公开(公告)号：US06683116B1

公开(公告)日：2004-01-27

申请号：US10356676

申请日：2003-01-31

申请人： Qi Jia ,  Ji-Fu Zhao

发明人： Qi Jia ,  Ji-Fu Zhao

IPC分类号： A01N3100

CPC分类号： A61K31/045 ,  Y10S514/925 ,  A61K2300/00

摘要： The present invention provides a novel method for the preparation of a unique profile of primary aliphatic alcohols, having 24 to 30 carbon atoms, from the wax secreted by the insect Ericerus pela. Included in the present invention is the composition of matter, referred to herein as “polycosanol” produced by the method of this invention. The polycosanol composition is comprised primarily of the four primary aliphatic alcohols, tetracosanol, hexacosanol, octacosanol and triacontanol. Further included in this invention is the use of said composition of matter for the prevention and treatment of obesity, syndrome X, diabetes, hypercholesterolemia, atherosclerotic complications, ischemia and thrombosis.

摘要翻译： 本发明提供了一种新颖的方法，用于制备具有24至30个碳原子的伯脂肪醇，其特征在于由昆虫螨属分泌的蜡。 本发明中包括由本发明的方法生产的物质组合物，这里称为“多可醇”。 多糖醇组合物主要由四种脂族醇，二十四烷醇，二十四烷醇，三十烷醇组成。 本发明还包括所述物质组合物用于预防和治疗肥胖症，综合征X，糖尿病，高胆固醇血症，动脉粥样硬化并发症，局部缺血和血栓形成的用途。

公开(公告)号：US07767661B2

公开(公告)日：2010-08-03

申请号：US12027090

申请日：2008-02-06

申请人： Qi Jia ,  Ji-Fu Zhao

发明人： Qi Jia ,  Ji-Fu Zhao

IPC分类号： A61K31/045

CPC分类号： A61K8/347 ,  A61K8/31 ,  A61K8/4973 ,  A61K8/97 ,  A61K31/015 ,  A61K31/05 ,  A61K31/085 ,  A61K31/09 ,  A61K31/357 ,  A61K31/40 ,  A61K31/704 ,  A61K2800/782 ,  A61Q19/02 ,  C07C39/15 ,  C07C39/367 ,  C07C41/26 ,  C07C41/32 ,  C07C43/23 ,  C07C45/673 ,  C07C49/835 ,  C07C215/74 ,  C07D321/12 ,  Y02A50/406 ,  Y02A50/411

摘要： The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

摘要翻译： 本发明实现了一种将酶抑制测定与化学去除方法结合以鉴别活性植物提取物和特异性抑制双核酶功能的那些提取物中的二芳基烷烃和/或二芳基链烷醇的策略。 包括在本发明中的是由一种或多种二芳基烷烃和/或二芳基链烷醇组成的物质组合物，其抑制双核酶，特别是酪氨酸酶的活性，并且其防止黑色素过量产生。 本发明还提供了抑制双核酶，特别是酪氨酸酶的活性的方法，以及用于预防和治疗与双核酶功能相关的疾病和病症的方法。 本发明还包括一种预防和治疗与其相关的黑色素过量产生及其疾病和病症的方法。 用于预防和治疗与双核酶功能和黑色素过量产生相关的疾病和病症的方法包括向有需要的宿主施用有效量的包含一种或多种二芳基烷烃和/或二芳基链烷醇的组合物，所述二芳基烷烃和/或二芳基链烷醇合成和/或分离自 更多的植物和药学上可接受的载体。

公开(公告)号：US07034060B2

公开(公告)日：2006-04-25

申请号：US10991340

申请日：2004-11-16

申请人： Qi Jia ,  Ji-Fu Zhao

发明人： Qi Jia ,  Ji-Fu Zhao

IPC分类号： A01N31/00 ,  A61K31/045

CPC分类号： A61K31/045 ,  A61K35/63 ,  Y10S514/925 ,  A61K2300/00

摘要： The present invention provides a novel method for the preparation of a unique profile of primary aliphatic alcohols, having 24 to 30 carbon atoms, from the wax secreted by the insect Ericerus pela. Included in the present invention is the composition of matter, referred to herein as “polycosanol” produced by the method of this invention. The polycosanol composition is comprised primarily of the four primary aliphatic alcohols, tetracosanol, hexacosanol, octacosanol and triacontanol. Further included in this invention is the use of said composition of matter for the prevention and treatment of obesity, syndrome X, diabetes, hypercholesterolemia, atherosclerotic complications, ischemia and thrombosis.

