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公开(公告)号:US08552002B2
公开(公告)日:2013-10-08
申请号:US11570983
申请日:2005-06-23
申请人: Qiang Ding , Nathanael Schiander Gray , Bing Li , Yi Liu , Taebo Sim , Tetsuo Uno , Guobao Zhang , Carole Pissot Soldermann , Werner Breitenstein , Guido Bold , Giorgio Caravatti , Pascal Furet , Vito Guagnano , Marc Lang , Paul William Manley , Joseph Schoepfer , Carsten Spanka
发明人: Qiang Ding , Nathanael Schiander Gray , Bing Li , Yi Liu , Taebo Sim , Tetsuo Uno , Guobao Zhang , Carole Pissot Soldermann , Werner Breitenstein , Guido Bold , Giorgio Caravatti , Pascal Furet , Vito Guagnano , Marc Lang , Paul William Manley , Joseph Schoepfer , Carsten Spanka
IPC分类号: A01N43/54 , C07D239/02
CPC分类号: C07D239/48 , C07D251/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要: The invention relates to compounds of formula (I) wherein the substituents X1, R1, R2, R3 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.
摘要翻译: 本发明涉及式(I)化合物,其中取代基X1,R1,R2,R3和R4具有本发明说明书中阐述和解释的含义,制备这些化合物的方法,含有它们的药物组合物 ,其任选与一种或多种其它药学活性化合物组合用于治疗对蛋白激酶活性的抑制作出反应的疾病的用途,以及治疗这种疾病的方法。
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公开(公告)号:US20090137804A1
公开(公告)日:2009-05-28
申请号:US11570983
申请日:2005-06-23
申请人: Qiang Ding , Nathanael Schiander Gray , Bing Li , Yi Liu , Taebo Sim , Tetsuo Uno , Guobao Zhang , Carole Pissot Soldermann , Werner Breitenstein , Guido Bold , Giorgio Caravatti , Pascal Furet , Vito Guagnano , Marc Lang , Paul W. Manley , Joseph Schoepfer , Carsten Spanka
发明人: Qiang Ding , Nathanael Schiander Gray , Bing Li , Yi Liu , Taebo Sim , Tetsuo Uno , Guobao Zhang , Carole Pissot Soldermann , Werner Breitenstein , Guido Bold , Giorgio Caravatti , Pascal Furet , Vito Guagnano , Marc Lang , Paul W. Manley , Joseph Schoepfer , Carsten Spanka
IPC分类号: A61K31/50 , C07D239/12 , A61P35/00
CPC分类号: C07D239/48 , C07D251/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要: The invention relates to compounds of formula (I) wherein the substituents X1, R1, R2, R3 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.
摘要翻译: 本发明涉及式(I)化合物,其中取代基X1,R1,R2,R3和R4具有本发明说明书中阐述和解释的含义,制备这些化合物的方法,含有它们的药物组合物 ,其任选与一种或多种其它药学活性化合物组合用于治疗对蛋白激酶活性的抑制作出反应的疾病的用途,以及治疗这种疾病的方法。
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公开(公告)号:US07329661B2
公开(公告)日:2008-02-12
申请号:US11828367
申请日:2007-07-26
申请人: Hans Michael Buerger , Giorgio Caravatti , Juerg Zimmerman , Paul William Manley , Werner Breitenstein , Margaret Amelia Cudd
发明人: Hans Michael Buerger , Giorgio Caravatti , Juerg Zimmerman , Paul William Manley , Werner Breitenstein , Margaret Amelia Cudd
IPC分类号: A61K31/506 , C07D403/10
CPC分类号: C07D401/04 , A61K31/506
摘要: The invention relates to N-phenyl-2-pyrimidine-amine derivatives of formula I wherein the substituents are defined as indicated in the description, to processes for the preparation thereof, to medicaments comprising those compounds, and to the use thereof in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans.
摘要翻译: 本发明涉及式I的N-苯基-2-嘧啶 - 胺衍生物,其中取代基如说明书所述定义,其制备方法,包括那些化合物的药物及其在制备 用于治疗温血动物(包括人)的药物组合物。
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公开(公告)号:US07655669B2
公开(公告)日:2010-02-02
申请号:US10528913
申请日:2003-09-26
IPC分类号: C07D401/14 , A61K31/506
CPC分类号: C07D401/04
摘要: The invention relates to novel substituted N-(3-benzoylaminophenyl)-4-pyridyl-2-pyrimidinamine derivatives, processes for the preparation thereof, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, especially a neoplastic disease, and a method for the treatment of such a disease.
摘要翻译: 本发明涉及新的取代的N-(3-苯甲酰氨基苯基)-4-吡啶基-2-嘧啶胺衍生物,其制备方法,含有它们的药物组合物,其用途任选与一种或多种其它药物活性化合物组合用于 治疗对抑制蛋白激酶活性,特别是肿瘤性疾病作出反应的疾病,以及治疗这种疾病的方法。
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公开(公告)号:US20090286821A1
公开(公告)日:2009-11-19
申请号:US12489049
申请日:2009-06-22
IPC分类号: A61K31/506 , C07D401/04
CPC分类号: C07D401/14 , C07D405/14
摘要: The invention relates to compounds of formula wherein the substituents R1, R2 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, especially a neoplastic disease, in particular leukaemia, and a method for the treatment of such a disease.
