公开(公告)号：US20140194451A1

公开(公告)日：2014-07-10

申请号：US14087662

申请日：2013-11-22

申请人： Qun Lu ,  Huchen Zhou ,  Yanhua Chen ,  Amy Friesland

发明人： Qun Lu ,  Huchen Zhou ,  Yanhua Chen ,  Amy Friesland

IPC分类号： C07D239/42 ,  C07C335/12

CPC分类号： C07D239/42 ,  C07C335/12 ,  C07D239/69

摘要： Compounds which inhibit the small G protein Rho GTPase cell division cycle protein Cdc42 are provided. Morphological analyses of filopodia, western blots of Ccd42 phosphorylation, and effects on cellular wound healing and on growth cone formation all demonstrate that the described compounds are able to inhibit all tested Cdc42-mediated processes. The compounds effectively inhibit, the effects of Cdc42 and effectively inhibit Cdc42-related cellular functions involving actin, such as Golgi organization and cell movement. Furthermore, the described Cdc42 inhibitor compounds may be provided as a medicament for the treatment of various conditions.

摘要翻译： 提供抑制小G蛋白Rho GTPase细胞分裂周期蛋白Cdc42的化合物。 丝状伪足，Ccd42磷酸化的蛋白质印迹以及对细胞伤口愈合和对生长锥形成的影响的形态学分析都证明所述化合物能够抑制所有测试的Cdc42介导的过程。 这些化合物有效抑制Cdc42的作用，并有效抑制涉及肌动蛋白的Cdc42相关细胞功能，如高尔基体组织和细胞运动。 此外，所述Cdc42抑制剂化合物可以作为治疗各种病症的药物提供。

公开(公告)号：US20170334863A1

公开(公告)日：2017-11-23

申请号：US15671388

申请日：2017-08-08

申请人： Qun Lu ,  Huchen Zhou ,  Yanhua Chen ,  Amy Friesland

发明人： Qun Lu ,  Huchen Zhou ,  Yanhua Chen ,  Amy Friesland

IPC分类号： C07D239/42 ,  C07D239/69 ,  C07C335/12

CPC分类号： C07D239/42 ,  C07C335/12 ,  C07D239/69

摘要： Compounds which inhibit the small G protein Rho GTPase cell division cycle protein Cdc42 are provided. Morphological analyses of filopodia, western blots of Ccd42 phosphorylation, and effects on cellular wound healing and on growth cone formation all demonstrate that the described compounds are able to inhibit all tested Cdc42-mediated processes. The compounds effectively inhibit the effects of Cdc42 and effectively inhibit Cdc42-related cellular functions involving actin, such as Golgi organization and cell movement. Furthermore, the described Cdc42 inhibitor compounds may be provided as a medicament for the treatment of various conditions.

公开(公告)号：US09725417B2

公开(公告)日：2017-08-08

申请号：US14807386

申请日：2015-07-23

申请人： Qun Lu ,  Huchen Zhou ,  Yanhua Chen ,  Amy Friesland

发明人： Qun Lu ,  Huchen Zhou ,  Yanhua Chen ,  Amy Friesland

IPC分类号： C07D239/42 ,  C07D239/69 ,  C07C335/12

CPC分类号： C07D239/42 ,  C07C335/12 ,  C07D239/69

摘要： Compounds which inhibit the small G protein Rho GTPase cell division cycle protein Cdc42 are provided. Morphological analyzes of filopodia, western blots of Ccd42 phosphorylation, and effects on cellular wound healing and on growth cone formation all demonstrate that the described compounds are able to inhibit all tested Cdc42-mediated processes. The compounds effectively inhibit the effects of Cdc42 and effectively inhibit Cdc42-related cellular functions involving actin, such as Golgi organization and cell movement. Furthermore, the described Cdc42 inhibitor compounds may be provided as a medicament for the treatment of various conditions.

