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    ARTIFICIAL STENT AND ITS PREPARATION METHOD
    1.
    发明申请
    ARTIFICIAL STENT AND ITS PREPARATION METHOD 审中-公开
    人工智能及其制备方法

    公开(公告)号：US20110202125A1

    公开(公告)日：2011-08-18

    申请号：US12682560

    申请日：2008-10-10

    申请人： Qiyi Luo ,  Zhirong Tang ,  Buzhong Zheng

    发明人： Qiyi Luo ,  Zhirong Tang ,  Buzhong Zheng

    IPC分类号： A61F2/82

    CPC分类号： A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/606 ,  C08L89/00

    摘要： An artificial stent and its preparation method. The artificial stent comprises a stent body and a coating on it. The artificial stent is characterized in that the coating comprises a drug-loaded layer containing silk fibroin and a drug. The drug-loaded layer has a microporous structure substantially consists of silk fibroin and loaded with the drug. The microporous structure is obtained by a method comprising: uniformly coating the surface of the stent body with a solution of silk fibroin, denaturing by heat or chemical reagents; soaking the stent with purified water; then freeze drying and warming-drying, so as to from a microporous structure of the coating; loading the drug into the micropores in the coating; and removing the stent and drying. Silk fibroin used to coat the stent is a natural bio-material with great bio-compatibility; an can be absorbed and metabolized slowly by human body without adverse side effects, overcoming certain adverse effects of conventional drug-coated stents.

    摘要翻译： 人造支架及其制备方法。 人造支架包括支架主体及其上的涂层。 人造支架的特征在于，该涂层包含含有丝素蛋白和药物的药物负载层。 药物负载层具有基本上由丝素蛋白组成并加载药物的微孔结构。 通过以下方法获得微孔结构：通过丝素蛋白溶液均匀地涂覆支架体的表面，用热或化学试剂变性; 用纯水浸泡支架; 然后冷冻干燥并加温干燥，从而从涂层的微孔结构中得到; 将药物装入涂层中的微孔中; 取出支架并干燥。 用于涂层支架的丝心蛋白是具有极好生物相容性的天然生物材料; 人体可以缓慢吸收和代谢，无不良副作用，克服常规药物涂层支架的一些不良反应。

    INTERVENTION MEDICAL DEVICE AND PREPARATION THEREOF
    2.
    发明申请
    INTERVENTION MEDICAL DEVICE AND PREPARATION THEREOF 有权
    干预医疗设备及其准备

    公开(公告)号：US20130296806A1

    公开(公告)日：2013-11-07

    申请号：US13703855

    申请日：2011-06-13

    申请人： Junfei Li ,  Xi Hu ,  Chengyun Yue ,  Dawei Wang ,  Peng Huang ,  Zhirong Tang ,  Qiyi Luo ,  Zhaohua Chang

    发明人： Junfei Li ,  Xi Hu ,  Chengyun Yue ,  Dawei Wang ,  Peng Huang ,  Zhirong Tang ,  Qiyi Luo ,  Zhaohua Chang

    IPC分类号： A61L27/34

    CPC分类号： A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/42

    摘要： The present invention discloses an interventional medical device and methods of making the same. At least one coating layer is disposed on the outer surface of the interventional medical device and the material of the outmost layer of the coating layer is a sulfonate group-containing polymer. In the present invention, the material of the outmost layer of the interventional medical device is a sulfonate group-containing polymer. The polymer is endowed with a same surface property as that of heparin in addition to appropriate hydrophilicity due to the presence of the sulfonate group. After the interventional medical device is implanted into the human body, a hydrophilic surface is formed on the outer surface of the interventional medical device which is also negatively charged in the body fluid. Therefore, cells can easily adhere and grow on the outer surface thereof as a result of the enhanced cell compatibility. Furthermore, due to a surface property that is the same as that of heparin, the material is provided with excellent anticoagulant properties which inhibit the thrombosis and lower down the incidence rate of post-operational complications.