公开(公告)号：US06984666B2

公开(公告)日：2006-01-10

申请号：US10991179

申请日：2004-11-16

申请人： Qi Jia ,  Ji-Fu Zhao

发明人： Qi Jia ,  Ji-Fu Zhao

IPC分类号： A01N31/00 ,  A61K31/045

CPC分类号： A61K31/045 ,  Y10S514/925 ,  A61K2300/00

摘要： The present invention provides a novel method for the preparation of a unique profile of primary aliphatic alcohols, having 24 to 30 carbon atoms, from the wax secreted by the insect Ericerus pela. Included in the present invention is the composition of matter, referred to herein as “polycosanol” produced by the method of this invention. The polycosanol composition is comprised primarily of the four primary aliphatic alcohols, tetracosanol, hexacosanol, octacosanol and triacontanol. Further included in this invention is the use of said composition of matter for the prevention and treatment of obesity, syndrome X, diabetes, hypercholesterolemia, atherosclerotic complications, ischemia and thrombosis.

摘要翻译： 本发明提供了一种新颖的方法，用于制备具有24至30个碳原子的伯脂肪醇，其特征在于由昆虫螨属分泌的蜡。 本发明中包括由本发明的方法生产的物质组合物，这里称为“多可醇”。 多糖醇组合物主要由四种脂族醇，二十四烷醇，二十四烷醇，三十烷醇组成。 本发明还包括所述物质组合物用于预防和治疗肥胖症，综合征X，糖尿病，高胆固醇血症，动脉粥样硬化并发症，局部缺血和血栓形成的用途。

公开(公告)号：US20050124703A1

公开(公告)日：2005-06-09

申请号：US10991340

申请日：2004-11-16

申请人： Qi Jia ,  Ji-Fu Zhao

发明人： Qi Jia ,  Ji-Fu Zhao

IPC分类号： A61K31/045 ,  A61K35/63 ,  A61K35/64 ,  A01N31/00

CPC分类号： A61K31/045 ,  A61K35/63 ,  Y10S514/925 ,  A61K2300/00

摘要： The present invention provides a novel method for the preparation of a unique profile of primary aliphatic alcohols, having 24 to 30 carbon atoms, from the wax secreted by the insect Ericerus pela. Included in the present invention is the composition of matter, referred to herein as “polycosanol” produced by the method of this invention. The polycosanol composition is comprised primarily of the four primary aliphatic alcohols, tetracosanol, hexacosanol, octacosanol and triacontanol. Further included in this invention is the use of said composition of matter for the prevention and treatment of obesity, syndrome X, diabetes, hypercholesterolemia, atherosclerotic complications, ischemia and thrombosis.

公开(公告)号：US20100267839A1

公开(公告)日：2010-10-21

申请号：US12814190

申请日：2010-06-11

申请人： Qi Jia ,  Ji-Fu Zhao

发明人： Qi Jia ,  Ji-Fu Zhao

IPC分类号： A61K31/09 ,  C07C43/23 ,  A61P17/00

CPC分类号： A61K8/347 ,  A61K8/31 ,  A61K8/4973 ,  A61K8/97 ,  A61K31/015 ,  A61K31/05 ,  A61K31/085 ,  A61K31/09 ,  A61K31/357 ,  A61K31/40 ,  A61K31/704 ,  A61K2800/782 ,  A61Q19/02 ,  C07C39/15 ,  C07C39/367 ,  C07C41/26 ,  C07C41/32 ,  C07C43/23 ,  C07C45/673 ,  C07C49/835 ,  C07C215/74 ,  C07D321/12 ,  Y02A50/406 ,  Y02A50/411

摘要： The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

公开(公告)号：US20080132581A1

公开(公告)日：2008-06-05

申请号：US12027090

申请日：2008-02-06

申请人： Qi Jia ,  Ji-Fu Zhao

发明人： Qi Jia ,  Ji-Fu Zhao

IPC分类号： A61K31/047 ,  C07C39/15 ,  C12N9/99 ,  A61P43/00

CPC分类号： A61K8/347 ,  A61K8/31 ,  A61K8/4973 ,  A61K8/97 ,  A61K31/015 ,  A61K31/05 ,  A61K31/085 ,  A61K31/09 ,  A61K31/357 ,  A61K31/40 ,  A61K31/704 ,  A61K2800/782 ,  A61Q19/02 ,  C07C39/15 ,  C07C39/367 ,  C07C41/26 ,  C07C41/32 ,  C07C43/23 ,  C07C45/673 ,  C07C49/835 ,  C07C215/74 ,  C07D321/12 ,  Y02A50/406 ,  Y02A50/411

摘要： The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

摘要翻译： 本发明实现了一种将酶抑制测定与化学去除方法结合以鉴别活性植物提取物和特异性抑制双核酶功能的那些提取物中的二芳基烷烃和/或二芳基链烷醇的策略。 包括在本发明中的是由一种或多种二芳基烷烃和/或二芳基链烷醇组成的物质组合物，其抑制双核酶，特别是酪氨酸酶的活性，并且其防止黑色素过量产生。 本发明还提供了抑制双核酶，特别是酪氨酸酶的活性的方法，以及用于预防和治疗与双核酶功能相关的疾病和病症的方法。 本发明还包括一种预防和治疗与其相关的黑色素过量产生及其疾病和病症的方法。 用于预防和治疗与双核酶功能和黑色素过量产生相关的疾病和病症的方法包括向有需要的宿主施用有效量的包含一种或多种二芳基烷烃和/或二芳基链烷醇的组合物，所述二芳基烷烃和/或二芳基链烷醇合成和/或分离自 更多的植物和药学上可接受的载体。

