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    Optical microdisks for integrated devices
    2.
    发明授权
    Optical microdisks for integrated devices 有权

    公开(公告)号：US11977257B2

    公开(公告)日：2024-05-07

    申请号：US17893101

    申请日：2022-08-22

    申请人： Quantum-Si Incorporated

    发明人： Ali Kabiri ,  Bing Shen ,  Gerard Schmid ,  James Beach ,  Kyle Preston ,  Sharath Hosali

    IPC分类号： G02B6/122 ,  G02B6/12 ,  G02B6/136

    CPC分类号： G02B6/122 ,  G02B6/136 ,  G02B2006/12109 ,  G02B2006/12138

    摘要： Apparatus and methods for improving optical signal collection in an integrated device are described. A microdisk can be formed in an integrated device and increase collection and/or concentration of radiation incident on the microdisk and re-radiated by the microdisk. An example integrated device that can include a microdisk may be used for analyte detection and/or analysis. Such an integrated device may include a plurality of pixels, each having a reaction chamber for receiving a sample to be analyzed, an optical microdisk, and an optical sensor configured to detect optical emission from the reaction chamber. The microdisk can comprise a dielectric material having a first index of refraction that is embedded in one or more surrounding materials having one or more different refractive index values.

    Integrated sensor for multi-dimensional signal analysis
    5.
    发明授权
    Integrated sensor for multi-dimensional signal analysis 有权

    公开(公告)号：US11719639B2

    公开(公告)日：2023-08-08

    申请号：US17190331

    申请日：2021-03-02

    申请人： Quantum-Si Incorporated

    发明人： Gerard Schmid ,  Dajiang Yang ,  Eric A. G. Webster ,  Xin Wang ,  Todd Rearick ,  Changhoon Choi ,  Ali Kabiri ,  Kyle Preston ,  Brian Reed

    IPC分类号： G01N21/64 ,  H01L27/146

    CPC分类号： G01N21/6454 ,  G01N21/6408 ,  G01N21/6428 ,  H01L27/14603 ,  G01N2021/6463

    摘要： Some aspects relate to an integrated circuit, comprising at least one photodetection region configured to generate charge carriers responsive to incident photons emitted from a sample, at least one charge storage region configured to receive the charge carriers from the photodetection region, and at least one controller configured to obtain information about the incident photons, the information comprising at least one member selected from the group comprising pulse duration and interpulse duration and at least one member selected from the group comprising wavelength information, luminescence lifetime information, and intensity information. In some embodiments, the information comprises at least three, four, and/or five members selected from the group comprising wavelength information, luminescence lifetime information, intensity information, pulse duration information, and interpulse duration information. In some embodiments, the information obtained may be used to identify the sample.

    Integrated device with external light source for probing detecting and analyzing molecules
    9.
    发明授权
    Integrated device with external light source for probing detecting and analyzing molecules 有权

    公开(公告)号：US10288565B2

    公开(公告)日：2019-05-14

    申请号：US15641949

    申请日：2017-07-05

    申请人： Quantum-Si Incorporated

    发明人： Jonathan M. Rothberg ,  Ali Kabiri ,  Jason W. Sickler ,  Brett J. Gyarfas ,  Jeremy Lackey ,  Gerard Schmid ,  Lawrence C. West ,  Keith G. Fife ,  Benjamin Cipriany ,  Farshid Ghasemi

    IPC分类号： G01N21/64 ,  C12Q1/6874 ,  C12Q1/6869

    摘要： System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes at least one waveguide configured to propagate excitation energy to the sample wells from a region of the integrated device configured to couple with an excitation energy source. A pixel may also include at least one element for directing the emission energy towards a sensor within the pixel. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device. One of multiple markers distinguishable by temporal parameters of the emission energy may label the sample and configuration of the sensor within a pixel may allow for detection of a temporal parameter associated with the marker labeling the sample.