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1.发明申请SYNTHESIS OF ACYCLIC AND CYCLIC AMINES USING IRON-CATALYZED NITRENE GROUP TRANSFER 有权使用铁催化硝基转移合成环状和环状氨基公开(公告)号：US20160002145A1
公开(公告)日：2016-01-07
申请号：US14770217
申请日：2014-02-26
IPC分类号： C07C209/02 , C07D207/16 , C07F15/02 , C07D209/54 , C07D211/16 , C07D205/04 , C07D207/06 , C07D263/04
CPC分类号： B01J31/2273 , C07C209/02 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2603/74 , C07D205/04 , C07D207/06 , C07D207/16 , C07D209/54 , C07D211/16 , C07D263/04 , C07D263/06 , C07F15/025 , C07C211/40 , C07C211/38 , C07C211/41
摘要： The present invention provides novel synthetic methods for making acyclic secondary amines by reacting an azide with a compound bearing one or more C—H groups, catalyzed by a FeII-dipyrromethene complex. The acyclic secondary amines are thought to be formed through an intermolecular nitrene transfer. Also provided herein are methods of synthesizing protected (e.g., Boc- or Fmoc-protected) cyclic secondary amines (e.g., 5-, 6-, and 7-membered cyclic secondary amines) by reacting an azide that bears one or more C—H groups, catalyzed by a FeII-dipyrromethene complex. The protected cyclic secondary amines are thought to be formed through an intramolecular nitrene transfer and may be subsequently deprotected to yield cyclic secondary amines.
摘要翻译： 本发明提供了通过使叠氮化物与含有一个或多个C-H基团的化合物反应，由FeII-二吡咯亚甲基络合物催化制备无环仲胺的新型合成方法。 认为无环仲胺是通过分子间硝基转移而形成的。 本文还提供了通过使含有一个或多个C-H的叠氮化物反应合成受保护（例如，Boc-或Fmoc保护的）环状仲胺（例如，5-，6-和7-元环状仲胺）的方法 基团，由FeII-二吡咯亚甲基络合物催化。 保护的环状仲胺被认为是通过分子内的nitrene转移形成的，随后可以去保护以产生环状仲胺。
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公开(公告)号：US20220016613A1
公开(公告)日：2022-01-20
申请号：US17276855
申请日：2019-09-19
发明人： Theodore Alexander Betley , Alexandre Mikhailine , Claudia Kleinlein , Yuyang Dong , Yunjung Baek
IPC分类号： B01J31/18 , B01J31/22 , C07D471/08 , C07D471/04 , C07D207/06 , C07D211/70 , C07D263/04 , C07D401/04 , C07D209/54 , C07D487/08 , C07D403/04 , C07D209/04 , C07D209/44
摘要： Disclosed are compounds, methods, reagents, systems, and kits for the preparation and utilization of monomeric or polymeric metal-based compounds. These metal-based compounds are organometallic catalysts composed of substituted dipyrrin ligands bound to transition metals. C—H bond functionalization catalysis can be performed with the disclosed organometallic catalysts to yield C—N bonds to generate substituted bicyclic, spiro, and fused nitrogen-containing heterocycles, all common motifs in various pharmaceutical and bioactive molecules.
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公开(公告)号：US11918984B2
公开(公告)日：2024-03-05
申请号：US17276855
申请日：2019-09-19
发明人： Theodore Alexander Betley , Alexandre Mikhailine , Claudia Kleinlein , Yuyang Dong , Yunjung Baek
IPC分类号： B01J31/18 , B01J31/22 , C07D207/06 , C07D209/04 , C07D209/44 , C07D209/54 , C07D211/70 , C07D263/04 , C07D401/04 , C07D403/04 , C07D471/04 , C07D471/08 , C07D487/08
CPC分类号： B01J31/1815 , B01J31/2243 , C07D207/06 , C07D209/04 , C07D209/44 , C07D209/54 , C07D211/70 , C07D263/04 , C07D401/04 , C07D403/04 , C07D471/04 , C07D471/08 , C07D487/08 , B01J2231/4283 , B01J2531/0216 , B01J2531/842 , B01J2531/845 , B01J2531/847 , B01J2540/66
摘要： Disclosed are compounds, methods, reagents, systems, and kits for the preparation and utilization of monomeric or polymeric metal-based compounds. These metal-based compounds are organometallic catalysts composed of substituted dipyrrin ligands bound to transition metals. C—H bond functionalization catalysis can be performed with the disclosed organometallic catalysts to yield C—N bonds to generate substituted bicyclic, spiro, and fused nitrogen-containing heterocycles, all common motifs in various pharmaceutical and bioactive molecules.