    摘要翻译： 本发明公开了一种介入医疗装置及其制造方法。 至少一个涂层设置在介入医疗装置的外表面上，涂层的最外层的材料是含磺酸基的聚合物。 在本发明中，介入医疗装置的最外层的材料是含磺酸基的聚合物。 由于存在磺酸盐基，除了适当的亲水性之外，聚合物具有与肝素相同的表面性质。 在将介入医疗装置植入人体后，在介入医疗装置的外表面上形成亲水性表面，其也在体液中带负电。 因此，由于细胞相容性的增强，细胞可以容易地附着和生长在其外表面上。 此外，由于与肝素相同的表面特性，具有优异的抗凝血性，能够抑制血栓形成，降低手术后并发症的发生率。

    STENT FOR A BIFURCATED VESSEL
    4.
    发明申请
    STENT FOR A BIFURCATED VESSEL 审中-公开
    一个分支的船只

    公开(公告)号：US20130304191A1

    公开(公告)日：2013-11-14

    申请号：US13884642

    申请日：2011-08-16

    申请人： Xu Cai ,  Dadong Zhang ,  Changchun Wang ,  Zhirong Tang ,  Qiyi Luo ,  Zhaohua Chang

    发明人： Xu Cai ,  Dadong Zhang ,  Changchun Wang ,  Zhirong Tang ,  Qiyi Luo ,  Zhaohua Chang

    IPC分类号： A61F2/82

    CPC分类号： A61F2/82 ,  A61F2/856 ,  A61F2/915 ,  A61F2002/067 ,  A61F2002/91575 ,  A61F2250/0096 ,  A61F2250/0098

    摘要： A stent for a bifurcated vessel comprises a stent body having two open ends, wherein at least one of the open ends of the stent body is a wedge structure, a second opaque marker is provided on the two ends of the slant long axis of the wedge structure, the stent body is provided with two first opaque markers, and the connecting line between the two first opaque markers is parallel to the slant of the wedge structure. When the two first opaque markers overlap with each other, the slant of the wedge structure of the stent for a bifurcated vessel is precisely positioned during implantation so that the slant of the wedge structure of the stent for a bifurcated vessel fits the slant at the blood vessel bifurcation site.

    摘要翻译： 用于分叉血管的支架包括具有两个开口端的支架主体，其中支架主体的开口端中的至少一个是楔形结构，在楔形物的倾斜长轴的两端设置第二不透明标记 结构中，支架主体设置有两个第一不透明标记，两个第一不透明标记之间的连接线平行于楔形结构的倾斜。 当两个第一不透明标记彼此重叠时，用于分叉血管的支架的楔形结构的倾斜在植入期间被精确地定位，使得用于分叉血管的支架的楔形结构的斜面适合于在血液处的倾斜 血管分叉位置。

    METHOD AND DEVICE FOR LOADING MEDICAL APPLIANCE WITH DRUGS AND/OR POLYMERS
    5.
    发明申请
    METHOD AND DEVICE FOR LOADING MEDICAL APPLIANCE WITH DRUGS AND/OR POLYMERS 有权
    用于装载药物和/或聚合物的医疗器具的方法和装置

    公开(公告)号：US20120135132A1

    公开(公告)日：2012-05-31

    申请号：US13387927

    申请日：2010-07-09

    申请人： Jie Zhang ,  Bo Yi ,  Changsheng Wu ,  Zhirong Tang ,  Qiyi Luo

    发明人： Jie Zhang ,  Bo Yi ,  Changsheng Wu ,  Zhirong Tang ,  Qiyi Luo

    IPC分类号： B05D5/00 ,  B05C11/00

    CPC分类号： A61F2/915 ,  A61F2230/0054 ,  A61F2240/001 ,  A61F2250/0068 ,  G06T7/73 ,  G06T2207/10004 ,  G06T2207/30164

    摘要： A method for loading a medical appliance with a medicament and/or a polymer is disclosed, the medical appliance comprising one or more grooves or holes loaded with the medicament and/or polymer. The method comprising the steps of: 1) capturing an image of the grooves or holes of the medical appliance, wherein the image contains at least one complete pattern of the grooves or holes; 2) performing digital image processing on the captured image to obtain the pattern of the grooves or holes; 3) calculating a central position of the pattern of the grooves or holes, and determining an actual central position of the grooves or holes based on the central position; 4) adjusting a relative position of a loading device to the medical appliance to align an outlet of the loading device with the actual central position of the grooves or holes; and 5) opening the outlet of the loading device to load the grooves or holes. A device for loading a medical appliance with a medicament and/or a polymer is further disclosed.

