，II或III表示的二芳基取代的三唑化合物或其药学上可接受的盐，以及其制备方法。 药物组合物包含单独的或与一种或多种其它治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。 治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，癫痫，肠易激综合征，抑郁症，焦虑症，多发性硬化症和双相 包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。 施用局部麻醉的方法包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物和药学上可接受的载体组合施用。

    Substituted triazoles as sodium channel blockers
    3.
    发明申请
    Substituted triazoles as sodium channel blockers 有权
    取代的三唑作为钠通道阻断剂

    公开(公告)号：US20060020006A1

    公开(公告)日：2006-01-26

    申请号：US10985592

    申请日：2004-11-10

    申请人： Min Park ,  Prasun Chakravarty ,  Bishan Zhou ,  Edward Gonzalez ,  Hyun Ok ,  Brenda Palucki ,  William Parsons ,  Rosemary Sisco ,  Michael Fisher ,  Louis Zuegner

    发明人： Min Park ,  Prasun Chakravarty ,  Bishan Zhou ,  Edward Gonzalez ,  Hyun Ok ,  Brenda Palucki ,  William Parsons ,  Rosemary Sisco ,  Michael Fisher ,  Louis Zuegner

    IPC分类号： A61K31/4196 ,  C07D403/02

    CPC分类号： C07D249/10 ,  C07D403/10

    摘要： Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, migraine, headache pain, migraine headache, epilepsy, irritable bowel syndrome, diabetic neuropathy, multiple sclerosis, manic depression and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

    摘要翻译： 由式I，II或III表示的取代的三唑化合物或其药学上可接受的盐。 药物组合物包含单独的或与一种或多种其它治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。 治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，偏头痛，头痛，偏头痛，癫痫，肠易激综合征，糖尿病 神经病，多发性硬化症，躁狂抑郁症和双相性精神障碍，包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。 施用局部麻醉的方法包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物和药学上可接受的载体组合施用。

    Biaryl substituted 6-membered heterocycles as sodium channel blockers
    6.
    发明申请
    Biaryl substituted 6-membered heterocycles as sodium channel blockers 审中-公开
    二芳基取代的6元杂环作为钠通道阻断剂

    公开(公告)号：US20060293339A1

    公开(公告)日：2006-12-28

    申请号：US10550641

    申请日：2004-03-19

    申请人： Prasun Chakravarty ,  Michael Fisher ,  William Parsons ,  Jun Liang ,  Bishan Zhou

    发明人： Prasun Chakravarty ,  Michael Fisher ,  William Parsons ,  Jun Liang ,  Bishan Zhou

    IPC分类号： A61K31/506 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/455 ,  A61K31/4439 ,  C07D403/02 ,  A61K31/5377 ,  C07D413/02

    CPC分类号： C07D213/26 ,  C07D213/55 ,  C07D213/56 ,  C07D239/26 ,  C07D401/04 ,  C07D403/04

    摘要： Biaryl substituted pyridine, pyrimidine and pyrazine compounds are sodium channel blockers useful for the treatment of pain. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds.

    摘要翻译： 双芳基取代的吡啶，嘧啶和吡嗪化合物是可用于治疗疼痛的钠通道阻滞剂。 药物组合物包含单独的或与一种或多种治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。 治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，癫痫，肠易激综合征，抑郁症，焦虑症，多发性硬化症和双相 包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。