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4.发明申请SYNTHESIS OF ACYCLIC AND CYCLIC AMINES USING IRON-CATALYZED NITRENE GROUP TRANSFER 有权使用铁催化硝基转移合成环状和环状氨基公开(公告)号：US20170072390A1
公开(公告)日：2017-03-16
申请号：US15345266
申请日：2016-11-07
IPC分类号： B01J31/22 , C07C209/02 , C07D207/06 , C07D211/16 , C07D263/06 , C07D205/04 , C07D209/54 , C07F15/02 , C07D207/16
CPC分类号： B01J31/2273 , C07C209/02 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2603/74 , C07D205/04 , C07D207/06 , C07D207/16 , C07D209/54 , C07D211/16 , C07D263/04 , C07D263/06 , C07F15/025 , C07C211/40 , C07C211/38 , C07C211/41
摘要： The present invention provides novel synthetic methods for making acyclic secondary amines by reacting an azide with a compound bearing one or more C—H groups, catalyzed by a FeII-dipyrromethene complex. The acyclic secondary amines are thought to be formed through an intermolecular nitrene transfer. Also provided herein are methods of synthesizing protected (e.g., Boc- or Fmoc-protected) cyclic secondary amines (e.g., 5-, 6-, and 7-membered cyclic secondary amines) by reacting an azide that bears one or more C—H groups, catalyzed by a FeII-dipyrromethene complex. The protected cyclic secondary amines are thought to be formed through an intramolecular nitrene transfer and may be subsequently deprotected to yield cyclic secondary amines.
摘要翻译： 本发明提供了通过使叠氮化物与含有一个或多个C-H基团的化合物反应，由FeII-二吡咯亚甲基络合物催化制备无环仲胺的新型合成方法。 认为无环仲胺是通过分子间硝基转移而形成的。 本文还提供了通过使含有一个或多个C-H的叠氮化物反应合成受保护（例如，Boc-或Fmoc保护的）环状仲胺（例如，5-，6-和7-元环状仲胺）的方法 基团，由FeII-二吡咯亚甲基络合物催化。 保护的环状仲胺被认为是通过分子内的nitrene转移形成的，随后可以去保护以产生环状仲胺。
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公开(公告)号：US09724682B2
公开(公告)日：2017-08-08
申请号：US15345266
申请日：2016-11-07
IPC分类号： C07D263/04 , C07D211/16 , C07D209/54 , C07D207/06 , C07D207/16 , C07D205/04 , B01J31/22 , C07C209/02 , C07F15/02 , C07D263/06
CPC分类号： B01J31/2273 , C07C209/02 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2603/74 , C07D205/04 , C07D207/06 , C07D207/16 , C07D209/54 , C07D211/16 , C07D263/04 , C07D263/06 , C07F15/025 , C07C211/40 , C07C211/38 , C07C211/41
摘要： The present invention provides novel synthetic methods for making acyclic secondary amines by reacting an azide with a compound bearing one or more C—H groups, catalyzed by a FeII-dipyrromethene complex. The acyclic secondary amines are thought to be formed through an intermolecular nitrene transfer. Also provided herein are methods of synthesizing protected (e.g., Boc- or Fmoc-protected) cyclic secondary amines (e.g., 5-, 6-, and 7-membered cyclic secondary amines) by reacting an azide that bears one or more C—H groups, catalyzed by a FeII-dipyrromethene complex. The protected cyclic secondary amines are thought to be formed through an intramolecular nitrene transfer and may be subsequently deprotected to yield cyclic secondary amines.
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6.发明授权Synthesis of acyclic and cyclic amines using iron-catalyzed nitrene group transfer 有权使用铁催化的硝基转移合成无环和环胺公开(公告)号：US09487472B2
公开(公告)日：2016-11-08
申请号：US14770217
申请日：2014-02-26
IPC分类号： C07C209/02 , C07C211/40 , C07C211/41 , C07F15/02 , C07D205/04 , C07D207/06 , C07D207/16 , C07D209/54 , C07D211/16 , C07D263/04
CPC分类号： B01J31/2273 , C07C209/02 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2603/74 , C07D205/04 , C07D207/06 , C07D207/16 , C07D209/54 , C07D211/16 , C07D263/04 , C07D263/06 , C07F15/025 , C07C211/40 , C07C211/38 , C07C211/41
摘要： The present invention provides novel synthetic methods for making acyclic secondary amines by reacting an azide with a compound bearing one or more C—H groups, catalyzed by a FeII-dipyrromethene complex. The acyclic secondary amines are thought to be formed through an intermolecular nitrene transfer. Also provided herein are methods of synthesizing protected (e.g., Boc- or Fmoc-protected) cyclic secondary amines (e.g., 5-, 6-, and 7-membered cyclic secondary amines) by reacting an azide that bears one or more C—H groups, catalyzed by a FeII-dipyrromethene complex. The protected cyclic secondary amines are thought to be formed through an intramolecular nitrene transfer and may be subsequently deprotected to yield cyclic secondary amines.
摘要翻译： 本发明提供了通过使叠氮化物与含有一个或多个C-H基团的化合物反应，由FeII-二吡咯亚甲基络合物催化制备无环仲胺的新型合成方法。 认为无环仲胺是通过分子间硝基转移而形成的。 本文还提供了通过使含有一个或多个C-H的叠氮化物反应合成受保护（例如，Boc-或Fmoc保护的）环状仲胺（例如，5-，6-和7-元环状仲胺）的方法 基团，由FeII-二吡咯亚甲基络合物催化。 保护的环状仲胺被认为是通过分子内的nitrene转移形成的，随后可以去保护以产生环状仲胺。
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