    摘要翻译： 公开了一种用于装载具有药物和/或聚合物的医疗器具的方法，所述医疗器具包括装载有药物和/或聚合物的一个或多个凹槽或孔。 该方法包括以下步骤：1）捕获医疗器具的凹槽或孔的图像，其中图像包含凹槽或孔的至少一个完整图案; 2）对拍摄图像执行数字图像处理以获得凹槽或孔的图案; 3）计算凹槽或孔的图案的中心位置，并且基于中心位置确定凹槽或孔的实际中心位置; 4）调节装载装置相对于医疗器具的相对位置，以将装载装置的出口与凹槽或孔的实际中心位置对齐; 和5）打开装载装置的出口以加载凹槽或孔。 进一步公开了一种用于装载具有药物和/或聚合物的医疗器具的装置。

    Interventional medical device and manufacturing method thereof
    7.
    发明授权
    Interventional medical device and manufacturing method thereof 有权
    介入医疗器械及其制造方法

    公开(公告)号：US09433709B2

    公开(公告)日：2016-09-06

    申请号：US14677741

    申请日：2015-04-02

    申请人： Dadong Zhang ,  Xu Cai ,  Chengyun Yue ,  Junfei Li ,  Yan Hu ,  Peng Huang ,  Zhirong Tang ,  Qiyi Luo

    发明人： Dadong Zhang ,  Xu Cai ,  Chengyun Yue ,  Junfei Li ,  Yan Hu ,  Peng Huang ,  Zhirong Tang ,  Qiyi Luo

    IPC分类号： A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61F2/82

    CPC分类号： A61L31/10 ,  A61F2/82 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/02 ,  C08L75/04 ,  C08L67/04 ,  C08L89/00 ,  C08L33/10 ,  C08L5/08

    摘要： An interventional medical device and manufacturing method thereof. The interventional medical device comprises: a stent body (1); a surface of the stent body (1) being provided with a drug releasing structure (3), and drug in the drug releasing structure (3) being drug for suppressing proliferation of adventitial fibroblasts and a drug for suppressing proliferation of intimal and/or smooth muscle cells. In use, after interventional medical device is implanted into a human body, the drug for suppressing proliferation of adventitial fibroblasts carried thereon can promote the compensatory expansion of the vessel, and the drug for suppressing proliferation of intimal cells and/or smooth muscle cells carried thereon can suppress intimal proliferation of the vessel. The combination of the two kinds of drugs greatly reduces the occurrence rate of in-stent restenosis.

    摘要翻译： 介入医疗装置及其制造方法。 介入医疗装置包括：支架主体（1）; 支架体（1）的表面设有药物释放结构（3），药物释放结构（3）中的药物是抑制外膜成纤维细胞增殖的药物和抑制内膜和/或平滑增生的药物 肌肉细胞。 在使用中，将介入医疗装置植入人体后，用于抑制携带的外膜成纤维细胞增殖的药物可以促进血管的代偿性扩张，并且抑制其上承载的内膜细胞和/或平滑肌细胞增殖的药物 可以抑制血管的内膜增殖。 两种药物的组合大大降低了支架内再狭窄的发生率。

    Intervention medical device and preparation thereof
    8.
    发明授权
    Intervention medical device and preparation thereof 有权
    干预医疗器械及其制备

    公开(公告)号：US09226994B2

    公开(公告)日：2016-01-05

    申请号：US13703855

    申请日：2011-06-13

    申请人： Junfei Li ,  Xi Hu ,  Chengyun Yue ,  Dawei Wang ,  Peng Huang ,  Zhirong Tang ,  Qiyi Luo ,  Zhaohua Chang