公开(公告)号：US11439608B2

公开(公告)日：2022-09-13

申请号：US16141849

申请日：2018-09-25

申请人： Qun Lu

发明人： Qun Lu ,  Byron Aguilar ,  Yi Zhu ,  Yan-Hua Chen

IPC分类号： A61K31/18 ,  A61K31/166 ,  A61K31/343 ,  A61K31/505 ,  A61P25/28

摘要： Methods of treating Alzheimer's disease and other neurodegenerative and/or neurocognitive and/or neurodevelopmental diseases are described. The methods comprise the administration of compounds that modulate an activity of cell division control protein 42 (Cdc42), such as the interaction between Cdc42 and intersectin (ITSN). Exemplary modulator compounds include thioureas, disulfonamides of fused aromatic systems (e.g., benzofuran), and acyl hydrazones, among others. Some of the modulator compounds act as activators of Cdc42, while others act as inhibitors. In some cases, the modulator compound has dual functionality and the ability of the modulator compound to act as an inhibitor or activator depends on whether or not Cdc42 is already activated in a particular disease stage or biological environment by an upstream activating signal of Cdc42.

公开(公告)号：US10085991B2

公开(公告)日：2018-10-02

申请号：US15532721

申请日：2015-12-01

申请人： Merck Sharp & Dohme Corp. ,  Lei Zhu ,  Yvonne Cegielnik ,  Qun Lu

发明人： Lei Zhu ,  Yvonne Cegielnik ,  Qun Lu

IPC分类号： A61K31/52 ,  A61K9/00 ,  A61K47/26 ,  A61K47/02 ,  A61K47/20 ,  A61K47/12 ,  A61K47/32 ,  A61K9/10 ,  A61K47/38

摘要： The present invention is directed to formulations comprising PVP polymer, a dispersion of a compound of Formula I (API), and citric acid, which formulations mitigate the effects of coadministering the compound of Formula I with a proton pump inhibitor compound.

公开(公告)号：US08932824B2

公开(公告)日：2015-01-13

申请号：US13251481

申请日：2011-10-03

申请人： Qun Lu ,  Yan-hua Chen

发明人： Qun Lu ,  Yan-hua Chen

IPC分类号： G01N33/574

CPC分类号： G01N33/57415 ,  C12Q1/6886 ,  G01N33/574 ,  G01N33/57434

摘要： The present invention provides a method for detecting or screening for the presence of cancer in a subject. The method comprises obtaining, providing or collecting a tissue or fluid sample (such as a urine sample) from said subject, and then determining the presence or absence of delta-catenin in said sample, or increased levels of delta-catenin in said sample as compared to a normal or control subject. The presence of delta-catenin in said sample, or increased levels of delta-catenin in said sample, indicating said subject is afflicted with or at least at risk of developing cancer.

摘要翻译： 本发明提供了用于检测或筛选受试者中癌症存在的方法。 该方法包括从所述受试者获得，提供或收集组织或流体样品（例如尿液样品），然后确定所述样品中δ-连环蛋白的存在或不存在，或所述样品中δ-连环蛋白的增加水平为 与正常或对照对象相比。 所述样品中δ-连环蛋白的存在或所述样品中δ-连环蛋白的水平升高，表明所述受试者患有或至少具有发展为癌症的风险。

公开(公告)号：US5933343A

公开(公告)日：1999-08-03

申请号：US158221

申请日：1998-09-22

申请人： Qun Lu ,  Paul E. Grandmont ,  Shih-Chang Liu

发明人： Qun Lu ,  Paul E. Grandmont ,  Shih-Chang Liu

IPC分类号： H02M3/00 ,  H05K1/14 ,  H02M1/00

CPC分类号： H05K1/144 ,  H02M3/00 ,  H02M7/003

摘要： A multi-deck power converter module assembly for connection with a substrate (e.g., a host board) having connection regions disposed on its surface includes a second circuit board positioned over a first circuit board, the second circuit board having apertures extending from an upper surface to a lower surface of the second circuit board. At least two rail members are positioned over the second circuit board, each rail member having a first and a second plurality of holes. A pair of spacers are disposed between the first and second circuit boards, each spacer extending through one of the apertures of the second circuit board and received within one of the first plurality of holes of one of the rail members. Terminal pins are attached to the first circuit board, at least one terminal pin extending through the second circuit board and a corresponding one of the second plurality of holes for connection to one of the connection regions on the substrate. Each of the second plurality of holes is sized to allow the rail members to be slidably positioned over the terminal pins during assembly of the power converter module.