摘要翻译: 本发明涉及下式的化合物,其中取代基R 1,R 2和R 4具有本发明说明书中阐述和解释的含义,制备这些化合物的方法,含有它们的药物组合物,其任选组合的用途 与一种或多种用于治疗对蛋白激酶活性,特别是肿瘤性疾病,特别是白血病的抑制作出反应的疾病的其它药学活性化合物,以及治疗这种疾病的方法。
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公开(公告)号:US07169791B2
公开(公告)日:2007-01-30
申请号:US10520359
申请日:2003-07-04
IPC分类号: C07D401/14 , A06K31/506 , C07D213/38
CPC分类号: C07D401/14 , C07D405/14
摘要: The invention relates to compounds of formula wherein the substituents R1, R2 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, especially a neoplastic disease, in particular leukaemia, and a method for the treatment of such a disease.
摘要翻译: 本发明涉及下式的化合物,其中取代基R 1,R 2和R 4具有本发明说明书中阐述和解释的含义,制备这些化合物的方法,含有它们的药物组合物,其任选组合的用途 与一种或多种用于治疗对蛋白激酶活性,特别是肿瘤性疾病,特别是白血病的抑制作出反应的疾病的其它药学活性化合物,以及治疗这种疾病的方法。
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公开(公告)号:US20080188451A1
公开(公告)日:2008-08-07
申请号:US12061334
申请日:2008-04-02
IPC分类号: A61K31/337 , C07D239/24 , A61K31/505 , C07D403/14 , A61P35/00 , A61K31/496 , C07D413/14 , A61K31/5377
CPC分类号: C07D401/14 , C07D405/14
摘要: The invention relates to compounds of formula wherein the substituents R1, R2 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, especially a neoplastic disease, in particular leukaemia, and a method for the treatment of such a disease.
摘要翻译: 本发明涉及下式的化合物,其中取代基R 1,R 2和R 4具有本发明说明书中阐述和解释的含义,制备这些化合物的方法,含有它们的药物组合物,其任选组合的用途 与一种或多种用于治疗对蛋白激酶活性,特别是肿瘤性疾病,特别是白血病的抑制作出反应的疾病的其它药学活性化合物,以及治疗这种疾病的方法。
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公开(公告)号:US20070265292A1
公开(公告)日:2007-11-15
申请号:US11828367
申请日:2007-07-26
申请人: Hans Buerger , Giorgio Caravatti , Juerg Zimmermann , Paul Manley , Werner Breitenstein , Margaret Cudd
发明人: Hans Buerger , Giorgio Caravatti , Juerg Zimmermann , Paul Manley , Werner Breitenstein , Margaret Cudd
IPC分类号: A61K31/506
CPC分类号: C07D401/04 , A61K31/506
摘要: The invention relates to N-phenyl-2-pyrimidine-amine derivatives of formula I wherein the substituents are defined as indicated in the description, to processes for the preparation thereof, to medicaments comprising those compounds, and to the use thereof in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans.
摘要翻译: 本发明涉及式I的N-苯基-2-嘧啶 - 胺衍生物,其中取代基如说明书所述定义,其制备方法,包括那些化合物的药物及其在制备 用于治疗温血动物(包括人)的药物组合物。
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公开(公告)号:US07081532B2
公开(公告)日:2006-07-25
申请号:US10363841
申请日:2001-09-11
申请人: Hans M Buerger , Giorgio Caravatti , Juerg Zimmermann , Paul W Manley , Werner Breitenstein , Margaret A Cudd
发明人: Hans M Buerger , Giorgio Caravatti , Juerg Zimmermann , Paul W Manley , Werner Breitenstein , Margaret A Cudd
IPC分类号: C07D403/10
CPC分类号: C07D401/04 , A61K31/506
摘要: The invention relates to N-phenyl-2-pyrimidine-amine derivatives of formula (I) wherein the substituents are defined as in the description, to processes for the preparation thereof, to medicaments comprising those compounds, and the use thereof in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans.
摘要翻译: 本发明涉及式(I)的N-苯基-2-嘧啶 - 胺衍生物,其中取代基如说明书中所定义,其制备方法,含有这些化合物的药物及其在制备 用于治疗温血动物(包括人)的药物组合物。
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公开(公告)号:US07312216B2
公开(公告)日:2007-12-25
申请号:US11448649
申请日:2006-06-07
申请人: Hans M Buerger , Giorgio Caravatti , Uerg Zimmermann , Paul W Manley , Werner Breitenstein , Margaret A Cudd
发明人: Hans M Buerger , Giorgio Caravatti , Uerg Zimmermann , Paul W Manley , Werner Breitenstein , Margaret A Cudd
IPC分类号: A61K31/506 , C07D401/04
CPC分类号: C07D401/04 , A61K31/506
摘要: The invention relates to N-phenyl-2-pyrimidine-amine derivatives of formula I wherein the substituents are defined as indicated in the description, to processes for the preparation thereof, to medicaments comprising those compounds, and to the use thereof in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans.
摘要翻译: 本发明涉及式I的N-苯基-2-嘧啶 - 胺衍生物,其中取代基如说明书所述定义,其制备方法,包括那些化合物的药物及其在制备 用于治疗温血动物(包括人)的药物组合物。
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