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公开(公告)号：US11680949B2
公开(公告)日：2023-06-20
申请号：US17188855
申请日：2021-03-01
发明人： Michael P. Caulfield , Richard E Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
CPC分类号： G01N33/92 , C07K1/14 , G01N15/0266 , G16H50/30 , G16B99/00 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
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2.发明申请公开(公告)号：US20200241018A1
公开(公告)日：2020-07-30
申请号：US16588709
申请日：2019-09-30
摘要： The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.
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公开(公告)号：US20160041183A1
公开(公告)日：2016-02-11
申请号：US14726957
申请日：2015-06-01
发明人： Yanni Zhang , Nigel J. Clarke , Richard E Reitz
IPC分类号： G01N33/68
CPC分类号： G01N33/6848 , G01N33/68 , G01N33/6893 , G01N33/78 , G01N2800/52 , G01N2800/7028 , Y10T436/24
摘要： Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
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公开(公告)号：US09063119B2
公开(公告)日：2015-06-23
申请号：US14305897
申请日：2014-06-16
发明人： Qibo Jiang , Richard E Reitz , Sum Chan
IPC分类号： H01J49/04 , G01N33/82 , G01N33/84 , G01N33/487 , G01N30/72 , G01N30/84 , H01J49/26 , H01J49/00
CPC分类号： G01N33/82 , B01D15/08 , G01N30/7233 , G01N30/84 , G01N30/88 , G01N33/487 , G01N2030/884 , G01N2560/00 , G01N2800/02 , G01N2800/52 , H01J49/0027 , H01J49/0031 , H01J49/0036 , H01J49/004 , H01J49/0045 , H01J49/165 , H01J49/26
摘要： Provided are methods for determining the amount of vitamin C in a sample using mass spectrometry. The methods generally involve ionizing vitamin C in a sample and detecting and quantifying the amount of the ion to determine the amount of vitamin C in the sample.
摘要翻译： 提供了使用质谱法测定样品中维生素C的量的方法。 这些方法通常涉及电离样品中的维生素C，并检测和定量离子的量以确定样品中维生素C的量。
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公开(公告)号：US20230280360A1
公开(公告)日：2023-09-07
申请号：US18316402
申请日：2023-05-12
发明人： Michael P. Caulfield , Richard E Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
CPC分类号： G01N33/92 , C07K1/14 , G01N15/0266 , G16H50/30 , Y10T436/25375 , Y10T436/25 , Y10T436/25125 , G16B99/00
摘要： The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
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公开(公告)号：US11105821B2
公开(公告)日：2021-08-31
申请号：US16588709
申请日：2019-09-30
摘要： The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.
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公开(公告)号：US20190317109A1
公开(公告)日：2019-10-17
申请号：US16429941
申请日：2019-06-03
发明人： Yanni Zhang , Nigel J. Clarke , Richard E Reitz
摘要： Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
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公开(公告)号：US09791464B2
公开(公告)日：2017-10-17
申请号：US14726802
申请日：2015-06-01
发明人： Michael P. Caulfield , Richard E Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
CPC分类号： G01N33/92 , C07K1/14 , G01N15/0266 , G06F19/00 , G06F19/10 , G16H50/30 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
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9.发明申请公开(公告)号：US20170248620A1
公开(公告)日：2017-08-31
申请号：US15489551
申请日：2017-04-17
CPC分类号： G01N33/82 , G01N30/7233 , G01N30/88 , G01N2030/8813 , H01J49/0031 , H01J49/0045 , Y10T436/203332 , Y10T436/24
摘要： The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.
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公开(公告)号：US09645158B2
公开(公告)日：2017-05-09
申请号：US14746037
申请日：2015-06-22
发明人： Qibo Jiang , Richard E Reitz , Sum Chan
IPC分类号： H01J49/04 , G01N33/82 , G01N33/84 , G01N30/72 , G01N30/84 , H01J49/26 , G01N33/487 , H01J49/00
CPC分类号： G01N33/82 , B01D15/08 , G01N30/7233 , G01N30/84 , G01N30/88 , G01N33/487 , G01N2030/884 , G01N2560/00 , G01N2800/02 , G01N2800/52 , H01J49/0027 , H01J49/0031 , H01J49/0036 , H01J49/004 , H01J49/0045 , H01J49/165 , H01J49/26
摘要： Provided are methods for determining the amount of vitamin C in a sample using mass spectrometry. The methods generally involve ionizing vitamin C in a sample and detecting and quantifying the amount of the ion to determine the amount of vitamin C in the sample.
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