公开(公告)号：US20050267047A1

公开(公告)日：2005-12-01

申请号：US11139200

申请日：2005-05-27

申请人： Qi Jia ,  Ji-Fu Zhao

发明人： Qi Jia ,  Ji-Fu Zhao

IPC分类号： A61K31/015 ,  A61K31/05 ,  A61K31/704 ,  C07C39/15 ,  C07C39/367 ,  C07C43/23 ,  C07C45/67 ,  C07C49/835 ,  C07C215/74 ,  C07D321/12

CPC分类号： A61K8/347 ,  A61K8/31 ,  A61K8/4973 ,  A61K8/97 ,  A61K31/015 ,  A61K31/05 ,  A61K31/085 ,  A61K31/09 ,  A61K31/357 ,  A61K31/40 ,  A61K31/704 ,  A61K2800/782 ,  A61Q19/02 ,  C07C39/15 ,  C07C39/367 ,  C07C41/26 ,  C07C41/32 ,  C07C43/23 ,  C07C45/673 ,  C07C49/835 ,  C07C215/74 ,  C07D321/12 ,  Y02A50/406 ,  Y02A50/411

摘要： The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

摘要翻译： 本发明实现了一种将酶抑制测定与化学去除方法结合以鉴别活性植物提取物和特异性抑制双核酶功能的那些提取物中的二芳基烷烃和/或二芳基链烷醇的策略。 包括在本发明中的是由一种或多种二芳基烷烃和/或二芳基链烷醇组成的物质组合物，其抑制双核酶，特别是酪氨酸酶的活性，并且其防止黑色素过量产生。 本发明还提供了抑制双核酶，特别是酪氨酸酶的活性的方法，以及用于预防和治疗与双核酶功能相关的疾病和病症的方法。 本发明还包括一种预防和治疗与其相关的黑色素过量产生及其疾病和病症的方法。 用于预防和治疗与双核酶功能和黑色素过量产生相关的疾病和病症的方法包括向有需要的宿主施用有效量的包含一种或多种二芳基烷烃和/或二芳基链烷醇的组合物，所述二芳基烷烃和/或二芳基链烷醇合成和/或分离自 更多的植物和药学上可接受的载体。

公开(公告)号：US20050131078A1

公开(公告)日：2005-06-16

申请号：US10991179

申请日：2004-11-16

申请人： Qi Jia ,  Ji-Fu Zhao

发明人： Qi Jia ,  Ji-Fu Zhao

IPC分类号： A61K31/045

CPC分类号： A61K31/045 ,  Y10S514/925 ,  A61K2300/00

摘要： The present invention provides a novel method for the preparation of a unique profile of primary aliphatic alcohols, having 24 to 30 carbon atoms, from the wax secreted by the insect Ericerus pela. Included in the present invention is the composition of matter, referred to herein as “polycosanol” produced by the method of this invention. The polycosanol composition is comprised primarily of the four primary aliphatic alcohols, tetracosanol, hexacosanol, octacosanol and triacontanol. Further included in this invention is the use of said composition of matter for the prevention and treatment of obesity, syndrome X, diabetes, hypercholesterolemia, atherosclerotic complications, ischemia and thrombosis.

摘要翻译： 本发明提供了一种新颖的方法，用于制备具有24至30个碳原子的伯脂肪醇，其特征在于由昆虫螨属分泌的蜡。 本发明中包括由本发明的方法生产的物质组合物，这里称为“多可醇”。 多糖醇组合物主要由四种脂族醇，二十四烷醇，二十四烷醇，三十烷醇组成。 本发明还包括所述物质组合物用于预防和治疗肥胖症，综合征X，糖尿病，高胆固醇血症，动脉粥样硬化并发症，局部缺血和血栓形成的用途。

公开(公告)号：US06822004B2

公开(公告)日：2004-11-23

申请号：US10658881

申请日：2003-09-09

申请人： Qi Jia ,  Ji-Fu Zhao

发明人： Qi Jia ,  Ji-Fu Zhao

IPC分类号： A01N3100

CPC分类号： A61K31/045 ,  Y10S514/925 ,  A61K2300/00

摘要： The present invention provides a novel method for the preparation of a unique profile of primary aliphatic alcohols having 24 to 30 carbon atoms, from the wax secreted by the insect Ericerus pela. Included in the present invention is the composition of matter, referred to herein as “polycosanol” produced by the method of this invention. The polycosanol composition is comprised primarily of the four primary aliphatic alcohols, tetracosanol, hexacosanol, octacosanol and triacontanol. Further included in this invention is the use of said composition of matter for the prevention and treatment of obesity, syndrome X, diabetes, hypercholesterolemia, atherosclerotic complications, ischemia and thrombosis.