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公开(公告)号:US07851626B2
公开(公告)日:2010-12-14
申请号:US11604558
申请日:2006-11-27
申请人: Qingjie Ding , Bradford James Graves , Norman Kong , Jin-Jun Liu , Allen John Lovey , Giacomo Pizzolato , John Lawson Roberts , Sung-Sau So , Binh Thanh Vu , Peter Michael Wovkulich
发明人: Qingjie Ding , Bradford James Graves , Norman Kong , Jin-Jun Liu , Allen John Lovey , Giacomo Pizzolato , John Lawson Roberts , Sung-Sau So , Binh Thanh Vu , Peter Michael Wovkulich
IPC分类号: C07D403/02 , C07D233/06 , A61K31/497 , A01N43/50
CPC分类号: C07D233/22 , C07D233/26 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/06 , C07D407/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要: There is provided a compound of formula I and the pharmaceutically acceptable salts and esters thereof wherein X1, X2, R1, R2, R3, R4, R5 and R6 are herein described. The compounds exhibit activity as anticancer agents.
摘要翻译: 提供式I化合物及其药学上可接受的盐和酯,其中本文描述了X1,X2,R1,R2,R3,R4,R5和R6。 化合物表现出抗癌作用。
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公开(公告)号:US08088815B2
公开(公告)日:2012-01-03
申请号:US12939234
申请日:2010-11-04
申请人: David Joseph Bartkovitz , Xin-Jie Chu , Qingjie Ding , Bradford James Graves , Nan Jiang , Jing Zhang , Zhuming Zhang
发明人: David Joseph Bartkovitz , Xin-Jie Chu , Qingjie Ding , Bradford James Graves , Nan Jiang , Jing Zhang , Zhuming Zhang
IPC分类号: A61K31/4015 , C07D487/10
CPC分类号: C07D487/10
摘要: There are provided compounds of the formula wherein X, Y and R1 to R8 are described herein along with the enantiomers, pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.
摘要翻译: 提供下式的化合物其中X,Y和R 1至R 8与本文所述的对映异构体,其药学上可接受的盐和酯一起描述。 这些化合物可用作抗癌剂。
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公开(公告)号:US20110130398A1
公开(公告)日:2011-06-02
申请号:US12939234
申请日:2010-11-04
申请人: David Joseph Bartkovitz , Xin-Jie Chu , Qingjie Ding , Bradford James Graves , Nan Jiang , Jing Zhang , Zhuming Zhang
发明人: David Joseph Bartkovitz , Xin-Jie Chu , Qingjie Ding , Bradford James Graves , Nan Jiang , Jing Zhang , Zhuming Zhang
IPC分类号: A61K31/5377 , C07D487/10 , A61K31/4045 , C07D401/14 , A61K31/4439 , C07D417/14 , A61K31/427 , C07D403/14 , A61K31/506 , C07D413/14 , A61K31/41 , A61K31/4155 , A61P35/00
CPC分类号: C07D487/10
摘要: There are provided compounds of the formula wherein X, Y and R1 to R8 are described herein along with the enantiomers, pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.
摘要翻译: 提供下式的化合物其中X,Y和R 1至R 8与本文所述的对映异构体,其药学上可接受的盐和酯一起描述。 这些化合物可用作抗癌剂。
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