    发明人： Junfei Li ,  Xi Hu ,  Chengyun Yue ,  Dawei Wang ,  Peng Huang ,  Zhirong Tang ,  Qiyi Luo ,  Zhaohua Chang

    IPC分类号： A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16

    CPC分类号： A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/42

    摘要： The present invention discloses an interventional medical device and methods of making the same. At least one coating layer is disposed on the outer surface of the interventional medical device and the material of the outmost layer of the coating layer is a sulfonate group-containing polymer. In the present invention, the material of the outmost layer of the interventional medical device is a sulfonate group-containing polymer. The polymer is endowed with a same surface property as that of heparin in addition to appropriate hydrophilicity due to the presence of the sulfonate group. After the interventional medical device is implanted into the human body, a hydrophilic surface is formed on the outer surface of the interventional medical device which is also negatively charged in the body fluid. Therefore, cells can easily adhere and grow on the outer surface thereof as a result of the enhanced cell compatibility. Furthermore, due to a surface property that is the same as that of heparin, the material is provided with excellent anticoagulant properties which inhibit the thrombosis and lower down the incidence rate of post-operational complications.

    摘要翻译： 本发明公开了一种介入医疗装置及其制造方法。 至少一个涂层设置在介入医疗装置的外表面上，涂层的最外层的材料是含磺酸基的聚合物。 在本发明中，介入医疗装置的最外层的材料是含磺酸基的聚合物。 由于存在磺酸盐基，除了适当的亲水性之外，聚合物具有与肝素相同的表面性质。 在将介入医疗装置植入人体后，在介入医疗装置的外表面上形成亲水性表面，其也在体液中带负电。 因此，由于细胞相容性的增强，细胞可以容易地附着和生长在其外表面上。 此外，由于与肝素相同的表面特性，具有优异的抗凝血性，能够抑制血栓形成，降低手术后并发症的发生率。

    Method and device for loading medical appliance with medicaments and/or polymers
    9.
    发明授权
    Method and device for loading medical appliance with medicaments and/or polymers 有权
    用药物和/或聚合物装载医疗器具的方法和装置

    公开(公告)号：US09205180B2

    公开(公告)日：2015-12-08

    申请号：US13522819

    申请日：2011-01-19

    申请人： Jie Zhang ,  Bo Yi ,  Changsheng Wu ,  Zhirong Tang ,  Qiyi Luo

    发明人： Jie Zhang ,  Bo Yi ,  Changsheng Wu ,  Zhirong Tang ,  Qiyi Luo

    IPC分类号： A61L33/00 ,  A61L31/06 ,  A61L31/16 ,  A61F2/91

    CPC分类号： A61F2/82 ,  A61F2/91 ,  A61F2240/001 ,  A61F2250/0068 ,  A61L31/06 ,  A61L31/16 ,  A61L2300/416 ,  B05C21/00 ,  C08L67/04

    摘要： A method and a device for loading a medical appliance with a medicament and/or polymer includes capturing images of a plurality of grooves or holes of the medical appliance using an image capturing device; performing digital image processing on the image of each of the grooves or holes to obtain a pattern of each of the grooves or holes; calculating a central position of the pattern of each of the grooves or holes, and determining a loading position of each of the grooves or holes based on the central position; and adjusting a relative position between a loading device and the medical appliance to align an outlet of the loading device with the loading position of the medical appliance, and loading each of the grooves or holes with the medicament and/or polymer. The method and device can load the medical appliance with the medicament and/or polymer fast and efficiently.

    摘要翻译： 一种用于装载具有药物和/或聚合物的医疗器具的方法和装置包括使用图像捕获装置捕获医疗器具的多个凹槽或孔的图像; 对每个凹槽或孔的图像执行数字图像处理以获得每个凹槽或孔的图案; 计算每个凹槽或孔的图案的中心位置，以及基于中心位置确定每个凹槽或孔的装载位置; 以及调整加载装置和医疗器具之间的相对位置，以将装载装置的出口与医疗器具的装载位置对齐，并且用药物和/或聚合物装载每个凹槽或孔。 该方法和装置可以快速且有效地加载具有药物和/或聚合物的医疗器具。