摘要翻译： 用于与具有设置在其表面上的连接区域的基板（例如，主板）连接的多层电力转换器模块组件包括位于第一电路板上的第二电路板，第二电路板具有从上表面 到第二电路板的下表面。 至少两个轨道构件定位在第二电路板上方，每个轨道构件具有第一和第二多个孔。 一对间隔件设置在第一和第二电路板之间，每个间隔件延伸穿过第二电路板的一个孔并被接纳在一个轨道构件的第一多个孔中的一个孔内。 端子销附接到第一电路板，延伸穿过第二电路板的至少一个端子引脚和用于连接到基板上的一个连接区域的第二多个孔中的相应一个。 第二多个孔中的每一个的尺寸被设计成允许轨道构件在组装功率转换器模块期间可滑动地定位在端子销上方。

公开(公告)号：US5781093A

公开(公告)日：1998-07-14

申请号：US693878

申请日：1996-08-05

申请人： Paul E. Grandmont ,  Qun Lu ,  Fei Ma

发明人： Paul E. Grandmont ,  Qun Lu ,  Fei Ma

IPC分类号： H01F17/00 ,  H01F27/28 ,  H01F41/04 ,  H01F5/00

CPC分类号： H01F27/2804 ,  H01F17/0006 ,  H01F41/041

摘要： A planar winding assembly includes first and second windings, each winding having an axis and a pair of insulative sheet layers, laminated together, with at least one of each of the pairs of insulative sheets having a hole. Each winding further includes a metal strip conductor that is wound about the axis of its winding and is sealed between the laminated insulative sheet layers. The metal strip conductor has a portion projecting into the hole. The metal strip conductor of the first winding is electrically connected to the metal strip conductor of the second winding through the holes of the insulative sheets.

公开(公告)号：US20230165815A1

公开(公告)日：2023-06-01

申请号：US17942657

申请日：2022-09-12

申请人： Qun Lu

发明人： Qun Lu ,  Yan-Hua Chen ,  Yi Zhu ,  Byron Aguilar

IPC分类号： A61K31/18 ,  A61K31/166 ,  A61P25/28 ,  A61K31/505 ,  A61K31/343

CPC分类号： A61K31/18 ,  A61K31/166 ,  A61K31/343 ,  A61K31/505 ,  A61P25/28

摘要： Methods of treating Alzheimer’s disease and other neurodegenerative and/or neurocognitive and/or neurodevelopmental diseases are described. The methods comprise the administration of compounds that modulate an activity of cell division control protein 42 (Cdc42), such as the interaction between Cdc42 and intersectin (ITSN). Exemplary modulator compounds include thioureas, disulfonamides of fused aromatic systems (e.g., benzofuran), and acyl hydrazones, among others. Some of the modulator compounds act as activators of Cdc42, while others act as inhibitors. In some cases, the modulator compound has dual functionality and the ability of the modulator compound to act as an inhibitor or activator depends on whether or not Cdc42 is already activated in a particular disease stage or biological environment by an upstream activating signal of Cdc42.

公开(公告)号：US07663637B2

公开(公告)日：2010-02-16

申请号：US11669383

申请日：2007-01-31

申请人： Karen Elaine Mason ,  Qun Lu ,  Thomas Allen Stoeckel, Jr. ,  Stewart A. Sabadell ,  Jose Madeira de Freitas Garcia ,  John G. Ford, III

发明人： Karen Elaine Mason ,  Qun Lu ,  Thomas Allen Stoeckel, Jr. ,  Stewart A. Sabadell ,  Jose Madeira de Freitas Garcia ,  John G. Ford, III

IPC分类号： G09G5/00 ,  G06F17/00 ,  G06F17/50 ,  G06G7/70 ,  B60T7/12

CPC分类号： G06F17/50 ,  Y10S715/964

摘要： Embodiments of the invention provide techniques for overriding layer display properties in computer-aided design (CAD) viewports. A method of generating a display representation of a CAD drawing includes identifying one or more layers of the CAD drawing to include in the display representation. Each of the one or more layers may be associated with a set of drawing elements and a set of layer display properties. The method also includes identifying a viewport display property for a first layer of the one or more layers and generating the display representation. The display representation may include the drawing elements associated with the one or more layers, and the appearance of the drawing elements associated with the first layer is based on the viewport display property.

摘要翻译： 本发明的实施例提供了用于在计算机辅助设计（CAD）视口中覆盖层显示属性的技术。 生成CAD图形的显示表示的方法包括识别CAD绘图的一个或多个层以包括在显示表示中。 一个或多个层中的每一个可以与一组绘图元素和一组层显示属性相关联。 该方法还包括识别一个或多个层的第一层的视口显示属性并生成显示表示。 显示表示可以包括与一个或多个层相关联的绘图元素，并且与第一层相关联的绘图元素的外观基于视口显示属性。